Over the past 50 years, more than 20,000 natural compounds have been identified in the marine environment, with an increasing focus on marine metabolites as potential sources for developing effective therapeutic agents. The field of marine drug discovery has seen remarkable growth in recent years, with numerous marine-derived therapeutic candidates in various stages of clinical trials or awaiting approval. The ocean is a potential source of natural products with diverse pharmacological properties, including antimicrobial, anticancer, antiviral, antioxidative, and anti-inflammatory activities. However, commercializing marine natural products has been challenging due to low yields and specificity of specialized (secondary) metabolites. Marine Specialized (Secondary) Metabolites and their Diverse Applications provides a broad overview of marine specialized metabolites and their potential in various industries. With comprehensive coverage, relevance to current trends, interdisciplinary approach, and practical applications, this book includes specific compounds or organisms, with a particular focus on addressing the challenges and limitations associated with them.
Advances in Heterocyclic Chemistry, Volume 146 highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Recent Advances in the Synthesis and Reactions of Selenium Heterocycles, Recent advances in the synthesis and reactions of tellurium heterocycles, The Literature of Heterocyclic Chemistry, Part XXII, 2022, Olefin metathesis in the synthesis of benzopyran, benzofuran and flavonoid scaffolds, Bimanes in Retrospect: An In-Depth Analysis of Their Chemical Evolution and Applications of Derivatives Over the Last Half Century, Ring-Fluorination of Heterocycles using Chemical and Electrochemical Methods, and Heterocyclic Zwitterions Based on Coupled Polymethines.
Studies in Natural Products Chemistry, Volume 85 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts on fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects.With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
Antidiabetic Drug Discovery from Natural Products provides up-to-date and in-depth information, practical understanding, and guidance in a comprehensive, systematic and easy-to-understand manner to scientists, researchers, and graduate students on important and emerging biochemical topics related to current antidiabetic drug discovery research. This book analyzes and studies natural active substances and their medicinal chemistry in preventing and treating diabetes and its complications. It covers a wide range of critical issues to assist chemists in the discovery and development of safer, more affordable treatments, from identifying promising leads from medicinal plants to the extraction and synthesis of bioactive compounds.Following an introduction to bioactive chemical compounds from plants with antidiabetic effects, the book describes the discovery and extraction of antidiabetic drugs and antioxidants from natural sources. It also examines antidiabetic plants before delving deeper into the chemistry behind major medicinal substances and their derivatives like Mangiferin and Resveratrol, discussing both current and prospective uses.
Advances in Organometallic Chemistry, Volume 83, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Chapters in this new release include Pd-catalysis: a useful tool in the field of polymer synthesis. Recent advances and applications, Modern Mechanistic Approaches for the Depolymerization of Commodity Plastics via Homogeneous Metal Catalysis, Functionalization of fullerenes by transition metal catalyzed cyclization reactions, and Synergistic Metal-Ligand Reactivity in Half-Sandwich Complexes of Fe, Co, and Ni for Bond Activation and Catalysis.
The Alkaloids: Chemistry and Biology, Volume 93, the latest release in a series that has been exploring the topic for over 60 years, delves into key aspects of alkaloid chemistry, biology, and pharmacology. This volume discusses the chemistry of quinoline and quinazoline alkaloids, guanidine alkaloids from marine sponges, the chemistry and biology of stemona alkaloids, and the chemistry and biology of pyrazole and indazole alkaloids.
Organic Syntheses Based on Named Reactions: A Practical Encyclopedic Guide to Over 800 Transformations, Fourth Edition is an indispensable reference companion for chemistry students and researchers. The book provides an overview of name reactions based on reaction types and products formed and presents schemes, procedures and references in a simple, one-page format that offers a brief, representative procedure for each name reaction. The book is illustrated with real synthetic examples from literature, with about 3,400 references to primary literature that direct users to additional information. Extensive indexes (name, reagent, reaction) and a very useful functional group transformation index help the reader fully navigate this extensive collection of important reactions.With its comprehensive coverage, superb organization and quality of presentation, this new edition belongs on the shelf of every organic chemist.
Phytochemicals for Health presents the state of the art in the field of Phytochemicals. It highlights how, following the interactions of plants and the environment, an analytical approach for standardization and quality control is of fundamental importance to product quality control.Parts I and II cover the main problems relatied to natural products (plants, extraction, quantitative analysis, relationship with the surrounding environment). Part III presents the main classes of organic compounds identified and reported, and Part IV includes inorganic compounds. It also includes a chapter covering all the natural compounds that have become Active Principle Ingredients (API), highlighting next challenges.Phytochemicals for Health is a valuable tool for senior scientists working in natural products field interested in investigating the correlation between chemical profile and biological activity in order to obtain a product that is safe for human health.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.Studies in Natural Products Chemistry, volume 84 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Discovery and Development of Anti-Prostate Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This new volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogues that show promising potential to act as anti-prostate cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.It will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for prostate cancer, highlighting several key structures from natural products and exploring possible future developments in the area.