The aim of the Journal is to provide a forum for the critical analysis of advanced drug and gene delivery systems and their applications in human and veterinary medicine. The Journal has a broad scope, covering the key issues for effective drug and gene delivery, from administration to site-specific delivery.In general, the Journal publishes review articles in a Theme Issue format. Each Theme Issue provides a comprehensive and critical examination of current and emerging research on the design and development of advanced drug and gene delivery systems and their application to experimental and clinical therapeutics. The goal is to illustrate the pivotal role of a multidisciplinary approach to modern drug delivery, encompassing the application of sound biological and physicochemical principles to the engineering of drug delivery systems to meet the therapeutic need at hand. Importantly the Editorial Team of ADDR asks that the authors effectively window the extensive volume of literature, pick the important contributions and explain their importance, produce a forward looking identification of the challenges facing the field and produce a Conclusions section with expert recommendations to address the issues.Articles review the current status of a specific topic, giving equal emphasis to the identification of major conceptual and technological challenges to successful drug and gene delivery, to an evaluation of triumphs as well as shortcomings in current conceptual and technical approaches, and to a discussion of their possible solution.Theme issues are commissioned by one of the Executive Editors or the Editor-in-Chief. The Journal does not publish stand alone manuscripts. If you wish to submit a theme issue topic for consideration, please contact one of the editors.Benefits to authors We also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services .Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center
A journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental, security and engineering science.Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment.The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria.Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.Manuscripts describing the results of measurements of radioactive or other substances in any medium that have been obtained using well-established analytical methods will not be accepted unless they also describe substantial innovations or improvements in the analytical methodology. Relevant topics for Applied Radiation and Isotopes include the following, however, authors are encouraged to suggest other topics which might also be published in the journal:Radiation Sources: design, construction, production, characteristics.Radionuclides: production, activation cross-sections, target design, processing, quality control procedures.Synthesis of Labelled Compounds: synthesis, purification, quality control, in vitro testing of radionuclide-labelled compounds/ radiopharmaceuticals.Measurement of Radiation and Radioactivity: measurement of X-rays, γ-rays, α- and β-particles and other forms of radiation; nuclear instrumentation, including radiation spectrometry, dosimetry, novel counting systems and whole-body counters, novel radiation detector systems.Radioanalytical Methods: activation analysis, isotope dilution analysis, radioimmunoassay, radionuclide tomography, radiation spectrometry.Nuclear Physics and Chemistry topics including data compilations, directly relevant to practical applications.Nuclear Magnetic Resonance/Electron Spin Resonance: dosimetry, dating, imaging, biomedical applications and radiation accidents.Medical Radiation: the development of applications of ionising radiation and radioisotopes in radiation therapy, imaging and nuclear medicine.Accelerator Mass Spectrometry: methodology, biomedical, environmental and other applications.Nuclear Geophysics: studies of the earth's crust, the hydrosphere, the atmosphere and planetary bodies; nuclear methods for exploration, extraction, transport and use of water, oil, gas, coal and other minerals.Radiochemistry: chemical behaviour and speciation of radionuclides.Environment: chemical behaviour and speciation of radionuclides and labelled compounds other than those of direct clinical interest, in geological, environmental, human, animal or plant systems; factors which modify this behaviour.Manuscripts, which will be subject to peer review, should take one of the following forms:Full length articles, which should be definitive and describe a reasonably complete investigation.Short Communications, which may describe new, unpublished information, including preliminary communications and work in progress.Correspondence, containing comments related to articles previously published in the journal. This type of communication should not exceed two printed pages in order to expedite their publication.Review articles and conference proceedings may also be accepted for publication, following discussion with an editor of the journal.
The Tetrahedron Journal for Research at the Interface of Chemistry and BiologyBioorganic & Medicinal Chemistry publishes complete accounts of research of outstanding significance and timeliness on all aspects of molecular interactions at the interface of chemistry and biology, together with critical review articles. The journal publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents.The Journal welcomes papers on:the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targetsthe reporting of the discovery, design or optimization of potent new compounds or biological agentsthe analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental datathe reporting of "first-in-class" new therapeutic compoundsthe chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanismmethodological advances that are chemistry-based and which significantly impact on medicine or biologythe preparation and examination of biotherapeutics for the treatment of pathophysiological disease statesthe development of materials for specific therapeutic targetingAll manuscripts will be rigorously peer-reviewed by independent experts following an initial assessment by the Editors. Please note that BMC is not suitable for straightforward reports of incremental advances. Above all the presentation of a rational basis and a sound underlying hypothesis for the work is of particular importance, whatever its exact field.
BMCL (Bioorganic & Medicinal Chemistry Letters) publishes research communications of outstanding significance and timeliness on topics at the interface of chemistry and biology, together with concise review articles and perspectives. BMCL publishes reports of experimental results in medicinal chemistry, chemical biology and drug discovery and design, emphasizing new and emerging advances and concepts in these fields. The aim of BMCL is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. BMCL continues to be a major forum for the first publication of new chemical entities prior to them entering clinical trials.BMCL welcomes papers on: the medicinal chemistry and associated biology (including target identification and validation) of established or new disease targetsThe reporting of the discovery, design or optimization of potent new compounds or biological agentsthe analysis and discussion of structure-activity relationships and pharmacological issues relevant to drug design and action using in vitro and in vivo models, including the use of computational techniques when closely linked to experimental datathe reporting of "first-in-class" new therapeutic compoundsthe chemical biology or bioorganic/bioinorganic chemistry that significantly advances knowledge of a biological mechanismmethodological advances that are chemistry-based and which significantly impact on medicine or biologythe preparation and examination of biotherapeutics for the treatment of pathophysiological disease statesthe development of materials for specific therapeutic targetingManuscripts on phytochemistry, theoretical molecular dynamics and exclusively computational papers are out of scope. All manuscripts will be rigorously peer-reviewed by independent experts following an initial assessment by the Editors. Please note that BMCL is not suitable for straightforward reports of incremental advances. Above all the presentation of a rational basis and a sound underlying hypothesis for the work is of particular importance, whatever its exact field.
Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry.For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature.The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.Benefits to authors We also provide many author benefits, such as a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.Please see our Guide for Authors for information on article submission. If you require any further information or help, please visit our Support Center
Biosensors & Bioelectronics has an open access companion journal Biosensors &Bioelectronics: X . To submit to Biosensors & Bioelectronics: X visit https://www.editorialmanager.com/BIOSX/default.aspx.Biosensors are defined as analytical devices incorporating a biological material, a biologically derived material or a biomimic intimately associated with or integrated within a physicochemical transducer or transducing microsystem, which may be optical, electrochemical, thermometric, piezoelectric, magnetic or micromechanical (Turner et al., 1987; Turner, 1989). Biosensors & Bioelectronics is the principal international journal devoted to research, design, development and application of biosensors and bioelectronics. It is an interdisciplinary journal serving professionals with an interest in the exploitation of biological materials and designs in novel diagnostic and electronic devices including sensors, DNA chips, electronic noses, lab-on-a-chip and μ-TAS. Biosensors usually yield a digital electronic signal which is proportional to the concentration of a specific analyte or group of analytes. While the signal may in principle be continuous, devices can be configured to yield single measurements to meet specific market requirements. Examples of Biosensors include immunosensors, enzyme-based biosensors, organism- and whole cell-based biosensors. They have been applied to a wide variety of analytical problems including uses in medicine, biomedical research, drug discovery, the environment, food, process industries, security and defence. The design and study of molecular and supramolecular structures with molecular biorecognition and biomimetic properties for use in analytical devices is also included within the scope of the journal. Here the focus is on the complementary intersection between molecular recognition, nanotechnology, molecular imprinting and supramolecular chemistry to improve the analytical performance and robustness of devices.The emerging field of Bioelectronics seeks to exploit biology in conjunction with electronics in a wider context encompassing, for example, biological fuel cells, bionics and biomaterials for information processing, information storage, electronic components and actuators. A key aspect is the interface between biological materials and micro- and nano-electronics.While endeavouring to maintain coherence in the scope of the journal, the editors will accept reviews and papers of obvious relevance to the community, which describe important new concepts, underpin understanding of the field or provide important insights into the practical application, manufacture and commercialisation of biosensors and bioelectronics.
A Journal Devoted to Scientific and Technological Aspects of Industrially Relevant PolysaccharidesCarbohydrate Polymers is a major journal within the field of glycoscience, and covers the study and exploitation of polysaccharides which have current or potential application in areas such as bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering and wood, and other aspects of glycoscience.The role of the well-characterized carbohydrate polymer must be the major proportion of the work reported, not a peripheral topic. At least one named carbohydrate polymer must be cited and be the main focus of the paper and its title. Research must be innovative and advance scientific knowledge.Characterization - For all polysaccharides or their derivatives, including those obtained from a supplier, essential structural information which will affect their behavior in the subsequent work should be given, along with a description of how that information was ascertained. Editors are unlikely to send papers for formal review if the glycan is not adequately characterized. Please read the guidelines Characterization of carbohydrates and related products carefully as it contains all relevant information.Hypotheses - Nearly all scientific papers benefit from inclusion of a statement of hypothesis. Such statements should be concise, declarative, and should describe the one or more key hypotheses that the studies upon which the manuscript is based were intended to confirm or refute. Inclusion of a hypothesis statement makes it simple to contrast the hypothesis with the most relevant previous literature and point out what the authors feel is distinct about the current hypothesis (novelty). It also permits the authors to describe why they feel it would be important to prove the hypothesis correct (significance).Topics of interest to the journal: structure-property relationships analytical methods chemical, enzymatic and physical modifications biosynthesis natural functions interactions with other materialsTopics not of interest to the journal: Bibliometric reviews Studies that involve only modelling without any comparison of model results with experimental data, either carried out by the authors or from the literature. biological, physiological and pharmacological aspects of non-carbohydratemolecules attached to, or mixed with, carbohydrate polymers, unless the polysaccharide has a relevant and specific role materials science of biocomposites where there is no mention of any specific carbohydrate polymer, or the role of the carbohydrate polymer is not the major proportion of the study polyalkanoates, polylactic acid, or lignin routine studies of extraction yields without characterisation of the extracted polysaccharide under the different conditions routine studies of complexation of a drug with a single cyclodextrin studies of newly discovered natural polysaccharides or new polysaccharide derivatives where the structure of the polysaccharide (derivative) is unknown production and isolation of enzymes which act on polysaccharides (studies on the mode of action of an enzyme on a polysaccharide are within the journal scope)carbohydrate oligomers where the degree of polymerization is equal to or less than four treatments of cotton fabrics and cellulose-based paper where the research is largely not about the component cellulose itself use of carbohydrate polymers as a support material (e.g. in enzyme immobilization, chromatography, etc.) where there is no specific involvement of the chemistry of the carbohydrate polymer production of chars from polysaccharides, regardless of the application to which the char will be used. Such manuscripts are out of scope since they do not focus on the science of well-characterized polysaccharidesStudies of routine preparation of polysaccharides such as cellulose nanocrystals or cellulose nanofibers where the focus is on preparation from a particular plant source, including “new” plant sources, rather than advancing the science of polysaccharide structure, properties, and synthetic methods.Carbohydrate Polymers has an open access companion journal, Carbohydrate Polymer Technologies and Applications, which is devoted to scientific and technological aspects and applications of polymers and oligomers containing carbohydrate.
An International Journal of Molecular GlycoscienceCarbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects.Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence.Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".
The journal Carbon is an international multidisciplinary forum for communicating scientific advances in the field of carbon-based materials, including low-dimensional carbon-based nanostructures. The journal reports new, relevant and significant findings related to the formation, structure, properties, behaviors, and technological applications of carbons, which are a broad class of ordered or disordered solid phases composed primarily of elemental carbon. These materials can be either synthetic or of natural origin, and include, but are not limited to: carbon black; carbon fibers and filaments; carbon nanotubes; diamond and diamond-like carbon; fullerenes; glassy carbon; graphite; graphene; graphene-oxide; porous carbons; pyrolytic carbon; and other sp2 and non-sp2 hybridized carbon systems.Papers may also be considered by the Editors provided:(i) the carbon component is the major focus of the paper's scientific content, for example, in composites (including vertical stacking of two-dimensional (2D) systems); or (ii) the focus is on organic substances if they are new precursors for carbon materials with novel characteristics; or, (iii) relate to carbon compounds such as nitrides and carbides (e.g. C3N4, MXenes) if the new properties or findings can be attributed to the carbon compositions; or (iv) topics related to net zero and sustainability that have the potential to impact carbon science.Relevant application areas for carbon materials include, but are not limited to: biology and medicine; catalysis; electronic, optoelectronic, spintronic, high-frequency, and photonic devices; energy storage and conversion systems; environmental applications and water treatment; smart materials and systems; and, structural and thermal applications.In addition to regular issues, Virtual Special Issues on selected topics are organized from time to time in this journal. Each submission will be evaluated using the same editorial process as that used for regular submissions, and once accepted, will be published online as soon as possible, and featured as part of the Virtual Special Issue. To find out more about the ongoing special issues, please refer to the Announcement section of the journal homepage.Carbon is the companion title to the open access journal Carbon Trends.
Cell Chemical Biology (originally Chemistry & Biology) is a Cell Press journal that aims to publish and promote the most important advances in chemical biology with integrity, responsiveness, fairness, and friendliness. Chemical biology is a multidisciplinary discipline that harnesses chemical principles to discover the molecular mechanisms of biological function and disease etiology and develop solutions for life sciences, biotechnology, and human health.Cell Chemical Biology encourages submission of basic, translational, and clinical research articles that provide significant conceptual advancements of broad general interest to researchers within the biological sciences, the biomedical sciences, and associated fields. Research areas that we consider within our scope include but are not limited to cancer biology, immunology, cell biology, microbiology, virology, RNA biology, synthetic biology, protein engineering, genome editing, drug discovery, metabolism, and physiology.We are interested in papers that report molecular mechanisms underlying cellular processes or disease biology, those that report new therapeutics derived from utilizing chemical biology tools, and those that report technologies that perturb, visualize, or measure biological processes. Examples of chemical or molecular tools include but are not confined to nucleic acids and/or their modifications, small molecules, antibodies, biologics, probes, engineered proteins, metabolites, lipids, sugars, and post-translational modifications.We also welcome submissions reporting significant technical advancements in molecular probes, sensors, tools, and technologies, including a proof-of-principle demonstration that the new methodology/tool will help address important questions in biomedical research that are of interest to our broad readership (from basic scientists to clinicians).For further clarifications or questions about our aims and scope, please feel welcome to contact us at [email protected] or email editors directly. You can also submit your manuscript as a presubmission inquiry.Visit the Cell Press website for more information about Cell Chemical Biology - http://www.cell.com/cell-chemical-biology/home