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Elsevier

Books in Immunology

Elsevier's Immunology collection equips researchers with valuable insights to address the complexities of the immune system and its role in health and disease, offering original research, insightful analysis, and current theory on diagnosing, managing, and advancing treatments for allergies, asthma, and immunologic disorders.

  • The Vaccine Book

    New Insights, Approaches, and Technologies
    • 3rd Edition
    • Fabio Bagnoli + 2 more
    • English
    The Vaccine Book: New Insights, Approaches and Technologies, Third Edition provides comprehensive information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. Edited by a new, highly experienced team of editors, the 3rd edition provides new approaches, design, and vaccine platform tools to develop vaccines quicker.This new edition is fully updated and designed for students, researchers, public health offcials, and all others interested in increasing their understanding of vaccines.

  • Microbiome and Tumorigenesis in Different Cancers

    • 1st Edition
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis in Different Cancers delves into the intricate relationship between the human microbiome and various health conditions, with a particular focus on cancer. It is divided into five parts, each addressing a critical aspect of microbiome research and its implications for health and disease. In 4 parts, the book provides a foundational understanding of the human microbiome, examines the dual role of the microbiome in cancer development, discusses the role of dysbiosis in gastrointestinal, skin, oral, lung, genitourinary, and hematological malignancies, and gives an overview of the methodologies used to study the microbiome.The final part explores the emerging field of pharmacomicrobiomics... focusing on the interaction between the microbiome and cancer therapies. This book serves as a valuable resource for researchers, clinicians, and students interested in understanding the complex interplay between the microbiome and cancer, offering insights into potential therapeutic strategies and future directions in microbiome research.

  • Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology

    • 1st Edition
    • Swagat Kumar Das + 2 more
    • English
    Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology delves into historical perspectives, current trends, and future projections for research and development of immunological and biopharmaceutical products. Sections explore immunostimulants, natural and synthetic immunostimulants in aquaculture and animal husbandry, immunomodulators, immune boosters, pre- and probiotics in health promotion, cutting-edge immunological techniques for disease diagnosis, immunotherapy in cancer treatment, and transplantation immunology. Following chapters explore the impact on pharmaceutical biotechnology, with discussions on traditional and modern approaches in drug delivery, in silico drug delivery modeling, biocomposites and their pharmaceutical applications, recent advances in monoclonal antibodies production, vaccine development, and much more. Finally, the book covers the pivotal role of AI, machine learning, and data analytics in the clinical study of immunotherapy and pharmaceutical drugs, thus paving the way for enhanced research and development efficiency. Researchers in industry and academia alike will gain valuable insights into the novel principles behind designing and developing immunological and drug products, making this title an essential resource.

  • Immunotherapy for Autoimmune Disorders

    Innovations and Insights
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Immunotherapy for Autoimmune Disorders: Innovations and Insights revolutionizes the therapeutic paradigm for autoimmune illnesses, offering new perspectives over traditional medication therapies. This complete and accessible resource examines how immunotherapy teaches the immune system to detect and fight targeted cells, enhancing the body's immune response by providing additional components to strengthen its defense mechanisms. The book covers a wide range of topics, including the pathophysiology, diagnosis, and classification of autoimmune diseases, the immunopathogenesis of these disorders, and the development and application of monoclonal antibodies. It explores immune checkpoint inhibitors, T-cell modulation therapies, cytokine targeting therapies, B-cell depletion strategies, and more.Additionally, it addresses immunomodulatory agents, small molecules, personalized immunotherapy approaches, and the application of immunotherapeutic strategies for specific autoimmune diseases. Future directions and emerging therapies, as well as regulatory and ethical considerations, are also discussed. This is essential reading for medical professionals, researchers, and students seeking to learn about immunotherapy as an alternative approach to treating autoimmune disorders.

  • Immunological Insights and Emerging Therapeutics in Medical Mycology

    • 1st Edition
    • Paschalis Vergidis + 1 more
    • English
    Immunological Insights and Emerging Therapeutics in Medical Mycology summarizes the current knowledge on interactions between host cells and human fungal pathogens and explains how certain immune defects lead to vulnerability to fungal infection.Chapters focus on immune response to such fungal infections as candidiasis, aspergillus, cryptococcosis, mucormycosis, pneumocystis.This title provides a basis for further study on antifungal immunity by enhancing understanding of antifungal immune responses. Further, this title offers new insights from the host immune response, improving understanding of disease pathogenesis and informing novel prophylactic and therapeutic approaches to fungal infections.

  • Building Blocks of Neuroimmunometabolism

    From Molecular Pathways to Therapeutic Strategies
    • 1st Edition
    • Sachchida Nand Rai + 2 more
    • English
    Building Blocks of Neuroimmunometabolis... From Molecular Pathways to Therapeutic Strategies offers an authoritative exploration of the intricate relationship between the immune system and neurodegenerative diseases. This essential resource addresses the critical gap in understanding how immune responses and metabolic processes jointly influence the onset and progression of conditions such as Alzheimer’s, Parkinson’s, and multiple sclerosis. The book provides an examination of key molecular pathways and cellular interactions, emphasizing the role of immunometabolism in disease mechanisms. Beginning with an introduction to the concept of immunometabolism, it explores the connections between the immune and nervous systems, setting the stage for understanding neurodegenerative diseases.In addition, the book discusses pivotal topics such as the role of microglia and macrophages in neuroinflammation, the metabolic regulation of T cells, and the impact of oxidative stress and mitochondrial dysfunction. The gut-brain axis is examined for its influence on brain health, alongside innovative therapeutic strategies targeting immunometabolic pathways and lifestyle interventions.

  • Glycobiology of the Immune System and Disease

    • 1st Edition
    • Shyamasree Ghosh + 1 more
    • English
    Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, it is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.

  • Inflammation in Tumorigenesis and Cancer Treatment, Volume 9

    From Molecular Mechanisms to Personalized Therapeutic Strategies
    • 1st Edition
    • Chunxiang Zhang + 1 more
    • English
    Inflammation in Tumorigenesis and Cancer Treatment: From Molecular Mechanisms to Personalized Therapeutic Strategies explores the pivotal role of inflammation in cancer. It uncovers the molecular dialogue between inflammatory factors and tumor cells, illuminating pathways that drive oncogenesis and metastasis. Highlighting the rapid pace of discovery, the book bridges the gap by translating complex data into actionable clinical strategies, catering to students and professionals and addressing personalized medicine. Early chapters focus on the fundamental concepts of inflammation in cancer and recent advances in research, while also covering the impact of inflammatory mediators on signaling pathways and oncogenesis.Other sections explore therapeutic strategies targeting inflammatory pathways and the role of immunometabolism and discuss biomarker discovery and personalized treatment plans. The final section examines the tumor microenvironment, the microbiome's role, and the intersection of immunotherapy and inflammation. The book offers numerous benefits to its audience. For scientists and researchers, it provides cutting-edge knowledge to inspire new research directions and foster interdisciplinary collaboration while serving as a valuable educational tool for the next generation of researchers.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 172
    • English
    Advances in Cancer Research, Volume 172 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Memantine and its Analogs: Potential Applications in Cancer Therapy, The role of epigenetic modifications in mediating cancer health disparities, Tumor Associated Macrophages: Ontogeny, Plasticity, Spatial Ecosystems, and Therapeutic Targeting, Recognizing the significance of cancer-nerve crosstalk in advanced prostate cancer, and much more.

  • The Inflammatory Ecosystem and Inflammazones

    Mapping the Complex Terrain of Inflammatory Diseases
    • 1st Edition
    • Erwei Song + 1 more
    • English
    The Inflammatory Ecosystem and Inflammazones: Mapping the Complex Terrain of Inflammatory Diseases offers a groundbreaking framework for understanding inflammation across multiple spatial and molecular levels. The book introduces the concept of distinct inflammazones—local, regional, distal, and systemic—and explores how their interactions influence disease development, progression, and resolution. This holistic approach integrates cellular, molecular, microbiome, and systemic responses, addressing a critical gap in current knowledge and advancing diagnostics and therapies for diseases like autoimmunity and cancer. The book is organized into six sections, starting with foundational principles and progressing through mechanisms of local, regional, and systemic inflammazones.It covers key components such as cytokines, chemokines, immune cells, and the roles of non-immune cells like fibroblasts and epithelial cells. The final sections focus on systems-level insights, including inflammaging, metabolism, and multi-omics technologies, culminating in strategies for personalized medicine and clinical translation. Each chapter combines cutting-edge research with clinical relevance, making complex concepts accessible and actionable.

  • The Dual Role of Inflammation in Cancer

    • 1st Edition
    • Surajit Pathak + 1 more
    • English
    The Dual Role of Inflammation in Cancer Genesis and Therapy explores the pivotal role inflammation plays in the development and progression of cancer. The book delves into how chronic inflammation creates a microenvironment that supports tumor growth by promoting cellular proliferation, survival, and migration while suppressing immune responses. It traces historical observations, linking inflammation to cancer while also examining how inflammatory cells and mediators contribute to various stages of tumorigenesis. In addition, it discusses the implications of inflammation on cancer treatment, highlighting the potential of anti-inflammatory agents and immunotherapy in targeting the inflammatory tumor microenvironment.By elucidating on the intricate relationship between inflammation and cancer, the book aims to pave the way for more effective and personalized cancer treatment strategies. As such, it is a valuable resource for researchers in immunology and oncology.

  • The Microbiome and Cancer Treatment

    Overcoming Resistance and Enhancing Efficacy
    • 1st Edition
    • Sadhna Aggarwal + 3 more
    • English
    The Microbiome and Cancer Treatment: Overcoming Resistance and Enhancing Efficacy delves into the intricate relationship between the microbiome and cancer treatment, highlighting the microbiome's critical role in drug resistance and therapeutic efficacy. The book's chapters are meticulously organized to provide a deep understanding of how the microbiome interacts with the immune system and influences cancer development and response to therapies. This book opens new avenues for investigation by providing a better understanding of the mechanisms of resistance and the role of microbiome alterations in chemoresistance.Sect... also address the complex "chicken-or-egg" relationship between microbiome alterations and chemoresistance. A diverse blend of chapters foster interdisciplinary collaboration across fields such as immunology, microbiology, oncology, and pharmacology, promoting holistic approaches to cancer treatment. Readers will benefit by gaining awareness and a better understanding of how the microbiome impacts health, particularly in the context of cancer, leading to more informed health choices.

  • The Immunology of Horses and Donkeys

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Horses and Donkeys offers a comprehensive overview of the immune systems of equids, bridging a critical gap by combining current research with foundational concepts and emphasizing both mechanisms and practical applications. The book covers immune development, disease resistance, vaccination, and immune disorders, supporting improved health management in horses and donkeys. Organized logically, it begins with the evolutionary history and domestication of equids and then explores immune ontogeny, innate and adaptive responses, and lymphoid tissue structure. Chapters detail the major histocompatibility complex, cytokine signaling, antigen-presenting cells, and mucosal immunity.Additional sections address the microbiota, vaccine strategies, and immune responses to bacterial, viral, and parasitic infections, providing a holistic view of equine immune health. Users will find content that advances understanding in immunology, biomedical research, and veterinary medicine, supporting the development of better diagnostics, vaccines, and therapies. The book's clear, thorough approach benefits both scientific discovery and clinical application, ultimately improving equine health and informing broader mammalian immunology studies.

  • Microglial Advances in Neurodegenerative Diseases

    • 1st Edition
    • Volume 171
    • English
    Microglial Advances in Neurodegenerative Diseases, Volume 170 in the Advances in Immunology series, presents current developments and comprehensive reviews focused on the role of microglia and neuroinflammation in neurological and psychiatric disorders. This volume brings together contributions from leading researchers, offering up-to-date insights into microglial biology in health and disease, as well as their involvement in major neurodegenerative conditions. Chapters in this new release explore Cross-talk between Tau and Neuro-glia Axis of Alzheimer’s Disease, Microglia in Health and Disease, Amyloid-beta (Aβ) and Neuroinflammation in Microglia, Chemokine Receptor CX3CR1 Interacts with Tau and Regulates Microglial Activity in Alzheimer’s Disease, and much more.Additional chapters explore Human-Induced Pluripotent Stem Cells in Psychiatric Disorders, GPCR-Mediated Internalization and Endosomal Sorting of the Tau–GPCR Complex in Microglia, iPSC-Derived Microglia: A Cellular Platform for Tau and Alzheimer’s Disease Immunotherapy, Advancements in Invasive and Non-Invasive Neuromodulation for Parkinson’s Disease, LRRK2-I1371V Disrupts Microglial Membrane Homeostasis and Enhances α-Synuclein Toxicity, Microglial Advances in Parkinson’s Disease, Microglial Advances in Alzheimer’s Disease, and more.

  • Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications

    Part B
    • 1st Edition
    • Volume 170
    • English
    Advances in Immunology, Volume 170 presents current developments and comprehensive reviews in immunology. This volume focuses on mechanisms of gasdermin activation and pyroptosis, providing insights into inflammatory cell death and immune signaling, and serving as a valuable reference for researchers in the field.

  • Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications

    Part A
    • 1st Edition
    • Volume 169
    • English
    Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Therapeutic Implications, Volume 169 in the Advances in Immunology series, presents an authoritative exploration on how microbial communities contribute to the initiation, progression, and treatment of head and neck cancers. Chapters highlight The Microbiome of the Head and Neck Region, Overview Head and Neck Microbiota and the Factors Influencing the Head and Neck Microbiome, Mechanistic Pathways of Dysbiosis in Cancer Development, Oral Microbiota and OPMDs, Oral Potentially Malignant Disorders (OPMDs): An Overview, Oral Microbiota and Oral Cancer, Oral Squamous Cell Carcinoma (OSCC): An Overview, and much more.Additional chapters cover the Role of the Oral Microbiome in Oral Cancer (OSCC), Microbiome as a Prognostic Indicator in Oral Cancer, Diagnostic and Therapeutic Applications, Microbiome-Based Diagnostic Approaches, Modulating the Head and Neck Microbiome for Cancer Prevention, Microbiome-Targeted Therapeutics in Head and Neck Cancer, Artificial Intelligence in Microbiome Data Analysis: Applications in Head and Neck Cancer, and Challenges and Future Directions in Head & Neck Microbiome Research.

  • The Cytokines of the Immune System

    The Role of Cytokines in Disease Related to Immune Response
    • 2nd Edition
    • Zlatko Dembic
    • English
    Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response, Second Edition is a comprehensive and essential resource for graduate and postgraduate training of physicians, dentists, biomedical specialists, and those interested in scientific research in biology and biochemistry. The book provides an up-to-date, textbook-like description of immunology, focusing on the critical role of cytokines in immune responses. With advancements in cytokine research and signal transduction, this new and improved edition offers a deeper understanding of cytokine-receptor interactions, supported by novel figures based on crystal-structure conformations from the protein database.These insights are invaluable for inspiring new drug designs and therapeutic strategies. The book delivers a thorough overview of immunology, detailing the development and regulation of the immune system, with a special focus on cytokines. It presents an upgraded description of interleukins, immune-modulatory cytokines, and chemokines, exploring their structure, sources, functions, receptors, disease associations, and therapeutic potentials. This edition also introduces the latest information on innate lymphoid cells and their cytokines, as well as their adaptive immunity counterparts. A dedicated chapter on the cytokine storm provides critical insights into this phenomenon.

  • Systemic Lupus Erythematosus

    Basic, Applied and Clinical Aspects
    • 3rd Edition
    • George C. Tsokos
    • English
    Systemic Lupus Erythematosus: Basic, Applied and Clinical Aspects has been an essential resource for scientists and clinicians in this field since its original publication in 2015. The third edition of this work has been completely updated and expanded with the latest scientific and clinical developments in Systemic Lupus Erythematosus (SLE) to date. Contributors at the forefront of each topic come together to enhance content on epidemiology and diagnosis, pathogenesis, mechanisms of tissue damage, clinical aspects of the disease, antiphospholipid syndrome, and treatments. Also added is the latest information on new treatments, criteria, monogenic forms of lupus, insights on the role of microbiome, and advances in understanding disease pathogenesis. This must-have reference is an indispensable resource for specialists in the diagnosis and management of patients with SLE as well as early career or experienced investigators studying basic aspects of the disease. It is a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a key reference work for hospital libraries.

  • Advances in Immunology

    • 1st Edition
    • Volume 168
    • English
    Advances in Immunology, Volume 168, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Sample topics in this new release include Alarmins in mucosal tissues and how they regulate health and disease, and more.

  • Innovative Nanotechnology: Transforming Skin Cancer Diagnosis and Treatment

    • 1st Edition
    • Volume 169
    • English
    Innovative Nanotechnology: Transforming Skin Cancer Diagnosis and Treatment, Volume 169 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include an Introduction to Nanotechnology in Dermatology, Basics of Skin Cancer: Types, Diagnosis, and Current Challenges, Current Challenges in Skin Cancer Diagnosis and Treatment, Nanocarriers for Drug Delivery in Skin Cancer, Nanotechnology in Skin Cancer Diagnosis, Therapeutic Nanoparticles and Targeted Therapy, and much more.Additional chapters cover Nanotechnology in Photodynamic and Photothermal Therapy for Skin Cancer, Challenges in Translating Nanotechnology from Research to Clinical Practice, Nanotechnology and Immunotherapy Synergies in Skin Cancer, Patient-Centric Approaches and Personalized Nanomedicine in Skin Cancer, The Role of Theranostics and Nanotheranostics in Skin Cancer Management, Preclinical and Clinical Trials in Nanotech Skin Cancer Treatment, Safety, Ethical, and Regulatory Considerations in Nanotechnology for Skin Cancer, and many more interesting chapters on topics of current interest.

  • Inflammation and Cancer

    Mechanisms, Diagnosis, and Therapeutic Strategies
    • 1st Edition
    • Anoop Kumar + 4 more
    • English
    Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.

  • Immunity to Immunotherapy in Cancer

    Mechanisms and Limitations
    • 1st Edition
    • Mukesh Nandave + 1 more
    • English
    Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and scientific solutions in development. The book examines molecular strategies of immune evasion within the tumor microenvironment, providing insights into factors like tumor heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, the book aims to enhance patient outcomes and advance cancer immunotherapy.Design... as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.

  • Inflammatory Arthritis Beyond the Joints

    Comorbidities and other Manifestations
    • 1st Edition
    • Volume 18
    • Fabiola Atzeni + 1 more
    • English
    Inflammatory Arthritis Beyond the Joints, Volume 18 in Elsevier’s Handbook for Systemic Autoimmune Diseases series, provides an extensive review of the most recent research on various comorbidities and EAMs associated with inflammatory arthritis. The book emphasizes early detection, which is crucial for improving patient quality of life and survivability outcomes, as many adults with inflammatory arthritis also suffer from other chronic conditions. The book's chapters cover comorbidities and EAMs in both early and late disease stages.They delve into the mechanisms behind the development of these conditions and examine the impact of new treatment strategies specific to inflammatory arthritis and related diseases, including cardiovascular disease, metabolic syndrome, metabolic bone disease, infection, neoplasia, respiratory disease, gastrointestinal disorders, kidney issues, mental health conditions, and neurological diseases. This book serves as a valuable reference for researchers and clinicians focused on inflammatory arthritis and its associated conditions.

  • Immunological Aspects of Preterm Birth

    • 1st Edition
    • Volume 4
    • Irina Burd MD
    • English
    Immunological Aspects of Preterm Birth, a volume in the Reproductive Immunology book series, bridges reproductiveimmunolo... of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. This book reviews therole of the different immune mechanisms during pregnancy leading to preterm birth and fetal programming effects thatare connected to maternal immune activation. This book also discusses immune cells and their products, cytokines andchemokines, as central for the success of the pregnancy, from the process of implantation to parturition and the effects ofthe changes on fetal programming.While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentiallyin the last 10 years, connecting basic science to clinical science and development of new therapeutics has not progressedas rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processesassociated with preterm birth and fills an urgent need for the development of therapeutics in this space.

  • Advancing Early Diagnosis in Chronic Diseases

    Tools, Techniques, and Technologies
    • 1st Edition
    • Sachchida Nand Rai + 2 more
    • English
    Advancing Early Diagnosis in Chronic Diseases: Tools, Techniques, and Technologies explores the transformative potential of early detection strategies and technologies in reshaping chronic disease outcomes. Addressing the urgent need for innovative approaches for managing conditions such as cardiovascular diseases, diabetes, cancer, neurodegenerative disorders, and pediatric, chronic conditions, this book underscores the importance of timely interventions to reduce disease burden. The book provides a comprehensive overview of cutting-edge tools, including predictive biomarkers, artificial intelligence, genomic and proteomic screening, wearable health devices, digital twins, and point-of-care testing. Readers will gain insights into how these advancements revolutionize early diagnosis and personalized treatment.Written by experts from interdisciplinary fields, the book bridges the gap between scientific discovery and clinical application, addressing challenges such as knowledge gaps, integration barriers, and accessibility of diagnostic innovations. It covers a broad spectrum of chronic conditions, including metabolic, inflammatory, respiratory, renal, hepatic, and neurodegenerative diseases, with added focus on pediatric patients and early detection in childhood disorders.

  • Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments

    • 1st Edition
    • Tuan Anh Nguyen + 2 more
    • English
    Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments provides a balanced exploration of the dual roles of nanotechnologies in oncology. Structured in four parts, the book begins with foundational knowledge of nanovaccines and nanomedicines, detailing their applications in cancer care and highlighting their precision in targeting cancer cells while reducing systemic toxicity. Importantly, the book addresses potential drawbacks, discussing side effects and safety concerns associated with these innovations. The final section emphasizes ethical, regulatory, and safety challenges, underscoring the need for careful oversight as nanotechnologies advance.For the academic audience, this book serves as a vital resource, offering insights that equip researchers and healthcare professionals to make informed decisions regarding clinical applications. Its focus on both benefits and risks, alongside forward-looking perspectives, ensures that readers are well-prepared for future developments in the field of nanomedicine and cancer therapy.

  • Lateral Flow Assays for Rapid Point-of-care Testing

    Recent Advances, Emerging Trends, and Future Direction
    • 1st Edition
    • Seema Nara + 2 more
    • English
    The emergence and re-emergence of new infectious diseases places emphasis on the need for greater investment in rapid healthcare diagnostic solutions. As a result, lateral flow immunoassay technology is quickly evolving with new inventions. Lateral Flow Assay for Rapid Point-of-Care Testing covers today’s most significant advancements, emerging trends, and future directions linked with this technology. The book begins with a review of the format, flow, and design of old-generation lateral flow assays and the challenges impeding performance before moving into innovation in materials for rapid test strips, advances in manipulating sample flow, and the latest developments in molecular imprinting and bioconjugation techniques. Subsequent sections cover various biorecognition elements and review signal amplification as well as quantification trends. Final chapters delve into recent applications for infectious diseases detection, monitoring antibiotic resistance, multiplex detection of analytes, as well as future directions leading to the next generation of healthcare. Academicians, researchers, industrialists, and device manufacturers linked to the development of rapid and affordable point-of-care immunodiagnostics will find value in this resource.

  • Inmunología

    • 10th Edition
    • David Male + 2 more
    • Spanish
    Nueva edición de uno de los textos de referencia en inmunología de nuestro portfolio en el que se abordan de forma equilibrada e integrada los conceptos pertenecientes a la inmunología básica y clínica. La estructura general de esta edición de Inmunología es la misma que la de la novena edición, Las secciones 1 y 2 describen el funcionamiento del sistema inmunitario. La sección 3 se ocupa de las respuestas inmunitarias contra los microorganismos patógenos (la función principal del sistema inmunitario), y las secciones 4 a 6 abordan aspectos de inmunología clínica, como las enfermedades autoinmunitarias, la inmunodeficiencia, los trasplantes, la inmunología tumoral y la hipersensibilidad. Todos los capítulos se han actualizado por completo e incluyen numerosos diagramas nuevos. Especial atención merecen los Caps. 17,18,20 y 22 por su profunda actualización en temas relativos a las nuevas vacunas de mRNA, inmunización pasiva, autoinmunidad, nuevos anticuerpos y nuevas terapias celulares y los nuevos descubrimientos a raíz de la epidemia de Covid. Las secciones de razonamiento crítico que siguen a cada capítulo requieren la comprensión del material presentado y de las implicaciones en un entorno de laboratorio o clínico, y sirven como base para el debate en el aula. Otro importante instrumento pedagógico son los resúmenes que recogen los puntos clave de cada capítulo, así como los numerosos esquemas, diagramas y figuras. La nueva edición ofrece contenido adicional online en español a través de la plataforma e-book+. Incluye apartados, tablas y figuras adicionales, así como una colección de 15 videos.

  • Endotoxin in Critical Illness

    • 1st Edition
    • John Kellum + 1 more
    • English
    Endotoxin in Critical Illness intricately explores the theme of endotoxin and sepsis through the lenses of basic, clinical, and translational science. This work consolidates and synthesizes novel clinical insights and groundbreaking scientific discoveries into one comprehensive resource on endotoxic septic shock and sheds light on cutting-edge approaches in treatment. Beginning with a historical journey, the book traces the evolution of understanding from ancient concepts to modern molecular insights. It covers the physiological aspects of endotoxin sensitivity, tolerance, and human response variation. The crucial role of the gut microbiome in critical illness serves as a translational link between foundational science and clinical implications, and the complex language of bacterial communication is introduced, merging basic science with potential translational applications. In the clinical arena, chapters cover the critical role of endotoxin in septic shock, trauma, and its relevance in COVID-19, providing a translational bridge between laboratory findings and real-world clinical scenarios. The historical context of anti-endotoxin drug development is revisited, emphasizing the translational challenges faced in bridging basic science discoveries to clinical applications. The discussion on quantifying endotoxin concentration as well as the exploration of therapeutic rationale and clinical experiences with endotoxin removal therapy serve as a culmination of basic understanding translated into practical applications. The book concludes by contemplating the complexity of sepsis and acknowledging the challenges in achieving personalized medicine and underscoring the dynamic nature of the translational journey. In essence, this comprehensive exploration provides clinicians, researchers, and scientists with a holistic understanding of endotoxin and sepsis and potential advancements in patient care.

  • Myasthenia Gravis

    Disease, Diagnosis and Management
    • 1st Edition
    • Bhupendra G. Prajapati + 2 more
    • English
    Myasthenia Gravis: Disease, Diagnosis and Management is a comprehensive resource that explores recent advancements in diagnosing and treating Myasthenia Gravis, a rare autoimmune disease affecting the neuromuscular junction. With contributions from global experts, this book addresses the increasing prevalence of Myasthenia Gravis, reflecting the latest in diagnostic techniques and novel therapies such as complement inhibitors and FcRn antagonists. It aims to support healthcare professionals in delivering optimal care through evidence-based insights and patient-centered approaches. The book is divided into several chapters, beginning with an overview of the pathogenesis and immunoregulatory defects in Myasthenia Gravis. Subsequent chapters cover diagnostic methods, non-immunosuppressiv... treatments, and biological therapies targeting the immune system. Key topics include the role of intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) in severe exacerbations, thymectomy, molecular mechanisms, and the potential of hematopoietic stem cell transplants. The book also delves into precision medicine, AI applications, clinical trial considerations, and novel therapeutics like anti-FcRn antibodies. Management strategies for ocular Myasthenia Gravis, and a holistic view of living with the disease are also discussed. Myasthenia Gravis: Disease, Diagnosis and Management is invaluable for healthcare providers, physicians, immunologists, ophthalmologists, rheumatologists, physical therapists, pharmacists, and translators. It offers a modern guide to understanding and managing Myasthenia Gravis, integrating clinical expertise with the latest research to improve patient outcomes.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 168
    • English
    Advances in Cancer Research, Volume 168 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Plasticity in cell adhesion during cancer progression, AEG-1 on Cancer Drug Resistance: From Molecular Insights to Therapeutic Challenges, Multimodal AI to differentiate tumor progression from treatment effect in glioblastoma, The Role of Epigenetic Modifications in Mediating Cancer Health Disparities, In search of a targetable immune profile for acute myeloid leukemia, Notch signaling in tumorigenesis and maintenance of cancer stem cells, and much more.

  • The Immunology of the Pig

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of the Pig is a comprehensive and detailed exploration of the immune systems of domestic pigs, offering an invaluable resource for researchers, veterinarians, and students in the fields of immunology, veterinary medicine, and biomedical science. This text covers both the innate and adaptive immune systems of pigs, highlighting the unique features that make them an excellent model for human immune system studies. By examining the applied immunity of pigs, including available vaccines and immune-mediated diseases, this book addresses a critical need for understanding porcine immunology in both agricultural and biomedical contexts. The book is meticulously structured to cover a wide range of topics. It begins with the evolutionary origins and domestication of pigs, providing a historical context that enriches the understanding of their immune systems. Subsequent chapters explore key aspects of porcine immunology, including piglet ontogeny, reproduction, and lactation; innate immunity; hematology; cytokine functions; antigen processing cells; and lymphoid organs. Detailed discussions on the major histocompatibility complex, innate lymphoid cells, B and T cell systems, and immunity on body surfaces offer a thorough insight into the complex mechanisms at play. Additionally, the text addresses the microbiota's role, vaccination strategies, and immunity to various bacterial, viral, and parasitic diseases, rounding out a holistic view of porcine immune health.The Immunology of the Pig is an essential reference for anyone involved in veterinary science, immunology, or biomedical research. It provides a deep dive into the pig's immune system, presenting a wealth of information that is both scientifically rigorous and practically applicable. By understanding the parallels between porcine and human immune systems, researchers can leverage this knowledge to advance medical science, particularly in the areas of xenotransplantation and disease modeling. This book is a vital tool for advancing our understanding of immunology and improving health outcomes for both pigs and humans.

  • Encyclopedia of Immunobiology

    • 2nd Edition
    • Paul Kaye
    • English
    Encyclopedia of Immunobiology, Second Edition, Five Volume Set covers the full range of Immunology, presenting topics logically and making extensive use of "hot links" to refer the reader to related content. The new edition is not just an update of the original title; it vastly expands fields like immunotherapy, immunity to viral infection, vaccine development, inflammatory responses, and high throughput analyses. Containing 350 chapters written by world-leading experts, this edition integrates all concepts coherently and logically to paint a comprehensive picture of the evolving field of Immunology.The immune system, complex and multi-layered, has evolved to differentiate between "self" and foreign pathogens, providing protection against infections while dysregulation can cause diseases like autoimmunity, allergies, and inflammatory disorders. This understanding has led to numerous therapeutic interventions crucial for human health improvement.

  • Advances in Immunology

    • 1st Edition
    • Volume 167
    • English
    Advances in Immunology, Volume 167, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Recent Advances in Antifungal Immunity, Neuroimmunology beyond the CNS: nerve-macrophage interactions in peripheral tissues, Regulatory T cell functions in peripheral tissues, Alarmins in mucosal tissues and how they regulate health and disease, Ontogeny and function of microglia and nerve-associated macrophages, and Modulation of humoral immunity by γδ T cells.

  • Mitochondrial Signaling and Regulation

    Immune Responses and Diseases
    • 1st Edition
    • Seyyed Shamsadin Athari + 1 more
    • English
    Mitochondrial Signaling and Regulation: Immune Responses and Diseases delves into the latest research on molecular pathophysiology mechanisms and cell signaling pathways in the pathogenesis of diseases via mitochondrial regulation. This comprehensive study underscores the importance of mitochondria in cellular processes and their role in disease development. Early chapters discuss the crucial role, regulation, and crosstalk of mitochondria, highlighting their significance in maintaining cellular health. The exploration of mitochondria mutations and mitochondria-related diseases follows, providing a detailed understanding of the genetic aspects involved.Final chapters focus on mitochondria's involvement in immune responses and allegro-inflammation... presenting the intricate connections between mitochondrial function and the immune system. The book also explores the use of biotechnology in developing new treatments and targeted therapies against mitochondrial dysfunction. This resource sets the foundation for new classifications, prevention methods, therapies, and treatments of mitochondria-related diseases, making it invaluable for scientists and researchers dedicated to this field.

  • Advances in DNA and mRNA-Based strategies for Cancer Immunotherapy: Part B

    • 1st Edition
    • Volume 166
    • English
    Advances in Immunology, Volume 166, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Primary Brain Tumors in Adults: Advances in Mechanistic Understanding, Evaluation, and Management

    • 1st Edition
    • Volume 166
    • English
    Primary Brain Tumors in Adults: Advances in Mechanistic Understanding, Evaluation, and Management, Volume 166 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Molecular drivers in primary brain tumor formation, Novel CSF pathways in the glioma (DIPG), Volumetric analysis in low grade gliomas and other advanced MR imaging techniques, Liquid biopsy in the diagnosis of primary brain tumors, Intraoperative imaging techniques to improve tumor detection, and much more.Additional chapters focus on Supramaximal resection in primary brain tumors, Radiotherapeutic approaches: IMRT, re-irradiation, Molecularly driven therapies in the treatment of primary brain tumors, and Changes in the immune microenvironment and immunotherapeutic strategies in the treatment of gliomas.

  • Reproductive Immunogenetics: A Molecular and Clinical Overview

    Immune Cells and Immunotherapeutics in Recurrent Pregnancy Loss
    • 1st Edition
    • Shafat Ali + 2 more
    • English
    Immunogenetics: A Molecular and Clinical Overview: Immunogenetic Factors and Signaling Pathways in Recurrent Miscarriage, Volume Four provides an overview of the scientific knowledge, achievements, and findings in the field of immunogenetics of recurrent pregnancy loss. With a strong focus on the role immune cells can play in recurrent pregnancy loss, the book also examines immune therapeutic aspects. In seventeen chapters, the book describes the roles of several different signaling pathways and the role of JLA and microRNAs in recurrent pregnancy loss. Several chapters are dedicated to the role autoimmune antibodies play in recurrent pregnancy loss. This book is a valuable resource for health professionals, scientists, researchers, and all those who wish to broaden their knowledge in the allied field.

  • Reproductive Immunogenetics: A Molecular and Clinical Overview, Vol. 3

    Immunogenetic Factors and Signaling Pathways in Recurrent Pregnancy Loss
    • 1st Edition
    • Shafat Ali + 2 more
    • English
    Immunogenetics: A Molecular and Clinical Overview, Vol. 3, Immune Cells and Immunotherapeutics in Recurrent Miscarriage provides an overview of the scientific knowledge, achievements, and findings in the field of immunogenetics of recurrent pregnancy loss. With a strong focus on the role immune cells can play in recurrent pregnancy loss, the book also examines immune therapeutic aspects. In fifteen chapters, the book describes the roles of both helper cells, nature killer cells, lymphoid cells, regulatory cells and macrophages in recurrent pregnancy loss. In addition, it describes clinical outcomes of several therapies and gives insight into new treatments. This new release is a valuable resource for health professionals, scientists and researchers, and all those who wish to broaden their knowledge in the allied field.

  • Cerebral Metastases: Translational Advances, Evaluation and Management

    • 1st Edition
    • Volume 165
    • English
    Cerebral Metastases: Translational Advances, Evaluation and Management, Volume 165 in this ongoing series, highlights new advances in the field, with this new volume covering many interesting topics, including Molecular Drivers in CNS metastasis, Role of the tumor microenvironment in CNS metastatic disease, Advanced Imaging to improve early diagnosis and evaluate treatment response, Liquid biopsy in early detection of CNS metastasis, Precision medicine approaches to CNS metastatic disease, IMRT/conventional RT, Single and hypofractionated SRS, Brachytherapy for recurrent metastases, LITT for treatment of active brain metastasis and radiation necrosis, and much more.Other topics covered include Minimally-invasive surgical approaches in the management of brain metastases.

  • Advances in DNA and mRNA-Based Strategies for Cancer Immunotherapy: Part A

    • 1st Edition
    • Volume 165
    • English
    Advances in DNA and mRNA-Based Strategies for Cancer Immunotherapy, Volume 165 in the Advances in Immunology series, presents current developments and comprehensive reviews in DNA and mRNA vaccines: Significant therapeutic approach against cancer management, Nanoparticles for mRNA-based cancer immunotherapy, Nucleic acid Delivery as a therapeutic approach in cancer immunotherapy, Plasmid DNA and mRNA: Delivery approaches and challenges, Viral & Non-viral Delivery of mRNA against Cancer Cell, Progress in Modifying and Delivering mRNA therapies for Cancer Immunotherapy, and more.Other chapters cover mRNA-Based Cancer Vaccines: A Novel Approach to Melanoma Treatment, Therapeutic mRNAs for cancer immunotherapy: from structure to delivery, Harnessing the immune system: Insights into cancer vaccines, Lipid Nanoparticle-Mediate... mRNA Delivery in Cancer Immunotherapy, Immunotherapy Perspectives in the Era of B-Cell Editing in Cancer Treatment, Personalized Precision: Revolutionizing Cancer Treatment with mRNA-Based Vaccines in Melanoma Therapy, Revolutionizing Cancer Treatment: Exploring Novel Immunotherapeutics, Checkpoints, bispecifics, and Vaccines in Development, and more.

  • Metabolites as Signals in Immunity and Inflammation

    • 1st Edition
    • Zbigniew Zasłona + 2 more
    • English
    Metabolites as Signals in Immunity and Inflammation describes the revolution in the definition of the word metabolism, highlighting changes in thinking about the whole field of immunology. These changes occur thanks to breakthrough experiments in basic research, and with the help of new technologies that allow for the testing of immunology hypotheses. In recent years, a substantial number of findings have been made around immunometabolism. What is emerging is a complex interplay between metabolic reprogramming and immunity, which is providing an extra dimension to our understanding of the immune system in health and disease.

  • Handbook of Food Allergen Detection and Control

    • 2nd Edition
    • Simon Flanagan
    • English
    Handbook of Food Allergen Detection and Control, Second Edition continues to be an essential resource of scientific and technical information in the food and analytical communities. This book provides information on current and emerging technologies for detecting and reducing allergens to improve allergen control overall. Written by experts in the field, it offers a wide scientific perspective on allergens and includes hot topics such as food allergen labeling and consumer perspectives on food allergen labels. Chapters are fully revised to include the latest information in the industry, including practical applications of new methods and control strategies. The book is useful for anyone in the food supply chain.The book reviews current and emerging technologies for detecting and reducing allergens, as well as issues such as traceability, regulation, and consumer attitudes. Following an introductory chapter by a distinguished expert, Part One covers allergen management throughout the food chain. Part Two details current and emerging methods of allergen detection in food, with Part Three covering methods for reducing and eliminating allergens in food. Finally, Part Four focuses on the control and detection of individual food allergens and the risks each one presents in food manufacturing.

  • The Immunology of the Domestic Ruminants

    Cattle, Sheep, and Goats
    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of Domestic Ruminants: Cattle, Sheep, and Goats provides a thorough examination of the immune systems of these animals. It explores their normal immune functions and their roles in combating infectious and parasitic diseases, chronic inflammatory conditions, and immunodeficiency disorders. The book incorporates new data from the bovine genome project and highlights significant breed differences. Both innate and adaptive immunity are systematically covered, offering insights into basic and applied aspects of bovine immunology. In addition to detailing the immunology of major bacterial, viral, and parasitic diseases in cattle, the book reviews bovine vaccines and emphasizes the importance nutrition.This essential resource caters to professionals in large animal research and practice, providing comprehensive information on the immunology of domestic cattle, sheep, and goats.

  • Fundamental Neuroscience for Basic and Clinical Applications

    • 6th Edition
    • Duane E. Haines + 2 more
    • English
    Designed to help you comprehend and retain the challenging material you need to know, Fundamental Neuroscience for Basic and Clinical Applications, Sixth Edition, covers the essential neuroscience information needed for coursework, exams, and beyond. Using a rigorous yet clinically-focused approach, it integrates neuroanatomy, pharmacology, and physiology, with separate sections devoted to essential concepts, regional neurobiology, and systems neurobiology.

  • Advances in Immunology

    • 1st Edition
    • Volume 164
    • English
    Advances in Immunology, Volume 164, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology.

  • Role of Medicinal Plants in Autoimmune Diseases

    Concepts, Perspectives, and Utilization
    • 1st Edition
    • Reetika Mahajan + 4 more
    • English
    Role of Medicinal Plants in Autoimmune Diseases: Concepts, Perspectives, and Utilization provides comprehensive knowledge of autoimmune diseases and the role of various medicinal plant products in their treatment. The book discusses the immune system as a group of complex biological structures and processes in an organism which gives protection against a wide range of pathogenic organisms while simultaneously distinguishing these pathogens from the organism’s own healthy cells and tissues, thus maintaining homeostasis in the body.It has been an age-old practice to use extracts and other parts of various plants in treating many diseases. Several plants contain various pharmacologically active substances which can be used to treat different diseases. Among these medicinal plants, many have shown good immunomodulatory properties and could act as natural immunosuppressant agents in treating autoimmune disorders.

  • Cytokine Response Against Major Human Viral Infections

    • 1st Edition
    • Mukesh Samant + 1 more
    • English
    Cytokine Response Against Major Human Viral Infections provides in-depth coverage of the immunological response against human viral infections and the role and impact of cytokines on disease pathogenesis and host immune response.Cytokines, as a part of innate immunity, initiate the development of antiviral and TH 1-type immune responses. Cytokines also affect the adaptive immune response and disease manifestation. In five sections, this book gives a comprehensive introduction to the clinical manifestations of viral and infectious diseases; details the role of cytokines in DNA virus infections, RNA virus infections, and reverse transcribing virus infections; and gives insights into the recent advances and strategies in diagnostic tools and therapeutic and prophylactic measures.Cytokine Response Against Major Human Viral Infections is valuable resource for both researchers in immunology and virology, as well as for those in the biotech and pharmaceutical industries, engaged in the study of cytokines and their immunological response against human viral infections.

  • A New Era in Alzheimer's Research

    Pathogenesis, Prevention, and Treatment
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    A New Era in Alzheimer's Research: Pathogenesis, Prevention, and Treatment is focused on the research and perspectives in Alzheimer's disease (AD), offering an update on the challenging aspects of neurodegenerative disorders. Each chapter of this book contains unique and valuable scientific information on the latest progress of research in neurodevelopmental diseases. Even after years of research, Alzheimer's disease is still far from being cured; this book addresses the most current issues within the many dimensions relevant to the pathogenesis, diagnosis, and prevention under one cover, making it useful for researchers, students, and clinicians, as well as those in pharmaceuticals.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 164
    • English
    the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research, with this updated edition covering chapters on A bioinformatic-driven prediction of MDA9 transcriptional variants’ roles in cancer progression and treatment, Redox, cysteines, and kinases - A triad sustaining myeloid leukemia, The RAF cysteine-rich domain: structure, function, and role in disease , Membrane Potential: a new hallmark of cancer, Recent Advances and Progress in Immunotherapy of Solid Cancers, and much more.Other sections explore Precision Medicine: Non-Invasive Therapeutic Agent Delivery with Focused Ultrasound and Microbubbles and Anti-Cancer Activity of Capsaicin and its Analogs in Gynecological Cancers.

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