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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Brain Point-of-Care Ultrasound

    Practical Guide and Protocols
    • 1st Edition
    • Camilo N. Rodríguez + 6 more
    • English
    Brain Point-of-Care Ultrasound: Practical Guide and Protocols explores brain hemodynamics and parenchyma examination, providing an orderly and protocolized approach that facilitates individualized clinical decisions with ease. Covering ultrasound configuration, in-depth anatomical knowledge, and advanced parameters, this guide aims to integrate brain ultrasound seamlessly into the Point-of-Care Ultrasound (POCUS) modality, addressing the critical need for comprehensive patient assessment. From basic principles to specialized clinical situations, each section of this guide is meticulously crafted to empower practitioners with practical insights. Chapters explore Doppler spectral wave interpretation, angle correction nuances, autoregulation dynamics, and non-invasive pressure estimations, among others, thus enabling precise monitoring and targeted decision-making. With a focus on integration across disciplines and specialties, this book bridges the gap between classical pathology and contemporary practice, positioning brain ultrasound as a pivotal tool in the armamentarium of modern critical care.

  • Traumatic Brain Injury Rehabilitation

    • 1st Edition
    • Vishal K. Chavda + 4 more
    • English
    Traumatic Brain Injury Rehabilitation addresses the critical need for an integrated resource spanning traumatic and vascular brain injury models. This reference consolidates diverse experimental platforms from classical rodent systems to advanced human brain organoids and AI-driven simulations, targeting researchers and clinicians navigating the complexities of neurotrauma and stroke. The book responds to the growing demand for translational approaches that link bench-side discoveries with bedside applications to improve therapeutic development. The content is systematically organized into sections covering foundational principles, preclinical models of traumatic brain injury and stroke, pediatric brain injury models, in vitro and ex vivo platforms, clinical biomarkers and neuroimaging, and emerging future directions including personalized medicine and AI modeling. Each chapter offers detailed methodologies, comparative evaluations, and clinical translation insights, supported by extensive visuals such as flowcharts, neuroimaging figures, and infographics to enhance comprehension.

  • Systems Biology of Addiction Medicine

    Gut–Brain Axis, OMICS, and Molecular Technologies
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    Systems Biology of Addiction Medicine: Gut–Brain Axis, OMICS, and Molecular Technologies is a cutting-edge reference that explores the complex neurobiological mechanisms underlying substance use disorders (SUD). This volume emphasizes the importance of the microbiome-gut-brain axis (MGBA), multi-OMICS approaches, and molecular tools such as CRISPR-Cas9 in advancing addiction research. It addresses the urgent need for integrated frameworks to understand the bidirectional communication between the gut and brain in disorders like nicotine, opioid, alcohol, neurostimulant, and cannabis use. The book synthesizes foundational knowledge with recent developments, offering detailed methodologies, case studies, and translational strategies that bridge basic science and clinical application. Its comprehensive scope makes it invaluable for researchers and clinicians seeking to develop personalized, evidence-based therapies for SUDs. The contents include dedicated sections on the MGBA's role across various substances, detailed chapters on multi-OMICS, SNP, and immunotherapy techniques, and discussions on emerging molecular technologies like CRISPR. Each chapter combines literature reviews, recent advances, and practical applications, supported by schematic figures designed for clarity. The volume aims to empower neuroscientists, psychiatrists, pharmacologists, and biotech professionals with the latest scientific insights and tools to address the global challenge of addiction. By fostering interdisciplinary understanding, this resource supports hypothesis generation, research innovation, and the development of targeted interventions to improve patient outcomes.

  • Substance Use Disorders and Behavioral Addictions

    Neurochemical Mechanisms and Clinical Implications
    • 1st Edition
    • Mohammad Shabani + 2 more
    • English
    Substance Use Disorders and Behavioral Addictions: Neurochemical Mechanisms and Clinical Implications offers an in-depth exploration of the neurochemical foundations of addiction, addressing both substance-related and behavioral disorders. This volume is essential for neuroscientists, psychiatrists, and pharmacologists seeking to understand the complex neurobiological pathways involved in addiction. It covers key neurochemical systems such as dopamine, glutamate, serotonin, and endocannabinoids, and examines their roles across a spectrum of disorders including nicotine, opioids, alcohol, stimulants, cannabis, psychedelics, sedatives, caffeine, antihistamines, and behavioral addictions like gambling, gaming, pornography, and binge eating. This content synthesizes cutting-edge preclinical techniques—such as optogenetics and neuroimaging—with clinical models like cue-reactivity and pharmacogenomics, providing a translational perspective that bridges research and practice. The purpose of this book is to fill existing gaps where neurochemical insights are often isolated from clinical application, especially in the context of rising addiction rates globally and emerging treatments like psilocybin and neuromodulation. It aims to equip researchers and clinicians with current, practical knowledge to develop innovative interventions, improve diagnostics, and personalize treatment strategies. Whether used as a reference for research, clinical decision-making, or advanced coursework, this volume offers a vital resource for advancing understanding and management of addiction in diverse settings.

  • Clinical Brain Stimulation Part A

    • 1st Edition
    • Volume 308
    • English
    Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Vagus Nerve

    From Homeostatic Regulations to Disease Etiopathogenesis, Treatment, and Prevention
    • 1st Edition
    • Boris Mravec
    • English
    Vagus Nerve: From Homeostatic Regulations to Disease Etiopathogenesis, Treatment, and Prevention is a comprehensive reference that encapsulates every critical aspect of the vagus nerve, tracing its anatomy, phylogeny, and physiology while exploring its pivotal role in both maintaining homeostasis and the development of various diseases. This groundbreaking work details the potential of vagus nerve stimulation as a therapeutic and preventive measure for a wide range of conditions, including neurological, psychiatric, inflammatory, cardiovascular, and gastrointestinal disorders. This book demystifies the mechanisms of vagus nerve function and its implications for health and disease. Each section delves into the historical context of vagus nerve research, its anatomical and functional characteristics, and its regulatory roles across multiple organ systems. Additionally, the book investigates the etiopathogenesis of diseases linked to vagus nerve dysfunction and outlines experimental methods for investigating its functions. With a focus on prognosis and therapy, this book highlights the prognostic value of vagus nerve activity and explores various therapeutic modalities that influence it. Concluding with directions for future research, this essential resource aims to foster a deeper understanding of the vagus nerve's significance in health and disease, opening new avenues for therapeutic innovation and clinical application.

  • The Autism Spectrum

    Identification, Understanding, and Treatment in Global Context
    • 1st Edition
    • Matthew K. Belmonte + 1 more
    • English
    The Autism Spectrum: Identification, Understanding, and Treatment in Global Context provides an update to the basic and clinical sciences of autism with an understanding of how research and clinical treatments are affected by recent shifts of focus: from diagnostic categories to symptomatic dimensions, from provider-centered to patient-centered treatment approaches, from high-resource, individualistic country insights to those contributed from global cultures.This volume discusses the field’s current state, whence it has come, where it is going, and how to get there. The volume weds basic and clinical understandings, state-of-the-art multivariate analyses, historical and cross-cultural information and relevance, and a patient-centered focus.

  • Decision Neuroscience

    • 2nd Edition
    • Jean-Claude Dreher
    • English
    Decision Neuroscience: An Integrative Perspective, Second Edition, Volume Two presents the most recent and compelling lesional, neuroimaging, electrophysiological... and computational studies in combination with hormonal and genetic studies that have led to a clearer understanding of the neural mechanisms behind reward and decision-making. The neural bases of reward and decision-making processes are of critical interest to scientists because of the fundamental role that reward plays in a number of behavioral processes (such as motivation learning, and cognition), and because the neural bases have theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders.This book provides a comprehensive update on groundbreaking work that addresses fundamental questions about the nature of behavior, including how does the brain process reward and how does it make decisions when facing multiple options? It features entirely new content, as well as expanded coverage on drug and behavioral addiction and the role of subthalamus stimulation in neurological disorders and neuroeconomics.

  • Animal Cognition

    Fundamentals, Models, and Therapeutic Advances
    • 1st Edition
    • Shampa Ghosh + 3 more
    • English
    Animal Cognition: Fundamentals, Models, and Therapeutic Advances provides a comprehensive overview of cognitive processes in various animal species, spanning fundamental concepts, species-specific studies, and therapeutic applications. Sections cover the foundation of animal cognition, including definitions, key concepts, and an overview of cognitive abilities, such as memory, problem-solving, and learning, delve deeper into the cognitive processes in mammals, birds, and marine animals, and more, and review the latest technological advancements in studying cognition, such as neuroimaging, machine learning, and virtual reality. With a multidisciplinary approach, this volume highlights current research while identifying gaps for future exploration, and will be of interest to researchers involved in animal cognition and behavioral neuroscience.

  • Neurological and Neuropsychiatric Disorders

    Substance Use and Addictive Behaviors
    • 1st Edition
    • Alexander Baldacchino + 1 more
    • English
    Neurological and Neuropsychiatric Disorders: Substance Use and Addictive Behaviors is an essential resource that delves into the intricate relationship between substance use, addictive behaviors, and their profound impact on neurological and neuropsychiatric health. The book presents a comprehensive examination of the various disorders and conditions that arise from, or are exacerbated by, substance use and addictive behaviors, offering a multidisciplinary approach to understanding these complex interactions. This volume provides a detailed and updated exploration of the neurological and neuropsychiatric consequences of substance use and addictive behaviors.By compiling the latest research and clinical insights, this volume aims to fill a critical gap in the existing literature, which often treats substance use disorders and neurological impacts as separate entities. This integrated approach is crucial for both researchers and clinicians who need a thorough understanding of the co-morbidities associated with addiction. This book solves the problem of fragmented knowledge by offering a unified perspective that is crucial for developing effective treatment strategies and understanding the full spectrum of addiction-related disorders.

  • Endovascular Therapy for Intracranial Atherosclerotic Stenosis

    • 1st Edition
    • Ning Ma + 1 more
    • English
    Endovascular Therapy for Intracranial Atherosclerotic Stenosis presents selected cases of endovascular treatment for intracranial atherosclerotic stenosis (ICAS), providing detailed information on periprocedural medical management, endovascular strategies, device selection, and follow-up outcomes. The book serves to improve understanding of ICAS and share clinical experiences from high-volume stroke intervention centres with neuro-interventional... The book reviews recent developments in ICAS management and presents evidence that appropriate patient selection and peri-operative planning may contribute to the effectiveness of endovascular therapy for ICAS

  • Cognitive Remediation in Psychiatric Disorders Part B

    Other Conditions, Contexts and Considerations
    • 1st Edition
    • Volume 307
    • English
    Cognitive Remediation in Psychiatric Disorders is a two-volume work comprising Part A: Core Psychiatric Conditions (Volume 306) and Part B: Other Conditions, Contexts and Considerations (Volume 307). Together, the volumes provide a comprehensive, contemporary account of cognitive remediation and related cognition-oriented interventions across psychiatric, neurodevelopmental, lifespan, and other clinical contexts. Part A establishes the historical, conceptual, and practical foundations of cognitive remediation and examines its application across psychosis, serious mental illness, depression, bipolar disorder, obsessive-compulsive disorder, substance use disorders, and trauma-related disorders. Part B extends the discussion to personality disorders, eating disorders, behavioral addictions, ADHD, autism spectrum disorder, intellectual and developmental disabilities, cognitive concerns in older adults, HIV-associated neurocognitive disorders, multiple sclerosis, cognitive difficulties following electroconvulsive therapy, and emerging technology-enabled approaches. Across both volumes, contributors address intervention principles and mechanisms, clinical integration, adaptation and accessibility, metacognition and subjective cognition, memory, real-world skill acquisition, and functional and vocational outcomes. Together, the volumes provide a broad, integrated framework for understanding how cognition-oriented interventions can support recovery, participation, and everyday functioning across diverse clinical populations.

  • Reasoning

    An Integrative Approach
    • 2nd Edition
    • Daniel Krawczyk
    • English
    Reasoning: An Integrative Approach, Second Edition provides an overview, summary, and synthesis of research approaches to the psychology of reasoning. Representing historical perspectives, state-of-the art research, and coverage of upcoming future directions, this volume offers an integrative approach including research on animal behavior, neuroscience, cognitive psychology, AI, development, medicine, and philosophy. The contents range from animal studies through applied situations, and present historical perspectives, discussion of both animal reasoning and human reasoning to provide a cross-species context, and an examination of human reasoning across the lifespan. Though intended primarily for neuroscientists, the book will provide an interdisciplinary examination of reasoning, synthesizing perspectives from neuroscience, cognitive psychology, animal behavior, development, and philosophy, to provide readers with a well-rounded understanding of what reasoning is, various types of reasoning, and its role in decision making and social interactions. New to this edition is research on the influence of technology throughout the book, as well as a greater emphasis on the way that cultural backgrounds and variations in our exposure to information influence our thinking. This will enhance the scope, relatability, and diversity of the book, making it more applicable to future practices and research.

  • Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part B

    • 1st Edition
    • Volume 193
    • English
    Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part B, published as Volume 193 of the serial International Review of Neurobiology, provides a comprehensive examination of emerging blood-based biomarkers and related biological mechanisms relevant to Alzheimer's disease, Parkinson's disease, vascular cognitive impairment, stroke, and other neuropsychiatric disorders. The volume highlights advances in biomarker discovery, genetic and epigenetic determinants of neurodegeneration, extracellular vesicles and exosomes, protein misfolding, microRNA dysregulation, blood-brain barrier dysfunction, and biofluid-based biosensing technologies. It also explores the integration of artificial intelligence with multimodal biomarker datasets to improve diagnosis, prognosis, and precision medicine approaches. Bringing together contributions from international experts, this volume offers researchers and clinicians an up-to-date resource on translational developments that are shaping the future of neurodegenerative disease detection and management.

  • The Brain Histaminergic System in Health and Disease

    • 1st Edition
    • Zhong Chen + 2 more
    • English
    Histamines in Neurology and Psychiatry summarizes histamines and their impact on neuroinflammation and brain development in key neural circuits. This book presents the latest research on the physiological regulation of a neuroendocrine responses and releases, broadly discussing histamine receptor modulators and histamine effects in neurology and psychiatry, and also including clinical applications that will be of interest to practitioners.

  • Adult Hydrocephalus and Disorders of CSF Dynamics

    • 1st Edition
    • Benjamin D. Elder + 1 more
    • English
    Adult Hydrocephalus and Disorders of CSF Dynamics reviews the pathophysiology, evaluation, differential diagnosis, management and treatment of adult hydrocephalus and disorders of cerebrospinal fluid (CSF). The introductory section begins with the anatomy and physiology of the cerebrospinal fluid system, with a review of adult hydrocephalus management, including longitudinal care and management of comorbidities. The following technical section devoted to shunt design and development, and then management of patients with idiopathic normal pressure hydrocephalus (iNPH). Coverage includes differential diagnosis and treatment of iNPH, as well as common presentations, neuroimaging, genetic studies, CSF biomarkers, and using artificial intelligence. Confirmatory testing discusses high volume lumbar punctures, lumbar drainage trials, and CSF infusion testing. Medical and surgical treatments are reviewed with expected functional outcomes. A subsequent section discusses secondary normal pressure hydrocephalus, caused by other etiologies such as hemorrhage, tumors, or infection, and covers longstanding overt ventriculomegaly (LOVA), management of adult patients who were shunted as children, and Chiari malformations. The book concludes with high and low pressure CSF dynamics disorders, including idiopathic intracranial hypertension and secondary intracranial hypertension, followed by a review of the medical, surgical, and ophthalmological management of these disorders.

  • Bacterial Infections of the Central Nervous System

    • 1st Edition
    • Karen L. Roos + 1 more
    • English
    "Bacterial Infections of the Central Nervous System" consolidates recent discoveries and best practices on diagnosis and treating infection to minimize morbidity and mortality. The book discusses advancements in neuroimaging techniques, diagnostic studies performed on cerebrospinal fluid, adjunctive therapy, and antimicrobial therapy. Beginning with pathogenesis and pathophysiology of bacterial CNS infections, the book reviews when to suspect a bacterial infection of the central nervous system. The majority of the chapters review specific disease entities, including meningitis, focal CNS infections (e. g., brain abscess, subdural empyema and epidural abscess), CNS diseases caused by selected infectious pathogens (Mycobacteria, Rickettsiae, Anaplasmataceae, Treponema pallidum, Borrelia burgdorferi and other Borrelia species), the neurological complications of infective endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, bacterial etiologies of movement disorders, Guillain-Barre syndrome, toxin-mediated syndromes of the nervous system and infectious encephalopathy.

  • The Zebrafish Model of Neurodegenerative Disorders

    Knowing the Unknown
    • 1st Edition
    • Wael Mohamed
    • English
    The Zebrafish Model of Neurodegenerative Disorders: Knowing the Unknown reveals a ground-breaking method for decoding neurodegenerative disorders such as Parkinson's, Alzheimer's, ALS, and Huntington's through the lens of the zebrafish. This volume bridges the divide between fundamental science and clinical innovation, demonstrating how the genetic malleability, transparent embryos, and conserved neural pathways of zebrafish provide unparalleled insights into neurodegeneration. It illustrates the potential to uncover concealed pathological mechanisms, expedite drug discovery, and surmount the translational failings that impede current research using this gold-standard model species. Featuring contributions from global experts, this volume is systematically structured into five topical sections for ease of navigation. These sections explore the role of cutting-edge tools such as CRISPR-Cas9, AI-driven phenotyping, and high-throughput drug screening in the study of α-synuclein aggregation in Parkinson's Disease and amyloid-β toxicity in Alzheimer's Disease. The volume offers real-world applications, comparative analyses of zebrafish and mammalian models, and actionable protocols that translate zebrafish discoveries to clinical trials. The Zebrafish Model of Neurodegenerative Disorders is designed to empower researchers, clinicians, and healthcare professionals by addressing existing gaps in knowledge, particularly fragmentation in protocols and the translational disconnect between preclinical models and human trials. By fostering an integrated understanding of zebrafish as a model for neurodegeneration, it enhances research reproducibility, accelerates drug discovery, and promotes ethical, scalable research practices. Whether used as a teaching resource or a reference for experimental design, this volume offers invaluable insights to advance the understanding and treatment of devastating neurodegenerative diseases.

  • Sleep Neurology

    • 1st Edition
    • Anne Marie Morse
    • English
    Sleep Neurology explores the intricate relationship between sleep and neurological health, bridging the gap between theoretical knowledge and practical application. This comprehensive reference highlights the role of sleep in overall health and provides an examination of how sleep influences a wide range of neurological disorders. From neurodevelopmental issues to neurodegenerative diseases, this book offers a detailed review of how sleep science can be applied to improve patient outcomes in various neurological conditions. Structured around key neurological topics, the book offers insights into conditions such as epilepsy, stroke, and traumatic brain injury, emphasizing the importance of sleep management in their treatment. Each chapter not only discusses the scientific underpinnings of sleep but also provides tangible strategies for integrating sleep health into primary neurological care.

  • Roles of the Cerebellum in Motor Control

    Foundations, Experimental Approaches and Clinical Applications
    • 1st Edition
    • Mario Manto + 2 more
    • English
    Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease.From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.

  • The Human Nervous System

    • 4th Edition
    • George Paxinos + 2 more
    • English
    The 4th Edition of the classic book The Human Nervous System continues to assemble contributions from world leaders in research on the brain, spinal cord and peripheral nervous system. This book has been edited by the best-known team of brain cartographers, and it has been completely revised to present the cutting edge of human neuroscience. The structure, connections and function are explained in depth, making this book essential to any student or scientist interested in brain anatomy and function.

  • Gold Nanoparticle Therapeutics in Alzheimer's Disease

    Revolutionizing Diagnosis and Treatment
    • 1st Edition
    • Arun Kumar Singh + 2 more
    • English
    Gold Nanoparticle Therapeutics in Alzheimer's Disease: Revolutionizing Diagnosis and Treatment is an essential resource that delves into the groundbreaking use of nanotechnology in the fight against one of the most challenging neurodegenerative disorders. This volume offers an in-depth exploration on how gold nanoparticles can be used to enhance the diagnosis, treatment, and overall understanding of Alzheimer's disease. By examining the molecular mechanisms that enable nanoparticles to cross the blood-brain barrier, the book highlights their role in inhibiting amyloid fibrils and their potential as precise diagnostic tools.Covering a wide range of topics, this comprehensive guide serves as an invaluable reference for researchers, clinicians, and industry professionals at the forefront of Alzheimer's research and nanomedicine.

  • Central Nervous System Viral Infections

    • 1st Edition
    • Karen L. Roos + 1 more
    • English
    Central nervous system viral infections pose one of the greatest threats to humanity, as evidenced by recent history with SARS-CoV-2 (COVID 19), HIV, and others. Understanding their effects, therapeutics, and prevention are a top priority for all. "Central Nervous System Viral Infections" reviews the mechanisms of viral infections, current viruses of interest, diagnosis, course, and therapeutics, as well as prevention. Post infection syndromes and complications are also reviewed. Coverage includes Covid, HIV, Zika, EBOLA, Marburg, Herpes, Measles, Mumps, Polio, and more.

  • The Neurobiological Underpinnings of Addiction Medicine

    Focusing on Novel Approaches
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    The Neurobiological Underpinnings of Addiction Medicine: Focusing on Novel Approaches provides a comprehensive review of the biological mechanisms that drive addiction and innovative strategies for treatment. This book begins by examining the crucial role of the microbiome and the gut-brain axis in various substance use disorders, including opioid, alcohol, neurostimulant, and cannabis use disorders. It highlights how gut health can significantly influence addiction behaviors and treatment outcomes. Following this, the second section discusses the interplay between addiction and neuropsychiatric disorders such as depression, anxiety, schizophrenia, ADHD, bipolar disorder, PTSD, and OCD.This section emphasizes the impact of neurotransmitter systems and intracellular pathways on the development and persistence of these disorders. The final section introduces cutting-edge methodologies reshaping addiction research, including multi-OMICS approaches and the implications of CRISPR-Cas9 technology. By integrating these diverse topics, this book offers vital insights for clinicians and researchers alike.

  • Basic Neurochemistry

    Principles of Molecular, Cellular, and Medical Neurobiology
    • 9th Edition
    • Scott Brady + 1 more
    • English
    Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, Ninth Edition is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions).This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.

  • Tourette Syndrome and Other Tic Disorders

    • 1st Edition
    • Mariam Hull
    • English
    The Neuroscience of Tourette's Syndrome and Other Tic Disorders provides a foundation of the latest research into tic disorders and the brain, as well as including a comprehensive framework for the evaluation of tics. Authors across multiple specialties present the most thorough and latest knowledge of Tourette syndrome to include underlying pathophysiology, clinical presentation, how to differentiate it from other tic disorders, particularly functional tics. Clinical case studies will also feature throughout to outline challenging cases with expert commentary on evaluation and management strategies.

  • Neurochemical Substrates of Addiction Medicine

    • 1st Edition
    • Mohammad Banazadeh + 2 more
    • English
    Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction.Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2nd Edition
    • João L. de Quevedo + 2 more
    • English
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition follows the success of the first edition, synthesizing the basic neurobiology of major depressive disorder (MDD) with discussions on the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and novel optogenetic techniques revolutionizing depression research. This new edition includes comprehensive foundational understandings of the disorder and highlights recent advances, aiding advanced students and researchers in their understanding of MDD. The book introduces new chapters exploring groundbreaking topics such as the neurobiology of treatment-resistant depression, the antidepressant mechanisms of ketamine, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression. This edition also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help to provide a broader and more comprehensive understanding of depression and its treatment.

  • Primer on Cerebrovascular Research

    • 1st Edition
    • Dong-Eog Kim + 3 more
    • English
    Primer on Cerebrovascular Research provides both clinical and basic cerebrovascular knowledge that is required for physicians, vascular researchers, biomedical students, and trainees to understand or conduct evidence-based clinical practice and cutting-edge experimental research. This book outlines how to a design experimental cerebrovascular research in the context of clinical relevance, conduct the study using proper methods, analyze the data accurately, and make conclusions in an unbiased and statistically correct way. Chapters will include representative examples and experimental protocols.

  • Neuroinflammation and Biomarker Discovery

    From Mechanisms to Clinical Application
    • 1st Edition
    • Arun Kumar Singh + 1 more
    • English
    Neuroinflammation and Biomarker Discovery: From Mechanisms to Clinical Application offers a detailed exploration of the molecular and cellular processes underlying neuroinflammatory conditions. This essential reference addresses the urgent need for advanced biomarkers that can facilitate early diagnosis, monitor disease progression, and guide personalized treatments in neurodegenerative and autoimmune disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. The book synthesizes current knowledge on neuroimmune interactions, glial cell activation, blood-brain barrier integrity, and innate immune signaling pathways, providing a comprehensive framework for understanding neuroinflammatory mechanisms. It also covers state-of-the-art platforms for biomarker discovery, including transcriptomics, proteomics, lipidomics, epigenomics, extracellular vesicles, and neuroimaging techniques, emphasizing their translational potential. The inclusion of disease-specific biomarker landscapes enhances its relevance for clinicians and researchers working in diagnostics and drug development. The final sections focus on translational applications, such as clinical trial design, biomarker validation, and the integration of AI-driven multi-omics data for personalized neuroimmunology. This volume is an indispensable resource for neuroscientists, clinicians, graduate students, biotech professionals, and data scientists seeking to advance understanding and innovation in neuroinflammatory research and clinical practice. By bridging basic science and clinical application, it aims to accelerate the development of targeted therapies and diagnostic tools, ultimately improving patient outcomes in neuroinflammatory diseases

  • Inherited Metabolic Diseases and the Brain

    • 1st Edition
    • Fanny Mochel + 2 more
    • English
    Inherited Metabolic Diseases and the Brain explores the latest research on the neurological aspects of inherited metabolic diseases such as epilepsy, encephalotomy and more. With a strong research driven foundation and clinical applications, this book provides a primer which will help practicing pediatric and adult neurologists recognize, diagnose and treat neurometabolic disorders. This volume will also present a number of more common disorders in more detail, describing the variability in clinical presentation, the life course of the disease and the intricacies of diagnosis and treatment.

  • Neurosurgical Neuropsychology

    The Practical Application of Neuropsychology in the Neurosurgical Practice
    • 2nd Edition
    • Caleb M. Pearson + 2 more
    • English
    The second edition of Neurosurgical Neuropsychology: The Practical Application of Neuropsychology in the Neurosurgical Practice offers an in-depth review of the critical role neuropsychology plays in neurosurgical settings. This comprehensive resource covers essential preoperative techniques, including advanced functional neuroimaging methods such as fMRI and connectivity-based imaging, alongside traditional approaches like neurocognitive testing and the Wada procedure. This book highlights the significant contributions of neuropsychologists to the neurosurgical team, emphasizing their value in managing diverse patient populations, from candidates for Deep Brain Stimulation to those undergoing adult and pediatric epilepsy surgeries and neuro-oncology interventions. New chapters in this edition address contemporary topics such as the cognitive impact of epilepsy and epilepsy surgery, concussion, neuroplasticity, and the future role of artificial intelligence in neurosurgery. By updating existing content and incorporating fresh insights, this book serves as an essential guide for neurosurgeons, neuropsychologists, neuro-oncologists, epileptologists, and general neurologists who wish to enhance their understanding of neuropsychology's application in both preoperative and postoperative care.

  • Neurobiology of Psychiatric Disorders: New Perspectives on Mental Illness Associated with High Penetrance Genetic Variants

    New Perspectives on Mental Illness Associated with High Penetrance Genetic Variants
    • 1st Edition
    • Noboru Hiroi
    • English
    "The Neurobiology of Psychiatric Disorders" provides a conceptually innovative framework to understand psychiatric disorders including autism spectrum disorders, schizophrenia, intellectual disability, bipolar disorder, and ADHD. This book will allow readers to learn diverse mechanistic bases of psychiatric disorders causally associated with genetic variants. Because rare genetic variants have unprecedentedly high levels of penetrance for psychiatric disorders, this book provides reliable genetic links and their mechanistic substrates, thereby providing the starting points of precision medicine.

  • Non-Invasive Brain Stimulation and Modulation of Auditory Processing

    Basic Principles and Clinical Application
    • 1st Edition
    • Jos J. Eggermont
    • English
    Non-invasive Brain Stimulation and Modulation of Auditory Processing: Basic Principles and Clinical Application provides a comprehensive overview of innovative techniques designed to address auditory processing disorders while highlighting their underlying mechanisms and clinical applications. This book addresses the distinction between hearing loss and hearing impairment, emphasizing the need for interventions that target the brain's neural processes. With a focus on both transcranial and transcutaneous stimulation methods, including transcranial magnetic stimulation (TMS) and transcutaneous electrical stimulation (TES), it explores their effects on auditory functions, cognitive processes, and long-term conditions such as tinnitus and developmental disorders. Each chapter investigates the biophysical mechanisms, therapeutic applications, and potential limitations of these non-invasive techniques, while also discussing their role in enhancing auditory attention, speech processing, and cognitive function in aging populations. By integrating neuroimaging techniques and addressing the importance of brain state, this book serves as an essential resource for researchers and clinicians seeking to understand and apply non-invasive brain stimulation methods to improve auditory processing and overall cognitive health.

  • Epigenetics and miRNA in Neurodegenerative Diseases

    From Molecular Mechanisms to Clinical Applications
    • 1st Edition
    • Lance R. McMahon + 2 more
    • English
    Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatment

  • The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care

    • 1st Edition
    • Volume 192
    • English
    The Alzheimer’s Spectrum: From Neural Stress to AI-Driven Care, published as Volume 192 of the serial International Review of Neurobiology, provides a comprehensive and multidisciplinary examination of Alzheimer’s disease (AD) across its biological, psychological, and technological dimensions. This volume integrates current research on neuropsychiatric factors such as depression, stress, and anxiety with advances in neuroanatomy, systems neuroscience, and emerging AI-driven diagnostic and therapeutic approaches. Chapters explore key brain regions and circuits implicated in AD—including the thalamus, prefrontal cortex, hippocampus, and memory-emotion networks—while also addressing comorbidities, extracellular vesicles as biomarkers, and innovative treatment strategies. The inclusion of computational approaches, model organisms, and novel therapeutic avenues reflects a strong translational focus, bridging mechanistic understanding with clinical and digital health applications. Collectively, this volume serves as an authoritative resource for understanding the Alzheimer’s continuum from early cognitive impairment to advanced disease and care optimisation.

  • Algorithmic Approaches for the Diagnosis of Common Neurological Emergencies

    • 1st Edition
    • Gentle Sunder Shrestha + 3 more
    • English
    Algorithmic Approaches for the Diagnosis of Common Neurological Emergencies is a practical resource aimed at clinicians working in the field of neurology. By providing an algorithmic approach to diagnosing patients, this volume helps clinicians quickly and systematically approach patients, minimizing the risk of missing common neurological emergencies. Offering case studies and various common neurological scenarios, readers will be able to pick up on warning signs of serious neurological emergencies and treat patients effectively. Users will find this to be a valuable guide to help manage patients with neurological emergencies with limited resources.

  • The NeuroComplex Interaction of Appetite Regulation

    Brain, Body and Environment
    • 1st Edition
    • Nasrollah Moradikor + 1 more
    • English
    The NeuroComplex Interaction of Appetite Regulation: Brain, Body and Environment presents the latest research on why we eat, what makes us hungry, and how our brain controls our cravings. The book covers the data for how the brain, hormones, and different factors such as stress, the environment, and even food itself affects our desire to eat. Written for academics and researchers, this book helps facilitate a comprehensive understanding on how the brain influences appetite regulation, allowing readers to understand how neurobiological mechanisms can help treat patients involved with obesity, eating disorders, or other related conditions.Readers will find this to be a reliable resource that connects current neuroscience research with practical applications in appetite and behavior.

  • Lysosomal Pathophysiology of Parkinson’s Disease

    • 1st Edition
    • Mattia Volta + 1 more
    • English
    Lysosomal Pathophysiology of Parkinson’s Disease delves into the genetic and genomic revelations that have transformed our understanding of Parkinson’s Disease at the molecular level. The book highlights the critical role of the autophagy-lysosome pathway in the disease's pathogenic processes, drawing a comprehensive timeline of disease onset and progression. It offers a detailed examination of how disruptions in this pathway contribute to the hallmarks of Parkinson’s Disease, providing invaluable insights for researchers and clinicians alike. Subsequent chapters extend these insights by comparing Parkinson’s Disease to other neurodegenerative disorders such as Alzheimer’s Disease and Frontotemporal Dementia. By exploring protein pathology and synaptic alterations, the book underscores the broader implications of autophagy-lysosome dysfunction. Additionally, it discusses how the molecular perspectives gleaned from Parkinson’s Disease can inform our understanding of these other conditions, presenting a unified approach to studying neurodegeneration.

  • Protein Misfolding

    • 1st Edition
    • Timir Tripathi
    • English
    Protein Misfolding explores the structural and biochemical foundations of protein misfolding, highlighting its wide-reaching implications for cellular function, disease progression, and biomedical innovation. This book provides a comprehensive understanding of how proteins deviate from their native conformations and the resulting biological consequences. Focusing on both physiological and pathological misfolding, the volume covers essential topics such as folding quality control, molecular chaperones, degradation pathways, and proteostasis. It presents in-depth analyses of protein aggregation mechanisms, amyloid formation, and misfolding-associate... diseases including Alzheimer's, Parkinson's, and prion-related disorders. Additional chapters explore structural approaches to understanding misfolded states, computational modeling of aggregation kinetics, and current efforts to design therapeutics that restore folding homeostasis or prevent toxic accumulation. The book also addresses the cellular response to misfolding stress and the integration of folding dynamics with cellular signaling pathways.This book is a valuable resource for researchers, educators, and professionals in biochemistry, structural biology, molecular medicine, biotechnology, and related disciplines. It supports efforts to understand the fundamental principles of protein structure and function, while offering insight into emerging therapeutic strategies and future research directions in disease-focused protein science.

  • Precision Functional Mapping

    From Human Neuroscience to Engineering
    • 1st Edition
    • Prantik Kundu
    • English
    Precision Functional Mapping explores next-generation functional neuroimaging techniques, focusing on the pursuit of accuracy and scalability in understanding the human brain, to the extent of enabling individual-subject level insights on brain function. Precision Functional Mapping: From Neuroscience to Engineering provides a clear and practical guide to implementing precision functional mapping. It uniquely balances the theoretical foundations of advanced functional neuroimaging with actionable strategies for implementation. With an emphasis on precision, scalability, and practical relevance, it addresses both current limitations and future possibilities in the field. By focusing on underexplored areas such as sparsity, temporal precision, and regulatory considerations, it offers a fresh perspective. Readers interested in neuroscience research, clinical applications, or technology development will find this book gives them tools and insights to push the boundaries of what is possible with functional neuroimaging.

  • Neuroreceptors

    Physiology, Pathology, and Therapeutic Targeting
    • 1st Edition
    • Deepa S. Mandlik + 1 more
    • English
    Neuroreceptors: Physiology, Pathology, and Therapeutic Targeting offers an in-depth exploration of the cellular and molecular mechanisms underlying brain receptor function and their critical roles in health and disease. This authoritative reference addresses ionotropic, metabotropic, receptor tyrosine kinases, and nuclear receptors, detailing their structures, signaling pathways, and physiological functions. The book emphasizes how receptor malfunctions contribute to neurological and psychiatric conditions such as Parkinson’s disease, Alzheimer’s, schizophrenia, and epilepsy, bridging fundamental biology with clinical relevance. Through comprehensive coverage of experimental methodologies—includ... imaging, electrophysiology, and molecular pharmacology—it equips researchers and clinicians with practical insights for investigating receptor dynamics and developing targeted therapies. The final sections focus on innovative therapeutic strategies, including gene editing, receptor modulation, and personalized medicine approaches, reflecting current advances in translational neuroscience. This resource is designed to serve as a vital tool for scientists, healthcare professionals, and students seeking a cohesive understanding of receptor biology and its therapeutic potential, fostering progress in neuropharmacology and neurotherapeutics

  • A Guide to Brief Clinical Interventions in Inpatient and Abbreviated Settings

    • 1st Edition
    • Elaheh Ashtari + 3 more
    • English
    There are many resources available for evidence-based psychotherapies in outpatient and other long-term settings, but limited resources are available for inpatient and other brief settings. A Guide to Brief Clinical Interventions in Inpatient and Abbreviated Settings offers a problem-focused psychotherapeutic approach applicable to brief and long-term care settings. The text will this text will include explicit cultural considerations when applying brief treatment, and promote cultural responsiveness across treatment providers and care settings. This multimodal, evidence-informed handbook is intended for behavioral health and mental health practitioners alike who desire to deliver high quality interventions in time limited settings, such as acute and subacute inpatient units.

  • Rhythmic Regulation in Neuroscience and Clinical Practice

    • 1st Edition
    • Barbara Minton + 2 more
    • English
    Rhythm and Entrainment in Neuromodulation covers cutting-edge and up-to-date information on currently available rhythm-related treatment procedures, as well as the interplay between music and cognition. The book contains contributions from leading experts in the across several fields, exploring the ways in which rhythmic stimulation serves as a powerful neuromodulator, enhancing cognitive function and promoting healing. Best suited for clinicians and researchers interested in neuromodulation, this volume offers profound insights into how rhythm shapes our cognition, influences our well-being, and paves the way for innovative therapeutic practices.

  • Biomarkers in Neurological Disorders and Treatment

    • 1st Edition
    • Arun Kumar Singh + 3 more
    • English
    Decoding the Brain: Biomarkers in Neurological Disorders and Treatment provides a comprehensive exploration of the latest advances in neurological biomarkers, detailing their discovery, validation, and application in clinical practice. By offering insights into the biological underpinnings of various neurological disorders, this book aims to bridge the gap between cutting-edge biomarker research and its practical implementation in patient care.

  • Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology

    • 1st Edition
    • Varun Sasidharan Nair + 1 more
    • English
    Epigenetic Mechanisms at the Crossroads of Development, Immune Response, and Neuropathology offers an in-depth exploration of how epigenetic mechanisms shape neural development, immune interactions, and disease progression in the central nervous system. This interdisciplinary volume synthesizes current knowledge across neuroscience, immunology, and pathology, addressing the critical need for integrated frameworks that connect molecular regulation with clinical outcomes. The book covers foundational epigenetic processes such as DNA methylation, histone modifications, and non-coding RNAs, illustrating their roles in neural differentiation, circuit formation, and brain plasticity.It further examines how environmental factors influence epigenetic landscapes, impacting resilience and vulnerability to neuropsychiatric and neurodegenerative disorders. The volume also delves into the epigenetic drivers of neuropathologies including glioblastoma, neuroinflammation, and neurodegeneration, highlighting emerging therapeutic strategies. With contributions from leading international experts, this resource bridges basic science and translational research, providing valuable insights for researchers, clinicians, and advanced students seeking to understand and target complex CNS disorders.

  • Nanomedicine for Neurological Disorders

    Design, Delivery, and Clinical Perspectives
    • 1st Edition
    • Malik Zainul Abdin + 4 more
    • English
    Nanomedicine for Neurological Disorders: Design, Delivery, and Clinical Perspectives addresses the urgent need for innovative solutions in treating complex neurological and neurodegenerative diseases. As the global burden of conditions such as Alzheimer's, Parkinson's, multiple sclerosis, and brain tumors continues to rise, the scientific community faces the critical challenge of safely and effectively delivering therapeutics across the blood-brain barrier. This reference meets the needs of neuroscientists, clinicians, pharmaceutical scientists, and biomedical engineers seeking advanced strategies and translational insights in neuro-nanomedicine. The contents are structured to provide a comprehensive, interdisciplinary exploration of the field. Chapters cover the anatomy and connectivity of the human brain, the global burden and mechanisms of neurological disorders, conventional and nanomedicine-based drug delivery systems, and the intricacies of the blood-brain barrier. Readers will benefit from detailed analyses of nanocarrier engineering, stability, analytical techniques, toxicological safety, regulatory challenges, and artificial intelligence-driven drug design. Real-world case studies, clinical trial data, and future outlooks are presented alongside ethical and patient-centric considerations, ensuring a holistic perspective on the evolving landscape of neuro-nanomedicine. Nanomedicine for Neurological Disorders delivers essential benefits by bridging the gap between laboratory innovation and clinical practice. It equips readers with practical knowledge, foundational advances, and visionary insights to inspire new research directions, inform better decision-making, and accelerate the development of safer, more precise treatments for brain-related disorders. This reference is an indispensable resource for researchers, clinicians, and innovators at the forefront of neurological therapeutics.

  • Complications in Neuroanesthesia

    • 2nd Edition
    • Hemanshu Prabhakar
    • English
    Complications in Neuroanesthesia, Second Edition offers an extensive examination of the complications associated with neuroanesthesia practice, emphasizing both new and existing challenges in the field. This updated edition introduces critical topics such as locked-in syndrome, cerebellar mutism syndrome, delirium, awareness, memory loss, perioperative stroke, and coma, alongside established complications like brain herniation, hydrocephalus, and seizures. Each complication is meticulously examined in separate chapters, detailing the pathophysiology, mechanisms, diagnosis, treatment, and prevention strategies. This book also addresses cardiovascular issues, including stunned myocardium, as well as fluid and electrolyte disturbances like glucose dysregulation and conditions like post-dural puncture headache, malignant hyperthermia and reperfusion injury. Written in an accessible format for quick navigation, this resource provides invaluable insights into the perioperative management of neurosurgical and neurologic patients. This book is a practical tool for trainees, clinicians, and researchers in anesthesia, neuroanesthesia, neurosurgery, neurocritical care, and neurology. By highlighting preventable mishaps, this edition aims to enhance the safety and efficacy of neuroanesthesia and neurocritical care practice.

  • Neuroscience-Informed Psychoeducation (NIPE) for Brain and Mental Health

    Part D
    • 1st Edition
    • Volume 305
    • English
    Neuroscience-Informe... Psychoeducation (NIPE) for Brain and Mental Health series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Neurogynecology and Associated Neurological Disorders

    • 1st Edition
    • Vishal K. Chavda + 2 more
    • English
    Neurogynecology and Associated Neurological Disorders addresses the emerging interdisciplinary field linking neurology and gynecology, focusing on how neurological disorders impact female reproductive health throughout the lifespan. The book covers foundational neuroanatomy, hormonal influences on neurological function, and specific disorders including headaches, epilepsy, pelvic neuropathies, and mental health conditions related to reproductive stages. It includes clinical guidelines, case studies, diagnostic tools, and treatment protocols tailored to hormonal phases and life stages. The integration of neurobiological mechanisms with gynecological considerations offers readers a robust framework for interdisciplinary collaboration.Reader... will find this to be a great reference that responds to the growing clinical need for integrated understanding and management of conditions such as menstrual migraines, pregnancy-related neuropathies, and menopausal neurological changes.

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