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Elsevier

Books in Molecular neuroscience

This portfolio investigates the molecular basis of nerve function, signaling pathways, and neuroplasticity. Supporting biochemists, geneticists, and neuroscientists, it features innovative techniques and disease mechanisms that foster breakthroughs in neurodegenerative diseases, synaptic function, and targeted therapies.

  • Epigenetics and miRNA in Neurodegenerative Diseases

    From Molecular Mechanisms to Clinical Applications
    • 1st Edition
    • Lance R. McMahon + 2 more
    • English
    Epigenetics and miRNA in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications explores the crucial role of epigenetic modifications and microRNAs in the onset, progression, and treatment of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, ALS, and Huntington’s disease. This comprehensive book bridges cutting-edge molecular research with real-world clinical applications, covering biomarker discovery, novel therapeutics, gene editing, and AI-driven bioinformatics. With clear explanations, case studies, and future perspectives, it serves as an essential resource for researchers, clinicians, and biotech professionals working toward innovative solutions for neurodegenerative disease diagnosis and treatment

  • Basal Ganglia Dynamics

    From Motor Units to Networked Chaotic Oscillators
    • 1st Edition
    • Erwin B. Montgomery Jr.
    • English
    Basal Ganglia Dynamics: From Motor Units to Networked Chaotic Oscillators addresses the critical need for new theoretical frameworks in understanding the basal ganglia–thalamic–cor... system, particularly in the context of movement disorders such as Parkinson’s disease. Despite significant therapeutic advances, current dopamine replacement and Deep Brain Stimulation therapies remain limited due to incomplete and oversimplified prevailing theories. This reference provides a comprehensive alternative approach grounded in complexity science, nonlinear dynamics, and chaotic systems theory.The book's contents span foundational concepts, including motor unit orchestration, networked nonlinear oscillators, information theory, and methodological considerations. Detailed chapters cover the shortcomings of current models, the application of chaotic system mathematics to basal ganglia physiology, and the implications for pathophysiology and treatment. The book also includes extensive simulations, operational hypotheses, and a rigorous critique of existing paradigms that is supported by principles such as Causational and Informational Synonymy.

  • Cholinergic Drugs for Alzheimer's Disease

    From Central Cholinergic Neurotransmission to Drug Therapies and Natural Products with Multitarget Actions
    • 1st Edition
    • Cheorl-Ho Kim
    • English
    Cholinergic Drugs for Alzheimer’s Disease: From Central Cholinergic Neurotransmission to Drug Therapies and Natural Products with Multitarget Actions addresses the urgent need for advanced resources in neuropharmacology. The first section presents mechanistic insights into cholinergic drugs, current hypotheses for Alzheimer’s Disease progression, neurotransmitter systems, receptor biology, and the evolution of acetylcholinesterase inhibitors, including hybrid and multi-target drugs. It also covers clinical status, neuromuscular blockers, non-adrenergic neurotransmitters, protein kinase inhibitors, inflammation modulation, NMDA antagonism, biomarkers, and AI-assisted drug discovery.The second section explores natural alkaloidal and non-alkaloidal compounds, molecular docking, SAR analysis, and daily consumable resources, with the third section investigating marine-derived AChE inhibitors, dual- and multi-target drug concepts, and emerging therapeutic compounds. This book equips the scientific community with a robust foundation for understanding and innovating in Alzheimer’s Disease therapy. By integrating molecular biology, pharmacology, and computational approaches, it empowers researchers and clinicians to address treatment challenges, optimize drug design, and leverage natural products for multifactorial intervention.

  • The Itch Spectrum

    • 1st Edition
    • Xinzhong Dong + 2 more
    • English
    The Itch Spectrum: The Neurological and Immunological Basis of Itch and Dermatological Disorders covers the latest research on the itch signalling pathway from the skin to the brain. With a multidisciplinary approach, this book will cover the mechanisms underlying the sensation of itch from the fields of neuroscience, immunology, genetics, and dermatology as they have intersected in the study of one somatosensory system. The purpose of this comprehensive reference is to summarize the revelatory discoveries in the field of itch and provide a comprehensive overview of what is known about this remarkable sensation and how various pathologies contribute to chronic pruritis.

  • The Molecular Neurobiology of Depression

    • 1st Edition
    • Subir Ranjan Kundu + 1 more
    • English
    The Molecular Neurobiology of Depression is a comprehensive reference covering the most up to date neurobiological evolution research in relation to suicide biology. This book explores the structural and functional traits of DNA, including non-coding DNA, in order to identify a genetic trigger of depression or suicidal behavior among individuals. This book intends to provide an in-depth perspective on the molecular footprints of the development of suicidal behavior of many individuals through case studies and an interdisciplinary approach.

  • Regulated Cell Death in Neurodegenerative Disorders

    • 1st Edition
    • Heba Mohamed Mansour + 1 more
    • English
    Regulated Cell Death in Neurodegenerative Disorders is a comprehensive exploration of the mechanisms and implications of RCD within the realm of neurodegenerative diseases. The book delves into various forms of RCD such as apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death, shedding light on their specific roles in disorders like Alzheimer’s, Parkinson’s, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington’s. Written by leading experts, each chapter offers unique insights into cellular demise, providing valuable information on treatment options and therapeutic targets. The book features 14 chapters that cover molecular, cellular, and pharmacological mechanisms from an applied science perspective.Topics include the importance of chaperones, kinases, growth factors, inflammaging, mitochondrial dynamics, and oxidative stress. It presents targeted strategies to prevent cell death, reflecting ongoing pursuits in understanding and innovating treatments for neurodegenerative diseases. By offering therapeutic strategies to modulate RCD, this book not only shares knowledge but also provides hope for future advancements in combating these debilitating conditions.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition

    Volume 1
    • 7th Edition
    • Volume 1
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. This volume has been thoroughly revised and includes newly commissioned chapters on ethics, genetic counselling and genet therapy for the central nervous system disorders. A favorite of over four generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the previous edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community at large.

  • Neuroscience Research in Short-Duration Human Spaceflight

    • 1st Edition
    • Bader Shirah
    • English
    Neuroscience Research in Short-duration Human Spaceflight encapsulates a groundbreaking neuroscience portfolio conducted during the Axiom Mission 2 in May 2023, offering an examination of the effects of short-duration orbital spaceflight on aspects of the human brain. Addressing limitations in existing literature, the research includes astronauts of diverse ages, genders, and ethnic backgrounds, broadening the understanding of the impact of spaceflight on human physiology. A significant aspect of the suite of studies is the validation of two novel devices providing unprecedented information about the pupillary light reflex and neuroimaging in microgravity: automated pupillometry and functional near-infrared spectroscopy. The portfolio extends to explore spaceflight-associat... neuro-ocular syndrome, offering valuable contributions to the evolving field of space medicine. Furthermore, the research delves into the utilization of electroencephalograp... to monitor brain activity, acknowledging its potential in assessing cognitive health, stress levels, and mental workload in real time. Despite promising prospects, challenges in electroencephalograp... system adaptability within the International Space Station environment are highlighted, emphasizing the need for specialized design considerations. In addition, analysis is extended into the molecular biomarkers through minimally invasive blood monitoring. This book represents a pivotal advancement in space neuroscience, laying the foundation for safer space travel and fostering the development of monitoring tools crucial to observing adverse changes and potentially developing countermeasures that can aid in the establishment of a permanent human presence beyond Earth.

  • Integrative Omics in Parkinson's Disease

    • 1st Edition
    • Joanne Trinh
    • English
    Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinson's disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinson's disease.

  • From Brain Dynamics to the Mind

    Spatiotemporal Neuroscience
    • 1st Edition
    • Georg Northoff
    • English
    From Brain Dynamics to the Mind: Spatiotemporal Neuroscience explores how the self and consciousness is related to neural events. Sections in the book cover existing models used to describe the mind/brain problem, recent research on brain mechanisms and processes and what they tell us about the self, consciousness and psychiatric disorders. The book presents a spatiotemporal approach to understanding the brain and the implications for artificial intelligence, novel therapies for psychiatric disorders, and for ethical, societal and philosophical issues. Pulling concepts from neuroscience, psychology and philosophy, the book presents a modern and complete look at what we know, what we can surmise, and what we may never know about the distinction between brain and mind.

  • Natural Molecules in Neuroprotection and Neurotoxicity

    • 1st Edition
    • Marcos Roberto de Oliveira
    • English
    Natural Molecules in Neuroprotection and Neurotoxicity brings together research in the area of natural compounds and their dual effects of neuroprotection and neurotoxicity when interacting with brain cells. This two volume set is organized into four sections that address molecular mechanism underlying neuroprotection and neurotoxicity, neuroprotection mediated by natural molecules, neurotoxicity induced by natural compounds and nanotechnology-relat... strategies utilized in neuroprotection.Writ... by well-known researchers all over the world, chapters provide an in-depth analysis of numerous molecules, such as algae, plant and fungus-derived molecules, and comprehensively discuss their mechanisms of action and possible clinical applications. This set provides an essential reference for researchers and clinical scientists interested in the effects of natural compounds on the human health and disease.

  • Nutrition and Neurological Disorders

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Nutrition and Neurological Disorders offers readers a comprehensive reference on the effect of dietary regimes in a wide variety of neurological diseases. With its broad coverage of different types of diets, including the Mediterranean diet, this book allows readers to learn about the results of diets and their correlation with specific disorders. This includes diseases such as Alzheimer’s, Parkinson’s, ALS, and MS and severe neurological conditions such as brain injury, stroke, headache and migraine. Examining various compounds, the book's broad coverage allows readers to learn more about the role nutrient deficiency plays in the pathology of many conditions, along with treatment potential. This volume provides a platform for research on vitamins and minerals and on future investigations of these compounds.

  • Advances in Resting-State Functional MRI

    Methods, Interpretation, and Applications
    • 1st Edition
    • Jean Chen + 1 more
    • English
    Advances in Resting-State Functional MRI: Methods, Interpretation, and Applications gives readers with basic neuroimaging experience an up-to-date and in-depth understanding of the methods, opportunities, and challenges in rs-fMRI. The book covers current knowledge gaps in rs-fMRI, including "what are biologically plausible brain networks," "how to tell what part is noise," "how to perform quality assurance on the data," "what are the spatial and temporal limits of our ability to resolve FC," and "how to best identify network features related to individual differences or disease state". This book is an ideal reference for neuroscientists, computational neuroscientists, psychologists, biomedical engineers, physicists and medical physicists. Both new and more advanced researchers alike will be able to discover new information distilled from the past decade of research to become well-versed in rs-fMRI-related topics.

  • Cannabis, Cannabinoids, and Endocannabinoids

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Cannabis, Cannabinoids, and Endocannabinoids offers a comprehensive reference on natural and synthetic cannabinoids, providing coverage on both adverse and non-adverse effects, including reactivity to pain, changes in behavior and neuroactivity. This volume updates on research on the effects of these compounds in brain function and neurological dysfunction, offering readers a comprehensive reference on medical usage and the symptom relief provided by these compounds. With coverage of neurological diseases like Alzheimer’s and Parkinson’s, and a wide range of other afflictions, including depression, anxiety, nausea and cancer, this broad coverage expounds on the physiological, psychological and pharmacological effects of these compounds. Unique case reports are also provided, creating a platform for research on the use of these compounds in improving patient care, brain function and neurological dysfunction. As the endocannabinoid system has been implicated in various neurological conditions, this book is a welcomed resource on the topics presented.

  • Treatments, Nutraceuticals, Supplements, and Herbal Medicine in Neurological Disorders

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Treatments, Nutraceuticals, Supplements and Herbal Medicine in Neurological Disorders offers readers a comprehensive reference on their potential for treatment in a wide variety of neurological diseases. Spanning various types of these compounds, this broad coverage allows readers to learn about the use of nutraceuticals and botanicals alone, or in combination with, other dietary regimes and/or vitamins and minerals. It covers diseases including Alzheimer’s, Parkinson’s, ALS and MS, and severe neurological conditions including brain injury, stroke, headache and migraine. This volume provides a platform for research on nutraceuticals and botanical agents and on future investigations of these compounds. There are over 600 neurological disorders affecting both the central and peripheral nervous systems, some of which have been treated by nutraceuticals and herbal medicine, hence this is a timely resource on the topics covered.

  • Diet and Nutrition in Neurological Disorders

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Diet and Nutrition in Neurological Disorders offers readers a comprehensive reference on the effect of dietary regimes in a wide variety of neurological diseases. With coverage of different types of diets, including Mediterranean or DASH, this broad coverage allows readers to learn about diets and their affect on specific disorders which may well be relevant to other conditions. This includes diseases such as Alzheimer’s, Parkinson’s, ALS, MS and severe neurological conditions such as brain injury, stroke, headache and migraine. This volume provides a platform for research on new dietary regimes and on future investigations of diet and nutrition.

  • Vitamins and Minerals in Neurological Disorders

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    **Selected for 2026 Doody's Core Titles in Nutrition**Vitamins and Minerals in Neurological Disorders offers readers a comprehensive reference addressing their relationship to brain health in a wide variety of neurological diseases. Examining various compounds, this broad coverage allows readers to learn about the role nutrient deficiency plays in the pathology of many conditions, as well as their potential in treatment. The book covers diseases including Alzheimer’s, Parkinson’s, ALS, and MS, along with severe neurological conditions like brain injury, stroke, headache and migraine. This volume provides a platform for research on vitamins, minerals and future investigations of these compounds.

  • Cannabis Use, Neurobiology, Psychology, and Treatment

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Cannabis Use, Neurobiology, Psychology, and Treatment offers readers a comprehensive reference on neurological changes, both transient and long-term, and other factors surrounding the use of these compounds and extracts. With coverage of both natural and synthetic cannabinoids, this broad coverage allows readers to learn about both adverse and non-adverse effects, including reactivity to pain, changes in behavior, and neuroactivity. This volume provides a platform for research on the effects of these compounds in brain function and neurological dysfunction. Extracts from the Cannabis sativa plant contain scores of psychoactive compounds in addition to the principal agent tetrahydrocannabinol... many of which are neuroactive.

  • Clinical Neuroepidemiology of Acute and Chronic Disorders

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Clinical Neuroepidemiology of Acute and Chronic Disorders explores the epidemiology of disorders that affect the nervous system, providing comprehensive discussions on incidence, prevalence, and more. With thorough coverage of a variety of disorders, chapters detail etiology, risk factors, pathophysiology, clinical manifestations, diagnosis, global incidence and prevalence, age-specific incidence, global mortality, prevention, treatment and prognosis for each disorder. Chapters uniquely discuss the effects of the COVID-19 coronavirus upon the nervous system and in relation to several diseases, including new discoveries and treatments for Alzheimer’s disease and migraine headaches. Real-world case studies with critical thinking questions and "Focus On" boxes highlight important information.

  • Neuroglia: Function and Pathology

    • 1st Edition
    • Alexei Verkhratsky + 1 more
    • English
    Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment. In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function. Neuroglia: Function and Pathology provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates.

  • COVID-19 in Alzheimer's Disease and Dementia

    • 1st Edition
    • P. Hemachandra Reddy + 1 more
    • English
    COVID-19 in Alzheimer’s Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity among those with COVID-19. The first section includes chapters that provide a general description of COVID-19, including SARS-CoV-2 structure, function, and biology, and its impact on the elderly with chronic conditions include hypertension, diabetes, obesity, kidney disease, respiratory illnesses, and infectious diseases. Also discussed are effects of the virus on the immune system. The second section shifts to the impact of COVID-19 on those with dementia or Alzheimer’s disease, with special emphasis on age, gender, ethnic background, and lifestyle. Bringing this focus on neurodegenerative disease in one comprehensive resource, this volume is an essential reference for neuroscientists, clinicians, biomedical scientists, and all others working or interested in the field.

  • Handbook of Animal Models in Neurological Disorders

    • 1st Edition
    • Colin R. Martin + 2 more
    • English
    Handbook of Animal Models in Neurological Disorders will better readers’ understanding of a large variety of animal models and their applicability in studying a number of neurological disorders. Featuring sections on brain injury, stroke and neuroinflammation, this volume discusses in detail the utility, success and pitfalls of multiple models for each condition. Multiple disorders are covered, ranging from neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS, to multiple sclerosis, headache, migraine, and others. With expert authors, this book has applicability for anyone pursuing neuroscience or biomedical research working to better understand, study and ultimately treat neurological dysfunction.

  • Neuroinflammation in Vascular Dementia

    • 1st Edition
    • Gary Rosenberg
    • English
    Neuroinflammation in Vascular Dementia describes the molecular mechanisms that drive this transition to mixed pathology, along with the newer lifestyle and pharmacological approaches that can reduce the incidence of dementia. The book describes the practical aspects of neuroimaging methods, along with novel neuroimaging methods, using MRI, that are becoming important clinically. The author also discusses how the diagnosis of dementias will be greatly aided by biomarkers from neuroimaging, blood and CSF biochemistry and neuropsychological testing in the future. This information will be used in precision medicine to design treatment strategies based on the most likely causes of the disease. Dementia research has undergone dramatic growth driven by current and projected increases in the aging of the population, and thus leading to a larger number of patients with dementia by 2050. Hence, advances in neuroimaging, brain chemistry, and genetics have accelerated our understanding of diseases that lead to cognitive decline.

  • Autophagy Dysfunction in Alzheimer's Disease and Dementia

    • 1st Edition
    • Tadanori Hamano + 1 more
    • English
    Autophagy Dysfunction in Alzheimer’s Disease and Dementia provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. The book discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.

  • Plant Extracts in Neurodegenerative Diseases

    • 1st Edition
    • Magisetty Obulesu
    • English
    Plant Extracts in Neurodegenerative Disease examines the therapeutic efficacy of plant extracts and the lead compounds contained therein that can significantly improve symptoms of diseases of the brain. Providing insights into the protective mechanisms of these bioactive plant compounds to treat Alzheimer’s Disease, Parkinson’s Disease, motor neuron disease, and other neurodegenerative diseases, the book also discusses the pros and cons of using these types of treatments, along with perspectives to overcome current challenges. With chapters looking at individual diseases, readers will learn about studies unique to each condition, including Huntington’s Disease, spinocerebellar ataxia, SMA, ALS and prion disease.

  • Diagnosis and Treatment of Traumatic Brain Injury

    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    Diagnosis and Treatment of Traumatic Brain Injury will improve readers’ understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

  • Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury

    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.

  • Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury

    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

  • Diagnosis and Treatment of Spinal Cord Injury

    • 1st Edition
    • Rajkumar Rajendram + 2 more
    • English
    Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries.

  • Arrestins

    Structure and Function in Vision and Beyond
    • 1st Edition
    • Vsevolod V. Gurevich
    • English
    Arrestins: Structure and Function in Vision and Beyond examines the structural basis of the function of arrestin proteins in the brain. Linking basic, translational and clinical research, this volume begins with history and basic signaling principles and then expands to the use of proteins as potential therapeutic targets. Multiple cellular activities are detailed, including activation, signaling, GPCR endocytosis, and ERK signaling, with chapters examining both visual and non-visual arrestins. Experts in their respective fields are featured throughout, making this book essential reading for anyone who wants to explore the basic science underlying these signaling proteins.

  • Neurological Complications of Systemic Cancer and Antineoplastic Therapy

    • 2nd Edition
    • Herbert B. Newton + 1 more
    • English
    Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist. Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more.

  • Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases

    • 1st Edition
    • Anil Gupta
    • English
    Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases elucidates elaborately the role of caspase enzymes implicated in the initiation of molecular events leading to neuronal apoptosis in the neurodegenerative disease. The book starts with introduction to neuropathology, neurogenetics, and epidemiology of neurodegenerative disease and illustrates the involvement of human caspases, neuronal apoptosis, apoptotic pathways, genetic polymorphisms, and several other factors and underlying mechanisms in the pathology of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. An important focus in all chapters is the intricate mechanisms and interplay that occur during or leading to neuron death in neurodegenerative diseases, along with disease pathobiology.

  • TDP-43 and Neurodegeneration

    From Bench to Bedside
    • 1st Edition
    • Vijay Kumar + 1 more
    • English
    Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43’s structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

  • Methodological Approaches for Sleep and Vigilance Research

    • 1st Edition
    • Eric Murillo-Rodriguez
    • English
    Methodological Approaches for Sleep and Vigilance Research examines experimental procedures used to study the sleep-wake cycle, with topics covered by world leaders in the field. The book focuses on techniques commonly used in the sleep field, including polysomnography, electrophysiology, single- and multi-unit spiking activity recording, brain stimulation, EEG power spectra, optogenetics, telemetry, and wearable and non-wearable tracking devices. Further chapters on imaging techniques, questionnaires for sleep assessment, genome-wide association studies, artificial intelligence and big data are also featured. This discussion of significant conceptual advances into experimental procedures is suitable for anyone interested in the neurobiology of sleep.

  • Neuroinflammation, Resolution, and Neuroprotection in the Brain

    • 1st Edition
    • Akhlaq A. Farooqui
    • English
    Neuroinflammation, Resolution, and Neuroprotection in the Brain discusses the molecular aspects of neuroinflammation in neurological disorders. The book examines the effect of diet and exercise on neuroinflammatory diseases. Chapters focus on bioactive lipids, cytokines and chemokines, as well as the involvement of neuroinflammation, resolution and neuroprotection in neurotraumatic diseases, neurodegenerative diseases and neuropsychiatric diseases. The comprehensive information in this monograph will help readers understand molecular cross-talk among mediators of phospholipid, sphingolipid and cholesterol metabolism. The book's goal is to jumpstart more studies on molecular mechanisms and the therapeutic aspects of neurological disorders in human subjects.

  • Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders

    • 1st Edition
    • Moyra Smith
    • English
    Mechanisms and Genetics of Neurodevelopmental Cognitive Disorders connects neurodevelopment with genetics and behavior to better understand the underlying factors leading to cognitive neurodevelopmental disorders. This book focuses on mechanisms of disease and follows the development of specific brain regions, functions, and gene expression to causes and processes in autism, attention deficit disorder, and learning disabilities. Topics include brain mapping, brain plasticity, epigenetics, neuroimmunology, and many other factors that influence the development of these diseases. This book will promote understanding of recent investigations and developments related to brain development from fetal life onward with specific relevance to neurodevelopmental cognitive disorders and conditions. This is an essential reference for anyone who is looking to learn more about different aspects of neurodevelopment and emerging concepts in psychiatric disorders.

  • The Molecular Immunology of Neurological Diseases

    • 1st Edition
    • Sunil Kumar
    • English
    The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches.

  • Synuclein and the Coelacanth

    The Molecular and Evolutionary Origins of Parkinson's Disease
    • 1st Edition
    • James M. Gruschus
    • English
    Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease.

  • Turmeric and Curcumin for Neurodegenerative Diseases

    • 1st Edition
    • Magisetty Obulesu
    • English
    Turmeric and Curcumin for Neurodegenerative Diseases examines protective mechanisms of turmeric products and novel nanotechnological therapeutics and biomaterial design strategies to circumvent Alzheimer’s Disease, Parkinson’s, and liver diseases. With neurodegenerative and liver diseases posing a serious threat to health care systems worldwide, this book addresses how existing nanotechnology and therapeutic strategies have not been as successful in their treatment. In addition to discussing drawbacks, possible future perspectives to overcome these challenges are also examined. Chapters also focus on therapeutic efficacy and drug delivery systems, providing readers with a full summary of research in this field in one handy reference.

  • The Neuroscience of Dementia

    • 1st Edition
    • Colin R. Martin + 1 more
    • English
    The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

  • The Neuroscience of Parkinson's Disease

    • 1st Edition
    • Colin R. Martin + 1 more
    • English
    The Neuroscience of Parkinson’s Disease (two volume set) provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. The book also fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

  • Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders

    • 1st Edition
    • Akhlaq A. Farooqui
    • English
    Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs.

  • Genetics, Neurology, Behavior, and Diet in Parkinson's Disease

    The Neuroscience of Parkinson’s Disease, Volume 2
    • 1st Edition
    • Colin R. Martin + 1 more
    • English
    Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

    Volume 1
    • 6th Edition
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume One, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format.

  • Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

    Volume 2
    • 6th Edition
    • Roger N. Rosenberg + 1 more
    • English
    Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling.

  • Synapse Development and Maturation

    Comprehensive Developmental Neuroscience
    • 1st Edition
    • Pasko Rakic + 3 more
    • English
    Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns.

  • Lymphatic Structure and Function in Health and Disease

    • 1st Edition
    • Felicity N.E. Gavins + 1 more
    • English
    Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

  • Synaptic Transmission

    • 1st Edition
    • Stephen D. Meriney + 1 more
    • English
    Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winni... researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders.

  • The Molecular and Clinical Pathology of Neurodegenerative Disease

    • 1st Edition
    • Patrick A. Lewis + 1 more
    • English
    The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration.

  • Neuroinflammation

    • 2nd Edition
    • Alireza Minagar
    • English
    Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics. Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.