Neuroglia: Function and Pathology
- 1st Edition - May 12, 2023
- Authors: Alexei Verkhratsky, Arthur Butt
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 6 5 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 6 6 - 1
Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous sy… Read more
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Request a sales quoteDiverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment.
In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function.
Neuroglia: Function and Pathology
provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates.- Single volume covering key aspects of glial cell physiology and pathology
- In depth overview of the history of glial cell research
- Comprehensive review of glial cell physiology and pathology
- Authoritative special chapters on the major neurological diseases
- Full colour throughout, with 360 illustrations
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Biography
- Preface
- Chapter 1. History of neuroglial research
- 1. Early history of neuroscience
- 2. Nerve cells
- 3. Neurophysiology: animal electricity, excitability and ion channels (from 1500 to present)
- 4. Neurophysiology: chemical neurotransmission
- 5. The concept of neuroglia
- 6. Early views on functions of neuroglia
- 7. The beginning of the modern era
- 8. Recapitulation
- Chapter 2. The concept of neuroglia: definition, classification and evolution
- 1. General perspective: multicellular brain and the active milieu of nervous tissue
- 2. Neuroglia—the homeostatic cells of the nervous system
- 3. Classification
- 4. Numbers: how many glial cells are in the brain?
- 5. Evolution of neuroglia
- 6. Recapitulation
- Chapter 3. Astroglial physiology
- 1. Definition and nomenclature
- 2. Origins and development
- 3. Identification, visualisation and numbers of astroglia
- 4. Physiology of astrocytes: ions and channels
- 5. Physiology of astroglia: receptors to neurotransmitters and neuromodulators
- 6. Physiology of astroglia: membrane transporters
- 7. Intracellular astroglial excitability: ionic signalling
- 8. Recapitulation
- Chapter 4. Astroglial functions
- 1. General remarks
- 2. Astroglia as neural stem cells in development and adulthood
- 3. Astroglia and brain fluids
- 4. Ionostasis of the CNS interstitium
- 5. Neurotransmitters homeostasis
- 6. Astrocytes and metabolic homeostasis
- 7. Astroglia in systemic homeostasis
- 8. Astrocytes as secretory cells of the CNS
- 9. Astrocytes, synaptic transmission and neuroplasticity
- 10. Astrocytes in higher cognitive functions
- 11. Recapitulation
- Chapter 5. Oligodendroglial physiology and function
- 1. Definition and nomenclature
- 2. Oligodendroglial origins and development
- 3. Identification and anatomy of oligodendrocytes and myelin
- 4. Physiology of oligodendrocytes
- 5. Functions of oligodendrocytes
- 6. Recapitulation
- Chapter 6. Microglial physiology and function
- 1. Definition
- 2. Origins and development
- 3. Visualisation and identification of microglia
- 4. Morpho-functional heterogeneity of microglia
- 5. Physiology of microglia
- 6. Recapitulation
- Chapter 7. Peripheral glia physiology and function
- 1. Definitions and nomenclature
- 2. Origins and development of peripheral glia
- 3. Identification and anatomy of peripheral glia
- 4. Physiology of peripheral glia
- 5. Functions of peripheral glia
- 6. Recapitulation
- Chapter 8. Glia of special senses
- 1. General remarks
- 2. Visual system
- 3. Glia of sensory end-organs of the skin
- 4. Hearing (auditory) and balance (vestibular)
- 5. Olfaction (smell)
- 6. Taste (gustation)
- 7. Recapitulation
- Chapter 9. Principles of gliopathology
- 1. Neuroglia in neurological diseases: general remarks
- 2. Stratification of gliopathology
- 3. Neuroglia in ageing
- 4. Neuroglia define cognitive reserve and are susceptible to life-style modifications
- 5. Recapitulation
- Chapter 10. Inflammatory diseases of the CNS
- 1. Neurotrauma
- 2. Brain ischaemia and stroke
- 3. Neuroinfection
- 4. Multiple sclerosis
- 5. Neuromyelitis optica spectrum disorder
- 6. Recapitulation
- Chapter 11. Neurodegenerative diseases
- 1. General remarks
- 2. Senile dementia – the outcome of neurodegeneration
- 3. Motor neurone diseases
- 4. Astrotauopathies
- 5. Alzheimer's disease
- 6. α-Synucleopathies
- 7. Polyglutamine (PolyQ) diseases
- 8. Other dementias
- 9. Recapitulation
- Chapter 12. Neuropsychiatric disorders
- 1. General remarks
- 2. Astrocytes and stress
- 3. Mood disorders and anxiety
- 4. Schizophrenia
- 5. Addictive disorders
- 6. Eating disorders
- 7. Autism spectrum disorders and obsessive-compulsive disorders
- 8. Recapitulation
- Chapter 13. Other diseases of the CNS
- 1. Epilepsy and migraine
- 2. Leukodystrophies
- 3. Toxic encephalopathy
- 4. Duchenne muscular dystrophy
- 5. Cerebellar ataxia: pathology of Bergmann glia
- 6. Diseases of metabolism
- 7. Neuropathic pain and itch
- 8. Neurodevelopmental disorders
- 9. Diseases of the retina
- 10. Gliomas
- 11. Recapitulation
- Chapter 14. Pathology of the peripheral nervous system
- 1. General remarks
- 2. Traumatic injury of peripheral nerves
- 3. Inflammatory/autoimmune diseases of the PNS
- 4. Hereditary diseases of the PNS
- 5. Metabolic neuropathies
- 6. Toxic neuropathies of the PNS
- 7. Infectious peripheral neuropathy
- 8. Tumours of peripheral nerves
- 9. Recapitulation
- Epilogue
- Index
- No. of pages: 730
- Language: English
- Edition: 1
- Published: May 12, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780128215654
- eBook ISBN: 9780128215661
AV
Alexei Verkhratsky
AB