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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Medical and Health Genomics of South Asia

    • 1st Edition
    • Dhavendra Kumar + 1 more
    • English
    Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region. Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

  • Legal Issues in Quality for Healthcare Institutions

    • 1st Edition
    • Ramesh Sachdeva
    • English
    Legal Issues in Quality for Healthcare Institutions provides the perspective of practicing physicians, lawyers, and academic legal scholars to comprehensively address the implications for quality of care and patient safety both from a legal, medical, and improvement science standpoint. Hospital administrators, physicians, nurses, researchers, legal scholars, as well as regulatory and compliance officers working in hospitals and acute care facilities will find this to be a helpful resource in understanding and addressing the many facets and issues in the field of medicine and law related to quality and patient safety.

  • Alternative Splicing

    Recent Advances in Health and Disease
    • 1st Edition
    • Sayeed ur Rehman A. Kalam + 1 more
    • English
    Alternative Splicing: Recent Advances in Health and Disease offers a comprehensive study of this cellular process, its fundamental characteristics, latest advances, and clinical utilization. Opening with an introduction to alternative splicing and its function in generating transcriptome and protein diversity, the book considers the role of this process across a range of diseases and disorders, including cardiovascular disease, cancer, obesity, and viral infections. Key methods used to study alternative splicing are also investigated, including high-throughput sequencing-based methods, bioinformatics tools, computational methods, single-cell sequencing techniques and mass-spectrometry based proteomics.This is followed with analysis of therapeutic approaches associated with alternative splicing. This is an ideal reference for those involved in investigating alternative splicing and its impact to health and disease, and is therefore relevant to researchers across cell biology, molecular biology, pharmacology and related areas.

  • Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B

    • 1st Edition
    • Lung-Yi Loey Mak + 1 more
    • English
    Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B offers a comprehensive examination of the therapeutic potentials of Tenofovir Alafenamide (TAF) in hepatitis B, providing a succinct and up-to-date summary of all relevant evidence for this first-line oral antiviral agent. The text delves into key topics such as the pharmacological profile of TAF, its comparative efficacy against traditional antiviral agents, safety and tolerability, and the impact of TAF on drug resistance. Additionally, it explores the use of TAF in special populations, including pediatrics, the elderly, and individuals with renal impairment, as well as future directions in hepatitis B treatment strategies.Readers will discover the diverse potential applications of TAF in chronic hepatitis B, informed by valuable lessons learned from HIV treatment while also gaining insights into future therapeutic possibilities. Authored by leading experts in the field, each chapter presents focused and insightful perspectives, making this book an indispensable resource for practitioners and researchers alike. Serving as a critical resource for physicians, researchers, pharmacologists, and biomedical scientists, this book highlights the core knowledge necessary for understanding TAF and its clinical applications.

  • Innovation in Emergency Medicine

    Technology Development and Commercialization Handbook
    • 1st Edition
    • Nancy Patterson + 3 more
    • English
    Innovation in Emergency Medicine: Technology Development and Commercialization Handbook is a step-by-step guide to emergency medicine technology innovation reflecting recent trends of industry globalization and value-conscious healthcare. Written by a team of medical, engineering, and business experts, the authors provide a comprehensive resource that leads engineers, clinicians, students, researchers, and entrepreneurs through a clear process for the identification, invention, and implementation of new solutions. Case studies on innovative products from around the world, successes and failures, practical advice, and end-of-chapter 'Getting Started' sections encourage readers to learn from real projects and apply important lessons to their own work. This new volume in the Clinical and Medical Innovation Series will be of interest to every biomedical engineer and those working in emergency medicine who has ever had a good idea for an invention but does not know where and how to start bringing it to the bedside.

  • Microplastics and the Hidden Threat to Human Reproduction

    Plastic Peril
    • 1st Edition
    • Nimra Afzal + 1 more
    • English
    Microplastics and the Hidden Threat to Human Reproduction: Plastic Peril explores the intricate relationship between microplastics and reproductive health, delving into the sources and distribution of microplastics in the environment, human exposure routes, associated risks, the toxicological effects on reproductive health, potential connections to fertility, endocrine disruption, and developmental consequences due to maternal exposure. It includes impacts on both male and female reproductive health, risks during pregnancy, population-level health concerns, strategies for mitigating microplastic exposure, and the policy and regulatory frameworks surrounding this issue. The book also provides insights into the future direction of research and public health initiatives.In essence, it explores how tiny microplastic particles can have significant and far-reaching consequences on human reproductive health, making this a vital and emerging area of concern. This is a comprehensive resource for anyone interested in understanding the various aspects of the microplastics-reprod... health connection and a go-to reference for researchers, healthcare professionals, policymakers, and concerned individuals.

  • Melanin-Concentrating Hormone

    From Metabolism to Sleep Disorders
    • 1st Edition
    • Jackson C. Bittencourt + 1 more
    • English
    Melanin-Concentratin... Hormone: From Metabolism to Sleep Disorders, the latest volume in the Molecular Mediators in Health and Disease series, offers a comprehensive understanding of this multifunctional peptide. The book covers a wide range of topics, including molecular biology of MCH, MCH in organ function, pharmacology, and MCH in disease. Recent developments in MCH imaging and pharmacological modulation are explored, along with the impact of MCH in psychiatric and neurodegenerative disorders and its role in the neuroimmunological modulation of vitiligo. Additionally, MCH is considered in the context of reproductive behavior, sleep, cognition, memory, and peripheral function.The book also explores MCH across various species such as humans, reptiles, non-primate mammals and teleosts. This is an ideal reference for researchers working with MCH across the fields of cell biology, molecular biology, pharmacology, neuroscience, endocrinology, and beyond.

  • Pain Conditions of the Head and Face

    A Practical Guide to Diagnosis and Management
    • 1st Edition
    • Anat Galor + 1 more
    • English
    Pain Conditions of the Head and Face: A Practical Guide to Diagnosis and Management provides a user-friendly guide on diagnosing and managing common head and facial pain conditions using new methods and therapies. The book contains practical information, reviewing epidemiology, presenting key features, contributing mechanisms, and including treatment algorithms for common pain conditions of the head and face. Focus is given to aspects of disease that are novel and evolving, and all conditions are discussed within the framework of the latest advances in research and patient care.Doctors seeking to ameliorate their patients’ pain from such maladies as (among many others) neuropathic ocular pain, trigeminal neuralgia, herpetic neuralgia, temporomandibular disorders, burning mouth disorder, and neuropathic ear pain will require no other book to identify their patients’ illnesses and make sure they receive the care they need.

  • Social Determinants of Health in Surgery

    Research Methods and Clinical Review
    • 1st Edition
    • Steven A. Toms + 4 more
    • English
    Social Determinants of Health in Surgery: Research Methods and Clinical Review is a groundbreaking resource dedicated to examining the role of social determinants within surgical care. This book is designed for surgical trainees, healthcare providers, researchers, and policy administrators, offering a thorough exploration of how social factors impact surgical outcomes and practice. Featuring a detailed analysis of eleven key domains, it addresses the challenges and opportunities of integrating social determinants into surgical research and practice. The text provides essential guidance for those seeking to understand and improve patient outcomes through a broader, community-driven lens.In addition to its comprehensive coverage, the book delves into specialized topics such as big data analytics, ethical considerations, global health perspectives, pediatric surgical care, and clinical applications for research. It presents methodological guidance, including valuable tips and common pitfalls useful for readers at any stage of their surgical careers. The book also offers an in-depth review of social determinants research across ten major surgical specialties, highlighting significant trends, key studies, and current gaps in knowledge. Case studies and reflective interviews from experienced clinicians further enrich the reader’s understanding.

  • Introduction to Structural Bioinformatics

    • 1st Edition
    • Yang Zhang + 2 more
    • English
    Introduction to Structural Bioinformatics offers a complete overview on the fundamental concepts and methodologies of structural bioinformatics and computational structural biology. The book is divided into three sections, beginning with a discussion of the key principles of bioinformatics and fundamental aspects, including bioinformatics databases, multiple sequence alignment, and machine learning. Section two then moves on to structural bioinformatics, where topics include Monte Carlo simulation, protein structure prediction, RNA structure prediction, and protein design. The final section of the book focuses on experimental structural determination, where chapters focus on techniques including X-ray crystallography, nuclear magnetic resonance and cryo-electron microscopy. This is an ideal guide on key principles, methods, and the most up-to-date developments across structural bioinformatics and computational structural biology. It will be a comprehensive reference for postgraduate students, instructors, and researchers working in these and adjacent subjects.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1st Edition
    • Deepak Kumar + 4 more
    • English
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • Applications of Microfluidics Device Technology

    • 1st Edition
    • Volume 227
    • English
    Microfluidics is a rapidly expanding field that is recognized as a powerful platform for accelerating biological science research and innovation. It has the potential to reduce the cost and reagent consumption by enabling the precise manipulation of a small amount of fluids through microchannel ranging from ten to hundreds micrometres in size. It is a multidisciplinary domain, which integrates molecular analysis, molecular biology, and microelectronics. It has demonstrated practical applications in the design and fabrication of systems capable of processing low volumes of fluids while enabling multiplexing, automation, and high-throughput screening. Since its emergence in early 1980s, microfluidics has significantly contributed in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Microfluidic chips comprise intricate networks of microchannels and chambers designed to manipulate fluids at the microscale. This volume highlights the applications of microfluidics in the detection and analysis of infectious diseases caused by bacteria, viruses, fungi, and protozoa. It also explores the use of microfluidic technologies in the diagnosis and study of non-infectious diseases, including cardiovascular disorders, cancer, metabolic diseases, and neurological conditions. It also covered single-cell analysis, high-throughput drug screening, cell sorting, and both preclinical and clinical applications. It also used in role of microfluidics in organ culture, regenerative medicine, and personalized healthcare. It also addresses ethical and regulatory issues in the development and use of microfluidic devices. This volume is designed to serve as valuable resource for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand microfluidics and apply microfluidics technology/devices in various fields. It provides a strong foundation to help the extension of microfluidics knowledge and accelerate research, innovation, technology and practical applications.

  • Electrocardiography of Laboratory Animals

    • 3rd Edition
    • Meg M. Sleeper + 1 more
    • English
    Electrocardiography of Laboratory Animals, Third Edition, provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book begins with the fundamental principles of electrocardiography and its applications in drug safety evaluation but then covers electrocardiography in a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees.Addition... it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. It is an essential resource for biological and medical researchers, veterinarians, zoologists, and students.

  • Advances in Hepatorenal Syndrome Research

    Untangling Pathophysiology, Improving Diagnostic Strategies, and Leveraging Therapeutic Innovations
    • 1st Edition
    • Justin Belcher
    • English
    Advances in Hepatorenal Syndrome Research: Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations is a comprehensive review of the historical perspectives, prevalence, and prognosis of HRS, offering insights into its evolving clinical recognition and shifting paradigms of pathophysiology. Explore the multifaceted pathophysiology of HRS as experts navigate the complexities of cardiac dysfunction, inflammatory cytokines, and other modern understandings shaping the field. Explore differential diagnosis, uncovering alternative etiologies and current diagnostic criteria, while shedding light on biomarkers and novel diagnostic tests revolutionizing patient assessment. Contents will also guide readers through the utility of point-of-care ultrasound in intravascular volume assessment sets the stage for exploring medical therapy options, including vasoconstrictors and albumin usage. Written by a team of experts, this comprehensive reference highlights the intricate pathophysiology of hepatorenal syndrome while delivering the most up-to-date insights into diagnostic and therapeutic approaches. Historically overshadowed by grim prognoses, hepatorenal syndrome has undergone a renaissance of interest due to recent breakthroughs, revolutionizing treatment paradigms. Whether you're a seasoned practitioner or a burgeoning researcher immersing yourself in this dynamic field, this resource offers a thorough examination, encompassing novel diagnostic criteria, innovative biomarkers, and state-of-the-art treatments.

  • Neurogenetic Therapies

    Advancements in Treating Nervous System Disorders
    • 1st Edition
    • Ashutosh Pareek + 4 more
    • English
    Neurogenetic Therapies: Advancements in Treating Nervous System Disorders offers a comprehensive resource on the latest gene therapy techniques and their applications in treating neurological disorders. The book delves into various gene therapy methods, including genomic DNA-based therapies, vector-mediated delivery, and RNA interference-based gene silencing. It explores the use of these techniques in treating conditions such as Alzheimer's disease, Parkinson's disease, spinal muscular atrophy, and Duchenne muscular dystrophy. Key topics include the molecular and genetic basis of nervous system disorders, the role of epigenetics, and the development of stem cell and genome editing therapies.With contributions from leading experts, the book also addresses regulatory and ethical considerations in gene therapy, providing a balanced perspective on the challenges and opportunities in this rapidly evolving field. Case studies and practical examples illustrate successful gene therapy treatments, offering valuable insights into translating research into clinical practice. This book is an essential resource for students, researchers, and scientists in neurogenetics, neurology, and molecular biology, as well as clinicians interested in the mechanisms and treatment of neurodegenerative diseases.

  • Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases

    • 1st Edition
    • Riccardo De Robertis
    • English
    Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases addresses the critical need for detailed comparisons between advanced ultrasound (US) techniques and CT/MRI findings in the evaluation of liver diseases. While many books exist, few provide the in-depth analysis and practical guidelines necessary for accurate diagnosis and effective treatment planning. This book fills that gap, offering a multiparametric approach to the assessment of fibrotic and steatotic liver diseases. Inside, readers will find essential topics such as indications for liver US in diffuse liver diseases, advanced Ultrasound techniques for assessing liver fibrosis and steatosis, and the correlation between US, CT, and MRI findings.Key chapters cover the basics of liver ultrasound, conventional Doppler and microvascular flow imaging, ultrasound elastography, and the quantification of liver steatosis. Additionally, the book explores cutting-edge topics like artificial intelligence in liver ultrasound and the application of US in pediatric patients. Contributions from leading experts in the field ensure that each chapter provides valuable insights and practical advice. This is an indispensable resource for scientists, researchers, and clinicians alike. It offers clear guidelines on performing liver ultrasounds, understanding and interpreting results, and making informed comparisons with CT and MRI findings.

  • Practice-Based Physiology in Allied Health Sciences

    From Evidence to Clinical Application
    • 1st Edition
    • Satyajit Tripathy + 3 more
    • English
    Practice-Based Physiology in Allied Health Sciences: From Evidence to Clinical Application provides a comprehensive, systems-based exploration of human physiology specifically designed for applied health sciences. It moves beyond conventional textbook knowledge to integrate cardiovascular, respiratory, neurological, endocrine, and musculoskeletal systems within the context of real-world clinical and functional applications. By emphasizing translational physiology, the text helps readers understand how cellular and systemic mechanisms directly inform therapeutic assessment, intervention planning, and patient-centered care. The book’s multidisciplinary perspective supports students and practitioners in physiotherapy, occupational therapy, nursing, sports medicine, and behavioral science—highlighting physiology as a common language that unites diverse healthcare disciplines. Through detailed explanations, case studies, and applied scenarios, readers learn to interpret physiological data, identify dysfunctions, and design interventions grounded in scientific evidence. Ultimately, this resource bridges the gap between science and practice by linking physiological understanding to outcomes such as recovery, mobility, pain management, fatigue reduction, and overall well-being. It encourages critical thinking, clinical reasoning, and interprofessional collaboration—ensuri... that learners not only grasp how the human body functions but also how that knowledge can meaningfully improve health, performance, and quality of life.

  • Artificial Intelligence in Point-of-Care Nanobiosensors Technology

    Enhancing Disease Diagnostics and Improved Healthcare Outcomes
    • 1st Edition
    • Tharmaraj Vairaperumal + 2 more
    • English
    Artificial Intelligence in Point-of-Care Nanobiosensors Technology: Enhancing Disease Diagnostics and Improved Healthcare Outcomes delves into the revolutionary integration of artificial intelligence (AI) with nanobiosensors to elevate point-of-care (POC) diagnostics for both communicable and non-communicable diseases. Readers will find insightful chapters covering topics ranging from foundational AI and machine learning techniques to specific applications in cardiovascular disease, diabetes, cancer, chronic respiratory ailments, and infectious diseases. Each chapter not only highlights recent breakthroughs in nanobiosensors but also emphasizes the pivotal role of AI in enhancing diagnostic accuracy and facilitating personalized health interventions. Additional discussions around regulatory considerations and the future landscape of AI in biomedical research make this an essential read for those navigating this rapidly evolving field. This book primarily targets researchers and professionals engaged in the interdisciplinary realms of AI, nanomaterials, and biomedical sciences. By providing a critical understanding of emerging AI-based diagnostic technologies and their applications in POC settings, this book fosters collaboration across diverse scientific domains.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Andrew Vinard + 1 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Tissue Organization in Development

    • 1st Edition
    • Volume 171
    • English
    Tissue Organization in Development explores how cells coordinate, communicate, and arrange themselves to build functional tissues during embryonic and postnatal development. The book brings together current perspectives on the molecular, cellular, and mechanical principles that govern tissue patterning, morphogenesis, and structural organization across developing systems. Covering key topics such as cell fate specification, cell–cell interactions, extracellular matrix dynamics, polarity, migration, and tissue remodeling, it highlights how complex biological form emerges from coordinated developmental processes. This volume provides a valuable resource for researchers, students, and professionals interested in developmental biology, cell biology, and tissue formation.

  • Self-Learning AI in Healthcare

    Agentic Systems for Smarter Medicine
    • 1st Edition
    • Rajesh Kumar Dhanaraj + 4 more
    • English
    Self-Learning AI in Healthcare: Agentic Systems for Smarter Medicine covers the transformative potential of advanced artificial intelligence within modern medicine. The book addresses the critical need for self-learning and agentic AI systems that autonomously adapt, refine decision-making, and navigate complex clinical environments with minimal intervention. Chapters provide foundational insights into the rise of self-learning AI and neural networks tailored for adaptive medical systems. Subsequent chapters delve into unsupervised, semi-supervised, and reinforcement learning for autonomous healthcare decision-making, alongside decentralized edge AI approaches. Specialized sections cover personalized medicine, hospital workflow optimization, remote patient monitoring, early disease detection, federated learning for privacy preservation, and more.Further, this book explores AI applications in drug discovery, mental health support, radiology, digital twins, and medical robotics, culminating with an examination of future challenges, ethics, and regulatory frameworks shaping self-learning AI’s trajectory in healthcare. It is tailored to serve a diverse yet specialized audience spanning academic, professional, and research sectors. Healthcare IT professionals and clinical informatics specialists will gain practical guidance for implementing adaptive AI solutions within complex healthcare environments. AI researchers and data scientists focused on developing self-learning models will find cutting-edge methodologies and case studies that advance medical applications.

  • Introduction to Tactile Intelligence

    • 1st Edition
    • Shan Luo
    • English
    Introduction to Tactile Intelligence emphasizes the growing importance of tactile intelligence, essential for robots to interact effectively with the physical world. This book explores the science of tactile intelligence, equipping robots and intelligent machines with the ability to touch and feel the world, recognize textures, develop fine motor skills, and even convey emotions through physical contact. It anticipates a future where robots seamlessly integrate with the physical world through tactile intelligence and offers solutions for its development and application in various domains. This book is a good resource for students in robotics to experienced professionals, providing a solid foundation in tactile sensing, tactile-based control, and learning, as well as the integration of tactile data into broader robotic systems. This book provides valuable insights and practical guidance, and it serves as a reference for researchers at all stages of their careers in the dynamic field of tactile development and applications.

  • Machine Learning in Enzymology

    • 1st Edition
    • Volume 742
    • English
    This volume surveys cutting-edge machine learning–based approaches for the study of enzyme catalysis, dynamics, and design. It brings together computational and experimental approaches that integrate molecular simulation, machine learning, and high-throughput data to interrogate enzymatic catalysis at multiple scales. The chapters in the volume highlight how data-driven frameworks complement physics-based models to advance mechanistic understanding and enable rational enzyme engineering.

  • Omics Approaches in Rhizosphere Microbiology: Part A

    • 1st Edition
    • Volume 60
    • English
    Omics Approaches in Rhizosphere Microbiology: Part A series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Glial Mechanisms in Sleep and Circadian Biology

    • 1st Edition
    • Marcos G. Frank
    • English
    Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

  • Gallin and Ognibene's Principles and Practice of Clinical Research

    • 5th Edition
    • John I. Gallin + 2 more
    • English
    Gallin and Ognibene’s Principles and Practice of Clinical Research, Fifth Edition provides the definitive text on clinical research as written by internationally recognized experts from the National Institutes of Health, the US Food and Drug Administration, academia, and global researchers. This new edition contains more than 30 new authors and 9 new chapters. Topics covered emphasize the role of informatics in clinical research, incorporating clinical outcome assessment into endpoints for decision-making, inclusion of diverse and vulnerable research subjects, patient advocacy groups, rare disease research, preparing research for pandemics, public health emergencies, research opportunities for surgeons, and content on preclinical animal studies.For the international researcher, two new chapters detail international clinical research experiences in South Africa, India, and Pakistan. As with the previous edition, the new release provides readers with summary questions and answers after each chapter.

  • Essentials of Stem Cell Biology

    • 4th Edition
    • Robert Lanza + 1 more
    • English
    Essentials of Stem Cell Biology, Fourth Edition is designed for the growing community of scientists, researchers, practitioners, and students embracing the latest advancements in stem cells. This comprehensive book, a collaboration of 7 editors and over 200 pioneering scholars and scientists, provides a thorough understanding of adult and embryonic stem cells. It combines fundamental concepts with cutting-edge research in specific organ systems, ensuring a robust foundation for anyone entering the field. Beyond the basics, the book delves into early development and the differentiation of ectoderm, mesoderm, and endoderm.It covers methods, applications to human diseases, regulation, ethics, and patient perspectives, leaving no stone unturned in the stem cell domain.

  • Congenital Adrenal Hyperplasia

    A Comprehensive Guide
    • 2nd Edition
    • Peter C. Hindmarsh + 1 more
    • English
    Congenital Adrenal Hyperplasia: A Comprehensive Guide, Second Edition provides a fully-illustrated edition that outlines the basics of CAH and its interrelation with hormones and bodily function, including updated content on the latest clinical research. A new chapter dedicated to gene therapy covers principles, current status, the latest research developments, and potential treatments for congenital adrenal hyperplasia. In addition, this new release updates patient profiles due to several new clinical studies in CAH for improved condition management, with practical information on how to deal with emergencies, medic alert emergency kits, emergency injection needles, handling illness, surgery, and more.In addition, new assays are incorporated for the analysis of pituitary and adrenal hormones for the determination of the disease. This new edition continues to be a vital reference to pediatric endocrinologists as well as primary care providers to help affected patients with an updated model of care and appropriate treatment. Patients and family members will continue to benefit from the new trend-forward information presented and will be empowered to approach their health care providers with the expectation of receiving individualized care and treatment of the disorder.

  • Artificial Intelligence (AI) in cancer biology

    Advancements in Diagnosis and Treatment
    • 1st Edition
    • Sadhna Aggarwal
    • English
    Artificial Intelligence (AI) in cancer biology: Advancements in Diagnosis and Treatment explores the revolutionary impact of AI on cancer biology and oncology. This comprehensive volume delves into AI technologies, including machine learning and deep learning, enhancing our ability to understand, diagnose, and treat cancer with unprecedented precision. The book covers a wide range of topics, from cancer biology fundamentals to AI-driven techniques in diagnosis and personalised treatment. It discusses medical imaging, genomics, drug discovery, and predictive modelling, along with ethical and regulatory considerations, offering a holistic view of AI in cancer research. For academic audiences, this book provides invaluable insights into improving clinical outcomes and patient care. Researchers and clinicians will benefit from the detailed analysis of AI applications, while students and scholars will find a wealth of information to support their studies and future innovations in cancer treatment.

  • AI and Global Health

    Unlocking Transformative Potential
    • 1st Edition
    • Adil Haider
    • English
    AI and Global Health: Unlocking Transformative Potential provides a roadmap for practitioners to apply and leverage artificial intelligence to strengthen health systems using the World Health Organization's health systems approach. The book's combination of case studies and secondary research inspires the possibility of what can happen using AI in healthcare, ensuring the use of robust, scientific evidence to draw conclusions. Additionally, readers will learn from others in settings where AI has been a tool for change, providing healthcare practitioners and policymakers with what they need to think through how it can be applied in resource limited settings.The book provides a strong call to action for policymakers and healthcare leaders of governments, international organizations, and healthcare institutions to take the lead in AI implementation as a key lever for advancing global health goals through a systems approach. As AI is a rapidly evolving field with significant investment made in this industry in recent years from government and the private sector, this book articulates how this growth can be harnessed for countries that need a different approach to addressing global health problems.

  • Smart Approaches for Cancer Diagnosis, Therapy, and its Associated Challenges

    • 1st Edition
    • Paul A. Millner + 2 more
    • English
    Smart and Translational Approaches in Cancer Diagnosis and Therapy: Innovations and Challenges presents a comprehensive exploration of cutting-edge technologies transforming cancer care. This edited volume bridges foundational science with clinical relevance, offering insights into theranostics, nanomedicine, and molecular therapeutics. The book delves into advanced diagnostic tools such as biosensors and theranostic nanoparticles, and therapeutic innovations including peptide-drug conjugates, epigenetic modulation, and nucleic acid-based treatments. It addresses key challenges in glioblastoma, pediatric brain tumors, and drug-resistant cancers, while highlighting translational strategies that integrate diagnostics and therapy. Academics benefit from a multidisciplinary reference that supports research, fosters innovation, and enhances understanding of emerging cancer therapies. It equips researchers with the latest developments to advance precision medicine and improve patient outcomes.

  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1st Edition
    • Anthony Chang + 1 more
    • English
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.

  • Fluid Dynamics of Viral Transmission

    • 1st Edition
    • Mehrzad Shams + 1 more
    • English
    Fluid Dynamics of Viral Transmission is an essential exploration into the transmission dynamics of COVID-19, focusing specifically on the airborne spread of respiratory aerosols carrying infectious viruses. In light of the recent global pandemic, it offers crucial insights into the complex interaction between fluid dynamics and viral transmission and provides practical solutions for minimizing risks in indoor environments. The book delves into CFD simulations, optimizing ventilation systems, air filtration strategies, and spatial layout modifications. It evaluates mitigation measures such as mask-wearing, physical distancing, and occupancy limits, aiming to equip readers with the knowledge to create safer indoor spaces. This book is ideal for public health officials, policymakers, healthcare professionals, engineers, researchers, and academics in fluid mechanics, computational fluid dynamics, epidemiology, and virology.

  • Quick Guide to Hemostasis and Transfusion Medicine

    • 1st Edition
    • George A. Fritsma + 3 more
    • English
    Quick Guide to Hemostasis and Transfusion Medicine is a patient reference that recommends indication-based laboratory test selection and interpretation to diagnose and treat hemorrhagic and thrombotic disorders using blood components, biologics, and synthetic therapeutics. The book introduces hemostasis and transfusion medicine for students, residents, and fellows, supplementing standard texts. It uses headings, bulletpoints, telegraphic syntax, tables, figures, and speedy lookup features and is an essential quick reference for health care providers who order, perform, and interpret hemostasis and immunohematology assays and administer hemostasis therapy.

  • Human-AI-Cognitive Intelligence Software, System, and Services for Quality Assurance

    Theories and Methods with Systems Thinking for Behaviour Change in the Medical Decision-Making Pathway
    • 1st Edition
    • Pantea Keikhosrokiani
    • English
    Habit-based Behavior Change Medical Information Support System and Artificial Intelligence: Theories, Methods, and Data Analytics Approach provides a guideline to design and implement Habit-based Behavior Change Support Systems (HBCSS) which can change patient’s unhealthy habits to prevent the development of diseases. It presents theories, methods, management, and data analytics approach required to design, implement, and prescribe the use of HBCSS for several diseases’ management.It discusses topics such as theories of behavior change, ontologies and knowledge management, data mining, privacy and security, descriptive and prescription analytics. In addition, it discusses how to measure habit-change, future directions of the field, and case studies based on real-world examples.It is a valuable resource for clinicians, researchers, students, and member of the biomedical and medical fields who want to learn more about the use of medical systems to improve patients’ health.

  • Human Reproduction

    From basics to Biotechnology
    • 1st Edition
    • Marc yeste
    • English
    Human Reproduction: From Basics to Biotechnology is a complete reference for anyone in the field of life, health, and biomedical sciences. The book provides an overview of basics in human reproduction to advanced knowledge of the field, including some evidence from other mammalian species that complement our current knowledge on the anatomy and physiology of the male and female reproductive tract and gametes. This resource covers the most used assisted reproductive techniques and technical advances, human reproduction and infertility disorders, their diagnosis and available treatment options.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • GANs in Medical Diagnostics and Classification

    • 1st Edition
    • Abhishek Kumar + 1 more
    • English
    GANs in Medical Diagnostics and Classification explores the role of Generative Adversarial Networks (GANs) in addressing underdiagnosed and overlooked health challenges. The book bridges cutting-edge AI research with real-world medical applications, presenting interdisciplinary insights into how GANs enhance diagnostics, treatment precision, and disease surveillance across domains such as antimicrobial resistance, rare genetic disorders, and environmental health risks. It also examines ethical, policy, and accessibility dimensions of AI in healthcare. By combining technical depth with practical case studies, this volume equips medical researchers, AI engineers, and healthcare professionals with actionable knowledge to tackle silent epidemics using GAN-based tools.

  • Geographic Atrophy in Age-related Macular Degeneration

    • 1st Edition
    • Jay Chhablani + 1 more
    • English
    Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinical trials, differential diagnoses, and both established and emerging treatment options. The book details diagnostic processes using techniques such as visual acuity tests, dilated eye exams, fundus photography, optical coherence tomography (OCT), and fluorescein angiography, emphasizing the importance of early detection. It also differentiates geographic atrophy from other retinal conditions with similar symptoms, such as dystrophies, equipping practitioners with the knowledge for accurate diagnosis.Additional... it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

    • 1st Edition
    • Cheng Xue + 3 more
    • English
    Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals. From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine.Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 136
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Biomechanics of the Heart

    From Model to Patient
    • 1st Edition
    • Peter Bovendeerd + 3 more
    • English
    Biomechanics of the Heart: From Model to Patient provides readers with a comprehensive overview of the modeling and assessment of the heart’s biomechanics. The book addresses topics such as the physiology of normal and diseased hearts, cardiovascular imaging, modeling of myocardial tissue in the passive and active states, as well as state-of-the-art approaches for patient specific modeling of the heart’s mechanical function. This is all augmented by case studies and examples of exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases. Readers are introduced to modeling of the heart’s anatomical and muscular structure, a review of imaging techniques to analyze the geometry, content and dynamics of the heart, as well as an in-depth look at the biomechanical properties of normal and diseased hearts. Finally, chapters cover modeling cardiac passive and contractile mechanics, biomechanical finite element simulations of the heart, patient-specific modeling of the heart and circulatory system, as well as the exploitation of models for computer-aided diagnosis, treatment, and monitoring of heart diseases.

  • An Essential Guide to Radiation Dosimetry for Medical Applications

    Principles, Technologies, and Clinical Applications
    • 1st Edition
    • Jayachandran Venkatesan + 1 more
    • English
    An Essential Guide to Radiation Dosimetry for Medical Applications: Principles, Technologies, and Clinical Applications provides a comprehensive overview of the fundamental concepts, advanced methodologies, and emerging technologies in radiation dosimetry. This book serves as an essential resource for researchers, clinicians, and students involved in cancer research, bioinformatics, medical physics, radiology, and radiation therapy, offering in-depth insights into both theoretical principles and practical applications. The content covers core topics such as radiation interactions, dosimetry materials, and simulation techniques, alongside clinical and diagnostic applications.In addition, it also explores innovative approaches like artificial intelligence, nanodosimetry, and quality assurance, ensuring readers stay current with technological advancements. This book benefits the academic audience by enhancing their knowledge of dosimetry science and fostering the development of safer, more effective radiation practices. It supports education, research, and clinical decision-making, ultimately advancing the field of radiation physics and improving patient outcomes.

  • Advances in Medical Simulation

    Techniques, Applications and Innovations
    • 1st Edition
    • Noor Zaman Jhanjhi + 2 more
    • English
    Advances in Medical Simulation: Techniques, Applications, and Innovations explores cutting-edge developments in medical simulation, focusing on its transformative role in medical education, training, and patient care. The book examines various simulation techniques, including virtual and augmented reality, high-fidelity mannequins, and task trainers, showcasing their applications in surgical training, clinical diagnostics, and emergency response. Sections provide an in-depth discussion of the challenges and future directions in medical simulation, highlighting innovations such as robotics and artificial intelligence. By addressing gaps in existing literature, this book offers a comprehensive understanding of how advanced simulation techniques can enhance healthcare professionals' skills and competencies.For the academic audience, this book serves as a vital resource that bridges research and practical applications in clinical settings. It identifies trends and opportunities for future innovation, ultimately aiming to reduce medical errors and improve patient safety through effective simulation-based practices.

  • Nanoengineered Drug Delivery Systems for Oral and Head & Neck Cancer

    Targeting the Tumor Microenvironment
    • 1st Edition
    • Raghvendra Ashok Bohara
    • English
    Nanoengineered Drug Delivery Systems for Oral and Head & Neck Cancer: Targeting the Tumor Microenvironment explores innovative nanotechnologies designed to improve treatment outcomes for oral and head and neck cancers. The book integrates molecular design, nanotechnology, and clinical translation, emphasizing targeted drug delivery strategies that modulate the tumor microenvironment. It provides comprehensive coverage of tumor biology, early detection, molecular targets, and advanced delivery systems like liposomes and stimuli-responsive nanocarriers.The content also highlights emerging areas such as immune engineering, AI-assisted design, and clinical case studies, fostering a translational approach from laboratory research to clinical application. This resource benefits researchers, clinicians, and students by offering insights into cutting-edge nanomedicine, fostering interdisciplinary collaboration, and guiding future innovations in personalized cancer therapy and commercialization pathways.

  • Nanocarrier-Based Immunotherapy

    Emerging Frontiers in Cancer
    • 1st Edition
    • Bhupendra G. Prajapati + 1 more
    • English
    Nanocarrier-Based Immunotherapy: Emerging Frontiers in Cancer explores innovative nanotechnology approaches to enhance cancer immunotherapy. This comprehensive volume addresses the design, mechanisms, and clinical potential of nanocarriers such as polymeric nanoparticles, liposomes, dendrimers, exosomes, and inorganic nanomaterials in modulating immune responses against tumors. The book provides in-depth coverage of foundational principles, recent advancements, and translational strategies. In addition, it discusses how nanocarriers improve targeted delivery, overcome tumor immune evasion, and enable combination therapies.Chapters highlight cutting-edge topics like AI integration, safety profiles, and regulatory considerations, offering a multidisciplinary perspective. Designed for an academic audience, this resource facilitates understanding of nanomedicine’s role in cancer treatment. It equips researchers, clinicians, and students with scientific insights, novel strategies, and practical solutions to accelerate the development of next-generation immunotherapies.

  • Health Impacts of Climate Change

    A Global Perspective
    • 1st Edition
    • Mohammad Hadi Dehghani + 2 more
    • English
    Health Impacts of Climate Change: A Global Perspective confronts the most urgent reality of our time: the climate crisis is, at its core, a health crisis. Drawing from the latest research in climate science, public health, and policy, this book offers a comprehensive, interdisciplinary look at how global warming is already endangering lives—and what can be done to protect them. Readers will gain a deep understanding of direct health threats like heatstroke, air pollution, and disaster-related trauma, as well as the less visible dangers: rising zoonotic diseases, crop failures leading to malnutrition, and mental health challenges driven by climate-induced displacement.What sets this book apart is its unwavering focus on equity. It explores how climate change disproportionately impacts the most vulnerable—low-incom... communities, people in the Global South, and marginalized groups—who contribute the least to global emissions but bear the brunt of the damage. Through case studies, personal narratives, and policy analysis, the book amplifies frontline experiences and calls for climate justice as an essential part of any effective health response. From practical strategies for healthcare professionals to frameworks for policymakers, this book empowers a wide range of readers—from students and researchers to community leaders and concerned citizens.

  • Translational Medicine in Dry Eye Disease

    A Comprehensive Clinical and Scientific Strategy
    • 1st Edition
    • Marco Zeppieri + 2 more
    • English
    Translational Medicine in Dry Eye Disease: A Comprehensive Clinical and Scientific Strategy offers clinicians, researchers, and healthcare professionals a comprehensive, multidisciplinary resource that translates the latest scientific advances into practical strategies for diagnosing, managing, and treating dry eye disease. By bridging laboratory research and clinical application, this book equips end users with up-to-date insights, innovative diagnostic tools, and evidence-based therapies to improve patient outcomes in the rapidly evolving field of ocular surface health.

  • PROTACs Overcome Resistance to Cancer Therapies

    • 1st Edition
    • Daohong Zhou
    • English
    PROTACs Overcome Resistance to Cancer Therapies explores the transformative potential of proteolysis targeting chimeras (PROTACs) in addressing one of oncology’s greatest challenges: drug resistance. Edited by Dr. Daohong Zhou, this volume brings together leading experts to present the latest advances in targeted protein degradation for cancer treatment. The book covers foundational principles of PROTAC design, mechanisms of action, and their advantages over traditional small molecule inhibitors. It delves into strategies for targeting undruggable proteins, overcoming resistance in various cancer types, and mitigating emerging resistance to PROTACs.Case studies include BCL-xL, KRAS, STAT3, and EGFR-targeting PROTACs, with insights into clinical translation and precision medicine. This resource equips cancer researchers, oncologists, and pharmaceutical scientists with practical guidance and cutting-edge knowledge. It serves as both a reference and a roadmap for developing next-generation therapeutics, making it essential for those advancing cancer drug discovery and translational medicine.

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