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Elsevier

Books in Life sciences

Elsevier's Life Sciences collection helps researchers get comprehensive coverage and up-to-date information on the study of living organisms, their processes, and interrelationships, spanning disciplines like biology, genetics, and biochemistry, and addressing emerging trends such as genomics, biotechnology, and sustainability, essential for advancing knowledge and driving innovation in the field.

  • Research Methods

    Principles in Practice
    • 1st Edition
    • Samy A. Azer
    • English
    Research Methods: Principles in Practice provides undergraduate research students, novice researchers, and instructors with engaging approaches to understanding research and how to apply and use different research methods. The book helps students develop skills in conducting literature searches, reading literature, designing research projects, selecting research methods, collecting data, interpreting findings, and writing research reports. Topics covered include research philosophy; study design; developing research questions; the use of theories in research; research ethics; qualitative, quantitative, and mixed-methods research; social media research; and writing a research report. The book provides practical activities, model answers at the end of each chapter, and further reading, enabling students to gain a deeper understanding of research methods and to master their application.

  • Artificial Intelligence in Point-of-Care Nanobiosensors Technology

    Enhancing Disease Diagnostics and Improved Healthcare Outcomes
    • 1st Edition
    • Tharmaraj Vairaperumal + 2 more
    • English
    Artificial Intelligence in Point-of-Care Nanobiosensors Technology: Enhancing Disease Diagnostics and Improved Healthcare Outcomes delves into the revolutionary integration of artificial intelligence (AI) with nanobiosensors to elevate point-of-care (POC) diagnostics for both communicable and non-communicable diseases. Readers will find insightful chapters covering topics ranging from foundational AI and machine learning techniques to specific applications in cardiovascular disease, diabetes, cancer, chronic respiratory ailments, and infectious diseases. Each chapter not only highlights recent breakthroughs in nanobiosensors but also emphasizes the pivotal role of AI in enhancing diagnostic accuracy and facilitating personalized health interventions. Additional discussions around regulatory considerations and the future landscape of AI in biomedical research make this an essential read for those navigating this rapidly evolving field. This book primarily targets researchers and professionals engaged in the interdisciplinary realms of AI, nanomaterials, and biomedical sciences. By providing a critical understanding of emerging AI-based diagnostic technologies and their applications in POC settings, this book fosters collaboration across diverse scientific domains.

  • Autophagy and Neurodegeneration

    • 1st Edition
    • Volume 409
    • English

  • Genome Editing and Human Health

    • 1st Edition
    • Volume 157
    • English

  • The Biomechanics of Osseointegration

    • 1st Edition
    • Adriano Piattelli + 1 more
    • English
    The Biomechanics of Osseointegration offers a comprehensive, evidence-based exploration of the biomechanical, anatomical, and biological principles essential to safe and effective use of dental implants. By integrating core sciences with clinical applications, it equips both current and future practitioners with the tools to deliver long-term success in implant therapy. From fundamental concepts such as bone biology and stress-strain relationships to advanced topics like finite element modeling, fatigue testing, and real-world clinical implications, this work bridges the divide between theory and practice. Readers gain deep insight into the biomechanics of standard, short, pterygoid, and zygomatic implants across varying bone types, loading conditions, and anatomical challenges. Examined are long-term histological findings from retrieved human implants, unpacking the reasons behind the success of design elements such as the Cone Morse connection. Grounded in both research and practical examples—including case studies and data spanning three decades—the importance of connecting basic science with clinical expertise is highlighted. Designed primarily for dentists considering the integration of implantology into their practice, as well as postgraduate students in Periodontology, Prosthodontics, Oral Surgery, and Biomedical Engineering, The Biomechanics of Osseointegration also serves as a valuable resource for undergraduate dental and biomechanical engineering students who are entering the field with limited formal education in implant science. With an interdisciplinary approach and emphasis on biomechanics and biology, it provides a critical foundation for anyone committed to advancing in the field of dental implants—ensuring their work is not only innovative but also grounded in safe and effective treatment principles.

  • Smart Microscopy, AI, and Robotics

    Automated Future Disease Detection
    • 1st Edition
    • Priyadarshini Pattanaik + 2 more
    • English
    Smart Microscopy, AI, and Robotics: Automated Future Disease Detection addresses the need to combine automated microscopy with artificial intelligence and robotics to improve accuracy, throughput, and safety in disease detection. It surveys methods for image acquisition, processing, segmentation, and interpretation across sample types, including blood smears, tissue biopsies, cytology, and cytopathology, equipping researchers, clinicians, and technologists with actionable knowledge for deploying AI-powered diagnostic pipelines.The book covers foundational principles and advanced applications, beginning with microscopy and contrast-enhanced imaging, followed by automated microscope–robotics integration, image acquisition and analysis pipelines, and AI methods for disease detection. It then explores applications such as blood disorders, infectious diseases, and cancer diagnostics, including AI-based analysis of neurological and cellular imaging, advanced deep-learning architectures, and foundation models for smart microscopy. System-level considerations address performance metrics, explainability, bias mitigation, ethics, clinical governance, regulation, safety, and human–AI interaction and interoperability. The book also examines AI-enabled drug discovery, therapeutic target identification, smart laboratories, automated diagnostics, and global health impact.Readers will gain practical guidance on building high-throughput, AI-assisted diagnostic systems that are robust, interpretable, and scalable, with insights into data annotation, model validation, and integrating AI with robotic microscopy in clinical and research settings. The work anticipates developments such as self-calibrating instruments, autonomous laboratory workflows, and digital pathology ecosystems.

  • Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics

    • 1st Edition
    • Vivek Kumar + 2 more
    • English
    Redefining the MicroRNA Functionality in Cancer Diagnostics and Therapeutics is an authoritative volume that explores the pivotal role of microRNAs (miRNAs) in precision oncology. The book integrates fundamental biology, cutting-edge bioinformatics, and translational research, providing a comprehensive overview of miRNA mechanisms, regulation, and clinical applications. It emphasizes technological advances such as single-cell profiling, CRISPR engineering, and AI-driven diagnostics. The content covers miRNA biology, multi-omics integration, innovative therapeutic strategies, and clinical translation, including liquid biopsies and biosensors.In addition, it also addresses industry and regulatory aspects, offering practical insights for translating research into clinical and commercial settings. Rich with case studies and visual aids, the book bridges the gap between bench research and bedside implementation. For the academic audience, this book offers a multidisciplinary resource that enhances understanding of miRNA-based diagnostics and therapeutics, fostering innovation and accelerating clinical adoption in cancer care.

  • Epigenetics of Alzheimer's and Parkinson's Disease Part A

    • 1st Edition
    • Volume 118
    • English
    Epigenetics of Alzheimer's and Parkinson's Disease Part A, published as Volume 118 of the serial Advances in Genetics, provides a focused survey of the epigenetic mechanisms underlying two of the most prevalent neurodegenerative disorders. Contributions from international researchers examine microRNA-based therapeutic strategies, exosome-mediated pathways, noncoding RNA regulation, DNA and histone modifications, and gene-environment-epi... interactions in Alzheimer's and Parkinson's disease. The volume offers researchers a current reference point for understanding how epigenetic regulation contributes to disease onset and progression, and how these mechanisms might be targeted therapeutically.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 138
    • English

  • Human-AI Interaction for Digital Healthcare Systems

    • 1st Edition
    • Jinwoo Kim
    • English
    Human-AI Interaction for Digital Healthcare Systems defines Human‑AI Interaction (HAII) as the next evolutionary phase of Human‑Computer Interaction, addressing the shift from reactive systems to proactive AI agents. Using digital healthcare as its primary application domain, it introduces a rigorous, evidence‑based methodology for designing AI systems that are effective, safe, and trusted in real‑world clinical contexts. The text integrates the Sensing–Reasoning–Ac... (SRA) loop into human‑centered design, balancing system efficacy with environmental conformance. It provides structured guidance across the full lifecycle, analysis, planning, design, and evaluation,ensuring AI systems deliver measurable clinical and user value. Beyond theory, the book emphasizes empirical validation, detailing controlled experiments (e.g., RCTs) and real‑world performance analysis using Real‑World Data (RWD) and Real‑World Evidence (RWE), with explicit consideration of regulatory requirements for Software as a Medical Device (SaMD).

  • Mitochondria Part A

    • 1st Edition
    • Volume 216
    • English

  • Microbiome Profiling, Techniques, and Therapeutic Management

    • 1st Edition
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis: Microbiome Profiling, Techniques, and Therapeutic Management, vol. 2 offers a comprehensive exploration of cutting-edge methodologies and clinical applications in microbiome research. This book focuses on the intersection of microbiome science with cancer therapy, bioinformatics, and environmental influences, making it a valuable resource for researchers, clinicians, and graduate students in biomedical and life sciences. The book is structured into three parts: tools and techniques for microbiome analysis, the role of the microbiome in cancer therapy, and the impact of diet, environment, and epigenetics on microbiome–tumor interactions. Topics include sampling strategies, AI-driven data analysis, microbiome-based biomarkers, and therapeutic interventions, with contributions from experts across academia and industry. This book equips the academic audience with both foundational and advanced insights into microbiome research. It supports interdisciplinary learning, fosters translational thinking, and provides practical knowledge for designing experiments, interpreting data, and developing novel therapeutic strategies.

  • Wearable Sensors for Healthcare Monitoring

    Smart Tools for Real-time Applications
    • 1st Edition
    • Pushpesh Ranjan + 1 more
    • English
    Wearable Sensors for Healthcare Monitoring: Smart Tools for Real-time Applications addresses the growing need for advanced diagnostic tools amid increasing global health challenges. The reference explores state-of-the-art wearable biosensors that enable non-invasive, continuous, and real-time monitoring of disease biomarkers in biofluids such as sweat, saliva, and tears. This technology offers promising solutions to overcome limitations of conventional diagnostics, providing sensitive, portable, and user-friendly healthcare management tools. The contents cover fundamental to advanced topics including nanoengineered materials, design and fabrication methods, classifications of biosensors, and detection techniques for various biomarkers. Additional chapters focus on applications in diabetic care, inflammatory biomarker monitoring, wound healing, infectious disease detection, personalized nutrition, and integration with intelligent wireless technologies.The book also addresses self-powered wearable devices and market commercialization prospects, offering a holistic view of the wearable biosensor landscape. This books benefits researchers, academicians, clinicians, diagnostic laboratories, and industry professionals by delivering comprehensive insights into the design, development, and application of wearable biosensors. It serves as a valuable platform for innovation, enabling the creation of high-performance, affordable, and smart diagnostic tools that can transform personalized healthcare and point-of-care monitoring.

  • Cancer Progression and the Immune System

    Mechanisms, Microenvironment, and Immunotherapy
    • 1st Edition
    • Pranav Kumar Prabhakar + 3 more
    • English
    Cancer Progression and the Immune System: Mechanisms, Microenvironment, and Immunotherapy examines the dynamic interplay between cancer and immunity, highlighting how immune responses shape tumor growth and therapeutic outcomes. The book explores immune surveillance, tumor immunoediting, and evasion strategies, alongside the role of the tumor microenvironment, chronic inflammation, and immunosuppressive factors. It provides detailed coverage of cutting-edge immunotherapies, including checkpoint inhibitors, CAR-T cell therapy, cancer vaccines, and NK cell-based approaches, as well as molecular and cellular insights into immune regulation. Designed for oncologists, immunologists, and researchers, this resource bridges foundational immunology with translational applications. It equips readers with knowledge of emerging therapies, biomarkers, and systems-level approaches, offering a roadmap for innovative cancer treatment strategies.

  • Structure, Function, and Regulation of G Protein-Coupled Receptors Part A

    • 1st Edition
    • Volume 748
    • English
    G protein-coupled receptors constitute one of the largest classes of cell surface receptors in the human genome and drug targets for approximately one third of the currently prescribed medicines. The has been a tremendous advance in understanding the activation, signaling, and regulation of these receptors over the past couple of years using cellular, biochemical, structural, and pharmacological approaches. These two volumes of Methods in Enzymology cover these recent advances in the form of short overview of the key topics as well as step-by-step protocols developed to probe the functional attributes of these versatile receptors.

  • Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine

    • 1st Edition
    • Anthony Chang + 1 more
    • English
    Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book vastly improves the speed of adoption of AI in pediatric and neonatal healthcare by providing a framework of AI deployment in children and healthcare. In addition to a large section on the principles and theories of artificial intelligence as well as its application in a number of pediatric subspecialties, the book will have about 50 commentaries that all have the same structure The book is presented in a systematic manner for all clinicians to understand the in-depth thinking of the leaders in the pediatric AI domain from an international perspective. Artificial Intelligence and Clinical Cognition in Pediatric and Neonatal Medicine is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. It also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In addition, current state of the art of pediatric subspecialties will be presented with future directions to guide the pediatric and neonatal clinicians. Finally, a colorful collection of commentaries by leaders of AI use in children’s health is inserted throughout the book.

  • Clinical Management of Pancreatic Cancer

    From Diagnosis to Palliative Care
    • 1st Edition
    • Takuji Okusaka + 1 more
    • English
    Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care provides comprehensive guidance and support at every step of the pancreatic cancer journey, covering all aspects from initial diagnosis to compassionate and holistic care, ensuring healthcare professionals have the knowledge and resources they need for effective management and improved quality of life. The book not only presents the latest advancements in pancreatic cancer management, including innovative surgical techniques, targeted therapies, radiotherapy approaches, and palliative care interventions but also focuses on maintaining and improving patients' quality of life throughout their journey, incorporating palliative medicine and supportive care to alleviate symptoms and enhance overall well-being. IN 4 sections and 29 chapters Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care Advocates for patient-centered care by emphasizing communication, shared decision-making, and tailoring treatment approaches to individual needs and preferences. It raises awareness about pancreatic cancer, its challenges, and the importance of early detection, while also dispelling misconceptions and offering hope through informed management strategies. The book also highlights the significance of palliative medicine and comprehensive supportive care to manage symptoms, alleviate pain, and address psychosocial and emotional needs of both patients and their families.Clinical Management of Pancreatic Cancer: From Diagnosis to Palliative Care serves as a bridge between research and clinical practice, offering researchers a broader perspective and equipping clinicians with a valuable resource that enhances their knowledge, decision-making, and patient care skills in the realm of pancreatic cancer management.

  • Advancements in Digital Cytopathology and Artificial Intelligence

    • 1st Edition
    • Keluo Yao + 2 more
    • English
    Advancements in Digital Cytopathology and Artificial Intelligence offers an extensive and reliable resource for those intrigued by the opportunities for employing artificial intelligence in cytopathology, within both clinical and research settings. The book provides advances in research and commercial technologies, regulatory and business environment updates and special considerations in cytopathology that impacts AI applications in the medical field. It describes the current state of cytopathology digitization and AI technologies, the current cytopathology practice environment, including laws and compliance issues in the context of digitization and AI technologies. This an essential reference for cytologists and trainees who are interested in AI and digital pathology and AI researchers and industry partners who are interested in developing applications for cytopathology.

  • Advances in Pancreatic Cancer Immunotherapy

    • 1st Edition
    • Vivek P. Chavda + 2 more
    • English
    Advances in Pancreatic Cancer Immunotherapy explores cutting-edge strategies to combat one of the most lethal malignancies. This book provides a focused, comprehensive resource on immunotherapy innovations for pancreatic cancer. It examines the tumor microenvironment, mechanisms of immune evasion, and the latest therapeutic modalities, including immune checkpoint inhibitors, cancer vaccines, and adoptive cell therapies. Chapters cover clinical and preclinical studies, combination strategies, biomarker-driven personalization, and regulatory considerations, offering a deep dive into both foundational science and translational applications. For researchers, clinicians, and graduate students, this book delivers actionable insights into overcoming treatment resistance, integrating immunotherapy into clinical practice, and shaping future research directions. It serves as an essential reference for understanding and applying immunotherapeutic advances to improve patient outcomes.

  • Decoding Cancer

    Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics
    • 1st Edition
    • Pawan Kumar Maurya + 1 more
    • English
    Decoding Cancer: Precision Oncology through AI, Machine Learning, and Multi-Omics Analytics offers an integrated perspective on how computational technologies are transforming cancer research and care. It bridges cancer biology with advanced data-driven approaches to enable precision oncology. The book covers fundamentals of cancer biology alongside applications of artificial intelligence, machine learning, and big data analytics in biomarker discovery, early detection, and personalized treatment. Chapters explore multi-omics integration, predictive modeling, radiomics, surgical robotics, and ethical considerations, supported by diagrams, case studies, and annotated workflows. For academics and professionals, this resource provides actionable insights into cutting-edge tools and methodologies, helping readers understand how computational oncology accelerates translational research and clinical decision-making. It serves as a comprehensive guide for students, researchers, and clinicians navigating the future of data-driven cancer care.

  • Understanding PCR

    A Practical Bench-Top Guide
    • 2nd Edition
    • Rowena Jenkins + 1 more
    • English
    Understanding PCR: A Practical Bench-Top Guide delivers a comprehensive resource offering researchers the information they need to plan their polymerase chain reactions, from reagents and conditions to analysis and beyond. This updated edition covers a broad spectrum of topics including laboratory preparation, primer design, DNA analysis, quantitative PCR, cloning, protein expression, and the latest applications. The book equips researchers with the knowledge to confidently design and execute PCR experiments, enhancing reproducibility and efficiency. By integrating updated techniques and practical insights, this revised reference supports researchers, laboratory professionals, and students working across molecular biology and related fields.

  • Statistics in Medicine

    • 5th Edition
    • Robert H. Riffenburgh + 1 more
    • English
    Statistics in Medicine, 5th Edition serves as an essential resource for health care students, professionals and researchers seeking to understand the application of statistical methods in medical research. This comprehensive text encompasses a wide range of topics, from foundational concepts to advanced techniques, ensuring that readers are well-equipped to design, analyse, and interpret health-related studies. The book includes updated chapters on critical subjects such as missing data, regression models for discrete outcomes, polytomous response regression, classification and regression trees, and the integration of machine learning and AI with statistical methodologies. Each chapter provides practical examples and step-by-step methods, helping readers understand complex concepts while reinforcing learning through exercises and real-world applications. For the academic audience, this book offers a user-friendly approach to medical statistics, making it accessible even to those with limited statistical training. By bridging the gap between theory and practice, it empowers health care professionals to conduct rigorous research, interpret findings accurately, and contribute meaningfully to advancements in medical science.

  • Antimicrobial Resistance in the 21st Century

    Equity, Technology, and One Health Approaches
    • 1st Edition
    • Ajmer Singh Grewal + 4 more
    • English
    Antimicrobial Resistance in the 21st Century: Equity, Technology, and One Health Approaches offers a timely, interdisciplinary exploration of one of the most pressing global health challenges. Moving beyond traditional clinical and microbiological perspectives, this volume integrates equity, digital innovation, and One Health principles into a cohesive framework for understanding and addressing antimicrobial resistance (AMR). It examines how social determinants, economic pressures, and policy environments intersect with biological drivers to shape resistance patterns and outcomes worldwide. Drawing on expertise across pharmacy, medicine, public health, veterinary science, and data science, the book combines foundational knowledge with advanced insights. Real-world case studies and applied examples highlight antimicrobial use in human and animal health, stewardship strategies, infection prevention, and surveillance of both common and neglected diseases. Special attention is given to vulnerable populations, including neonates, children, and marginalized communities, alongside critical discussions of ethics, gender, and global inequities. The integration of artificial intelligence, data analytics, and digital surveillance tools demonstrates how emerging technologies can enhance prediction, monitoring, and decision-making in AMR. By bridging theory, practice, and policy, this book equips readers with the tools to design sustainable, evidence-based interventions. It is an essential resource for researchers, students, and professionals seeking to navigate and address the complex, interconnected dimensions of AMR in a rapidly evolving global landscape.

  • Advances in Agronomy

    • 1st Edition
    • Volume 203
    • English
    Advances in Agronomy, Volume 203, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • Virtual Possibilities

    Extended Reality as Assistive Technology for Inclusive Care
    • 1st Edition
    • Samiya Khan
    • English
    Virtual Possibilities: Extended Reality as Assistive Technology for Inclusive Care provides invaluable insights for researchers and related medical professionals into the transformative potential of virtual reality as a technological aid. The book navigates through the diverse applications of virtual reality in healthcare, transcending traditional uses such as medical training and therapeutic interventions. It is a dedicated examination of virtual reality's role in social care, addressing the unique needs of individuals across the spectrum, from differently abled individuals and children with learning disabilities to those grappling with disorders, trauma, and the elderly. It presents the state-of-the-art in this field, acting as a bridge, facilitating the translation of theory into practice and fostering ongoing research. Users will find this to be a valuable resource for researchers, professionals, and policymakers interested in the future applications of virtual reality in healthcare and social care.

  • Intelligent Gait Assistive Technologies

    Gait Biomechanics and Machine Learning Applications in Rehabilitation and Injury Prevention
    • 1st Edition
    • Rezaul Begg + 1 more
    • English
    Intelligent Gait Assistive Technologies: Gait Biomechanics and Machine Learning Applications in Rehabilitation and Injury Prevention brings together contemporary research and applications to show how gait biomechanics combined with machine learning can be used to develop techniques to provide safer, more mechanically efficient locomotion to individuals with significant visual, musculoskeletal, or neurological deficits. Developments in gait rehabilitation and injury prevention outlined in this book will contribute to improved quality of life for individuals with gait-related impairments, with a major contribution to medical cost savings due to reduction in falls.Researchers, engineers, and students in biomedical engineering and biomechanics will find this a welcomed reference in better understanding the role of machine learning and intelligent technologies in the advancement of gait rehabilitation and injury reduction to both impaired and healthy individuals.

  • Exploring Infant Cry

    Medical and Technical Analysis and Signal Processing Perspectives
    • 1st Edition
    • Carlos Alberto Reyes Garcia + 3 more
    • English
    Exploring Infant Cry: Medical and Technological Analysis and Signal Processing Perspectives is a comprehensive exploration of the latest medical and technical advancements in the study of infant crying. This book presents a unified approach that integrates medical insights and computational techniques for analyzing and classifying cries, aiming to enhance diagnostic capabilities. Authored by experts, it emphasizes the growing significance of cry analysis as a powerful, non-intrusive tool for identifying pathologies from the earliest stages. As the field expands, researchers and clinicians are offered innovative perspectives and practical solutions for interpreting and understanding why babies cry. The book also explores the connection between infant cries and language development, as well as the communicative importance of these signals in human interaction. Addressing gaps in routine neonatal application, the book compiles recent advancements in signal processing, Artificial Intelligence, and soft computing for cry classification. This makes it a valuable resource for biomedical researchers, doctors, and clinicians seeking to deepen their knowledge of the acoustic, neurophysiological, and linguistic aspects of infant crying.

  • Avian Models of Development

    • 1st Edition
    • Volume 173
    • English
    Avian Models of Development provides practical and experimental approaches for using avian systems to study developmental processes. It covers key methods, model applications, and emerging techniques that support research in embryogenesis, tissue formation, gene function, and developmental mechanisms.

  • Cold-Adapted Enzymes

    Biochemistry and Biotechnology
    • 1st Edition
    • Diego Gomez-Casati + 1 more
    • English
    Cold-Adapted Enzymes: Biochemistry and Biotechnology provides a cutting-edge investigation into the molecular mechanisms, structural dynamics, and regulatory pathways of enzymes adapted to cold environments.Beyond classical microbiology, the book explores cold adaptation from psychrophilic bacteria and Antarctic fungi to microalgae, plants, and mammalian cell physiology. It provides biochemistry insights into carbohydrate (amylases, glucoamylases) and lipid metabolism, proteases, and redox enzymes, alongside the roles of molecular chaperones and prokaryotic proteomics. A key highlight is its focus on next-generation biotechnology, featuring AI-driven protein design, advanced computational modeling, and structural bioinformatics. Bridging foundational science with market reality, the volume explores applications from organic waste valorization to industrial biocatalysis, analyzing the global patent landscape and commercial players.As the latest volume in the Foundations and Frontiers of Enzymology series, this book is an indispensable reference for researchers across biochemistry, biotechnology, structural biology, and microbiology.

  • Gallin and Ognibene's Principles and Practice of Clinical Research

    • 5th Edition
    • John I. Gallin + 2 more
    • English
    Gallin and Ognibene’s Principles and Practice of Clinical Research, 5th Edition is the definitive text on clinical research, written by internationally recognized experts in their field, from the US National Institutes of Health, the US Food and Drug Administration, academia, and global researchers. The new edition contains fully updated chapters, with more than 50 new authors and 15 new chapters. The book continues a strong emphasis on study design and biostatistics in clinical research, with new chapters containing fresh information on a variety of topics, including chapters on how to engage a full range of research participants and research opportunities for people involved in patient care including surgeons, pharmacists, and other clinical researchers. For the international researcher, two new chapters detail international clinical research experiences in South Africa and India. As with the 4th edition, the new edition provides readers with summary questions and answers after select chapters.

  • Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing

    • 1st Edition
    • Lorenzo Moroni + 1 more
    • English
    Biofabrication Technologies for Tissue and Organ Engineering and Manufacturing is the fourth volume in the Regenerative and Transplant Medicine Series. The book offers a range of benefits tailored to its diverse audience. For students in biomedical engineering and related fields it provides a comprehensive understanding of biofabrication technologies in tissue and organ engineering and preparing them for future careers. Researchers and scientists in tissue engineering benefit from staying current with the latest advancements, fostering interdisciplinary collaboration, and offering practical insights for experimental design. Clinicians and healthcare professionals gain a deeper understanding of biofabrication applications, improving patient care and staying informed about emerging technologies. Industry professionals in medical devices and biofabrication find valuable insights for product development and market opportunities, while educators use the textbook to enrich curricula and provide real-world applications for students. Regulatory affairs specialists benefit from updates on ethical considerations and compliance in biofabrication, and government officials gain insights into shaping policies for responsible innovation.The authorship is intentionally diverse, encompassing professionals from various backgrounds, including gender, ethnicity, and geographical location. The authors explore applications of biofabrication technologies across different cultural and medical contexts, including voices from underrepresented groups in the fields of biomedical engineering and biofabrication.

  • Interstitial Lung Diseases

    New Frontiers in Research and Clinical Applications
    • 1st Edition
    • Carlo Vancheri + 1 more
    • English
    Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications is the book that professionals working with Interstitial Lung Diseases (ILDs) have been waiting for. ILDs encompass a complex group of diseases, characterized by varying degrees of inflammation and fibrosis in the lungs, leading to diverse clinical presentations and subtle differences in imaging findings. This complexity makes diagnosis challenging for pulmonologists, radiologists, and researchers, who must stay updated on evolving pathophysiology, diagnostic innovations, and new classification systems. This comprehensive, invaluable resource integrates the pathogenic, functional, clinical, and radiological aspects of ILDs, providing clinicians with a practical tool for patient care. This book elucidates the distinguishing features of different ILDs, empowering readers to navigate the diagnostic and therapeutic landscape confidently. It offers a practical, step-by-step approach to diagnosing ILDs and understanding their nuances, structured around the latest scientific evidence. Further, it covers etiology, epidemiology, pathogenesis, diagnostic processes, and therapeutic options, incorporating diagnostic and treatment algorithms to serve as both a reference and a practical guide for clinical decision-making. By filling gaps in the literature, “Interstitial Lung Diseases: New Frontiers in Research and Clinical Applications” equips respiratory professionals with the knowledge and skills necessary to enhance diagnostic accuracy, improve patient management, and foster ongoing innovation in the study of ILDs.

  • The Human Electroretinogram

    A Diagnostic Guide
    • 1st Edition
    • Benedetto Falsini
    • English
    The Human Electroretinogram: A Diagnostic Guide describes the physiological basis and clinical applications of the human electroretinogram (ERG). Several sub-types of ERGs are evoked by Full-Field stimuli, with characteristics that depend critically on the properties of the stimulus. This book discusses the human retina’s high sensitivity to light and its ability to respond robustly to even single quanta of light. Specifically, it clarifies that the major components of flash ERG, the a-wave and b-wave, are generated by photoreceptors and bipolar cells, respectively. This book explores how changes in light intensity, adaptation, and temporal frequency can alter the contributions of different retinal generators (e.g., rods, cones, and bipolar cell subtypes). In addition to Full Field ERG, other important diagnostic electroretinograms including focal, multifocal, and pattern ERGs are clarified. This book uniquely illustrates the combined use of these ERG tools, allowing clinicians to perform a functional dissection of the retina and achieve a layer-by-layer analysis.The approach of The Human Electroretinogram: A Diagnostic Guide correlates with retinal layer evaluations performed using modern multimodal imaging techniques, such as optical coherence tomography (OCT). ERG analysis exemplifies a critically important tool for early diagnosis, follow-up, and treatment monitoring of retinal diseases involving different retinal layers. This book is essential in providing ophthalmological professionals with the know-how to manage the interplay between these numerous elements.

  • Protein-Based Hydrogels

    Exploring the Roles of Protein Hydrogels in Membrane-less Organelles, Disease Mechanisms, and Therapeutic Applications
    • 1st Edition
    • Vladimir N. Uversky + 1 more
    • English
    Protein-Based Hydrogels: Exploring the Roles of Protein Hydrogels in Membrane-less Organelles, Disease Mechanisms, and Therapeutic Applications presents a comprehensive overview of natural and engineered protein hydrogels, examining their critical roles in cellular organization, disease pathology, and therapeutic innovation. This book contributes unique value by integrating fundamental biology, cutting-edge biotechnology, and translational biomedical science to address emerging questions about protein phase separation and gelation. Structured into three sections, the book begins by exploring the physiological functions of protein hydrogels in phase-separated organelles, cellular stress sensing, memory formation, and compartmentalization... It then investigates the pathological consequences of hydrogel dysregulation, including their roles in neurodegenerative diseases, cancer, and viral infections. Finally, it examines biomedical applications such as controlled drug delivery, regenerative medicine, biosensing, and the design of synthetic organelles. Each chapter is contributed by a leading expert, offering multidisciplinary perspectives from biochemistry, molecular biology, bioengineering, and medical research. This book is a valuable resource for academic researchers, graduate students, and professionals working in protein engineering, structural biology, molecular medicine, and pharmaceutical sciences. It supports readers in understanding the full spectrum of protein hydrogel biology—from cell physiology to disease mechanisms and therapeutic design—making it especially relevant for those interested in neurodegeneration, cancer biology, and translational bioengineering.

  • Accurate Results in the Clinical Laboratory

    A Guide to Error Detection and Correction
    • 3rd Edition
    • Amitava Dasgupta + 1 more
    • English
    Accurate Results in the Clinical Laboratory:A Guide to Error Detection and Correction, 3rd Edition continues to be an in-depth resource of common sources of errors in clinical laboratories. It provides strategies to avoid pre-analytical errors, including patient preparation, specimen collection, and anticoagulant use and Insights into major sources of pre-analytical errors such as sample processing and specimen misidentification. This book is an essential reference for professionals and students aiming to enhance accuracy and reliability in clinical laboratory testing. This new edition has fully updated chapters and new information on how to eliminate lab errors including avoiding post analytic phase of reporting results through laboratory informatics system. This is a guide for laboratory professionals and clinicians regarding sources of errors and misinterpretation in the clinical laboratory and how to resolve such errors and identify discordant specimens. Accurate laboratory result interpretation is essential for patient safety. This book is intended as a practical guide to laboratory professionals and clinicians who deal with erroneous results on a regular basis.

  • Solvent Interaction Analysis

    Physical Chemistry and Analytical Applications of Aqueous Two-Phase Systems
    • 1st Edition
    • Boris Y. Zaslavsky + 1 more
    • English
    Solvent Interaction Analysis: Physical Chemistry and Analytical Applications of Aqueous Two-Phase Systems explores Solvent Interaction Analysis (SIA) technology, a cutting-edge approach for protein characterization and proteomics in biological fluids. The book considers a broad spectrum of topics, from fundamental principles such as phase separation, blood-tissue distribution, and posttranslational protein modifications to advanced clinical applications for early detection of various malignancies, neurological disorders, and other diseases. The book opens with an introduction to aqueous two-phase system (ATPS), considering different types of ATPS, hydrophobic and electrostatic properties, and mechanisms of liquid-liquid phase separation, before moving on to specific properties of phases such as solute-water interaction and blood-tissue distribution, and analysis of partitioning individual proteins. It then explores solvent interaction analysis, investigating diagnostic applications and biomarker discovery. Final chapters explore fundamental consequences of ATPS-based analysis and its future opportunities.This comprehensive guide offers a detailed overview of aqueous two-phase systems from foundational knowledge to the latest developments in the field, and is an essential reference for students, researchers and practitioners across a wide range of disciplines, including biophysics, analytical and medicinal chemistry, proteomics, structural biology, pharmaceutical science, and biotechnology.

  • Contemporary Practice in Clinical Chemistry

    • 5th Edition
    • William Clarke + 1 more
    • English
    Contemporary Practice in Clinical Chemistry, Fifth Edition is a comprehensive, updated reference and teaching resource focused on Laboratory Medicine, specifically tailored for clinical chemistry faculty, trainees, clinical laboratory scientists, clinical pathologists, and laboratory managers. Edited by renowned experts, the book integrates cutting-edge developments in clinical chemistry with practical applications for professional practice. This new edition covers foundational and advanced topics in clinical chemistry and laboratory medicine, emphasizing the integration of new technologies and methodologies. It addresses precision medicine, medical biotechnology, and artificial intelligence applications within the clinical laboratory setting. The content is designed to support both learning and board exam preparation, providing a deep understanding of the field alongside practical insights.

  • Microbiome-Modulating Strategies in Diabetic Wound Healing

    • 1st Edition
    • Jeena Gupta + 2 more
    • English
    Microbiome-Modulatin... Strategies in Diabetic Wound Healing provides researchers with an in-depth analysis of the wound microbiome’s role in diabetic foot ulcers and chronic wound pathology. This reference elucidates microbial dysbiosis, biofilm formation, and host–microbe interactions that exacerbate impaired healing in diabetic patients. It critically evaluates emerging microbiome-targeted interventions—includ... probiotics, bacteriophages, antimicrobial peptides, and nanotechnology-enabl... drug delivery—supported by the latest molecular, microbiological, and clinical research. The book integrates advanced diagnostic methodologies such as next-generation sequencing and bioinformatics to facilitate precise microbial profiling and personalized therapeutic design. By bridging mechanistic insights with translational and clinical evidence, this resource equips diabetic researchers with comprehensive knowledge to innovate and optimize microbiome-based strategies, ultimately aiming to reduce infection rates, combat antibiotic resistance, and improve regenerative outcomes in diabetic wound management.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Joshua Z. Rappoport + 1 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Basics of Sleep Technology

    Fundamentals of Sleep Technology
    • 1st Edition
    • Ravi Gupta + 2 more
    • English
    Basics of Sleep Technology: Fundamentals of Sleep Technology covers the critical elements of sleep and sleep technologies. The book gives a thorough understanding of sleep physiology, neurophysiological concepts, the principles of operation of the numerous equipment types used to diagnosis sleep disorders, and contemporary methodologies for diagnosing sleep disorders. As sleep professionals must understand the fundamentals of signal creation, acquisition principles, and data grading from a sleep diary, actigraphy, and polysomnography, this book provides all of this and more to anyone wishing to develop a comprehensive understanding of sleep.The book underscores that sleep medicine and technology are dynamic and rapidly growing medical specialties, and that one must stay up with the newest innovations in the area, but not at the price of the fundamentals. Users will find a solid background on cutting-edge advances in sleep medicine, diagnostics, monitoring, and therapeutics.

  • Flavoproteins and Flavoenzymes

    • 1st Edition
    • Volume 747
    • English
    Flavoproteins and Flavoenzymes, Volume 738 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Kirisu2 and KiPaD: global analysis of rapid flavoprotein redox kinetics from stopped-flow multi, ilagros Mendina, A Generic First Approach to Dissecting Flavoenzyme Catalytic Cycles, Removing Covalent Constraints of Protein Loops and Lids by a Split-Gene Strategy, Designing Oxygen Reaction Sites in Flavoprotein Dehydrogenases, Converting Noncovalent Flavoproteins into Covalently Flavinylated Proteins, Complexities of Riboflavin Biosynthesis, Reactions of Riboflavin Catabolism, and much more.Additional sections cover Ferredoxin-dependent thioredoxin reductase, Thermophilic Methylenetetrahydrof... Reductases, Ion-Pumping NADH:Quinone Oxidoreductase, Loading E. coli Dihydroorotate Dehydrogenase with Coenzyme Q, and Single-Component Halogenases.

  • Current Approaches to Overcome Therapeutic Resistance of Leukemia

    • 1st Edition
    • Zhe-Sheng Chen + 2 more
    • English
    Current Approaches to Overcome Therapeutic Resistance of Leukemia presents a comprehensive academic resource addressing the persistent challenge of treatment resistance in leukemia. It explores biological, molecular, and clinical dimensions of resistance, bridging fundamental research with therapeutic innovation. The book examines key resistance mechanisms, including genetic mutations, leukemic stem cells, and tumor microenvironment interactions, alongside emerging insights such as epigenetic regulation, metabolic reprogramming, and immune evasion. It further highlights advanced therapeutic approaches, including immunotherapy, targeted therapies, combination strategies, and AI-driven tools for drug discovery and monitoring. This volume provides students, researchers, and clinicians with foundational and integrated knowledge essential for understanding resistance biology and translating discoveries into clinical practice. It supports evidence-based decision-making and promotes the development of innovative strategies to improve patient outcomes.

  • AI and Global Health

    Unlocking Transformative Potential
    • 1st Edition
    • Adil Haider
    • English
    AI and Global Health: Unlocking Transformative Potential provides a roadmap for practitioners to apply and leverage artificial intelligence to strengthen health systems using the World Health Organization's health systems approach. The book's combination of case studies and secondary research inspires the possibility of what can happen using AI in healthcare, ensuring the use of robust, scientific evidence to draw conclusions. Additionally, readers will learn from others in settings where AI has been a tool for change, providing healthcare practitioners and policymakers with what they need to think through how it can be applied in resource limited settings.The book provides a strong call to action for policymakers and healthcare leaders of governments, international organizations, and healthcare institutions to take the lead in AI implementation as a key lever for advancing global health goals through a systems approach. As AI is a rapidly evolving field with significant investment made in this industry in recent years from government and the private sector, this book articulates how this growth can be harnessed for countries that need a different approach to addressing global health problems.

  • Molecular Chaperones in Neurodegenerative Diseases

    • 1st Edition
    • Volume 156
    • English
    Molecular Chaperones in Neurodegenerative Diseases explores the roles of molecular chaperones in maintaining protein homeostasis and their involvement in the onset and progression of neurodegenerative disorders. The book highlights current research on chaperone-mediated mechanisms, disease pathology, and emerging therapeutic approaches targeting protein misfolding and aggregation.

  • Childhood Disorders of Rickets and Osteomalacia

    A Comprehensive Review
    • 1st Edition
    • Suma Uday
    • English
    Childhood Disorders of Rickets: A Comprehensive Review defines the pathophysiology of rickets and the various genetic and acquired conditions that present with rickets in childhood. This comprehensive review details the various forms of rickets, the histopathology, recent advances leading to new therapeutic options in treating rickets, and the role of Vitamin D and calcium in nutritional rickets. Additionally, the authors explore future research in various areas of nutritional and non-nutritional forms of rickets.Written by global experts for clinicians and researchers treating and studying the various forms of rickets, the book will also be of interest to those working in public health and policy makers working on the prevention of nutritional rickets worldwide.

  • Operative Strategies in Pelvic Exenteration Surgery

    • 1st Edition
    • Michael E Kelly + 1 more
    • English
    Operative Strategies in Pelvic Exenteration Surgery is a reference for the surgical management of Pelvic Exenteration Surgery. It covers all aspects of surgery from the colorectal, urological, gynecological, and orthopedic point of view. Coverage consolidates the research of world-leaders and includes the history of exenterative study, outlining the current state and indicating future developments. The book also discusses the current surgical operative strategies for the management of locally advanced and recurrent pelvic neoplasms with illustrations, intra-op photos, and supplementary video material.Created from the experiences of an international collaboration of surgeons, this reference is the perfect reference for surgical oncologists, colorectal, gynecology, urology, and vascular surgeons as well as any group involved in complex pelvic surgery including complex open, laparoscopic, and robotic surgery.

  • Emergent Nanotherapeutics in Diabetic Complications

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Emergent Nanotherapeutics in Diabetic Complications explores how cutting-edge nanotechnology is transforming the treatment of diabetes-related disorders beyond glycemic control. This comprehensive volume examines targeted, multifunctional nanoplatforms designed to address the wide range of comorbidities linked to diabetes, including vascular complications, metabolic dysfunctions, and impaired wound healing. Structured in five parts, the book spans from current nanoformulation strategies to emerging innovations such as CRISPR-Cas9 delivery, AI-guided nanoparticles, and 3D/4D printed nanostructures.Bridg... the gap between preclinical research and clinical application, it offers valuable guidance on stimuli-responsive systems, biocompatible materials, and regulatory pathways. This is essential resource for medical professionals, biomedical engineers, and pharmaceutical scientists seeking scalable, next-generation solutions for managing diabetic complications through nanomedicine.

  • Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities

    Evidence-Based Molecular Mechanisms and Clinical Outcomes
    • 1st Edition
    • Debidas Ghosh + 3 more
    • English
    Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities: Evidence-Based Molecular Mechanisms and Clinical Outcomes is a comprehensive, interdisciplinary reference addressing the complex link between diabetes mellitus and infertility in both men and women. This edited volume synthesizes molecular insights into diabetes-induced reproductive dysfunction—such as oxidative stress, inflammation, endocrine disruption, and tissue damage—with evidence-based evaluations of medicinal plants and their bioactive phytochemicals. It bridges laboratory research and clinical trials to highlight how plant-derived compounds can regulate glycemic control, restore hormonal balance, reduce oxidative damage, and improve gametogenesis. Targeting clinicians, researchers, and postgraduate students in biomedical and pharmaceutical sciences, the book offers detailed therapeutic profiles, safety assessments, and translational applications. By consolidating fragmented knowledge, it empowers healthcare professionals and scientists to develop integrative, cost-effective strategies for managing diabetes-related infertility.

  • Brain-Computer Interfaces (BCI)

    • 1st Edition
    • Volume 229
    • English
    Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Biopolymers for 3D Tissue Engineering

    Processing and Applications
    • 1st Edition
    • Narendra Reddy + 1 more
    • English
    Biopolymers for 3D Tissue Engineering: Processing and Applications explores the critical role of biopolymers in advancing tissue engineering and 3D cell culture—key technologies in drug discovery, personalized medicine, and disease treatment. The book provides a comprehensive overview of the structure, properties, and processability of biopolymers with a focus on innovative techniques for converting them into functional scaffolds suitable for 3D cell culture. Sections cover carbohydrates, proteins, and synthetic biopolymers in a single, authoritative source, making it invaluable for students, researchers, professionals, and industry stakeholders.As scaffolds form the foundation of these applications, current options—primarily synthetic polymers like polypropylene, polyethylene, or polystyrene, and some natural materials such as collagen and silk fibroin—are often expensive and lack optimal properties such as biocompatibility, biodegradability, and mechanical stability. This book addresses the global effort to develop next-generation scaffolds that overcome these limitations. As biopolymers offer a compelling solution, with inherent biodegradability, biocompatibility, and sustainability, this book guides on the latest technologies and innovations.

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