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Elsevier

Books in Biochemistry biophysics

This portfolio spans the molecular mechanisms of life, encompassing protein structure, enzyme function, and biophysical techniques. It supports biochemists, biophysicists, and molecular biologists in understanding complex biological processes. Featuring advanced research, experimental methods, and real-world applications, these resources drive innovations in drug development, disease research, and biomolecular engineering, fostering breakthroughs at the intersection of chemistry, physics, and biology.

  • Machine Learning in Enzymology

    • 1st Edition
    • Volume 742
    • English
    This volume surveys cutting-edge machine learning–based approaches for the study of enzyme catalysis, dynamics, and design. It brings together computational and experimental approaches that integrate molecular simulation, machine learning, and high-throughput data to interrogate enzymatic catalysis at multiple scales. The chapters in the volume highlight how data-driven frameworks complement physics-based models to advance mechanistic understanding and enable rational enzyme engineering.

  • Enzymes

    Biomarkers, Targets and Therapy
    • 1st Edition
    • Priyanka Bajaj + 1 more
    • English
    Enzymes: Biomarkers, Targets and Therapy examines the critical role of enzymes in drug discovery, diagnostics, and therapeutic applications, providing essential insights for clinicians, biomedical researchers, and pharmaceutical industry professionals. This book highlights the utility of enzymes as biomarkers for disease diagnosis, targets for innovative drug discovery, and therapeutic agents in treating various conditions. Within its comprehensive chapters, the book discusses enzymatic biomarkers in neurodegenerative disorders such as Alzheimer's disease and α-synucleinopathies, where enzymes are pivotal in understanding disease mechanisms and potential interventions. It covers enzymatic drug targets in cancers and diabetes, offering insights into harnessing enzymes for novel therapeutic strategies. Additionally, the book explores the role of enzymes in lipid and hypertensive disorders, emphasizing their potential in managing these conditions. Further, the book examines enzymes as therapeutic agents in autoimmune and infectious diseases, featuring approaches like CRISPR-Cas9 gene editing to tackle antimicrobial resistance. This resource is invaluable for biomedical researchers, neurologists, oncologists, diabetologists, endocrinologists, and pharmaceutical industry researchers aiming to expand their knowledge in enzyme-based therapeutic research. By providing curated information, it equips its audience with the necessary knowledge to explore new directions in drug discovery and enzymatic therapy.

  • Hyperspectral Imaging

    • 2nd Edition
    • Jose Manuel Amigo + 1 more
    • English
    Hyperspectral Imaging, Second Edition builds on the foundational insights of the first whilst reflecting the rapid advancements in hyperspectral and multispectral imaging technologies and methodologies in three directions: hardware, software, and applications. This heavily updated and expanded book not only covers the core analytical frameworks but also introduces new algorithms, hardware technology and cutting-edge applications that have emerged since the first edition. By incorporating the latest research findings and case studies, the contributions provide readers with enhanced tools and techniques for effective hyperspectral and multispectral image analysis across diverse scientific, industrial and field domains. Additionally, the book once again addresses evolving challenges and fresh opportunities in the field, ensuring that users are equipped with the most current knowledge and practices. This comprehensive update underscores the continued relevance and transformative potential of hyperspectral and multispectral imaging in contemporary research and industry. Hyperspectral Imaging, Second Edition is written for graduate students, academics and early researchers as well as industry scientists across various disciplines working with hyperspectral and multispectral images, including analytical chemistry, remote sensing, vegetation and crops, food and feed production, forensic sciences, biochemistry, medical imaging, pharmaceutical production, art studies, cultural heritage, among other topics.

  • Mannose Binding Lectin Associated Serine Proteases

    Structure, Function and Therapeutic Implications
    • 1st Edition
    • Krishnan Hajela
    • English
    Mannose Binding Lectin Associated Serine Proteases: Structure, Function and Therapeutic Implications provides a comprehensive and up-to-date overview of MASP-1, MASP-2, and MASP-3, highlighting their roles in immune defense, disease mechanisms, and therapeutic intervention. This authoritative reference covers the molecular structure and catalytic mechanisms of these key serine proteases, emphasizing their involvement in the lectin pathway of complement activation as well as their emerging functions in coagulation and bradykinin pathways. The book brings together the latest research on how MASPs contribute to pathogen recognition and clearance, and how their dysregulation is linked to a range of infectious, inflammatory, and thrombotic diseases. Chapters detail the biology of animal lectins and collectins, the classical and alternative complement pathways, and the specific biochemical activities of MASP-1, MASP-2, and MASP-3. Readers will find in-depth discussions on the clinical significance of MASP gene polymorphisms and serum levels, as well as the design and therapeutic relevance of natural and synthetic MASP inhibitors. Special focus is given to the application of MASP-2 inhibitors in the management of complications such as hematopoietic stem-cell transplantation-asso... thrombotic microangiopathy (HSCT-TMA). This book is an essential resource for researchers in immunology, biochemistry, and molecular medicine, as well as clinicians seeking to advance their understanding of complement biology and the therapeutic potential of targeting the lectin pathway.

  • Cold-Adapted Enzymes

    Biochemistry and Biotechnology
    • 1st Edition
    • Diego Gomez-Casati + 1 more
    • English
    Cold-Adapted Enzymes: Biochemistry and Biotechnology provides a detailed investigation into enzymes that adapt to cold environments. It covers the catalytic, structural and regulatory properties of this type of enzyme and the potential advances in their biotechnological applications.Topics covered include the evolution of enzymes in cold environments, enzymes involved in carbohydrate metabolism (such as xylanases, B-galactosidase, and B-glucosidase), cold-adapted enzymes in lipid metabolism (such as esterases and lipases) and redox enzymes. The book also explores bacterial cold-adapted enzymes and those from organisms which live in extreme environments like Antarctica. Recombinant expression methods, protein engineering and computational approaches are also featured. This book offers a complete overview of cold-adapted enzymes and is the latest volume in the Foundations and Frontiers of Enzymology series. This is a useful reference for researchers across a range of interdisciplinary fields including biochemistry, enzymology, biotechnology, molecular evolution, structural biology and microbiology.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 136
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Alternative Proteins

    • 1st Edition
    • Volume 155
    • English
    Alternative Proteins, Volume 154 provides a comprehensive overview of alternative proteins, exploring their sources, production technologies, nutritional profiles, and potential to transform the global food system. Covering plant-based, microbial, insect, and cultured (cell-based) proteins, the book examines the scientific advances, market trends, regulatory challenges, and sustainability implications of these innovative protein sources. Chapters in this new release include Introduction to Alternative Proteins, Molecular Properties of Plant-Based Proteins for Alternative Proteins, The Science of Alternative Proteins: Comparing Animal and Plant-Based Sources, Blue Proteins: Marine-Derived Alternatives for Sustainable Nutrition and Climate-Resilient Food Systems, and much more. Additional sections cover Insect Proteins for Alternative Proteins: Sustainable Solutions with Molecular Efficiency, Plant-Based Proteins: Key Sources and Production Methods, Fungal proteins as Eco-friendly Alternate Proteins, Algae and Microbial Proteins for Alternative Proteins: Untapped Molecular Resources, Integrating Siddha Dietary Principles with Alternative Protein Systems: A Pathway Toward Sustainable and Functional Nutrition, Alternative Proteins: Structure and Functional Properties, and a variety of extensive and timely topics.

  • Thiamine Pyrophosphate (TPP)-Dependent Enzymes

    • 1st Edition
    • Volume 736
    • English
    Thiamine Pyrophosphate (TPP)-Dependent Enzymes, Volume 736 in the Methods in Enzymology series covers this diverse group of ubiquitous enzymes with timely chapters on Methods for Studying ThDP-dependent Mycobacterial MenDs (SEPHCHC Synthases), Mammalian 2-hydroxyacyl-CoA lyases, discovery and assays, Anti-infective target 1-deoxy-d-xylulose-5... synthase (DXS) and drug design for enzyme inhibition, Expression, Purification, and Mechanistic Studies of DXP synthases from Deinococcus radiodurans, Plasmodium falciparum, and Plasmodium vivax, Comparison of the catalysis of ThPP-dependent enzymes AHAS, ALS, and DXS, and much more.Additional sections cover Plant and fungal acetohydroxyacid synthases (AHAS): Methods for heterologous expression, kinetic characterization, and structural analysis, Biochemical and Structural characterization of novel ‘split-gene’ archeal transketolases, 4-Hydroxybenzoylform... decarboxylase enzymes from Rhodococcus jostii RHA1 and Pseudomonas fluorescens Pf-5: characterization and involvement in bacterial lignin degradation, Engineering of phosphoketolase from Bifidobacterium adolescentis for increased activity on non-phosphorylated substrates and application in a cell-free reaction system for ATP regeneration, Repurposing TPP-dependent enzymes with anodic oxidation for the conversion of aldehydes to enantioenriched carboxylic acids, and much more.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 44
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 43 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Content in this new release covers Engineered probiotics for producing phosphoinositol-sn-l... as biosurfactant modulators: Their hydropathy, in potentiating surface tension and scaffold properties into model emulsions.

  • The Metabolon

    • 1st Edition
    • Volume 739
    • English
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Super-Resolution Nanoscopy for Protein Imaging

    • 1st Edition
    • Varun Vyas
    • English
    Super-Resolution Nanoscopy for Protein Imaging decodes the intricate world of protein visualization using cutting-edge nanoscopic techniques. This comprehensive guide is crafted to equip master students, PhD candidates, and early-stage researchers with essential knowledge and practical insights into advanced protein imaging technologies. The book covers foundational principles, innovative methodologies, and real-world applications, providing a complete resource for mastering the complexities of protein imaging. This book offers a unique compilation of diverse nanoscopic methods, overcoming the limitation of technique-specific texts currently available.By collecting scattered information into a single volume, it delivers an in-depth exploration of imaging techniques, from Atomic Force Microscopy (AFM) to Electron Microscopy (EM), and Single Molecule Fluorescence Imaging. Each section delves into instrumentation, sample preparation, data analysis, and the latest developments, making it an indispensable reference for understanding how to visualize proteins in their natural environments.

  • Bio-Click Chemistry

    Expanding Horizons Beyond the Click
    • 1st Edition
    • Flavia Zacconi + 2 more
    • English
    Bio-Click Chemistry: Expanding Horizons Beyond the Click delves into the dynamic intersection of biocatalysis and click chemistry, providing a comprehensive exploration of these rapidly evolving fields. This book offers in-depth insights into both historical perspectives and the latest advancements, ensuring readers gain a thorough understanding of fundamental principles, practical applications, and future directions. Readers will discover the versatile applications of biocatalysis and click chemistry in pharmaceuticals, biotechnology, biology, biomedicine, nanomedicine, and materials science, equipping researchers, educators, and industry professionals with the tools and techniques needed to foster innovation and real-world impact. Furthermore, the book investigates the emerging trends, challenges, and opportunities in biocatalysis and click chemistry, empowering readers to stay ahead of the curve and drive transformative developments in chemical synthesis and enzymatic engineering. This indispensable guide is designed for researchers, educators, and industry professionals dedicated to advancing their work and exploring new frontiers in chemical synthesis and biocatalytic processes.

  • Applications of Microfluidics Device Technology

    • 1st Edition
    • Volume 226
    • English
    Microfluidics is a rapidly expanding field that is recognized as a powerful platform for accelerating biological science research and innovation. It has the potential to reduce the cost and reagent consumption by enabling the precise manipulation of a small amount of fluids through microchannel ranging from ten to hundreds micrometres in size. It is a multidisciplinary domain, which integrates molecular analysis, molecular biology, and microelectronics. It has demonstrated practical applications in the design and fabrication of systems capable of processing low volumes of fluids while enabling multiplexing, automation, and high-throughput screening. Since its emergence in early 1980s, microfluidics has significantly contributed in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Microfluidic chips comprise intricate networks of microchannels and chambers designed to manipulate fluids at the microscale. This volume highlights the applications of microfluidics in the detection and analysis of infectious diseases caused by bacteria, viruses, fungi, and protozoa. It also explores the use of microfluidic technologies in the diagnosis and study of non-infectious diseases, including cardiovascular disorders, cancer, metabolic diseases, and neurological conditions. It also covered single-cell analysis, high-throughput drug screening, cell sorting, and both preclinical and clinical applications. It also used in role of microfluidics in organ culture, regenerative medicine, and personalized healthcare. It also addresses ethical and regulatory issues in the development and use of microfluidic devices. This volume is designed to serve as valuable resource for students, researchers, scientists, clinicians, stakeholders, policymakers, and practitioners to understand microfluidics and apply microfluidics technology/devices in various fields. It provides a strong foundation to help the extension of microfluidics knowledge and accelerate research, innovation, technology and practical applications.

  • Structural Biology of Ubiquitination

    From Mechanisms to Interventions
    • 1st Edition
    • Navaneet Chaturvedi + 1 more
    • English
    Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and their implications in diseases such as cancer and neurodegeneration. The book seamlessly integrates experimental insights with advanced computational methods, including AI-driven drug discovery, molecular modeling, and biophysical simulations, offering a comprehensive toolkit for researchers and clinicians. By bridging fundamental science with translational applications, the book empowers readers to design targeted therapeutics, understand disease mechanisms at the molecular level, and accelerate progress toward personalized medicine.

  • The Matrix Metalloproteinases

    • 1st Edition
    • Volume 60
    • English
    The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 135
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Ecology of Marine Rocky Shores

    • 1st Edition
    • Volume 105
    • English
    Ecology of Marine Rocky Shores, Volume 105 in the Advances in Marine Biology series, highlights new advances in the field, presenting comprehensive chapters written by an international board of authors. This volume explores key ecological processes shaping rocky shore environments, including the impacts of plastic pollution, the dynamics of warm-temperate and subtropical systems, and the roles of foundation species and community interactions.Additio... chapters examine conservation planning, kelp ecology and restoration, fisheries and indigenous knowledge, and the influence of ocean rafting on species distribution. The volume also addresses spatial and network approaches to ecology, coastal marine microbiology, and the ecological impacts of invasive species. Together, these contributions provide an integrated perspective on the structure, function, and resilience of rocky shore ecosystems, offering valuable insights for researchers, marine ecologists, and environmental scientists.

  • Ion Channels in Cellular Pathophysiology Part B

    • 1st Edition
    • Volume 98
    • English
    Ion Channels in Cellular Pathophysiology Part B, Volume 98 covers a variety of timely topics, including Nerve electrophysiological alterations in experimental diabetic neuropathy, Possible therapeutic effects of essential oils on Na channels in experimental diabetic neuropathy, Breast cancer and voltage gated ion channels, Cardioprotective effect of natural products on doxorubicin-induced acute cardiotoxicity and cardiac ischemia-reperfusion injury,and Modulation of ion channels by Group I metabotropic glutamate receptors.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 89
    • English
    Advances in Microbial Physiology, Volume 89 explores the latest research and developments in microbial physiology, providing a comprehensive overview on how microorganisms function, adapt, and interact with their environments. This volume brings together leading experts to discuss fundamental processes such as metabolism, growth, gene regulation, signal transduction, stress responses, and cellular differentiation in bacteria, archaea, and fungi. Chapters cover Steroids as Antibacterials, From Feeding Cell to Fruiting Body: Multidrug Transport in the Life cycle of Dictyostelium discoideum, Evolution of xenobiotic catabolism, Glycyl-radical enzymes, How anaerobes cope with oxygen, and Extracellular Electron Transfer: From Early Life to Modern Biogeochemistry and Applications.

  • Enzyme Technology for Environmental Sustainability, Waste to Wealth, and Circular Economy

    • 1st Edition
    • Shrikaant Kulkarni
    • English
    Enzyme Technology for Environmental Sustainability, Waste to Wealth, and Circular Economy offers a comprehensive look at how enzyme technology can drive environmental progress within the framework of biochemistry. Beginning with foundational concepts, the book introduces readers to the science behind enzymes and their practical applications. Each chapter builds upon these basics, illustrating how enzymes catalyze vital processes that contribute to sustainability and the transformation of waste into valuable resources. Through focused case studies and clear explanations, the book demonstrates the potential of enzyme-driven solutions to address urgent environmental challenges and promote a circular economy.Beyond its central focus, the book stands out by delivering pragmatic examples that remain within biochemical boundaries, avoiding broader discussions in public health or environmental science. It is designed as a valuable reference for biochemists, researchers, and industry professionals, emphasizing collaboration and innovation rooted in biochemical expertise. Readers will gain an enriched understanding of enzyme technology’s role in sustainable industrial practices and the future of environmentally responsible solutions.

  • Protein Kinase Inhibitors

    The Promise of Natural Products in Cancer Therapeutics
    • 1st Edition
    • Md. Imtaiyaz Hassan + 1 more
    • English
    Protein Kinase Inhibitors: The Promise of Natural Products in Cancer Therapeutics explores a novel therapeutic avenue for cancer treatment through nutraceutical-based kinase inhibitors. The book covers their historical background, outlook, mechanistic pathways, and clinical aspects, highlighting their relevance in cancer therapy. It also examines the potential of polyphenolic derivatives and other natural compounds in inhibiting key kinases involved in major cancer signaling pathways, focusing on their application in clinical trials and marketed drugs. Sections explore the implications of polyphenols in cancer management, novel sources of breast cancer inhibitors, the role of natural products in lymphoma therapy, and the multitarget potential of phytochemicals. Each chapter is designed to provide a thorough understanding of how natural products can be harnessed to develop innovative cancer therapeutics. It will serve as a valuable resource for academics, scientists, young researchers, students, and pharmacists working or interested in kinase biology and cancer therapeutics with its unique perspective on using nature's own arsenal to combat cancer.

  • Carrier-Free Enzyme Immobilization

    Fundamentals and Innovations in Biocatalysis
    • 1st Edition
    • Mehdi Mohammadi + 1 more
    • English
    Carrier-Free Enzyme Immobilization: Fundamentals and Innovations in Biocatalysis explores innovative techniques for immobilizing enzymes without the use of inert carriers, highlighting their advantages, applications, and integration into modern biocatalytic processes. The book begins by introducing the concept of enzyme immobilization and the transition from traditional carrier-bound methods to innovative carrier-free techniques. It discusses the fundamental principles behind carrier-free immobilization, including the types of cross-linkers used and the advantages in enhancing enzyme stability and activity. The book also covers various methods for the structural characterization of carrier-free immobilized enzymes.With a strong focus on practical implementation, it examines the applications of carrier-free immobilized enzymes across different industries, highlighting the pros and cons of the method. It explores novel approaches for producing carrier-free immobilized biocatalysts and provides a comparative analysis of carrier-free versus traditional carrier-bound immobilization techniques. The book also addresses the challenges associated with implementing carrier-free immobilization in industrial processes and proposes potential solutions to overcome these obstacles. It is an essential resource for biochemists, chemical engineers, and researchers in biotechnology who are involved in enzyme research and development.

  • Flavoproteins and Flavoenzymes

    • 1st Edition
    • Volume 738
    • English
    Flavoproteins and Flavoenzymes, Volume 738 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Kirisu2 and KiPaD: global analysis of rapid flavoprotein redox kinetics from stopped-flow multi, ilagros Mendina, A Generic First Approach to Dissecting Flavoenzyme Catalytic Cycles, Removing Covalent Constraints of Protein Loops and Lids by a Split-Gene Strategy, Designing Oxygen Reaction Sites in Flavoprotein Dehydrogenases, Converting Noncovalent Flavoproteins into Covalently Flavinylated Proteins, Complexities of Riboflavin Biosynthesis, Reactions of Riboflavin Catabolism, and much more.Additional sections cover Ferredoxin-dependent thioredoxin reductase, Thermophilic Methylenetetrahydrof... Reductases, Ion-Pumping NADH:Quinone Oxidoreductase, Loading E. coli Dihydroorotate Dehydrogenase with Coenzyme Q, and Single-Component Halogenases.

  • Fundamentals of Absorption Spectroscopy

    • 1st Edition
    • Imtaiyaz Hassan
    • English
    Fundamentals of Absorption Spectroscopy offers a clear and comprehensive introduction to the principles, instrumentation, and applications of absorption spectroscopy across UV-Visible, IR, and other spectral regions. Designed for students, researchers, and industry professionals, this book bridges theory and practice with practical illustrations and real-world case studies, providing a solid foundation in both fundamental concepts and contemporary applications in chemistry, biology, medicine, environmental monitoring, and materials science. It fills the gap between overly advanced and overly simplified texts by combining fundamental theory with practical insights, particularly from biological perspectives. This book addresses the need for an updated, student-friendly, and application-oriented resource in absorption spectroscopy. Readers will benefit from structured guidance that connects theoretical principles with experimental data, explains instrumentation and its limitations, and demonstrates applications across diverse fields such as pharmaceuticals, environmental analysis, and biomolecular sciences. The inclusion of case studies and recent advances in spectroscopic technology ensures relevance for both academic study and professional practice.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 134
    • English
    Advances in Clinical Chemistry, Volume 134 in this ongoing series, examines physiologic and pathophysiologic biochemistry and impacts on Clinical Chemistry testing and design. Sections cover Molecular mechanisms of disease and advances in the development of improved diagnostic and predictive biomarkers. Specific chapters in this new release include Biomarkers in Heart Failure, RNA biomarkers in antidoping, Cardiovascular disease and miRNA, Chronic low-grade inflammation in vegetarians and vegans: biomarker evidence and methodological considerations, Advances in microfluidic extracellular vesicle technology, and Biomarkers for Assessing Magnesium Status.As these evolving technologies and analytic strategies have become increasing relevant given the healthcare and socioeconomic impact worldwide, this book provides an essential reference.

  • Vertebrate Carbonic Anhydrases

    • 1st Edition
    • Volume 59
    • English
    Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.

  • Foundation of Microfluidics Device Technology

    • 1st Edition
    • Volume 225
    • English
    Foundation of Microfluidics Device Technology, Volume 225 presents the fundamentals of microfluidics and microfluidics devices, including computational design and fabrication, artificial intelligence and internet of things for microfluidics devices, materials, surface modifications and functionalization of microfluidics, fabrication of paper based microfluidics. Additional topics include microfluidics for generation of biomaterials, microfluidics for multi-omics analysis, lab-on-the-chip, microfluidics for 2D and 3D cell culture systems, microfluidics for drug and gene delivery, biomimetic models, and the economic considerations associated with microfluidics devices development.Specific chapters in this new release include An introduction to microfluidics and devices, Computational design and modeling of microfluidics devices, Artificial intelligence and IoT for microfluidics devices, Fabrication techniques for design of microfluidics devices, Materials, surface modification and functionalization of microfluidic devices, Fabrication of paper based microfluidics, Microfluidics in biomaterials generation and formulation, Microfluidics for chemical and biological analysis, and more.

  • Thiamine and Thiamine-Pyrophosphate (TPP) Riboswitches

    • 1st Edition
    • Volume 735
    • English
    This volume of "Methods in Enzymology" series is devoted to the cofactor thiamine, also known as vitamin B1, and its phosphorylated derivatives. The biosynthesis of thiamine is discussed in terms of key enzymes and their regulation, the evolution of metabolic pathways, and its importance in plant and yeast metabolism. The importance of quantifying and distinguishing between phosphorylated and unphosphorylated thiamine in animal and human tissues using chromatographic, enzymatic, and nanopore methods is also discussed. In addition to these methods, thiamine riboswitches are a major focus of this book, covering everything from their identification in plants and the elucidation of their structure to their application in detection.This book presents state-of-the-art methods and detailed protocols intended for all researchers interested in thiamine metabolism or its detection.

  • Enzyme Microfluidics

    • 1st Edition
    • Volume 737
    • English
    Enzyme Microfluidics, Volume 737 in the Methods in Enzymology series, presents detailed methodological descriptions and protocols that cover a wide range of microfluidics-based approaches for mechanistic enzymology, high-throughput screening, and enzyme engineering campaigns. The volume includes both established methods as well as advances in the field. Sections in this new release cover four unique sections, including Chips and Reagents, Enzyme Characterization, Enzyme Engineering, and Moving Beyond Microfluidics (from micro to nanoscale). Specific chapters delve into Joint Methods for Fabricating Microfluidic Chips, A liquid handling robotic workflow for quantifying the activity of antibiotic resistance genes (ARGs) in cell-free protein synthesis, and much more.Additional chapters cover Preparation of uniform microcrystals by droplet microfluidics for time-resolved serial crystallography, Droplet microfluidic HDX for investigating highly dynamic proteins, An Accessible, Low-Cost Platform for High-Throughput Microfluidic Enzyme Kinetics, High-Throughput Data Processing, DA-MEK, Mass Spectrometry of Droplets, Digital Bioassay Using a Femtoliter Reactor Array Device, Confocal absorbance droplet sorting, Sequence-Function Data Analysis from Microfluidics Screening, and much more.

  • Microbial Biofilms and Cancer

    • 1st Edition
    • Volume 224
    • English
    Microbial Biofilms and Cancer series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 104
    • English
    Advances in Marine Biology, Volume 104, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors. Chapters in this new release explore Integrative Fish Biomechanics and Advancing marine invertebrate biodiversity in South Africa: Addressing gaps in taxonomy and genetic knowledge.

  • Smart Biosensing Technologies for Early Detection of Metabolic Disorders

    • 1st Edition
    • Kanwal Rehman + 1 more
    • English
    Smart Biosensing Technologies for Early Detection of Metabolic Disorders gives a clear overview of the latest biosensor tools that help detect and monitor metabolic diseases like diabetes, obesity, and insulin resistance early. It explains how these sensors work using basic science and shows new wearable, non-invasive, and easy-to-use devices. This book is useful for researchers, doctors, and professionals working in healthcare technology. This book connects research from different fields to help solve real problems in making and using biosensors. It includes examples of how these sensors are used, new markers for disease detection, and how AI and digital health can improve care. Readers will learn how to develop better diagnostic tools and improve treatment for metabolic diseases.

  • Methods in Systems Bioinorganic Chemistry

    • 1st Edition
    • Volume 741
    • English
    Methods in Systems Bioinorganic Chemistry, Volume 741 provides understanding of high-level properties involving metals in biology that are founded on molecular or mechanistic level interactions. Currently, there is no established “tool kit” for studying bioinorganic systems, so the methods included in the book span a diverse range of topics and approaches, from imaging to proteomics, from metals-in-mice to mathematical modeling. Specific chapters cover Inductively Coupled Plasma Mass Spectrometry (ICP-MS)-based methods to quantify transition metals in cells and vertebrate models, ICP-MS elemental analysis in tissue samples, and much more.Additional chapters delve into An inductively-coupled-... triple quadrupole method with oxygen for the determination of essential elements and protein concentration, Calculating metal speciation of proteins inside cells, Probing biological copper in the subfemtomolar regime, Using LC-ICP-MS chromatography to detect and characterize Labile Metal Pools, Linking dynamic bioinorganic chemistry processes of toxic metals in the bloodstream to establish their exposure-response relationship in humans, Contextualizing X-ray fluorescent microscopy – high resolution X-rays meet subcellular morphology, Chemoproteomic profiling of transition metal binding sites in bacterial proteomes, Heme Labeling by Proximity (HeLP) to Identify Hemoproteins, and much more.

  • Recent Advances in Targeting Inflammation

    Ion channels, GPCR Signaling Tools, Therapies, and Beyond
    • 1st Edition
    • Senthilkumar Rajagopal + 3 more
    • English
    Recent Advances in Targeting Inflammation: Ion Channels, GPCR Signaling Tools, Therapies, and Beyond delves into the multifaceted occurrences of inflammation across different systems, such as neuroinflammation and gastric inflammation. The book's main goal is to present the latest highlights, covering advancements in inflammation, investigational therapies, animal models, and biomarkers. These insights are crucial for better diagnosis, monitoring, and potential therapeutic options for patients suffering from both acute and chronic inflammation. This comprehensive work explores various topics, including ion channel regulation in inflammation, GPCR regulation, signaling pathways, and therapeutic approaches.It emphasizes the importance of understanding the role of ion channels, GPCR, and nutrition in managing inflammation effectively. Additionally, the book discusses the global impact of chronic inflammation on health outcomes, stressing the need for improved healthcare planning and strategies.

  • Histone Deacetylases in Neurodegenerative Disease Part A

    • 1st Edition
    • Volume 733
    • English
    Histone Deacetylases in Neurodegenerative Disease, Part A, Volume 733 in the Methods in Enzymology series, highlights new advances, with this volume presenting chapters on topics such as HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress, Specific activation of p300/CBP Lysine acetyltransferases induces adult neurogenesis and synaptic plasticity, Chromatin immunoprecipitation assay for analyzing histone H3-mediated regulation of copper homeostasis, Histone Deacetylase 6 modulates Tau structure and function, Histone Acetylation in Parkinson Disease, DNA methylation and histone modification in hypoxic conditions, The extracellular Histone Deacetylase 6 modulates the actin networks in neuronal cells, Epigenetic modulators as therapeutics for neurodegenerative disorder/Alzheimer's disease, and much more.Additional chapters explore Sirtunins in mitochondrial physiology and energy homeostasis, Sirtunins in metabolic homeostasis, Conformational flexibility of histone variant CENP-ACse4 is regulated by histone H4: A mechanism to stabilize soluble Cse4, Analysis of copper toxicity by western blotting of secretory proteins translocated via Sec61 channel, Histone deacetylase as a potential therapeutic target for memory disorders, Histone deacetylases in Neurodegeneration, Role of Deubiquitinases in Regulating Tau Acetylation and Autophagic Clearance in Alzheimer’s Disease, Histone deacetylases in Neurodegeneration and neuronal plasticity, and more.

  • Cyclodextrin Glucanotransferase

    A Comprehensive Guide from Gene to Applications
    • 1st Edition
    • Kiransinh Rajput
    • English
    Cyclodextrin Glucanotransferase: A Comprehensive Guide from Gene to Applications explores the essential role of cyclodextrin glucanotransferase (CGTase) in starch degradation and its diverse industrial applications. This book serves as a valuable resource for researchers and industry professionals, offering comprehensive insights from the genetic basis of CGTase to its practical applications. The book covers the production of CGTase by different bacterial genera, including Bacillus spp., and their purification strategies. It delves into the structural and functional characteristics of CGTase, highlighting its catalytic mechanisms, substrate specificity, and factors affecting enzyme activity and stability. Additionally, the book explores recombinant CGTases, their properties, and advancements in protein engineering and enzyme immobilization. With a strong focus on practical applications, the book discusses the remarkable properties of cyclodextrins, such as inclusion complex formation, and their wide range of uses in various industries, including pharmaceuticals, textiles, bioremediation, and food. Detailed case studies and real-world examples illustrate how CGTase and cyclodextrins can address specific challenges and drive innovation in these fields.This book is an essential resource for applied science researchers working in the field of starch processing enzymes, providing them with the knowledge to advance their research and development. It also serves as a valuable reference for researchers in the starch processing industries, offering insights into the latest advancements and practical applications of CGTase and cyclodextrins.

  • Mpox

    • 1st Edition
    • Volume 59
    • English
    Monkeypox, Volume 59 covers the diagnosis of Mpox from clinical specimens and wastewater, while also discussing the neurological, dermatological, reproductive, and structural biology of Mpox. Specific chapters cover Tracking Mpox through Wastewater: Advances in Environmental Surveillance and Analytical Methodologies, Community-Based Monitoring of Mpox and Co-occurring Sexually Transmitted Infections (STIs), Clade-Level Differentiation of Mpox Virus: Molecular Diagnostic Strategies for Routine Testing in Low-Resource Settings, Comparative Analysis of Mathematical and Stochastic Modelling of MPOX in Human and Rodent Populations, Genomic Sequencing Methods for mpox Detection and Genotyping, and The gastrointestinal manifestations of mpox.Additional sections explore the Neurological complications of Mpox, Dermatological complications of Mpox infections, Reproductive complications of Mpox, and the Structural Biology of Mpox: Advanced Imaging Illuminate Viral Mechanisms.

  • Mucins

    • 1st Edition
    • Volume 732
    • English
    Mucins, Volume 732 serves as a valuable resource for researchers aiming to investigate mucin biology in greater depth, offering a wide range of experimental approaches and analytical strategies. Topics in this new release cover Enrichment/isolation... glycoproteomics, Mucinase cleavage characterization and usage in glycoproteomics, Fluorescent protein-based FRET substrates for activity screening of mucinases, Development of clinical lectin assays based on MS glycomic discovery, Enzymatic selective sulfation of synthetic mucins, cryoEM, Cell-based mucin arrays and glycoengineering, CRISPR screens to characterize and identify glycan-binding proteins, and much more.Additional sections cover MD Simulations, Interactions with pathogenic bacteria, Interactions with microbiota, Covalent crosslinking of mucins, Liquid Glycan and Liquid Lectin Array-based exploration of musin recognition, Quantification of mucins, Mucins in IBD, Investigations of mucins and innate immunity, Generating synthetic mucin glycopeptides, and Microscopy and imaging.

  • Advances in Biomembranes and Lipid Self-Assembly

    • 1st Edition
    • Volume 43
    • English
    Advances in Biomembranes and Lipid Self-Assembly, Volume 43 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Subjects in this new release cover engineered probiotics for producing phosphoinositol-sn-l... as biosurfactant modulators: Their hydropathy, in potentiating surface tension and scaffold properties into model emulsions.

  • Bioorthogonal Labeling

    • 1st Edition
    • Volume 731
    • English
    Biorthogonal Tagging, Volume 731 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters such as Staudinger Ligations and Related Reactions: Scope and Applications in Chemical Biology, Strain-Promoted Bioorthogonal Cycloadditions to Investigate Sialyltransferases Promiscuity Towards Unnatural Sialic Acids, Practical Guidelines for the Bioorthogonal AMI–Isonitrile Ligation, Nitrones and Other Dipoles in Bioorthogonal Chemistry Applications, 1,2-Aminothiol-Speci... Conjugation for Dual-Color Fluorescent Labeling via Ultrafast TAMMs, Genetic Incorporation of Bicyclononyne for Cell-Surface Protein Labeling via Tetrazine Ligation, and much more.Additional chapters cover Genetic Code Expansion for Single Noncanonical Amino Acid Incorporation into SARS-CoV-2 Omicron Spike on Amber-Free Lentiviral Particles, Bioorthogonal Click-Chemistry Labeling and Visualization of Dual Noncanonical Amino Acid–Incorporated HIV-1 Env on Intact Virions, Studying Bacterial Glycans with Azidosugars and Bioorthogonal Chemistry, Bioorthogonal Tagging of DNA and RNA, Efficient Labeling of Pathogenic Fungal Chitin with Bioorthogonal Probes, and many more timely topics.

  • Current Approaches to Cryo-electron Microscopy

    • 1st Edition
    • Volume 223
    • English
    Current Approaches to Cryo-electron Microscopy, Volume 223 provides a comprehensive overview of the field, tracing its evolution from early structural studies to modern pipelines powered by deep-learning algorithms for helical reconstruction. The book addresses the persistent bottleneck of sample preparation, detailing the physical challenges of fibril clumping and interfacial adsorption, alongside emerging solutions to these problems. Chapters in this new release include Advancing biological understanding of the poxvirus scaffold through breakthroughs in cryo-electron microscopy, Pursuing the physics of cryoEM image formation, AI Tools for Cryo-EM: Protein Particle Picking, Density Map Enhancement, and Atomic Model Building, and much more.Additional chapters cover Cryo-EM of Amyloid Fibrils: Advances, Challenges, and Translational Applications, Computational Approaches for Protein Complex Modeling for Intermediate Resolution Cryo-EM Maps, Calcium-sensing receptor, involved in the oral perception of the kokumi substances, Insights into the Structure and Diversity of the Bacterial Flagellum from cryo-EM studies, Overview and future potential in structural studies of bacteriophages by cryo-electron microscopy, and more.

  • Hypercortisolism: Diagnosis and Differential Diagnosis

    • 1st Edition
    • Volume 132
    • English
    Hypercortisolism: Diagnosis and Differential Diagnosis, Volume 132 presents a comprehensive series of chapters focused on the various aspects of endogenous hypercortisolism as contributed by an international team of specialists in endocrinology. Chapters in this new release include Cushing´s syndrome: Clinical presentation and associated comorbidities, Biochemical diagnosis of hypercortisolism: when and how?, ACTH independent Cushing syndrome: diagnosis and etiology, Bilateral macronodular and micronodular hyperplasia: biochemical, radiological and genetic diagnosis, Differential diagnosis between endogenous Cushing´s syndrome and pseudoCushing, and much more.Additional chapters delve into Differential diagnosis of ACTH dependent Cushing´s syndrome: hormonal and radiological studies, Ectopic Cushing´s syndrome: clinical presentation and diagnosis, Cyclic Cushing´s syndrome, Mild autonomous cortisol secretion: diagnosis, Cushing´s syndrome and pregnancy: clinical presentation and diagnosis, Molecular profile of Cushing´s syndrome, Cardiometabolic comorbidities in overt Cushing´s syndrome, and New tools for the diagnosis of hypercortisolism.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 133
    • English
    Advances in Clinical Chemistry, Volume 133 in this ongoing series, examines physiologic and pathophysiologic biochemistry and their impacts on Clinical Chemistry testing and design. Molecular mechanisms of disease processes are highlighted in the context of traditional, current, and emerging technologies, and advances in the development of improved diagnostic and predictive biomarkers are examined, especially those targeting early and emerging diseases. Specific chapters in this new release include Drug Induced Renal Injury (DIRI) Biomarkers, Unveiling tobacco markers in exhaled breath, Advances in small extracellular vesicle analysis, Piezoelectric Sensors in Point-of-Care Testing, Mitochondrial myopathy biomarkers, and Hormonal and Metabolic Biomarkers in Long COVID.

  • Advances in Microbial Physiology

    • 1st Edition
    • Volume 88
    • English
    Advances in Microbial Physiology, Volume 88 explores the latest research and developments in microbial physiology, providing a comprehensive overview on how microorganisms function, adapt, and interact with their environments. This volume brings together leading experts to discuss fundamental processes such as metabolism, growth, gene regulation, signal transduction, stress responses, and cellular differentiation in bacteria, archaea, and fungi. Chapters cover Steroids as Antibacterials, From Feeding Cell to Fruiting Body: Multidrug Transport in the Life cycle of Dictyostelium discoideum, Evolution of xenobiotic catabolism, Glycyl-radical enzymes, How anaerobes cope with oxygen, and Extracellular Electron Transfer: From Early Life to Modern Biogeochemistry and Applications.

  • Computational Approaches to Natural Products Discovery

    • 1st Edition
    • Volume 730
    • English
    Computational Approaches to Natural Products Discovery, Volume 720 provides descriptions of the latest techniques in computational methods for the study of natural products. Techniques covered are related to genome mining, natural product biosynthesis, natural product evolution, and natural product structure. Chapters in this new release cover Prediction of natural product bioactivity from BGC sequence to guide genome mining efforts, Genome mining for resistance genes to identify bioactive natural products with ARTS, Predicting lasso peptide structure with LassoPred, Predicting lanthipeptide structure with Rosetta, Using lsaBGC to investigate BGC Evolution, and an Analysis of BGC evolution with CORASON.

  • Artificial Intelligence for Multi-omics Analysis Part B

    • 1st Edition
    • Volume 222
    • English
    Artificial Intelligence for Multi-omics Analysis Part B, Volume 222 in the Progress in Molecular Biology and Translational Science series, highlights recent advances, with this new volume presenting chapters on a variety of topics, including Artificial Intelligence in multi-omics analysis of small molecule drug discovery, AI in multi-omics analysis in antimicrobial resistance, Artificial Intelligence and multi-Omics Approach in Vaccine Development, Artificial Intelligence in multi-omics Analysis of heart diseases, Artificial Intelligence in multi-omics Analysis of Kidney Diseases, Artificial Intelligence in multi-omics Analysis of Gastrointestinal Diseases, AI in multi-omics analysis in Stem cell research, and AI in multi-omics analysis in cancer, and more.Additional sections cover AI in multi-omics analysis in obstructive lung diseases, AI in multi-omics analysis in neurodiseases, AI in multi-omics analysis in autoimmune diseases, AI in multi-omics analysis of liver diseases, AI in multi-omics analysis of COVID-19 patient data, and AI in multi-omics analysis of Type 2 diabetes.

  • Immunomodulators Part B

    • 1st Edition
    • Volume 152
    • English
    Immunomodulators Part B brings together a curated set of research-focused chapters that explore how the immune system is influenced by microbes, immune checkpoint molecules, genetic regulation, and emerging therapeutic strategies. It covers the role of the microbiome and microbial products in shaping immune responses relevant to gastrointestinal cancers, examines VISTA as a “double-edged” checkpoint in cancer and autoimmunity, and uses bioinformatics to uncover immune-modulatory patterns in HPV-associated head and neck squamous cell carcinoma and bladder cancer.

  • Vector-Borne Diseases

    • 1st Edition
    • Volume 58
    • English
    Vector Borne Diseases, Volume 58 in the Methods in Microbiology series, highlights new advances in the field, with this new volume presenting interesting written by an international board of authors. Chapters in this new release cover Methods for Isolation and Characterization of Arthropod Hemocytes, Tick-to-Host Transmission of B. burgdorferi: In Vitro and In Vivo Methodologies, Decoding the Zika Virus outbreak and Infection Dynamics, Visual and molecular methods for studying pathogen persistence in flea vectors, Lipidomic Analysis of Virus-infected Cells, and Implementation of the Neutropenic Thigh Infection Murine Model with Francsiella tularensis for Development of New Antibacterials.

  • Arginase: Structure, Function, and Therapeutic Targeting

    • 1st Edition
    • Volume 740
    • English
    Arginase: Structure, Function, and Therapeutic Targeting, Volume 740 in the Methods in Enzymology series, provides a comprehensive, methodology-driven perspective on arginase research spanning molecular, biochemical, and translational domains. Chapters in this new release include Expression, Purification, and Structural Characterization of Human and Leishmania Arginase with Comparative Analysis of Structures from the Protein Data Bank, Synthesis of First-Generation Arginase Inhibitors, Computational and Structure-Guided Design of Arginase Inhibitors, Metal Substitution in Arginase: Experimental Approaches to Study Metal-Dependent Catalysis, Therapeutic Arginase Formulations: PEGylation, Stability, and Advanced Delivery Systems, and much more.Additional chapters cover Dual ARG1/ARG2 Inhibition: Experimental and Structural Strategies for Inhibitor Design and Optimization, Synthesis of Second-Generation Arginase Inhibitors, Cryo-EM Workflow and Structural Characterization of Arginase–Antibody Complexes, Development and Validation of an Electrochemical Assay for Arginase Activity, Experimental and Structural Analysis of H. pylori Arginase in Gastric Immune Evasion, Agmatinase and Alternative Arginine Utilization Pathways in Bacteria: Biochemical and Functional Perspectives, Catalytic Diversification of the Arginase Fold: Structural and Mechanistic Insights from DcsB, Beyond Arginase: Structural Biology of the Extended Guanidinase Family, Plant Arginase: Structural and Functional Roles in Nitrogen Metabolism, and much more.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 103
    • English
    Advances in Marine Biology, Volume 103, the latest release in this serial that highlights new advances in the field, includes comprehensive chapters written by an international board of authors.

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