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Elsevier

Mannose Binding Lectin Associated Serine Proteases

Structure, Function and Therapeutic Implications

  • 1st Edition - January 1, 2027
  • Latest edition
  • Editor: Krishnan Hajela
  • Language: English

Mannose Binding Lectin Associated Serine Proteases: Structure, Function and Therapeutic Implications provides a comprehensive and up-to-date overview of MASP-1, MASP-2, and MASP-3… Read more

Description

Mannose Binding Lectin Associated Serine Proteases: Structure, Function and Therapeutic Implications provides a comprehensive and up-to-date overview of MASP-1, MASP-2, and MASP-3, highlighting their roles in immune defense, disease mechanisms, and therapeutic intervention. This authoritative reference covers the molecular structure and catalytic mechanisms of these key serine proteases, emphasizing their involvement in the lectin pathway of complement activation as well as their emerging functions in coagulation and bradykinin pathways. The book brings together the latest research on how MASPs contribute to pathogen recognition and clearance, and how their dysregulation is linked to a range of infectious, inflammatory, and thrombotic diseases. Chapters detail the biology of animal lectins and collectins, the classical and alternative complement pathways, and the specific biochemical activities of MASP-1, MASP-2, and MASP-3. Readers will find in-depth discussions on the clinical significance of MASP gene polymorphisms and serum levels, as well as the design and therapeutic relevance of natural and synthetic MASP inhibitors. Special focus is given to the application of MASP-2 inhibitors in the management of complications such as hematopoietic stem-cell transplantation-associated thrombotic microangiopathy (HSCT-TMA). This book is an essential resource for researchers in immunology, biochemistry, and molecular medicine, as well as clinicians seeking to advance their understanding of complement biology and the therapeutic potential of targeting the lectin pathway.

Key features

  • Summarizes the latest research on the structure and function of Mannose Binding Lectin (MBL) associated serine proteases, including MASP-1, MASP-2, and MASP-3
  • Explores the roles of MBL-associated serine proteases in the lectin, coagulation, and bradykinin pathways
  • Discusses the clinical implications of MASPs, including their correlation with disease states and therapeutic potential
  • Provides insights into the design and application of natural and synthetic MASP inhibitors
  • Highlights the unique contribution of MASPs to both innate immunity and non-canonical proteolytic pathways

Readership

Researchers in immunology, biochemistry, molecular biology, structural biology, clinical researchers, translational scientists, clinicians (especially in immunology, hematology, infectious diseases), pharmaceutical scientists, drug development professionals

Table of contents

1. Animal lectins in human health and disease

2. Collectins: Structure and Function

3. The Classical and Alternative pathways of complement activation

4. Mannose Binding Lectin and Lectin pathway of complement activation

5. Mannose Binding Lectin associated Serine protease 1 (MASP-1): Structure, catalytic mechanism, function

6. Mannose Binding Lectin associated Serine protease 2 (MASP-2): Structure, catalytic mechanism, function

7. Mannose Binding Lectin associated Serine protease 3 (MASP-3): Structure, catalytic mechanism, function

8. Role of Mannose Binding Lectin associated serine proteases in activation of the coagulation pathways and Bradykinin production

9. Role of Mannose Binding Lectin associated serine proteases serum levels and implications in disease

10. Natural and synthetic inhibitors of Mannose Binding Lectin associated serine proteases: Application and therapeutic importance

11. Role of Mannose Binding Lectin associated serine protease 1 in endothelial wound healing

12. Complement in host defence and disease: Role of carbohydrates

Product details

  • Edition: 1
  • Latest edition
  • Published: January 1, 2027
  • Language: English

About the editor

KH

Krishnan Hajela

Prof. K. Hajela joined School of Life Sciences Devi Ahilya University as a Lecturer in 1989. He has done BSc Hons in Chemistry, MSc and MPhil in Biochemistry and obtained PhD in 1989 from Aligarh Muslim University Aligarh India. He later worked on MBL associated Serine Proteases at MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK in 2000-2001 on DBT Overseas fellowship, and at School of Biological Sciences, University of Southampton UK under Commonwealth Academic Staff fellowship 2005 and Marie Curie fellowship 2007-2009 and at Institute of Enzymology Budapest under Hungarian Visiting Fellowship. He is presently working as Professor at School of Life Sciences, Devi Ahilya University, Indore India. He has mentored 23 PhD students and 7 MPhil students as guide and co guide and authored more than 85 research papers. His research interest includes Lectins, lectins cell interactions, Lectin pathway of complement activation, innate immunity and MBL associated serine proteases (MASPs). He had completed ten research projects from ICMR, DST, DAE, CSIR, DST, UGC and MAPCOST. Presently he is having a project from ICMR in collaboration with AIIMS PATNA and IIT Indore, He was awarded several Travel Awards and has presented his work in many national and international conferences. Presently he is also Chairman, Central Board of Studies in Industrial Microbiology, Higher Education MP. Previously he was also Dean Faculty of Life Science at DA University from March 2017-2019 and was also Member of Executive Council DA University during that period.

Affiliations and expertise
School of Life Sciences, Devi Ahilya Vishwavidyalaya, India