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Elsevier

Books in Life sciences

  • Enzymology in Drug Discovery

    • 1st Edition
    • Volume 747
    • English
    This volume is focused on the application of enzymology to drug discovery, with the overarching objective of introducing the general audience to the important role that enzymology plays in modern, molecular targeted drug discovery. The volume opens with a chapter on the role of enzymes in normal human physiology and the causal role played by aberrant enzyme activity in various disease state. A second chapter provides a comprehensive review of inhibition modalities for therapeutic enzyme inhibitors. From there the volume is composed of chapters that cover two general categories of information: (1) methodologies for studying enzyme-ligand interactions and (2) case studies of molecular targeted drug discovery against specific enzyme targets. Chapters within the first category cover methods such as assay design, the role of structural biology in drug optimization, analysis of slow and tight binding inhibitors, enzyme-inhibitor complex dynamics, and covalent enzyme inactivators. The second category includes case studies of therapeutic inhibitors of various enzyme target classes: proteases, methyltransferases, histone demethylases, helicases, nucleic acid processing enzymes, kinesin motor proteins, and cytochrome P450s. Finally, a chapter is also devoted to therapeutic replacement or repair of defective enzymes.

  • Space Physiology

    From Earth to Space and Back Again
    • 1st Edition
    • Alan Hargens
    • English
    Space Physiology: From Earth to Space and Back Again provides readers with new and authoritative information about current and important topics related to risks and their countermeasures in space.This book covers translation of Earth-based physiology to astronaut health and Earth applications of space research. Topics include adaptations of various systems to space, including bone, microcirculation, microcirculation, skeletal and smooth muscles, headward fluid shifts, vision as well as integrated countermeasures to maintain well-being and health in space.This is a volume in Elsevier’s series Hot Topics in Physiology, published in association with the International Union of Physiological Sciences. It is an ideal reference for academics and researchers (space physiology and medicine, space radiation, rehabilitation medicine, exercise, wound healing, biochemistry and cell biology, molecular biology) at undergraduate, masters, PhD, and Post-Doc levels.

  • Supercritical Fluid Technology for Food Processing

    Fundamentals and Applications
    • 1st Edition
    • Julian Martínez + 2 more
    • English
    Supercritical Fluid Technology for Food Processing: Fundamentals and Applications aims to bring a didactic approach to supercritical fluid technologies, considering the specific aspects of their use in food processing, and including issues that must be considered in a food industrial plant. The book's chapters cover fundamentals and then move through extraction, separation, adsorption, impregnation, drying, physical processing, particle formation, coprecipitation, reaction, and enzyme and microorganism inactivation. It concludes with a chapter on current practice and future challenges, as well as a look at project formulation for developing new food products.Supercritic... fluids have gained increasing attention in the scientific community and industries where their application can lead to valuable products by means of green and sustainable processes. Food processing is one of the greatest application fields of supercritical technology, which can help produce new and natural ingredients. It is increasingly applied by research groups in universities, including food engineering schools.

  • Adult Hydrocephalus and Disorders of CSF Dynamics

    • 1st Edition
    • Benjamin D. Elder + 1 more
    • English
    Adult Hydrocephalus and Disorders of CSF Dynamics reviews the pathophysiology, evaluation, differential diagnosis, management and treatment of adult hydrocephalus and disorders of cerebrospinal fluid (CSF). The introductory section begins with the anatomy and physiology of the cerebrospinal fluid system, with a review of adult hydrocephalus management, including longitudinal care and management of comorbidities. The following technical section devoted to shunt design and development, and then management of patients with idiopathic normal pressure hydrocephalus (iNPH). Coverage includes differential diagnosis and treatment of iNPH, as well as common presentations, neuroimaging, genetic studies, CSF biomarkers, and using artificial intelligence. Confirmatory testing discusses high volume lumbar punctures, lumbar drainage trials, and CSF infusion testing. Medical and surgical treatments are reviewed with expected functional outcomes. A subsequent section discusses secondary normal pressure hydrocephalus, caused by other etiologies such as hemorrhage, tumors, or infection, and covers longstanding overt ventriculomegaly (LOVA), management of adult patients who were shunted as children, and Chiari malformations. The book concludes with high and low pressure CSF dynamics disorders, including idiopathic intracranial hypertension and secondary intracranial hypertension, followed by a review of the medical, surgical, and ophthalmological management of these disorders.

  • Legal Issues in Quality for Healthcare Institutions

    • 1st Edition
    • Ramesh Sachdeva
    • English
    Legal Issues in Quality for Healthcare Institutions provides the perspective of practicing physicians, lawyers, and academic legal scholars to comprehensively address the implications for quality of care and patient safety both from a legal, medical, and improvement science standpoint. Hospital administrators, physicians, nurses, researchers, legal scholars, as well as regulatory and compliance officers working in hospitals and acute care facilities will find this to be a helpful resource in understanding and addressing the many facets and issues in the field of medicine and law related to quality and patient safety.

  • Pain Conditions of the Head and Face

    A Practical Guide to Diagnosis and Management
    • 1st Edition
    • Anat Galor + 1 more
    • English
    Pain Conditions of the Head and Face: A Practical Guide to Diagnosis and Management provides a user-friendly guide on diagnosing and managing common head and facial pain conditions using new methods and therapies. The book contains practical information, reviewing epidemiology, presenting key features, contributing mechanisms, and including treatment algorithms for common pain conditions of the head and face. Focus is given to aspects of disease that are novel and evolving, and all conditions are discussed within the framework of the latest advances in research and patient care.Doctors seeking to ameliorate their patients’ pain from such maladies as (among many others) neuropathic ocular pain, trigeminal neuralgia, herpetic neuralgia, temporomandibular disorders, burning mouth disorder, and neuropathic ear pain will require no other book to identify their patients’ illnesses and make sure they receive the care they need.

  • Artificial Intelligence Based Primary Care

    Artificial Intelligence and Human Cognition in General Practice and Family Medicine
    • 1st Edition
    • Anthony C. Chang + 5 more
    • English
    Artificial Intelligence Based Primary Care: Artificial Intelligence and Human Cognition in General Practice and Family Medicine provides a comprehensive look into the integration of artificial intelligence within primary care. This book aims to bridge the gap between data scientists and primary care clinicians by presenting potential AI applications, implementation challenges, and real-world clinical scenarios in an accessible manner. Comprised of 5 sections and 20 chapters, it offers both theoretical insights and practical guidance for family medicine practitioners.Additi... the book includes a chapter dedicated to a day in the life of a General Practitioner, showcasing the practical impact of AI. It also features an extra compendium listing the Top 100 articles and best books on Artificial Intelligence. This resource is invaluable for academics, researchers, and clinicians eager to expand their knowledge in this emerging field.

  • Bacterial Infections of the Central Nervous System

    • 1st Edition
    • Karen L. Roos + 1 more
    • English
    "Bacterial Infections of the Central Nervous System" consolidates recent discoveries and best practices on diagnosis and treating infection to minimize morbidity and mortality. The book discusses advancements in neuroimaging techniques, diagnostic studies performed on cerebrospinal fluid, adjunctive therapy, and antimicrobial therapy. Beginning with pathogenesis and pathophysiology of bacterial CNS infections, the book reviews when to suspect a bacterial infection of the central nervous system. The majority of the chapters review specific disease entities, including meningitis, focal CNS infections (e. g., brain abscess, subdural empyema and epidural abscess), CNS diseases caused by selected infectious pathogens (Mycobacteria, Rickettsiae, Anaplasmataceae, Treponema pallidum, Borrelia burgdorferi and other Borrelia species), the neurological complications of infective endocarditis, suppurative venous sinus thrombosis, infections in the neurosurgical patient, bacterial etiologies of movement disorders, Guillain-Barre syndrome, toxin-mediated syndromes of the nervous system and infectious encephalopathy.

  • Trauma During Pregnancy

    • 1st Edition
    • Jorge Hidalgo + 2 more
    • English
    Surgical Care of the Critically Ill During Pregnancy, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women in all surgical aspects including trauma. The book's authors offer best practices and evidence-based material explicitly focused on the most common complications in pregnant patients that may occur to improve patient care. It not only covers critical care investigation from medical-surgical complications that any patient can present, but also how to prepare and anticipate complications in the critical care unit.

  • Application of Python in the Healthcare Technology

    Medical Data Analysis and Developing ML/AI Models
    • 1st Edition
    • Praveen Kumar M
    • English
    Application of Python in Healthcare Technology: Medical Data Analysis and Developing ML/AI Models provides comprehensive coverage of the Python programming language from a medical-based perspective. With a strong focus on utility-based learning rather than technical-based learning of Python, this title clarifies how the application of Python in the healthcare technology industry has a meaningful impact on patient care through the development of deep learning models for early prediction of diseases and the development of Clinical Decision Support System (CDS). In 13 chapters, an extensive range of topics pertaining to the intersection of Python and medical sciences is covered. Coverage defines how to set up an environment to work with python, describes Python class, methods, and functions, explains both basic and advanced statistical analysis in Python, and provides a tool to assist in the development of deep learning models such as API, Git, Github, NumPy, Pandas, and SciPy.

  • Baleen Whales

    Ridgway and Harrison's Handbook of Marine Mammals: Volume 4
    • 1st Edition
    • Thomas Allen Jefferson
    • English
    Some of the world's most beautiful, intelligent, and highly adapted mammals inhabit our seas and oceans and have stirred the human imagination for many centuries. As our knowledge of marine mammals grows, the need exists for a reliable and complete reference to the ecology and biology of these fascinating creatures. To address this need, the Handbook of Marine Mammals series has been founded. Scientists, conservationists, and informed laypersons alike will be able to find definitive reviews of all the world's living whales, dolphins, porpoises, seals, sea lions, sea cows, and marine otters and bears. Seven volumes cover all the living species of marine mammals.This fourth volume in the series, Baleen Whales, consists of species review chapters written by leading global experts on whale species that have baleen plates instead of teeth. Each chapter includes a description of the species, followed by sections on distribution and abundance, anatomy, physiology, behavior, ecology, reproduction, parasites and diseases, and the impacts of human activities on the species.

  • Operative Strategies in Pelvic Exenteration Surgery

    • 1st Edition
    • Michael E Kelly + 1 more
    • English
    Operative Strategies in Pelvic Exenteration Surgery is a reference for the surgical management of Pelvic Exenteration Surgery. It covers all aspects of surgery from the colorectal, urological, gynecological, and orthopedic point of view. Coverage consolidates the research of world-leaders and includes the history of exenterative study, outlining the current state and indicating future developments. The book also discusses the current surgical operative strategies for the management of locally advanced and recurrent pelvic neoplasms with illustrations, intra-op photos, and supplementary video material.Created from the experiences of an international collaboration of surgeons, this reference is the perfect reference for surgical oncologists, colorectal, gynecology, urology, and vascular surgeons as well as any group involved in complex pelvic surgery including complex open, laparoscopic, and robotic surgery.

  • Capsule Endoscopy in Pediatric Patients from Theory to Practice

    • 1st Edition
    • Thomas M. Attard
    • English
    Capsule Endoscopy in Pediatric Patients from Theory to Practice is a practical and authoritative guide that empowers pediatric gastroenterologists, physicians, and trainees to navigate the complexities of Video Capsule Endoscopy (VCE) in children. With a focus on bridging knowledge gaps and providing practical insights, this book offers updated information on understanding and utilizing VCE in the pediatric population. The book covers the background and technical aspects of VCE, including guidance on setting up a pediatric VCE service and an overview of indications and limitations. It delves into practical aspects such as preprocedural preparation, artifact reduction techniques, and management of capsule retention. By exploring VCE in various disease conditions such as inflammatory bowel disease, gastrointestinal bleeding, hereditary polyposis syndromes, and chronic abdominal pain, readers gain a comprehensive understanding of diagnosis, surveillance, and management. Special content elements, including key terms, case studies, and a timeline of recent advances, enhance the learning experience. This essential resource empowers readers to optimize patient care, make informed decisions, and confidently navigate the realm of VCE in children.

  • Plant Development

    • 1st Edition
    • Volume 172
    • English
    Plant Development provides an overview of the fundamental processes that govern the growth, differentiation, and organization of plants throughout their life cycle. The book explores key developmental stages, from embryogenesis and seed germination to organ formation, flowering, and senescence, highlighting the genetic, molecular, cellular, and environmental factors that regulate these events. By integrating classical concepts with modern advances in developmental biology, the volume offers valuable insight into how plants establish form, adapt to their surroundings, and coordinate growth in response to internal and external signals. It serves as a useful resource for researchers, students, and professionals interested in plant biology, developmental mechanisms, and related fields.

  • Biofeedback and Pain Management

    A Clinical Guide
    • 1st Edition
    • Anu Kotay
    • English
    Biofeedback and Pain Management: A Clinical Guide provides a detailed understanding of the psychophysiology of chronic pain, biofeedback treatments, the realities of living life with chronic pain limitations, and the role of pain in our lives and society. The book covers evidence on the effective uses of biofeedback interventions for pain management, including protocols, as well as case-based examples and strategies practitioners can use in real-life settings. Sections define biofeedback, including illustrations that depict how biofeedback is a useful part of any pain management treatment plan, cover procedures based on evidence and case examples, and present the social context of chronic pain.

  • Heavy Metal Stress Resilience in Plants

    Phytohormones and Nanomaterials Interactions
    • 1st Edition
    • Chandra Shekhar Seth + 3 more
    • English
    Heavy Metal Stress Resilience in Plants: Phytohormones and Nanomaterials Interactions provides comprehensive coverage of recent advancements about heavy metals (HMs) transport and stress, phytoremediation mechanisms, and how phytohormones and nanomaterials effectively mitigate the HMs stress in plants. It addresses the consequences of HM to plants, and presents the various approaches to mitigating those consequences. As the environment is increasingly impacted by human input, both intentionally and unintentionally, plant life of all kinds faces increasing challenges to achieving optimal health and production. This book highlights the responsive changes that have increased the genetic diversity of plants and how those changes affect HMs transport in plants. Other key features of the book are coverage of metal toxicity and detoxification mechanism, biochemical tools toward HMs remediation processes, molecular mechanism for HMs detoxification, and role of ROS metabolism in alleviation of HMs. Edited and authored by leading experts from around the world, the book covers the core aspects of plant physio-biochemical and molecular responses into heavy metals stress. Phytohormones and nanomaterials as well as innovative strategies for augmenting plant growth, development and productivity/quality through intrinsic and extrinsic manipulations are included.

  • Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care

    • 1st Edition
    • Neha Raina + 2 more
    • English
    Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care presents a comprehensive, biomarker-driven exploration of how natural and engineered biopolymers are transforming the management of acute, chronic, and non-healing wounds. Positioned at the intersection of biomaterials science, pharmaceutical innovation, and clinical practice, the book addresses one of the central challenges in wound care: persistent inflammation that delays tissue repair and regeneration. Beginning with the biological and clinical foundations of wound healing, the book systematically examines inflammatory pathways and key biomarkers such as TNF-α, IL-6, ROS, and VEGF.It then advances into in-depth coverage of natural biopolymers—includin... collagen, chitosan, hyaluronic acid, silk-derived polymers, and marine polysaccharides—and their roles in immune modulation, macrophage polarization, and redox balance. Dedicated sections explore advanced delivery platforms such as nanofibers, smart hydrogels, nanozymes, and stimuli-responsive dressings, alongside emerging precision technologies including 3D printing and AI-guided material design. With a strong translational focus, the book bridges laboratory research and real-world application, addressing regulatory pathways, manufacturing scalability, and commercialization challenges.

  • Nanotechnology in Brain Tumor Treatment

    Unveiling Molecular Mechanisms and Pioneering Therapies
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Nanobiotechnology in Brain Tumor Treatment: Unveiling Molecular Mechanisms and Pioneering Therapies is a groundbreaking resource that addresses the formidable challenges posed by brain tumors in oncology. This comprehensive book explores the etiology, symptoms, diagnosis, and treatment options for brain tumors, with a particular focus on the revolutionary impact of nanobiotechnology. By integrating cutting-edge research on nanotechnology with practical applications in neuro-oncology, this book offers a unique perspective on enhancing patient outcomes and advancing brain cancer treatment strategies.By offering a comprehensive overview of nanobiotechnology in brain tumor treatment, this resource serves as a vital tool for those involved in the research, diagnosis, and treatment of brain cancers, paving the way for innovative and personalized therapeutic approaches.

  • Brain-Computer Interfaces (BCI)

    • 1st Edition
    • Volume 229
    • English
    Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Synthetic Biology in Medicine

    Tools and Transformative Therapies
    • 1st Edition
    • Xie Zhen
    • English
    Synthetic Biology in Medicine: Tools and Transformative Therapies covers the design and optimization of artificial biological components, gene editing systems, principles for designing and constructing artificial gene circuits, cell engineering, delivery systems of artificial biomolecules, and the prospects and challenges of synthetic biology technologies applied in drug development. The book contains many application cases related to clinical practice and industry, offering references for solving industrial pain points.

  • Fungal Biodeterioration and Biodegradation

    Insights into Fungal Behaviour, Mechanisms, and Applications
    • 1st Edition
    • Adesh Kumar + 3 more
    • English
    Fungal Biodeterioration and Biodegradation: Insights into Fungal Behaviour, Mechanisms, and Applications offers a comprehensive, interdisciplinary overview of fungi’s dual roles in environmental processes and material deterioration. Fungi are Earth's main recyclers, capable of breaking down complex substances like lignin, plastics, and pollutants. However, they also cause biodeterioration of food, artworks, textiles, and infrastructure, posing challenges across industries and conservation efforts. This book bridges molecular mechanisms with practical applications, providing researchers, conservators, and industry professionals with essential knowledge on how fungi interact with materials, pollutants, and microbial communities. It covers foundational topics such as fungal biology, enzymatic pathways, and colonization processes. The volume explores fungi’s role in degrading natural and synthetic polymers, petroleum products, and environmental contaminants, supported by case studies on cultural heritage preservation, bioremediation, and industrial waste management. Cutting-edge omics, enzyme engineering, and scalable biotech solutions are highlighted, along with future directions in fungal biotechnology and genetic engineering.Fungal Biodeterioration and Biodegradation equips professionals with scientific insights and practical strategies to harness fungi’s power for environmental cleanup, sustainable industry practices, and cultural conservation.

  • Essentials of Medical Coordination in Complex Humanitarian Emergencies

    • 1st Edition
    • Joanna Kotcher
    • English
    Essentials of Public Health and Medical Coordination in Complex Humanitarian Emergencies provides a practical overview for health coordinators in assessing, coordinating, and implementing medical and public health responses in disaster and conflict environments. The book aims to achieve this in two parts. Part one covers foundational information such as the role of the coordinator; project assessment and start-up; standards, protocols, and guidelines; project strategy and accountability; and basic epidemiological measurements and tools. Part two goes on to discuss the implementation of programs and services like nutrition, mental health and psychosocial support (MHPSS), management of chronic disease, community health promotion, sexual and reproductive health, health information systems and disease surveillance. A health coordinator in the field is required to quickly assess the needs of a population in a humanitarian emergency, initiate start-up procedures, and coordinate the response over a period of months or longer. The efficiency and effectiveness of this process depends on the experience, knowledge, and skills of the coordinator, Essentials of Public Health and Medical Coordination in Complex Humanitarian Emergencies is a resource for those in the medical, public health, and international humanitarian aid sectors who care about the health of populations at risk and is written by an author who has coordinated emergency response in conflict environments in Kosovo, Central Asia (Tajikistan), Afghanistan, Darfur, Gaza and the OPT, Somaliland, Syria, and Iraq.

  • Endovascular Therapy for Intracranial Atherosclerotic Stenosis

    • 1st Edition
    • Ning Ma + 1 more
    • English
    Endovascular Therapy for Intracranial Atherosclerotic Stenosis presents selected cases of endovascular treatment for intracranial atherosclerotic stenosis (ICAS), providing detailed information on periprocedural medical management, endovascular strategies, device selection, and follow-up outcomes. The book serves to improve understanding of ICAS and share clinical experiences from high-volume stroke intervention centres with neuro-interventional... The book reviews recent developments in ICAS management and presents evidence that appropriate patient selection and peri-operative planning may contribute to the effectiveness of endovascular therapy for ICAS

  • Leveraging AI and ML in Cardiovascular Diagnosis and Management

    • 1st Edition
    • Rosaline Mishra + 3 more
    • English
    Leveraging AI and ML in Cardiovascular Diagnosis and Management examines how artificial intelligence and machine learning transform cardiovascular care. It gathers chapters from leading researchers to bridge clinical practice with cutting-edge analytics, imaging, and decision support. The volume details core topics across the field, including fundamentals of AI/ML, AI-driven cardiovascular imaging, predictive analytics for risk stratification, heart failure management, arrhythmia detection, wearable-enabled monitoring, and the integration of multi-omics with clinical data. It also addresses neurocardiology, clinical decision support systems, ethics, and regulatory considerations, all framed for cardiovascular scientists and clinicians. For academics, clinicians, and educators, the book offers actionable workflows, a cohesive framework for translating AI and ML advances into improved diagnosis, treatment personalization, and patient outcomes across diverse populations.

  • Robotics and Artificial Intelligence in Neuromuscular Performance

    Assessment, Training, Injury Prevention, and Return to Play in Athletes
    • 1st Edition
    • Wissem Dhahbi + 1 more
    • English
    Athletic performance depends on technologies that can measure, model, and guide neuromuscular function across the complete athlete lifecycle. Robotics and Artificial Intelligence in Neuromuscular Performance provides an evidence-based framework for applying robotics, artificial intelligence, computer vision, wearable sensing, virtual reality, and biofeedback to assessment, training, injury prevention, rehabilitation, and return-to-play decision-making. Organized across 18 chapters, the book connects neuromuscular physiology with intelligent athlete systems, progressing from foundational concepts in computational biomechanics and robotic dynamometry to applied protocols for training load management, injury risk prediction, exoskeletal resistance training, smart rehabilitation, and AI-enhanced return-to-play clearance. Written for sports scientists, clinicians, physiotherapists, athletic trainers, strength and conditioning professionals, biomechanics researchers, and technology developers, it equips readers to evaluate rapidly expanding sports technologies with scientific rigor rather than assuming that innovation is inherently beneficial. Each chapter addresses validation status, measurement error, algorithmic limitations, data governance, and ethical risk, translating research evidence into criteria practitioners can apply directly. The AICICA framework, six implementation checklists, and integrated case studies extend the book beyond synthesis into practical guidance for responsible technology adoption in elite, clinical, and research settings.

  • Bioinformatics, Computational Biology, and Multi-Omics–Driven Probiotic Design for Gut Microbiome Engineering

    • 1st Edition
    • Naheed Mojgani + 3 more
    • English
    Bioinformatics, Computational Biology, and Multi Omics–Driven Probiotic Design for Gut Microbiome Engineering presents an interdisciplinary framework for applying artificial intelligence to microbiome science, probiotic development, and personalized nutrition. The book integrates bioinformatics, computational biology, and clinical insight to address current challenges in gut microbiome research and translation. The volume covers AI driven microbiome profiling, multi omics integration, computational modeling of host–microbe interactions, and predictive analytics. It progresses from foundational concepts to advanced applications, including AI assisted probiotic design, gut–brain axis research, regulatory considerations, and real world case studies supporting translational and clinical relevance. The book equips bioinformaticians, translational microbiome researchers, and clinician scientists with actionable methodologies, conceptual clarity, and validated examples. It supports evidence based decision making, accelerates translational research, and bridges discovery science with implementation in personalized nutrition and probiotic innovation.

  • Current Approaches to Overcome Therapeutic Resistance of Leukemia

    • 1st Edition
    • Zhe-Sheng Chen + 2 more
    • English
    Current Approaches to Overcome Therapeutic Resistance of Leukemia presents a comprehensive academic resource addressing the persistent challenge of treatment resistance in leukemia. It explores biological, molecular, and clinical dimensions of resistance, bridging fundamental research with therapeutic innovation. The book examines key resistance mechanisms, including genetic mutations, leukemic stem cells, and tumor microenvironment interactions, alongside emerging insights such as epigenetic regulation, metabolic reprogramming, and immune evasion. It further highlights advanced therapeutic approaches, including immunotherapy, targeted therapies, combination strategies, and AI-driven tools for drug discovery and monitoring. This volume provides students, researchers, and clinicians with foundational and integrated knowledge essential for understanding resistance biology and translating discoveries into clinical practice. It supports evidence-based decision-making and promotes the development of innovative strategies to improve patient outcomes.

  • Euphorbiaceae Family Oriented Drug Discovery

    Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family
    • 1st Edition
    • Bingjie Li + 1 more
    • English
    Euphorbiaceae Family Oriented Drug Discovery, Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family, a volume in the Drug Discovery Opinions series, aims to comprehensively explore the isolation, identification, synthesis, and drug discovery based on natural products derived from the Euphorbiaceae family. Focused on the isolation, identification, synthesis of bioactive compounds, and drug discovery techniques, the contents of the book are organized into ten chapters. The book opens with an introduction to the Euphorbiaceae family, its botanical overview, medicinal significance, and the importance of exploring its natural products for drug discovery.The next chapters focus on specific techniques for identification and synthesis of natural products, cover the antitumor activities and mechanisms of action of natural products, and discuss the specific antimicrobial properties and mechanisms of action. Final sections discuss anti-inflammatory properties, pharmacology, drug discovery processes for Euphorbiaceae Natural Products, and describe challenges and future directions in research. The final chapter presents final considerations, summarizing key findings and insights from the book.

  • Tropical Fern Biology and Evolution

    • 1st Edition
    • Daniele Cicuzza + 2 more
    • English
    Tropical Fern Biology and Evolution is the first reference to focus on this important tropical flora. While other resources highlight the plants of temperate regions, this book focuses specifically on those of the tropics, where important insights have been discovered about phylogenetic relationship between several pteridophyte and lycophyte phylogeny, ecology and physiology. Ferns and lycophytes are vital elements of tropical ecosystems. They thrive in various environments, from the shaded, humid floors of terrestrial forests to the canopy, where epiphytic species have adapted to harsh ecological conditions. In regions of the tropics that have been impacted by human activity, ferns are crucial for colonizing extensive areas and preventing soil erosion. However, they can also hinder forest regeneration in certain contexts. Gaining insight into the structure, growth, and effects of these plants is essential for tackling the challenges and leveraging the benefits they present. Based on the latest research, Tropical Fern Biology and Evolution discusses their traits and community assemblies in the humid tropics and presents potential application uses for their phylogenetic information. Students and researchers will find this foundational information valuable as both an introductory guide to these tropical ferns and their characteristics, and as inspiration for further research and development of their potential in addressing environmental issues.

  • A Comprehensive and Practical Guide in Clinical Trials

    • 2nd Edition
    • Brenda Wright
    • English
    The Comprehensive and Practical Guide in Clinical Trials, Second Edition offers a thorough update to the foundational handbook on clinical trial conduct. It reflects the evolving landscape of clinical research since 2017, incorporating new regulatory guidelines, innovations in device trials, and the shift to electronic data capture and management. This resource addresses the needs of clinical trial staff by detailing processes essential to successful trial execution. Covering all aspects of clinical research, the book includes chapters on trial phases, site selection, regulatory requirements, contracts, protocol development, informed consent, and data management. New chapters focus on project management, electronic source documents, and pharmacy operations. Each chapter integrates practical tools such as checklists, templates, and case studies to facilitate understanding and application. This handbook uniquely supports the entire clinical trial team—including investigators, coordinators, pharmacists, data managers, and regulatory personnel—by clarifying roles and responsibilities and illustrating how their tasks interconnect. Its accessible style and comprehensive scope make it an indispensable guide for planning, conducting, and closing clinical trials effectively and in compliance with international standards.

  • Emergent Nanotherapeutics in Diabetic Complications

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Emergent Nanotherapeutics in Diabetic Complications explores how cutting-edge nanotechnology is transforming the treatment of diabetes-related disorders beyond glycemic control. This comprehensive volume examines targeted, multifunctional nanoplatforms designed to address the wide range of comorbidities linked to diabetes, including vascular complications, metabolic dysfunctions, and impaired wound healing. Structured in five parts, the book spans from current nanoformulation strategies to emerging innovations such as CRISPR-Cas9 delivery, AI-guided nanoparticles, and 3D/4D printed nanostructures.Bridg... the gap between preclinical research and clinical application, it offers valuable guidance on stimuli-responsive systems, biocompatible materials, and regulatory pathways. This is essential resource for medical professionals, biomedical engineers, and pharmaceutical scientists seeking scalable, next-generation solutions for managing diabetic complications through nanomedicine.

  • Next-Generation Food Bioactives

    Mechanisms, Technologies, and Translational Applications
    • 1st Edition
    • Karuppusamy Arunachalam + 3 more
    • English
    Next-Generation Food Bioactives: Mechanisms, Technologies, and Translational Applications offers a thorough examination of food-derived bioactive compounds such as polyphenols, flavonoids, polysaccharides, peptides, and saponins, and their significance in health promotion, disease prevention and the development of functional foods and nutraceutical products. Divided into six comprehensive sections, the book covers the fundamental properties of these compounds, advanced extraction and analysis methods, and explores their molecular mechanisms and interactions with the gut microbiome. Next-Generation Food Bioactives: Mechanisms, Technologies, and Translational Applications further discusses challenges related to bioavailability, safety, and regulatory considerations, while highlighting emerging trends such as the integration of artificial intelligence and omics technologies in bioactive discovery and functional food formulation. Designed for researchers, industry scientists, and healthcare professionals, this book provides valuable insights to support innovation and evidence-based development in the field of food bioactives.

  • Theranostics for Cancer Targeting

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    This groundbreaking Theranostic book delivers the definitive roadmap for the next generation of precision oncology by systematically detailing the clinical, regulatory, and drug delivery landscapes of theranostics—the revolutionary integration of therapy and diagnostics—across 20-22 major cancer types. Designed for medical publishers, clinicians, and biotech researchers, this chapter is a structural framework for each malignancy, bridging laboratory breakthroughs in nanotechnology, green nanochemistry, drug delivery, diagnostics, and AI with real-world clinical applications. It serves as an essential commercial and academic asset, offering unprecedented depth on FDA/EMA regulatory hurdles, technology transfer pathways, and actionable data tables that track active clinical trials and global research groups. By addressing key market trends and regulatory challenges, it serves as an essential, multidisciplinary resource for driving personalized oncology and improving patient outcomes

  • Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities

    Evidence-Based Molecular Mechanisms and Clinical Outcomes
    • 1st Edition
    • Debidas Ghosh + 3 more
    • English
    Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities: Evidence-Based Molecular Mechanisms and Clinical Outcomes is a comprehensive, interdisciplinary reference addressing the complex link between diabetes mellitus and infertility in both men and women. This edited volume synthesizes molecular insights into diabetes-induced reproductive dysfunction—such as oxidative stress, inflammation, endocrine disruption, and tissue damage—with evidence-based evaluations of medicinal plants and their bioactive phytochemicals. It bridges laboratory research and clinical trials to highlight how plant-derived compounds can regulate glycemic control, restore hormonal balance, reduce oxidative damage, and improve gametogenesis. Targeting clinicians, researchers, and postgraduate students in biomedical and pharmaceutical sciences, the book offers detailed therapeutic profiles, safety assessments, and translational applications. By consolidating fragmented knowledge, it empowers healthcare professionals and scientists to develop integrative, cost-effective strategies for managing diabetes-related infertility.

  • Fundamentals of 3D Food Printing and Applications

    • 2nd Edition
    • Fernanda C. Godoi + 4 more
    • English
    Fundamentals of 3D Food Printing and Applications, Second Edition offers a broad overview of 3D printing technology applied to food. This new edition outlines emerging 3D food printing technologies and their working mechanisms across a wide range of application areas, including the development of soft foods and confectionary designs. Chapters cover new trends and demands, such as changes in consumer preferences, new regulations, and new applications of 3D printing technology in the food industry. It also explores the use of natural and organic materials as printing materials to address end-user concerns about artificial food.In addition, the book covers the use of automated systems and advanced technologies, such as machine learning and artificial intelligence, to improve efficiency and consistency in 3D food printing. Case studies and best practices from industry professionals who have successfully scaled up their 3D food printing operations are presented throughout. Edited and written by a team of worldwide experts in 3D food printing, this book is the best resource covering the latest developments in 3D printing technology.

  • Laboratory Sleep Medicine

    Fundamentals of Sleep Technology
    • 1st Edition
    • Ravi Gupta + 2 more
    • English
    Laboratory Sleep Medicine: Fundamentals of Sleep Technology, is the second of the Fundamentals of Sleep Technology series, discusses balancing the fundamentals of sleep medicine with the newest innovations in the lab. High priority is given to practices that must be followed in sleep labs to guarantee the safety of patients and workers. To make information straightforward and easy to grasp, key events in each epoch of polysomnography are showcased. This serves to walk sleep professionals cogently through the history of sleep technology advancement.Laborato... Sleep Medicine: Fundamentals of Sleep Technology is keenly aware that manual titration with PAP is the gold standard treatment for sleep apnea. However, certain patients may require oxygen treatment, which is also covered in depth. In addition, case vignettes illustrate the development of a relevant report using the following: data from a sleep diary, actigraphy, and polysomnography. How to do sleep tests in unusual situations (such as at-home sleep apnea testing and testing in an intensive care unit) are also covered.

  • Trophic Rewilding

    Research, Policy and Practice
    • 1st Edition
    • Iain Gordon + 1 more
    • English
    Trophic Rewilding: Research, Policy and Practice provides a unique, up-to-date resource for environmental professionals seeking the latest guidance on ecosystem restoration and rewilding. Written and edited by a global team of experts, the book highlights the evidence for trophic interactions that form the basis of rewilding efforts. It demonstrates the importance of such evidence in the development of policy and ground management. Early chapters discuss the scientific, regulatory, economic, and ethical background of trophic rewilding, while latter chapters describe approaches to trophic rewilding in diverse settings and delve into successes and lessons learned from global case studies. With the biodiversity crisis continuing unabated, there are growing calls for new approaches to species and ecosystem recovery in landscapes that have been impacted by human activities. Trophic rewilding is one such approach whereby species reintroductions are used to engender top-down ecological processes and trophic cascades to promote self-regulating biodiverse ecosystems. This book provides the latest updates on the topics presented and is an indispensable resource for researchers, policymakers, and practitioners in rewilding projects and programs, as well as undergraduate and postgraduate students interested in environmental restoration and management.

  • Wilson and Mulcahy’s Prosthetic Urology

    A Comprehensive Guide to Surgery for Erectile Dysfunction and Male Incontinence
    • 1st Edition
    • Jay Simhan + 1 more
    • English
    Wilson and Mulcahy’s Prosthetic Urology: A Comprehensive Guide to Surgery for Erectile Dysfunction and Male Incontinence is a comprehensive reference that covers the surgical management of erectile dysfunction and male incontinence.This book's chapters cover a wide range of topics, including the history of penile prostheses, practice considerations, patient selection, placement techniques for malleable and inflatable penile prostheses, management of complications, and infection prevention and management. Additionally, specialized topics such as managing Peyronie's disease, priapism, and penile prosthesis placement in transgender patients are also addressed.Written by esteemed experts in the field, this reference offers valuable insights and guidance for healthcare professionals. Whether you are a practicing prosthetic urologist, a trainee looking to enhance your skills, or a device manufacturer aiming to improve surgical quality, this essential reference will elevate your knowledge and expertise.Tibor Imley's cover photo features Dr. Wilson and Dr. Mulcahy, after whom this title is named. This book honors their pioneering contributions to prosthetic urology.

  • Childhood Disorders of Rickets and Osteomalacia

    A Comprehensive Review
    • 1st Edition
    • Suma Uday
    • English
    Childhood Disorders of Rickets: A Comprehensive Review defines the pathophysiology of rickets and the various genetic and acquired conditions that present with rickets in childhood. This comprehensive review details the various forms of rickets, the histopathology, recent advances leading to new therapeutic options in treating rickets, and the role of Vitamin D and calcium in nutritional rickets. Additionally, the authors explore future research in various areas of nutritional and non-nutritional forms of rickets.Written by global experts for clinicians and researchers treating and studying the various forms of rickets, the book will also be of interest to those working in public health and policy makers working on the prevention of nutritional rickets worldwide.

  • Twin-to-Twin Transfusion Syndrome (TTTS)

    • 1st Edition
    • Michael W. Bebbington + 1 more
    • English
    Twin-to-Twin Transfusion Syndrome (TTTS) is a novel and comprehensive reference to understanding the pathophysiology of this condition, along with the latest diagnostic techniques and criteria for accurate identification, its treatment and management, and strategies for effective management and care. Beyond medical aspects, the book addresses the emotional and practical aspects of TTTS, offering guidance on patient/family support and coping strategies. It includes the latest guidelines and evidence-based practices for TTTS, helping clinicians stay current with advancements in the field and ensuring they adhere to the best standards of care.In addition, the book offers real-world case studies and practical guidance to enable clinicians to effectively apply their knowledge in clinical settings, enhancing their ability to diagnose and manage TTTS cases. Written by various experts in the field, this multidisciplinary perspective fosters collaboration and enables anyone involved in this field to make informed decisions in complex TTTS cases.

  • Metagenomics in Biotechnology

    Environmental, Industrial, and Clinical Applications
    • 1st Edition
    • Abd El-Latif Hesham + 3 more
    • English
    Metagenomics in Biotechnology: Environmental, Industrial, and Clinical Applications provides a comprehensive understanding of metagenomic biotechnology, including its underlying principles, techniques, and tools used for data analysis. It explores how metagenomics plays a crucial role in environmental and industrial applications, such as the identification and quantification of microbial communities, the bioremediation of pollutants, biofuel development, and sustainable agriculture. The book also delves into the clinical implications of metagenomics, from technological advancements, pathogen identification, detection, drug discovery, and development. This understanding helps aid in the design and implementation of innovative solutions to environmental, industrial, and clinical challenges. With current trends, challenges, and solutions in metagenomics rounding out the coverage, this book is a valuable resource for researchers, students, and professionals looking to deepen their knowledge of the various techniques used for data analysis and further leverage the potential of metagenomic biotechnology.

  • The Brain Histaminergic System in Health and Disease

    • 1st Edition
    • Zhong Chen + 2 more
    • English
    Histamines in Neurology and Psychiatry summarizes histamines and their impact on neuroinflammation and brain development in key neural circuits. This book presents the latest research on the physiological regulation of a neuroendocrine responses and releases, broadly discussing histamine receptor modulators and histamine effects in neurology and psychiatry, and also including clinical applications that will be of interest to practitioners.

  • Endoscopic Ultrasound in Pancreatic Diseases

    Best Practices and Recent Innovations in Technology and Techniques
    • 1st Edition
    • Masayuki Kitano
    • English
    In Endoscopic Ultrasound in Pancreatic Diseases: Best Practices and Recent Innovations in Technology and Techniques, leading experts share their insights, best practices, and the latest technological innovations revolutionizing the approach to pancreatic diseases. This practical reference provides step-by-step guidance, case presentations, and detailed images and procedures on advanced techniques in diagnosis and treatment with endoscopic ultrasound for pancreatic diseases.Organized into four sections, this book reviews the latest advances in endoscopic ultrasound equipment, techniques, complications, scanning methods, microbubbles and contrast harmonic imaging, elastography, fine needle tissue acquisition, and classification and safety management of interventional endoscopic ultrasound. Tumor detection, characterization, and diagnosis are reviewed, and pancreatic diseases treatment and intervention methods are covered extensively. The book concludes with the examination of groundbreaking methods and discussion of education and future directions. Endoscopic Ultrasound in Pancreatic Diseases: Best Practices and Recent Innovations in Technology and Techniques fully equips endoscopists with the most recent developments in endoscopic ultrasound and is a vital resource for navigating the evolving landscape, enabling practitioners to excel in advanced clinical practices and contribute to the field’s growth.

  • Roles of the Cerebellum in Motor Control

    Foundations, Experimental Approaches and Clinical Applications
    • 1st Edition
    • Mario Manto + 2 more
    • English
    Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease.From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.

  • Sleep Neurology

    • 1st Edition
    • Anne Marie Morse
    • English
    Sleep Neurology explores the intricate relationship between sleep and neurological health, bridging the gap between theoretical knowledge and practical application. This comprehensive reference highlights the role of sleep in overall health and provides an examination of how sleep influences a wide range of neurological disorders. From neurodevelopmental issues to neurodegenerative diseases, this book offers a detailed review of how sleep science can be applied to improve patient outcomes in various neurological conditions. Structured around key neurological topics, the book offers insights into conditions such as epilepsy, stroke, and traumatic brain injury, emphasizing the importance of sleep management in their treatment. Each chapter not only discusses the scientific underpinnings of sleep but also provides tangible strategies for integrating sleep health into primary neurological care.

  • The Evolution of Artificial Intelligence in Healthcare and Medicine

    From Basic Methods to Clinical Practice
    • 1st Edition
    • Mario Cannataro
    • English
    The Evolution of Artificial Intelligence in Healthcare and Medicine: From Basic Methods to Clinical Practice explores revolutionary technological advancements in the medical and healthcare realms due to generative AI and Deep Learning. This comprehensive guide not only explores cutting-edge technologies such as transformers and large language models for newcomers but also demystifies advanced applications like sequential decoding techniques and segmentation algorithms rarely explored in other literature. Sections cover foundational concepts and terminologies, explore deep learning and generative AI, provide AI's role in biomedical research, examine its integration into clinical practice, scrutinize its applications in public health, and discuss challenges and future prospects.This is an indispensable resource for healthcare professionals, scientists, researchers, students, and enthusiasts seeking to deepen their understanding of this rapidly evolving field.

  • Emerging Technologies in Bioengineering for Oncology

    Fundamentals, Research, and Future Prospects
    • 1st Edition
    • Saikat Das + 2 more
    • English
    Emerging Technologies in Bioengineering for Oncology: Fundamentals, Research, and Future Prospects explores the integration of engineering, biology, and medicine to tackle challenges in developing innovative tools for cancer diagnosis and treatment. This comprehensive resource addresses the evolving landscape of bioengineering in oncology, highlighting the intersection of various disciplines to drive advancements in diagnostic and therapeutic approaches. The book explores a range of cutting-edge technologies such as lab-on-chip devices, wearable biosensors, 3D bioprinting, and targeted nanomedicine, offering promising avenues for enhanced diagnostic precision, treatment effectiveness, and personalized healthcare.Geared towards medical students and professionals, the book provides detailed insights into the latest developments, practical applications, and future research directions in the field. By offering a deep dive into the realm of bioengineering for oncology, it serves as a valuable asset for those seeking to advance cancer care through interdisciplinary collaboration and innovation.

  • Neonatal Surgery

    Techniques, Evidence and Outcomes
    • 1st Edition
    • David J. Hackam
    • English
    Neonatal Surgery: Techniques, Evidence, and Outcomes addresses the growing need for specialized surgical care in neonates, whose unique physiology demands distinct considerations from other surgical populations. Written by leaders in the field, this definitive textbook is the first devoted entirely to neonatal surgery, filling a vital gap in the literature with evidence-based guidance on timing, technique, and postoperative management for optimal outcomes. The book opens with the general care of the neonatal surgical patient, covering anatomy and physiology, preoperative workup, anesthesia, pain management, nursing, family experience, transport, nutrition, pharmacy, vascular access, and radiographic considerations. Subsequent sections address specialized areas including head and neck, thoracic, abdominal, urologic, orthopedic, neurosurgical, plastic and reconstructive, and congenital heart surgery, each offering detailed, evidence-based guidelines and techniques for managing specific conditions. The book concludes with a look at the future of neonatal surgery and considerations for surgery in low- and middle-income countries. An invaluable resource for clinical learners and practicing surgeons alike, it serves as a critical how-to guide for students and residents and an authoritative reference for practicing surgeons, including evidence-based management strategies. Researchers will find it indispensable for understanding the metabolic and physiological responses to neonatal surgery, adding translational relevance to their work. This textbook is essential for anyone involved in the surgical care of neonates, providing the knowledge needed to achieve the best possible outcomes

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • Sarcoma Immunology and Immunotherapy

    From Cellular Mechanisms to Clinical Translation
    • 1st Edition
    • Joseph Crompton
    • English
    Sarcoma Immunology and Immunotherapy offers a timely and comprehensive review of the rapidly evolving field of sarcoma immunology and immunotherapy. This book serves as an essential resource for healthcare professionals, scientists, and patients, providing insights into the immunologic features of sarcoma and the latest immune-based treatments. Focussing on the recent advances, the book discusses the sarcoma microenvironment and the development of innovative immunotherapies tailored for sarcoma patients. Readers will benefit from a thorough overview of existing knowledge, encompassing foundational concepts in sarcoma immunology, a detailed examination of laboratory research, and a complete summary of ongoing immunotherapy trials. This holistic approach ensures a robust understanding of the current landscape in sarcoma research and treatment. By equipping readers with essential background information and comprehensive reviews, this book fosters a deeper understanding of sarcoma immunology and therapeutic strategies. It empowers healthcare professionals and scientists to stay abreast of critical studies, ultimately enhancing patient care and outcomes in this challenging field.

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