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Elsevier

Books in Life sciences

  • Handbook of Proteolytic Enzymes

    Serine and Threonine Peptidases
    • 4th Edition
    • Neil D. Rawlings
    • English
    The Handbook of Proteolytic Enzymes, Fourth Edition is the latest release in this esteemed publication that stands as the most comprehensive work in applied enzymology and biocatalysis since the first edition published in 1998. Extensively updated, the new edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

  • Microbial Tryptamine as a Causative Cofactor of Incurable Cell Death Diseases of Unknown Etiology

    The Cost of Related Healthcare in the US and Worldwide
    • 1st Edition
    • Elena L. Paley
    • English
    Microbial Tryptamine as a Causative Cofactor of Incurable Cell Death Diseases of Unknown Etiology: The Cost of Related Healthcare in the US and Worldwide investigates microbial tryptamine and its role in a range of diseases, such as Alzheimer’s disease and Parkinson’s disease, while also examining the economic burden of these conditions on global healthcare systems. The book begins with an examination of microbial tryptamine’s significance across neurodegenerative diseases, cancers, and gastrointestinal conditions. It covers the implications of tryptamine in cell and organ transplantation, as well as the roles of diet and environment in tryptamine-induced disease progression. Additionally, the latest advances in treatment and prevention are considered. It then provides a critical analysis of expenditure on diseases related to tryptamine-induced cell toxicity and neurodegeneration, alongside an evaluation of current funding and market analysis. Following this, the author delves into research-related issues that may hinder biomedical progress, such as competition, plagiarism, and retractions of funded peer-reviewed articles. Collaboration between researchers and medical doctors is also examined. The book concludes with the author’s own personal narrative and recommendations, emphasizing the need for open discussions to drive urgent changes in biomedical research funding and review processes.

  • Rice Production and Processing Sustainability

    • 1st Edition
    • Griffiths G. Atungulu + 1 more
    • English
    Rice Production and Processing Sustainability presents the challenges and opportunities facing this globally important crop as climate impact and environmental instability threatens production and ultimately food security. Food production, like other industries worldwide, is experiencing revolutions in automation, artificial intelligence, digitization, big data, and bioinformatics. The simultaneous increasingly volatile situation of environmental impact by climate requires careful and deliberate consideration of these issues, and their potential impact on sustainability. This book focuses on one of the world's most important commodities: rice. Rice must be produced en masse to support the rising global population; yet this must be done carefully and in balance and at a rate that is sustainable, in an ecosystem that is already unstable. Rice Production and Processing Sustainability discusses corrective measures, as well as serving to educate the reader of the need to balance food production and environmental protection.

  • Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms offers the latest insights into ESKAPE pathogen biofilms, including their formation, structure, and resistance mechanisms and highlights innovative therapeutic strategies to combat them, with a specific focus on combinatorial enzyme therapies. The book begins with an overview of the significant burden these pathogens impose across healthcare and the food industry, laying the groundwork for understanding the intricate relationship between antibiotic resistance and biofilm dynamics. It advocates novel approaches through combinatorial enzymatic therapy, detailing the mechanisms and synergies of various enzymes in effectively dismantling biofilms. With insights into cutting-edge delivery systems, including nanotechnology and the integration of CRISPR-Cas systems and artificial intelligence, the book charts a course for the future of advanced therapeutic strategies. It concludes by addressing regulatory considerations, positioning combinatorial enzyme therapy as a promising frontier in the fight against persistent infections caused by ESKAPE pathogens

  • Probiogenomics and Probiomics

    Concepts, Techniques, Applications, and Achievements
    • 1st Edition
    • Debmalya Barh + 1 more
    • English
    Probiogenomics and Probiomics: Concepts, Techniques, Applications, and Achievements is a pioneering reference book that marks a significant milestone in the emerging fields of probiogenomics and probiomics. As the first comprehensive resource in these disciplines, the book offers a detailed exploration of how genetic insights and omics technologies are revolutionizing our understanding of probiotics and their application in health and disease. Spanning three detailed sections, the book begins by grounding readers in the fundamental concepts of probiotics, including their roles in health enhancement and disease prevention. It progresses into a deep dive into advanced genomic and post-genomic technologies, revealing how these tools are used to dissect and harness the health-promoting capacities of probiotics. From the structure and function of probiotic genomes to the cutting-edge applications in synthetic biology and multi-omics, the book encapsulates the latest advancements and methodologies in the field. The final sections focus on the practical and clinical applications of these microbial marvels, discussing their impact on healthcare, biotechnology, and therapeutics. Whether it's developing new biotechnological products or enhancing therapeutic efficacy, this book covers a broad spectrum of applications, making it an invaluable resource for undergraduate and postgraduate students, researchers, clinicians, and industry professionals involved in drug and probiotics development. With contributions from over ten global experts, "Probiogenomics and Probiomics" not only educates but also inspires, providing a thorough understanding of modern probiogenomics and its potential to shape the future of personalized medicine and healthcare.

  • Prokineticins

    From the Gastrointestinal Tract to Neuroinflammation
    • 1st Edition
    • Roberta Lattanzi + 1 more
    • English
    Prokineticins: From the Gastrointestinal Tract to Neuroinflammation explores the intricate biology and pathophysiological roles of prokineticin peptides, from developmental processes in the heart and brain to the regulation of homeostasis in health and disease. Beginning with an introduction to prokineticins, the book moves on to discuss physiological functions across the human body, including the regulation of circadian rhythm, food intake, heart and kidney function and the reproductive system. Chapters then cover the prokineticin system in neurogenesis dysfunction, obesity and diabetes, reproductive system disorders and cardiovascular diseases.The prokinetcin system is also explored in the context of neurodegenerative disease and traumatic brain injury, pain, inflammation, infection and cancer. It also investigates natural and pharmacological inhibitors of PK receptors and closes with a look towards future research perspectives.

  • Optimizing the Plant Endosphere for Stress Management

    Enhancing Sustainable Agriculture
    • 1st Edition
    • Sankalp Misra + 2 more
    • English
    Optimizing the Plant Endosphere for Stress Management: Enhancing Sustainable Agriculture presents the latest insights on how plants manage various abiotic and biotic stresses by the interaction between plants and endophytes. The book explores the molecular and physiological mechanisms underlying plant-endophyte interactions, the contribution to stress mitigation, the identification of key traits that improve plant resilience, and the potential for using these beneficial endophytes to reduce the need for chemical fertilizers and pesticides. By deepening our understanding of these relationships, this book can help bring about innovative strategies that contribute to sustainable agriculture and food security while also confronting environmental challenges.These complex and multifaceted interactions influence plant health, growth, and resilience. Endophytes, primarily bacteria and fungi, inhabit the internal tissues of plants without causing harm. They play vital roles in enhancing plant growth and stress tolerance through various mechanisms including nutrient acquisition, pathogen resistance, and the production of bioactive compounds. As environmental stresses such as drought, salinity, and disease become increasingly prevalent due to climate change and agricultural intensification, understanding these interactions is crucial for developing effective stress management strategies.

  • Thiamine Pyrophosphate (TPP)-Dependent Enzymes

    • 1st Edition
    • Volume 736
    • English
    Methods in Enzymology: Thiamine pyrophosphate-depend... enzymes Thiamine pyrophosphate (TPP)-dependent enzymes are a diverse group of ubiquitous enzymes. They have in common the use of the biologically active form of vitamin B1 as a cofactor, which gives them the ability to catalyze the formation or cleavage of carbon-sulfur, carbon-oxygen, carbon-nitrogen, and especially carbon-carbon bonds. The specific characteristics of TPP-dependent enzymes, related to both the chemistry of thiamine pyrophosphate and their organization into multimeric subunits, have always aroused the interest of scientists. During these last years they developed original experimental approaches, and also new analytical tools to study, understand and modulate the activity of these enzymes. In the first section of this volume, we propose to address a wide range of methods related to TPP-dependent enzymes as target in health and agrochemistry. Then in a second section, we will focus more particularly on TPP-dependent enzymes in biocatalysis, and in particular on the associated techniques in the field of enzymatic engineering and repurposing. In a third section, we will then address an exciting topic, namely that of the assimilation of one-carbon compounds such as formaldehyde. We will see how TPP enzymes are a tool of choice in biotechnology to address this issue. Finally, we will focus on dual cofactor TPP-dependent enzymes and multi-enzyme complexes using structural and metabolic approaches.

  • Cell Death Part F

    • 1st Edition
    • Volume 211
    • English
    Cell Death: Part F, Volume 211 presents the latest advances and comprehensive reviews in the rapidly evolving field of cell death. This volume explores the molecular mechanisms, regulatory pathways, and biological consequences of various forms of cell death—including apoptosis, necrosis, autophagy, and other non-canonical processes. Chapters in this new release include Flow cytometry analysis of mitochondrial apoptotic priming with BH3 profiling on senescent cells, Methods to study PIDDOsome and caspase 2 signaling, Isolation, characterization, and experimental applications of apoptotic bodies in vitro, Lipid ROS Measurement by Spectral Flow Cytometry based on the ratiometric dye BODIPYTM C11 581/591, and much more.Additional chapters cover CRISPR-Cas9 Screen to Identify Genes Regulating Cell Death, Flow cytometry-assisted discrimination of early apoptotic, late apoptotic and primary necrotic morphological markers in Saccharomyces cerevisiae, Cytofluorometric analysis of cell death in primary human neutrophils, Real-time tracking of cell death in human intestinal organoids: a quantitative imaging approach, and more.

  • The Metabolon

    • 1st Edition
    • Volume 739
    • English
    Methods in Enzymology series: The Metabolon, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

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