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Elsevier

Books in Life sciences

  • PROTACs Overcome Resistance to Cancer Therapies

    • 1st Edition
    • Daohong Zhou
    • English
    PROTACs Overcome Resistance to Cancer Therapies explores the transformative potential of proteolysis targeting chimeras (PROTACs) in addressing one of oncology’s greatest challenges: drug resistance. Edited by Dr. Daohong Zhou, this volume brings together leading experts to present the latest advances in targeted protein degradation for cancer treatment. The book covers foundational principles of PROTAC design, mechanisms of action, and their advantages over traditional small molecule inhibitors. It delves into strategies for targeting undruggable proteins, overcoming resistance in various cancer types, and mitigating emerging resistance to PROTACs.Case studies include BCL-xL, KRAS, STAT3, and EGFR-targeting PROTACs, with insights into clinical translation and precision medicine. This resource equips cancer researchers, oncologists, and pharmaceutical scientists with practical guidance and cutting-edge knowledge. It serves as both a reference and a roadmap for developing next-generation therapeutics, making it essential for those advancing cancer drug discovery and translational medicine.

  • An Essential Guide to Radiation Dosimetry for Medical Applications

    Principles, Technologies, and Clinical Applications
    • 1st Edition
    • Jayachandran Venkatesan + 1 more
    • English
    An Essential Guide to Radiation Dosimetry for Medical Applications: Principles, Technologies, and Clinical Applications provides a comprehensive overview of the fundamental concepts, advanced methodologies, and emerging technologies in radiation dosimetry. This book serves as an essential resource for researchers, clinicians, and students involved in cancer research, bioinformatics, medical physics, radiology, and radiation therapy, offering in-depth insights into both theoretical principles and practical applications. The content covers core topics such as radiation interactions, dosimetry materials, and simulation techniques, alongside clinical and diagnostic applications.In addition, it also explores innovative approaches like artificial intelligence, nanodosimetry, and quality assurance, ensuring readers stay current with technological advancements. This book benefits the academic audience by enhancing their knowledge of dosimetry science and fostering the development of safer, more effective radiation practices. It supports education, research, and clinical decision-making, ultimately advancing the field of radiation physics and improving patient outcomes.

  • Food Packaging from Plant-Based By-products

    Sustainable Materials and Applications
    • 1st Edition
    • Preetam Sarkar + 3 more
    • English
    Food Packaging from Plant-Based By-products: Sustainable Materials and Applications addresses the growing need for sustainable, eco-friendly packaging solutions derived from agricultural plant by-products. The book benefits its audience by delivering up-to-date scientific knowledge, practical case studies, and strategies to overcome technical challenges in the packaging industry. The book’s extensive table of contents covers extraction methods, characterization techniques, and applications of biopolymers from diverse plant by-products such as mango, grape, citrus, apple, tomato, wheat, rice, and legumes. It also explores advanced topics including nanocomposites, active and intelligent packaging, regulatory frameworks, consumer acceptance, and industrial scale-up processes. Each chapter is authored by experts from multiple countries, ensuring a global perspective on sustainable packaging innovations. Food Packaging from Plant-Based By-products: Sustainable Materials and Applications provides a comprehensive resource for researchers, industry professionals, and policymakers focused on developing innovative food packaging systems that improve food quality and safety while reducing environmental impact. It equips the readers with valuable insights to drive innovation, regulatory compliance, and consumer acceptance of sustainable packaging technologies worldwide.

  • Rare and Complex Liver Diseases

    • 1st Edition
    • Ansgar Wilhelm Lohse + 2 more
    • English
    Rare and Complex Liver Diseases is a comprehensive guide that fills a critical gap in the literature, providing up-to-date, practical advice. The book is organized into distinct sections, each dedicated to a specific category of liver diseases. Topics covered include Autoimmune Liver Diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC); Cholestatic Liver Diseases including Biliary Atresia and Alagille Syndrome; Vascular Liver Diseases like Budd-Chiari Syndrome and Non-cirrhotic Portal Hypertension; Metabolic Liver Diseases such as Wilson Disease and Alpha-1 Antitrypsin Deficiency; Structural Liver Diseases including Polycystic Liver Disease; and Rare Liver Tumors like Cholangiocarcinoma and Hemangioendothelioma... chapters cover Liver Disease in Pregnancy and delve into Quality of Life issues, offering evidence-based insights and practical strategies for improving patient well-being. This book serves as an indispensable resource for gastroenterologists, hepatologists, internists, and researchers specializing in liver diseases. It equips these professionals with the knowledge and practical advice necessary to improve patient outcomes and advance their field of study.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Sustainable Science and Technologies for Agriculture and Environment

    SDG Perspectives
    • 1st Edition
    • M. Iqbal R. Khan + 2 more
    • English
    Organized into five thematic sections, Sustainable Science and Technologies for Agriculture and Environment situates contemporary advances—spanning soil microbial ecology and biostimulants, nanotechnology, predictive computational modeling, and integrative omics—within the framework of the United Nations' Sustainable Development Goals and surveys how each contributes to measurable progress toward those targets.The book bridges two scales of inquiry that are often treated apart. At the level of the field, it addresses how productivity can be enhanced without depleting natural capital, drawing on biological inputs, nutrient enrichment of staple foods, and the accounting of emissions from cultivation. At the level of the organism, it traces the physiological and genetic mechanisms through which plants withstand abiotic stresses such as drought, salinity, and heat, together with the breeding and selection approaches that consolidate such resilience.Connectin... the two are cross-cutting methods—engineered materials, algorithmic forecasting, and molecular analysis—whose capabilities are assessed alongside their limitations.For researchers, graduate students, and practitioners alike, the value lies in seeing discovery and deployment held in a single frame, in the service of a common end: to secure food and nutritional sufficiency while safeguarding the integrity of the natural world.

  • Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms offers the latest insights into ESKAPE pathogen biofilms, including their formation, structure, and resistance mechanisms. In addition, the book highlights innovative therapeutic strategies to combat them, with a specific focus on combinatorial enzyme therapies. It begins with an overview of the significant burden these pathogens impose across healthcare and the food industry, laying the groundwork for understanding the intricate relationship between antibiotic resistance and biofilm dynamics. The book advocates for novel approaches through combinatorial enzymatic therapy, detailing the mechanisms and synergies of various enzymes in effectively dismantling biofilms.With insights into cutting-edge delivery systems, including nanotechnology and the integration of CRISPR-Cas systems and artificial intelligence, the book charts a course for the future of advanced therapeutic strategies. It concludes by addressing regulatory considerations, positioning combinatorial enzyme therapy as a promising frontier in the fight against persistent infections caused by ESKAPE pathogens.

  • Hysteroscopy and Female Infertility

    Diagnostic and Therapeutic Approaches in Clinical Practice
    • 1st Edition
    • Salvatore Giovanni Vitale
    • English
    Hysteroscopy and Female Infertility: Diagnostic and Therapeutic Approaches in Clinical Practice addresses the growing global challenge of infertility by focusing on the critical role of hysteroscopy in diagnosing and managing uterine factors that impair female fertility. The book fills a significant gap by providing an up-to-date, practical guide, including recent advances in hysteroscopic technology, such as AI-assisted diagnostics, to improve reproductive outcomes. Chapters cover a broad spectrum of uterine abnormalities such as polyps, fibroids, adhesions, Müllerian anomalies, endometritis, adenomyosis, and isthmocele, combining detailed diagnostic criteria, operative techniques, and evidence on reproductive outcomes.The inclusion of ultrasound correlations, decision-making algorithms, and QR-linked high-definition surgical videos enhances usability for both learning and clinical application. The book equips gynecologists, reproductive endocrinologists, and fertility specialists with a comprehensive, evidence-based resource designed to improve diagnostic precision and therapeutic efficacy.

  • Machine Learning and Urban Health

    Advancing Wellness through Data Analytics
    • 1st Edition
    • Deepak Kumar + 3 more
    • English
    Machine Learning and Urban Health: Advancing Wellness through Data Analytics explores how advanced data analytics and machine learning are reshaping the future of urban wellness. As cities worldwide evolve into highly interconnected, technology-driven spaces, new opportunities—and challenges—emerge for ensuring sustainable urban health. This timely volume addresses the critical question: how can we harness the power of data to improve health outcomes in complex urban environments? From predicting disease outbreaks to identifying vulnerable populations and optimizing resource allocation, this book highlights how machine learning is transforming the public health landscape.Drawing on real-world case studies and diverse datasets—including environmental sensors, population health indicators, and urban infrastructure metrics—the book provides actionable insights for researchers, policymakers, urban planners, and public health professionals. It emphasizes not only technical innovation but also the ethical and equitable use of health data to reduce disparities and enhance quality of life for all city residents.

  • Lobular Breast Cancer

    An All-Round Multidisciplinary Overview
    • 1st Edition
    • GIovanni Corso + 1 more
    • English
    Lobular Breast Cancer: An All-Round Multidisciplinary Overview is a comprehensive academic resource that addresses the complex biology, diagnosis, and treatment of invasive lobular breast cancer. This book synthesizes current research and clinical practices, offering an integrated perspective from leading international experts. It covers key topics such as genetics, pathology, imaging, surgical approaches, and systemic therapies, emphasizing recent advances and future directions. The content is organized into clearly delineated sections, including epidemiology, molecular biology, imaging techniques, and therapeutic strategies, with dedicated chapters on emerging technologies like artificial intelligence. The multidisciplinary approach ensures that clinicians and researchers gain a thorough understanding of lobular breast cancer’s unique features, diagnostic challenges, and tailored treatment options, fostering evidence-based decision-making. This book benefits its academic audience by providing up-to-date, evidence-based insights, practical guidance for clinical management, and a foundation for future research. It supports professionals in staying current with evolving standards, improving patient outcomes, and advancing scientific knowledge in this specialized field.

  • Molecular Pathology

    The Molecular Basis of Human Disease
    • 3rd Edition
    • Gregory J. Tsongalis + 1 more
    • English
    Molecular Pathology: The Molecular Basis of Human Disease, Third Edition is a comprehensive reference that explores the molecular mechanisms and basis of major human diseases. Expertly crafted, this book is designed for use as a teaching tool for medical students, biomedical graduate students, and allied health students. It serves as an advanced resource for pathology residents, postdoctoral fellows, basic scientists, and physician scientists engaged in disease-related research, presenting traditional pathology in the context of translational molecular medicine. In this new edition, the chapters have been fully updated and rearranged for better logical flow.Notably, four new chapters have been included, covering topics such as the pathogenesis of fibrotic diseases, mechanisms of mutation, molecular basis of soft tissue disease and pathology, and pathogenesis and pathophysiology. The book remains an invaluable reference for anyone seeking a deeper understanding of the molecular aspects of human disease.

  • Medical and Health Genomics of South Asia

    • 1st Edition
    • Dhavendra Kumar + 1 more
    • English
    Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region. Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

  • Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

    • 1st Edition
    • Theresa Coetzer
    • English
    Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolyti... Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

  • Intelligent Gait Assistive Technologies

    Gait Biomechanics and Machine Learning Applications in Rehabilitation and Injury Prevention
    • 1st Edition
    • Rezaul Begg + 1 more
    • English
    Intelligent Gait Assistive Technologies: Gait Biomechanics and Machine Learning Applications in Rehabilitation and Injury Prevention brings together contemporary research and applications to show how gait biomechanics combined with machine learning can be used to develop techniques to provide safer, more mechanically efficient locomotion to individuals with significant visual, musculoskeletal, or neurological deficits. Developments in gait rehabilitation and injury prevention outlined in this book will contribute to improved quality of life for individuals with gait-related impairments, with a major contribution to medical cost savings due to reduction in falls.Researchers, engineers, and students in biomedical engineering and biomechanics will find this a welcomed reference in better understanding the role of machine learning and intelligent technologies in the advancement of gait rehabilitation and injury reduction to both impaired and healthy individuals.

  • Microscopy in the Life Sciences from 1650 to the Present

    • 1st Edition
    • Joel B. Sheffield
    • English
    Microscopy in the Life Sciences from 1650 to the Present explores the transformation of the microscope and its applications and techniques over the course of history, illustrating how progress in optics and microscope design has informed our growing knowledge of cellular life. Beginning with early observations of cellular structure, the book tracks the movement towards understanding of cell biology and pathology, considering the changing landscape of microscopy, lens development, and limitations and challenges tackled. Users will also find content on recent advances, including fluorescence studies and the use of computational procedures to assemble images of individual molecules. This book traces the evolution of understanding that scientists have had regarding cellular life and how comprehension of this has been supported by the development of the microscope. It considers a range of experts central to its progression over the years, including Schleiden, Schwann, Abbe, Schott and Zeiss, and is a useful reference for researchers working with microscopy techniques across the biological sciences.

  • Toxicology Disasters

    Causes and Consequences
    • 1st Edition
    • Sue Ford
    • English
    Toxicology Disasters: Cause and Consequences, a volume in the History of Toxicology and Environmental Health series, provides an historical overview of significant toxicological disasters which involved chemical exposure of humans, animals or the environment. The book documents the timeline of events and the legacy of the resulting exposure which occurred within a specific period of time, but with long lasting consequences. Case studies of toxicological incidents and a wide range of categories, including environmental, industrial, pharmaceutical, domestic and international are not only discussed from a historical perspective but also regarding their impacted toxicology, regulation and our current use of these chemicals.The book will help toxicologists, academics and students from environmental health and toxicology departments, environmental/occupa... health regulators, and industrial hygiene/safety personnel gain a better understanding of the arc of a toxicological disaster from its origins, root causes of the problem, and initial and long-term assessments and management.

  • Aquatic Biodiversity

    Theories, Approaches, and Future Directions
    • 1st Edition
    • Bryan L Brown + 1 more
    • English
    Aquatic Biodiversity: Theories, Approaches, and Future Directions reviews the development of metacommunity ecology theory in aquatic systems. The book explores aquatic dispersal as a driver of community biodiversity, patterns, and processes. Considered a relatively new field, metacommunity ecology created a paradigm shift in the field of aquatic ecology by developing a novel, network-based theory that differences in connectivity throughout aquatic systems lead to predictable variations in the mechanisms of assembly for lentic and lotic communities. This book collates the cutting edge conceptual, theoretical, and empirical advancements of the field and its contributions to invasive species management, biomonitoring, and stream restoration. Written and edited by many of the key researchers contributing to the development of the field, this book is systematically structured for easy accessibility by diverse audiences. Introductory sections discuss the importance of spatial structure, dispersal dynamics in aquatic systems, the effects of disturbances, and eco-evolutionary dynamics. Latter chapters apply these theories by describing field experiments in lentic and lotic systems and highlighting the field's applications to stream restoration, invasive species monitoring, urban ecosystem management, and biomonitoring at varying spatial scales. As advancements and refinements to the field of metacommunity ecology develop, Aquatic Biodiversity presents the first compendium establishing its foundational theories and their applications in aquatic ecology. For this reason, it is an indispensable resource for students, researchers, community ecologists, and aquatic resource managers.

  • Diagnosis and Treatment of Infectious Diseases

    • 1st Edition
    • Saeed Soleiman Meigooni
    • English
    Diagnosis and Treatment of Infectious Diseases summarizes practical content in infectious diseases using keys topics for better coding and grasping of material. The book's author uses his experience from over 15 years of teaching and working in infectious diseases in more than ten hospitals with thousands of patients as a backdrop. All of its contents use a clinical perspective for a wide range of audiences, such as medical students, general practitioners, nurses, and others. As infectious diseases are among the most common diseases, and a cause of death in many societies, they can create health challenges in developed and developing countries.Medical students have a limited time for infectious diseases rotation in their curriculum and may not learn many infectious diseases syndromes during their entire medical course. Also, due to the high volume of infectious disease subjects in textbooks which overlap symptoms and signs of many microorganisms, they may forget some of the materials. Therefore, access to a comprehensive compact book such as this one seems necessary for any medical staff.

  • Pediatric Gastroenterological Diagnosis

    A Diagnostic Primer
    • 1st Edition
    • Richard Thomas Lee Couper
    • English
    Pediatric Gastroenterological Diagnosis: A Diagnostic Primer focuses on the theoretical aspects of diagnosing pediatric gastroenterology diseases, including historical and current information. Sections cover pediatric gastroenterology diseases and provide practical advice for quick and accurate diagnosis. In addition, the book provides multiple pediatric tables and references, as well as brief clinical vignettes that identify potential pitfalls clinicians may encounter. This is the perfect reference for clinicians who struggle with complex diagnosis and problem-solving, and will be ideal for pediatric gastroenterology trainees and pediatric gastroenterologists.

  • Critical Care in Pregnant Patients

    Ultrasound
    • 1st Edition
    • Jorge Hidalgo + 3 more
    • English
    Critical Care in Pregnant Patients: Ultrasound, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women with various health compromises. The book's chapters reflect the growing scope of critical care obstetrics and the increasing importance and recognition of the hospital structure's field. All intensivists, regardless of primary discipline, must possess a core set of critical care skills to manage critically ill patients. The book's authors have gathered the best evidence-based material explicitly focused on how ultrasound can successfully manage potential scenarios of common and rare health complications. Users will find the basics of ultrasound and the latest technological advances of ultrasound that foster research and improve health outcomes in pregnant patients.

  • Human-Centred AI For Intelligent Healthcare

    Approaches and Technologies
    • 1st Edition
    • Mahmoud Hassaballah + 1 more
    • English
    Human-Centred AI For Intelligent Healthcare: Approaches and Technologies provides state-of-the-art AI technologies and healthcare tailored to human needs, highlighting the various ways AI is reshaping patient care, diagnostics, treatment modalities, and overall healthcare systems. From the intricacies of precision medicine to interventions in mental health, this reference provides a diverse array of AI applications. It addresses ethical considerations while emphasizing the transformative potential that AI holds for the healthcare industry. This reference is an essential companion for healthcare professionals, researchers, policymakers, technologists, and enthusiasts navigating the swiftly evolving landscape of AI in healthcare. Bridging a critical gap in literature, it offers a consolidated resource that not only explores the multifaceted applications of AI in healthcare but also underscores the importance of maintaining a human-centric approach in the integration of these technologies. With a focus on forecasting future trends and implications, this reference equips readers with the knowledge to stay at the forefront of the dynamic field of healthcare technology and empowers them to anticipate changes and adapt their strategies proactively in the face of evolving healthcare landscapes.

  • New Trends in Methodological Approaches for Fish Biology

    • 1st Edition
    • Ignacio Fernandez Monzón + 1 more
    • English
    New Trends in Methodological Approaches for Fish Biology provides an extensive guide on the novel tools and methodologies that are available to fish biologists across diverse sectors. The book combines a historical overview of each research area with detailed descriptions of emerging cellular and molecular tools. Sections explore recent advances in fish genomics, nutrition, development, reproduction, health, and welfare. Given the breadth of subject matter, this is an essential resource for students, academic researchers, aquaculturists and fisheries biologists, and resource managers alike. Written by a globally diverse team of experts, it is systematically structured for easy navigation by technical and nontechnical audiences. As research in this area is growing exponentially, reflecting the global economic significance of fisheries and aquaculture industries, fish as model research organisms, and aquatic ecosystem health, this book is a welcomed resource.

  • Fundamentals of 3D Food Printing and Applications

    • 2nd Edition
    • Fernanda C. Godoi + 4 more
    • English
    Fundamentals of 3D Food Printing and Applications, Second Edition offers a broad overview of 3D printing technology applied to food. This new edition outlines emerging 3D food printing technologies and their working mechanisms across a wide range of application areas, including the development of soft foods and confectionary designs. Chapters cover new trends and demands, such as changes in consumer preferences, new regulations, and new applications of 3D printing technology in the food industry. It also explores the use of natural and organic materials as printing materials to address end-user concerns about artificial food.In addition, the book covers the use of automated systems and advanced technologies, such as machine learning and artificial intelligence, to improve efficiency and consistency in 3D food printing. Case studies and best practices from industry professionals who have successfully scaled up their 3D food printing operations are presented throughout. Edited and written by a team of worldwide experts in 3D food printing, this book is the best resource covering the latest developments in 3D printing technology.

  • Adaptogen Science and Wellbeing

    Use in Functional Foods, Dietary Supplements and Nutraceuticals
    • 1st Edition
    • Sreeraj Gopi + 3 more
    • English
    Adaptogen Science and Wellbeing: Use in Functional Foods, Dietary Supplements and Nutraceuticals explores the rich phytochemical constituents of adaptogens and their specific mechanisms of action. This book delves into the numerous phytosterols, vitamins, lignans, alkaloids, and flavonoids present in natural product adaptogens. By understanding these components, readers can appreciate their health benefits, how they enhance nutraceuticals, and how they improve functional food formulations. The book aims to provide a comprehensive overview of these natural substances and their potential applications in promoting overall well-being.The book identifies over 30 species of plants, roots, and fungi, such as sea buckthorn, holy basil, American ginseng, licorice root, maca, cordyceps, ashwagandha, and more. It explains the mechanisms of action and bioavailability of each adaptogen, discussing their immune function and anti-inflammatory benefits, cell energy metabolism for improved vitality, and neurotransmitter regulation for mental well-being. The book concludes with regulatory guidelines, protocols, and challenges for utilizing these natural products in functional foods and nutraceuticals.

  • The Safety Aspects of Food Waste Valorization

    Maintaining Quality Assurance in Resource Recovery
    • 1st Edition
    • Sidonia Martínez Suárez + 1 more
    • English
    The Safety Aspects of Food Waste Valorization: Maintaining Quality Assurance in Resource Recovery highlights the importance of safe food waste practices and strategies to effectively transform waste into valuable resources. Co-edited by two female authors with many global, female contributors represented, the book looks at the environmental consequences of food waste and its impact on human health. It details the risks associated with the use of food waste, analyzes food safety in valorized agri-food by-products, with a focus on mycotoxins, and demonstrates how to minimize safety risks from a variety of industries, including date-palm industrialization, wine, produce, cattle, olive oil and dairy. Finally, the book provides practical business strategies for bioactive ingredients derived from food by-products and details the recovery of food waste from an environmental and economic perspective.

  • Sustainable Livestock Nutrition through Alternative Feed Ingredients

    • 1st Edition
    • Prabhat Khanal + 2 more
    • English
    Sustainable Livestock Nutrition through Alternative Feed Ingredients synthesizes the latest knowledge on alternative feed ingredients in livestock diets. With the use of sustainable, low-waste, and circular feed ingredients, livestock can gain essential key nutrients while reducing their environmental impact. Through meticulous research and practical insights, the book explores alternative proteins and nutritional sources for a variety of animals. Cutting-edge, low-impact ingredients, including insects, algae, microalgae, seaweed, and freshwater plants are covered and compared. Written and edited by an international team of experts, and with a focus on enhancing animal health and welfare while minimizing environmental impact, this book serves as a vital resource for researchers, farmers, students, and policymakers.

  • Nutritional and Health Aspects of Food in Oceania

    • 1st Edition
    • Diana Bogueva + 1 more
    • English
    Nutritional and Health Aspects of Food in Oceania provides an analysis of traditional and ethnic foods from Australia, New Zealand, Fiji, Papua New Guinea, Tonga, Hawaii, Samoa, Tuvalu, Solomon Islands, and New Caledonia. The book addresses the history of use, origin, composition, preparation, ingredient origin, nutritional aspects, and effects on health for various foods and food products in each of these countries. In addition, it presents both local and international regulations while also providing suggestions on how to harmonize these regulations to promote global availability of these foods.

  • Polycystic Ovary Syndrome (PCOS)

    Current Status and Phytomedicine
    • 1st Edition
    • Mohammad Afzal Zargar + 3 more
    • English
    Polycystic Ovary Syndrome (PCOS): Current Status and Phytomedicine is a novel resource to understanding PCOS, its history, epidemiology, potential causes, symptoms, and potential treatment options as well as future implications and disease management. While the diagnosis and management of PCOS present challenges, understanding its impact on health and implementing appropriate treatment strategies are crucial for optimizing women's health in reproductive life. Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age and is typically treated with conventional pharmacological therapy and surgery, which may have side effects and limited long-term efficacy. Phytomedicine is an area of great potential for improved patient outcomes. Researchers of PCOS will find this book essential to help further research in this area.

  • The Future of Health and Economic Resiliency in Africa

    • 1st Edition
    • Muhammad Pate + 1 more
    • English
    Grown out of a Lancet Commission to look at the future of health and economic resiliency of Africa, The Future of Health and Economic Resiliency takes a multidisciplinary approach across numerous sectors of analysis, central to Africa’s future well-being. This book serves as a comprehensive analysis of the current state of the continent and what actions can be taken to improve health and resiliency moving forward. While previous analysis has been done regionally within the continent (sub-Saharan Africa, for example) or by specific health needs (HIV or poverty, for example), this book will be the first to synthesize a cross sector approach pan-Africa. By describing the context and through actionable solutions for the future, this book sets the framework for a more resilient Africa and global future. Future of Health and Economic Resiliency is a collaboration of top African experts and practitioners in public health, health systems, economics, financing, nutrition, climate, youth representation, and the private sector.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2nd Edition
    • Joao L. de Quevedo + 2 more
    • English
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition provides the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the novel optogenetic techniques revolutionizing depression research. This new edition aids advanced students and researchers in their understanding of MDD, presenting chapters that explore groundbreaking topics such as the neurobiology of treatment-resistant depression, the mechanisms that make ketamine a better antidepressant, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression.The book also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help provide a broader and more comprehensive understanding of depression and its treatment.

  • AI and Precision Oncology

    Innovations in Diagnosis and Drug Development
    • 1st Edition
    • Arun Kumar Singh + 2 more
    • English
    AI and Precision Oncology: Innovations in Diagnosis and Drug Development examines the transformative role of artificial intelligence and machine learning in oncology. The book addresses the urgent need for early cancer diagnosis and effective therapeutic treatments, highlighting how technological advancements enable rapid analysis of large datasets to enhance patient outcomes. The content explores clinical applications of next-generation sequencing (NGS) integrated with AI technologies, covering risk prediction, disease detection, biomarker identification, and therapeutic target discovery. The book emphasizes the importance of bioinformatics tools in analyzing NGS data and showcases AI-powered applications that improve cancer diagnosis and prognostication.For the academic audience, this book provides valuable insights into the latest advancements in AI and precision oncology. It equips researchers and clinicians with knowledge on personalized treatment strategies and recent clinical studies, ultimately enhancing understanding of how AI can revolutionize cancer care and improve patient management.

  • Animal Stress Biology

    Applications across Natural and Man-made Systems
    • 1st Edition
    • Edward Narayan
    • English
    Animal Stress Biology: Applications across Natural and Man-made Systems provides the fundamental aspects of stress endocrinology with a major focus on the applications of stress research in animal welfare. Early sections introduce the basics of animal stress biology in major taxa. Latter sections explore how animal stress varies across species and settings and how this research can be applied to improve animal welfare. The book incorporates chapter summaries, key term definitions, global case studies, and discussion sections throughout, making it an indispensable resource to students and early career professionals, as well as specialists in agriculture, zoos, clinical research settings, and resource management.Stress plays an integral part in the maintenance of homeostasis in animals and is a useful measure of animal responses to management interventions across natural, agricultural, and clinical settings. Written by experts in the field of animal stress biology, this book is systematically structured for easy student navigation.

  • Bioprospecting Native Microbiomes for Boosting Phytoremediation

    • 1st Edition
    • Vimal Chandra Pandey + 1 more
    • English
    Bioprospecting Native Microbiomes for Boosting Phytoremediation provides an inclusive overview of the use of metal-resistant native microbiomes for boosting the phytoremediation of polluted land for ecological and environmental restoration. The book offers a basic understanding of the principles and mechanisms of microbe-induced phytoremediation, microbiome resilience, adaptation to polluted lands, and metal-resistant native microbe-assisted phytotechnologies. It covers current trends, tools, and policies for the microbe-augmented remediation of an array of metals and metalloids. Other sections discuss key topics such as plant-metal-microbe interaction in polluted ecosystems, microbe-mediated phytoremediation for upgraded ecosystem services, and success stories on microbial-assisted phytoremediation.

  • Oil-Encapsulated Powders for Functional Foods

    Preparation and Practice
    • 1st Edition
    • Jian Zhong + 2 more
    • English
    Oil-Encapsulated Powders for Functional Foods: Preparation and Practice bridges the gap between fundamental research and industrial practice, emphasizing how encapsulation can enhance bioavailability, protect bioactives from environmental degradation, and improve sensory attributes. The book provides an in-depth guide for overcoming the scientific and technical challenges associated with stabilizing and delivering sensitive oils in food matrices, offering detailed insights into encapsulation science, advanced preparation techniques, and practical application strategies that are essential for creating effective, stable, and appealing functional foods. It covers core materials such as oils and wall substances, state-of-the-art encapsulation and drying methods, and robust characterization techniques.With real-world examples spanning formula foods, meat, dairy, and bakery products, this book is an essential resource for food scientists, nutritionists, and product developers dedicated to innovating health-oriented foods that meet modern consumer needs and promote overall wellness.

  • Lanzkowsky's Manual of Pediatric Hematology and Oncology

    • 8th Edition
    • Jonathan D. Fish + 2 more
    • English
    Lanzkowsky's Manual of Pediatric Hematology and Oncology, Eighth Edition covers a wide array of topics, from molecular and genomic methodologies to specific hematologic disorders and various types of cancer, along with supportive care strategies. Each chapter is authored by leading experts who provide the latest evidence-based practices, diagnostic techniques, and treatment modalities, ensuring that practitioners have access to authoritative insights for informed clinical decision-making. This manual offers the tools and strategies necessary for delivering high-quality, evidence-based care, ultimately enhancing patient outcomes and improving the quality of life for young patients.Whether you are a trainee, an early-career physician, or a seasoned practitioner, this manual is an indispensable reference that will support your journey in pediatric hematology and oncology.

  • Network Pharmacology in Natural Products Drug Discovery

    • 1st Edition
    • Devesh Tewari + 1 more
    • English
    Network Pharmacology in Natural Products Drug Discovery addresses the critical intersection of network pharmacology and natural product research, a rapidly evolving field essential for modern drug discovery. The book's content begins with foundational concepts of network pharmacology followed by an exploration of natural products as therapeutic agents. Its comprehensive Table of Contents covers a diverse range of topics, including omics integration, metabolomics, and case studies on various health conditions, thus ensuring a holistic understanding of the subject matter. Each chapter not only presents theoretical insights but also emphasizes practical applications, case studies, and emerging trends in network pharmacology related to natural products.The book empowers its audience by providing them with essential tools and methodologies to integrate network pharmacology into their research. It highlights the advantages of utilizing computational approaches alongside experimental validation, enabling researchers to uncover the mechanisms of action of natural compounds. With a focus on real-world applications, this reference is invaluable for advancing drug discovery and therapeutic development.

  • Plant Peptides

    Enzymatic Production and Health-Promoting Effects
    • 1st Edition
    • Tolulope Joshua Ashaolu + 2 more
    • English
    Plant Peptides: Enzymatic Production and Health-Promoting Effects provides up-to-date insights on the enzymatic production, bioactivity, and applications of plant-derived peptides. This comprehensive volume explores the role of plant-based proteins (PBPs) as sustainable alternatives to traditional animal proteins, highlighting their environmental and climatic benefits. The book examines the enzymology of proteolytic enzymes used to generate bioactive peptides from PBPs, detailing their bioaccessibility, stability, and bioavailability. It offers an in-depth analysis of the multifarious biological activities of these peptides, including their antioxidant, antimicrobial, and metal-binding properties. The book also addresses the technological and biological properties, limitations, and challenges of plant-based bioactive peptides for industrial uses.With a strong focus on practical implementation, the book discusses emerging strategies and advanced technologies for producing and analyzing bioactive peptides, such as in silico analysis, fermentation, and peptidomics. It provides insights into future research directions and potential applications, emphasizing the health-promoting effects of plant-based peptides in combating obesity, diabetes, hypertension, cancer, and neurodegenerative diseases. This book is an essential resource for food science researchers, nutritionists, and students of food science and nutrition.

  • AI and Food Systems

    Transforming Production, Safety, Sustainability and Consumer Experience
    • 1st Edition
    • Diana Bogueva
    • English
    AI in Food Systems: Transforming Production, Safety, Sustainability and Consumer Experience explores the transformative role of Artificial Intelligence (AI) in all aspects of food systems, analyzing its impact on food production, safety, quality, sustainability, and consumer behavior. It examines how AI-driven technologies such as machine learning, deep learning, and predictive analytics are revolutionizing agriculture, food processing, personalized nutrition, and supply chain management. As AI-driven innovations rapidly reshape the food industry, there is an urgent need for a resource that critically examines both opportunities and challenges, including ethical concerns, regulatory frameworks, and public perception. Rather than taking a topic-specific approach into aspects of AI in agriculture or food technology, this book takes a holistic approach, integrating insights from multiple disciplines to address the broader implications of AI on global food security, sustainability, and nutrition. By bridging gaps in current knowledge, AI and Food Systems: Transforming Production, Safety, Sustainability and Consumer Experience serves as a vital reference for academics, industry professionals, policymakers, and consumers, ensuring that AI’s role in food systems is both well-understood and responsibly harnessed for a more efficient, transparent, and equitable food future.

  • Bioactive Compounds

    Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability
    • 1st Edition
    • Cristobal Noe Aguilar + 3 more
    • English
    Bioactive Compounds: Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability covers nutrition, food science, and pharmacology, elucidating the intricate dynamics of bioactive compounds and their impacts on human health. This comprehensive volume delineates the crucial differences between bioaccessibility and bioavailability, providing insights into their implications for health outcomes. Readers will explore the behavior of key classes of bioactive compounds, including polyphenols, carotenoids, and peptides, as well as their sources and interactions within the food matrix. The book further examines the essential role of gut microbiota in absorption processes, highlighting how these interactions can influence bioactive compound efficacy in the human body.Sections not only discuss the mechanisms of absorption, distribution, metabolism, and excretion (ADME) of bioactive compounds but also introduce cutting-edge tools and strategies designed to enhance their bioaccessibility and bioavailability.

  • Avian Models of Development

    • 1st Edition
    • Volume 173
    • English

  • Drug Discovery Stories, Volume 3

    From Bench to Bedside
    • 1st Edition
    • Bin Yu
    • English
    Drug Discovery Stories: From Bench to Bedside, Volume 3 presents a collection of cases on the development of highly successful pharmaceuticals. The coverage of chapters in the book include the structural biology and biological functions of the targets of interest, the identification of hit compounds, hit-to-lead optimization, binding mode of the key compounds with the target of interest, key biological and PK data of lead compounds, clinical results if any, other candidate compounds in preclinical and clinical stage against the same target, and other relevant points in the journey to develop the drug. Chapters in this volume in the Drug Discovery Stories series include a discussion of technological innovations in drug discovery, the impact of AI and Machine Learning, and then move on to discuss drugs like Landiolol, Deuruxolitinib, Berdazimer sodium, Cefepime, Aprocitentan, Givinostat, Vadadustat, Danicopan, Tovorafenib, Lazertinib, Journavx, Symbravo, Grafapex, Alyftrek, and Tryngolza. A final chapter provide conclusions on all cases presented in the book. Drug Discovery Stories: From Bench to Bedside, Volume 3 accurately reflects the current advancements in drug discovery by sharing the path researchers took that led them to create these impactful drugs. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology.

  • Advances in Mitochondrial Drug Delivery

    From Molecular Mechanisms to Clinical Translation
    • 1st Edition
    • Prashant Kesharwani
    • English
    Advances in Mitochondrial Drug Delivery: From Molecular Mechanisms to Clinical Translation addresses the critical need for a comprehensive resource on mitochondrial-target... drug delivery systems. As recent advancements in drug delivery systems (DDS) have shown substantial promise in treating diseases linked to mitochondrial dysfunction, there is a pressing demand for a consolidated reference that covers both the foundational aspects and the latest innovations in this field. The book's Table of Contents encompasses a wide range of topics, beginning with the fundamentals of mitochondrial biology and drug delivery, followed by various mitochondrial-target... drug delivery strategies. It further explores advanced applications of these systems in treating cancer, neurodegenerative diseases, cardiovascular conditions, and more. Additionally, the book discusses future directions, clinical translation, and regulatory challenges, ensuring a holistic view of the subject matter. Advances in Mitochondrial Drug Delivery offers significant benefits to researchers, students, and professionals in pharmaceutical sciences and nanotechnology. By integrating diverse perspectives from leading experts, the book serves as an essential resource for understanding the complexities of mitochondrial-target... therapies, thereby fostering advancements in drug delivery systems and therapeutic strategies.

  • Autophagy – Part D

    • 1st Edition
    • Volume 407
    • English

  • The Plasticity of Sex

    The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior
    • 2nd Edition
    • Marianne Legato J
    • English
    The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior, Second Edition offers a thorough exploration of the biological, clinical, and social dimensions of human sexuality. This updated edition emphasizes the increasing recognition of the diversity of sexual identities and behaviors, particularly the spectrum between traditional male and female categories. It consolidates evidence-based research on the molecular and developmental biology of sex, gender identity, and sexual behavior, presenting a comprehensive resource for biomedical researchers, clinicians, and medical students. A key theme of this edition is the growing understanding of human sexuality as fluid and diverse, shaped by a variety of genetic, hormonal, and environmental factors. Over recent decades, there has been heightened interest in issues like gender identity, genital ambivalence, and sexual transition, with both the general public and medical professionals seeking more knowledge and guidance on these topics. The book underscores the need for a more inclusive approach, incorporating voices from diverse communities and recognizing the importance of broadening the scope of research beyond narrow sample sizes and traditional binary frameworks. The new edition highlights the ongoing challenges in understanding and addressing variations in human sexuality and the need for continued dialogue between science, society, and legal systems to create more inclusive frameworks for care and support. This work serves as an essential reference for anyone involved in the study or treatment of human sexuality.

  • Remote Sensing and Machine Learning in Conservation

    Applications and Techniques
    • 1st Edition
    • Alireza Sharifi
    • English
    In Remote Sensing and Machine Learning in Conservation: Applications and Techniques, readers will discover how cutting-edge technology is transforming our understanding of the natural world. This book explores how remote sensing and machine learning are being used to monitor wildlife populations, map critical habitats, predict the effects of climate change, and identify poaching hotspots. From the analysis of satellite imagery to the use of drones and artificial intelligence, this book provides a comprehensive overview of the latest tools and techniques available to conservationists. Written by a renowned expert in spatial information research, this book introduces readers to the exciting new possibilities opened by the combination of remote sensing and machine learning. Early chapters provide an overview of both emerging technologies and their integration into habitat mapping, species distribution, environmental monitoring, and climate change adaptation. Central chapters explore real-world applications and case studies for combating poaching, managing urban expansion, controlling invasive species, and more. Final chapters explore the funding and policy landscape and conclude with a reflection on the role of these technologies in transforming conservation practices. By equipping readers with an overview of these technologies, case studies of their real-world applications, and sample code, datasets, and open-source tools, Remote Sensing and Machine Learning in Conservation: Applications and Techniques promotes the innovative use of these technologies to address global environmental challenges. This is an essential resource for conservationists, resource managers, environmental scientists, and academics studying novel technological applications to conservation issues.

  • Artificial Intelligence in Clinical Medicine

    General Concepts and Specific Applications
    • 1st Edition
    • Marianne Legato J + 1 more
    • English
    Artificial Intelligence in Clinical Medicine: General Concepts and Specific Applications explores the evolution and application of artificial intelligence (AI) in medicine, highlighting both its potential and challenges. The initial discussion outlines past failures in integrating AI into healthcare, followed by a review of FDA-approved AI medical devices and their implications for diagnostics. Subsequent sections examine the transformative impact of large language models, the ethical application of AI in clinical settings, and the role of AI in enhancing patient safety. Various specialties, such as cardiology and pulmonary disease, illustrate AI's capabilities in improving diagnostics and treatment. The discussions extend to diabetes care, dermatology, obstetrics, and radiology, emphasizing the need for ethical considerations and quality assessments to ensure AI aligns with human values and improves patient outcomes across diverse healthcare contexts.

  • Omics Applications in Clinical Medicine

    • 1st Edition
    • Luis María Vaschetto
    • English
    Omics-Driven Healthcare: The Future of Medicine is a comprehensive reference piece that explores the potential of personalized medicine, where treatments are tailored to individual patients based on their unique genetic makeup. "Omics-Driven Healthcare: The Future of Medicine" bridges the critical gap between the exponentially growing omics technologies and their practical application in clinical settings. With approximately 18 chapters, this book is designed for advanced students and entry-level researchers in medical genetics and precision medicine who require a thorough understanding of omics technologies and their applications in healthcare. This book is an essential resource for anyone looking to gain insights into the latest advancements and real-world applications of omics technologies, and how these powerful tools are transforming the diagnosis, treatment, and prevention of diseases.

  • Practical Guide to Diagnosing and Treating Ocular Tumors

    • 1st Edition
    • Maura Di Nicola + 1 more
    • English
    Practical Guide to Diagnosing and Treating Ocular Tumors provides practical guidance on the diagnosis and management of ocular tumors. This comprehensive guide highlights the strengths, limitations, and applications of all imaging modalities in ocular oncology. It not only discusses new treatments in ocular oncology (including belzupacap sarotalocan and darovasertib for uveal melanoma, mTOR inhibitors for retinal astrocytic hamartomas in patients with ocular involvement of tuberous sclerosis complex, and belzutifan for retinal hemangioblastomas in patients with Von Hippel Lindau disease), but also offers a comprehensive and practical review of the techniques, complications, and applications of well-established treatments.Ophthalmo... and ocular oncologists will find this to be a practical guide to diagnosing and treating surface and intraocular tumors using a novel approach that will instruct readers on how to utilize and interpret multimodal imaging correctly to diagnose ocular tumors. Readers will gain an understanding of the risks and benefits of different treatment modalities and the most appropriate use scenario in each tumor type.

  • Cellular Therapy for Autoimmune Disease

    • 1st Edition
    • Samik Basu + 1 more
    • English
    Cellular Therapy for Autoimmune Disease provides a comprehensive exploration of the evolving landscape of cellular therapies for autoimmune diseases. The book delves into the evolution of the standard of care for autoimmune diseases, transitioning from chronic suppression to targeted replacement or suppression therapies. It covers a wide array of topics, including stem cell transplants, B-cell and plasma cell depletion strategies, and autologous regulatory and effector T-cell approaches. Additionally, it explores myeloid cellular approaches, allogeneic cellular therapies, and viral or nanoparticle-based strategies. Each chapter provides a thorough examination of mechanisms of action, clinical and non-clinical data, and the associated risks and benefits.Finally, the book addresses unique clinical and manufacturing considerations, offering a roadmap for the future state of cellular therapies in autoimmune diseases. This essential resource addresses the rapid advancements in cell therapies that have outpaced the availability of integrated, up-to-date resources. By bridging the gap between scientific research and clinical applications, it offers in-depth insights into mechanisms of action, disease-specific therapeutic strategies, and the latest innovations in clinical and manufacturing considerations for scientists and clinicians.

  • Inherited Metabolic Diseases and the Brain

    • 1st Edition
    • Fanny Mochel + 2 more
    • English
    Inherited Metabolic Diseases and the Brain explores the latest research on the neurological aspects of inherited metabolic diseases such as epilepsy, encephalotomy and more. With a strong research driven foundation and clinical applications, this book provides a primer which will help practicing pediatric and adult neurologists recognize, diagnose and treat neurometabolic disorders. This volume will also present a number of more common disorders in more detail, describing the variability in clinical presentation, the life course of the disease and the intricacies of diagnosis and treatment.

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