Aging in Ophthalmology examines the aging process of the eye and how this affects the future evolution of ophthalmology.With a strong focus on the aging process and therapeutic options, the book also shows the capabilities that prevent and treat the aging of the eye through the latest improvements in the medical and surgical possibilities of ophthalmology.In 18 chapters. Aging in Ophthalmology describes the aging process of the eye from a practical perspective as well as the consequences from the therapeutic point of view. The book describes both the risks of the aging of the eye, the aging of the different parts of the eye (like the retina, lens and iris), the therapeutic approaches to limit the aging processes of the eye and a glance into the future. This book is a valuable resource for ophthalmologists of all subspecialties and researchers interested in aging process in the human eye
Aquaculture Mycology and Bacteriology is a practical reference to address the steadily increasing importance of infectious diseases of aquatic animals. With the burgeoning expansion of the animal aquaculture industry to new geographic areas, new microbial and parasitic species with pathogenic potential will continue to emerge. This necessitates rapid identification of the new pathogens to enable their control. Each pathogenic bacterial or fungal species is accompanied by the full description of both taxonomic and clinical information for the three major aquatic food animals (fish, crustaceans and mollusks). The book takes a comprehensive approach to facilitate research to develop vaccines or other similar pathogen mitigation measures, and is useful to bacteriologists, mycologists, aquaculturists, clinical practitioners in aquatic animal health and all those in industry, government or academia who are interested in aquaculture, fisheries and comparative biology.
Biomarkers in Kidney Transplantation: Clinical Aspects and Laboratory Determination provides a focused study on traditional and emerging biomarkers to predict early rejection of kidney transplants supporting appropriate therapeutic interventions. Coverage includes predictive and diagnostic biomarkers for different types of rejections, including biomarkers of acute, chronic/sub chronic rejection or clinical rejection, T-cell mediated rejection, antibody mediated rejection and mixed rejection. Comparisons are provided for broad classification of pharmacokinetic versus pharmacodynamic biomarkers, and differentiation is shown between the susceptibility, diagnostic, predictive, prognostic and monitoring biomarkers.Coverage of the analytical aspects of biomarker measurement, the process of biomarker discovery and their clinical validation addresses both the clinical features of biomarkers as well as the pitfalls of determining such biomarkers in clinical laboratories. By combining all current markers known for kidney transplant in one collection, this easy-to-use reference is perfect for pathologists, clinical pharmacologists, clinical laboratory scientists and all physicians involved in organ transplantation, including immunologists and transplant surgeons.
Flow Cytometry in Immuno-oncology, Volume 173 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, Basic principles of Flow cytometry in immuno-oncology, Good practice and methods for flow cytometry in immuno-oncology, Automated flow cytometry in immuno-oncology, Flow cytometric analysis of Tregs in solid tumors, Multiparametric analysis of Tumor infiltrating lymphocytes in solid tumors, Analysis of tumor-infiltrating immune cells in intracranial glioblastoma, Assessing chromosomal abnormalities in leukemias by Imaging flow cytometry, Flow cytometric analysis of cellular alkaline phosphatase in acute myeloid leukemia, and much more.
Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.
Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation.This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, this is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.
The Vaccine Book: New Insights, Approaches and Technologies, Third Edition provides comprehensive information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. Edited by a new, highly experienced team of editors, the 3rd edition provides new approaches, design, and vaccine platform tools to develop vaccines quicker.This new edition is fully updated and designed for students, researchers, public health offcials, and all others interested in increasing their understanding of vaccines.
Carotid Artery Disease is a practical resource for those who need a detailed understanding of pathophysiologic and hemodynamic mechanisms that lead to development of atherosclerotic plaque which can provide a fertile environment to scientists for further discoveries. It provides the most up to date clinical practice and opinions from leading medical doctors who manage carotid artery disease. This book provides the most recent utilized diagnostic and treatment modalities, as well as clear guidelines pertinent to special diagnostic considerations and emerging novel surgical and non-surgical treatment techniques.
Atlas of Microsurgery of the Lateral Skull Base is a practical resource for all clinicians interested in training for lateral skull base surgery. This new atlas of lateral skull base surgery allows readers to become familiar with the delicate lateral skull base, an important part of the body’s neurological system. Featuring step-by step dissection images, this resource is perfect for those studying anatomy of this region. Clinical surgical cases are also presented and discussed for each surgical approach, including relevant clinical and radiological background. Decision-making discussions provided for each clinical case ensure readers will fill any gaps in their neurosurgery training.
Sustainable Process Intensification for Biocatalysis: Applications in Enzymology and Biotechnology, a new volume in the Foundations and Frontiers of Enzymology series, offers applied instruction in process intensification principles for applications in enzymology and biotechnology, helping researchers and practitioners implement these techniques across various uses and industries, from healthcare to food and biofuel. Here, leaders in the field discuss a full range of approaches and enabling technologies, from microwave to ultrasound, hydrodynamic cavitation, and combination chemical and biological catalysis techniques, such as multiphase reactors, microreactors, scale-bioprocesses, and enzyme cascades. Later chapters examine ongoing advances and their implementation across different industries, including pharmaceuticals, perfumes, polymers, and agrochemicals, with a final chapter discussing next steps in research and future directions. Throughout the book, and across applied examples, emphasis is placed on driving sustainable research approaches and manufacturing.