Seldin and Giebisch’s The Kidney, Sixth Edition: Physiology and Pathophysiology provides a common language for nephrology researchers, fellows and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of normal renal physiology, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation.This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise and readily accessible information. Academic, medical and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
Major advances in neurobiology and the clinical neurosciences have occurred in the past decade. Encyclopedia of the Neurological Sciences, Third Edition, Seven Volume Set, will cover and review all major areas of neuroscience and will be one of the few publications that can provide a complete overview of the neurological sciences in an easily accessible electronic format. All 21 sections and approx. 600 chapters will contain extensive supplemental links to useful references. Of special note are the new and paradigm shifting developments in genetics, immunology, molecular neurobiology, neuro-diagnostic tools and therapies for neurological disorders. This new edition will provide a thorough and easily accessible update in all areas of the neurological sciences. The sections and chapters will be written by internationally recognized experts from around the world and will be a valuable resource for all researchers, students and established scientists in the fields of neurology, psychiatry, and neurosurgery.
Lipases: Foundations, Applications, and Perspectives, a new volume in the Foundations and Frontiers of Enzymology series, offers a practical, in-depth discussion of lipases and instruction in their use across research and industry. Here, global experts in the field introduce readers to basic lipase biology and the history of the field, interfacial activation and lipase lids, evolving analytical techniques and technology for studying lipases, and a range of lipase applications, from health and drug discovery to biofuels, food, cosmetics, and waste treatment. Lipase sources and production methods discussed include mammalian lipases, microbial lipase production, biomass lipase production, immobilized lipases, and tailor-made recombinant lipases, among other approaches.
Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology.The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry.
Dissipative Particle Dynamics: Fundamentals and Applications in Soft Matter Science and Engineering comprehensively presents the fundamentals of DPD theoretical formulations and computational strategies, providing practical guidance on the application of DPD models to various colloidal and interfacial phenomena involving phase separations, self-assembly and transport in complex fluids, polymeric, surfactant, nanoparticle, and biological systems. In addition, the book contains instructive advice on efficient implementation of the DPD models in open-source computational packages. Since the introduction of the principles of DPD methodology, multiple efforts have been made to improve the computational basis of DPD, and to devise advanced versions and modifications.While there are numerous research papers on the topic, but no books until now, this resource is dedicated to the dissipative particle dynamics with a critical review of various DPD formulations. Readers will find this to be a comprehensive reference source of multifaceted interdisciplinary applications that provides practical guidance for efficient computational implementation.
Viral Hemorrhagic Fevers: Epidemiology, Pathogenesis, Management, and Preparedness covers the causative agents, outbreaks, and clinical management of emerging and re-emerging viral hemorrhagic fevers. Coverage includes a range of topics from basic virology, epidemiology, and disease pathogenesis of emerging and re-emerging hemorrhagic fever viruses. The book examines host-virus interactions, immune pathogenesis, and recent trends in disease diagnostics. It also covers current state-of-the-art in understanding molecular mechanisms of disease pathogenesis, the potential of molecular markers for disease prognostics, early prediction of disease outcome, advancements in diagnosis and drug development, and strategies in pandemic preparation, mitigation, and responses in public health security.With chapters written and compiled by a team of well-known virologists, clinicians as well as regulatory and public health experts. This book is a comprehensive guide that will help users understand the transmission, pathogenesis, and clinical management of emerging and re-emerging viruses causing hemorrhagic diseases.
Cryo-Electron Tomography: A Journey from Sample Preparation to Data Mining providing a holistic overview of this rapidly advancing field and equipping researchers with the knowledge and tools necessary to initiate their own investigations. The book begins with a section on advanced cryogenic sample preparation for in situ cellular tomography, covering a range of sample types including viruses, bacteria, eukaryotic cells, and perspectives for organoids and tissues. Specific chapters focus on essential approaches such as vitrification, sample thinning, and bimodal correlative techniques. The book then transitions to a section on data mining and validation.
Enzymatic Production of Oligosaccharides: From Basic Research to Industrial Production, a volume in the Foundations and Frontiers of Enzymology series, covers the enzymes used for the extraction, synthesis, or modification of oligosaccharides, the biochemical properties of those enzymes, and potential technological applications. The book is divided into three parts, the first of which shares the fundamentals on the enzymatic synthesis of oligosaccharides. The book then explores the enzymatic production of oligosaccharides, considering a range of different oligosaccharides and production processes. Final sections cover the technological properties of oligosaccharides and potential applications across the chemical, biochemical, biotechnology, and food industries.This is a useful reference for researchers working with oligosaccharides across biochemistry, enzymology, biotechnology, food chemistry and related fields.
Biotic Stress Tolerance in Horticultural Crops: Challenges and Mitigation Strategies explores concepts, strategies, and recent advancements in the area of biotic stress tolerance in horticultural crops, highlighting the latest advances in molecular breeding, genome sequencing, and functional genomics approaches. The book highlights a variety of aspects of biotic stress tolerance in horticultural crops, from classical breeding, hybrid breeding, speed breeding, epigenetics, gene/quantitative trait loci (QTL) mapping, transgenics, physiological and biochemical approaches to OMICS approaches, including functional genomics, proteomics, and genomics assisted breeding. This volume has been designed to include the advancements mitigating the effects of bacterial, viral, fungal, and insects-pests.Readers will find this to be a comprehensive resource for anyone working in the field of biotic stress management in horticultural crops, including students, educators, and scientists in industry and academia.
Ultra Widefield Imaging of the Retina covers basic anatomy and physiology of the retina, providing the technical aspects of ultra widefield retinal imaging that give readers a strong grounding in the discipline’s central tenets. The book provides a comprehensive view of the peripheral retina, enabling better detection of pathology and more accurate assessment of disease progression. It fills the knowledge gap among healthcare professionals with regard to principles, procedural aspects, and clinical applications of these innovations. In essence, anyone seeking in-depth information on imaging and the treatment of vascular chorioretinal disorders, inflammatory disorders, and chorioretinal tumors will find it here.New imaging modalities, improved image quality, and enhanced analysis techniques have proven valuable tools in the diagnosis and management of retinal diseases, hence this book will serve as a resource for clinicians and researchers to stay up-to-date in this rapidly evolving field.