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Elsevier

Books in Life sciences

  • Bioactive Compounds

    Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability
    • 1st Edition
    • Cristobal Noe Aguilar + 3 more
    • English
    Bioactive Compounds: Mechanisms, Challenges and Strategies for Bioaccessibility and Bioavailability covers nutrition, food science, and pharmacology, elucidating the intricate dynamics of bioactive compounds and their impacts on human health. This comprehensive volume delineates the crucial differences between bioaccessibility and bioavailability, providing insights into their implications for health outcomes. Readers will explore the behavior of key classes of bioactive compounds, including polyphenols, carotenoids, and peptides, as well as their sources and interactions within the food matrix. The book further examines the essential role of gut microbiota in absorption processes, highlighting how these interactions can influence bioactive compound efficacy in the human body.Sections not only discuss the mechanisms of absorption, distribution, metabolism, and excretion (ADME) of bioactive compounds but also introduce cutting-edge tools and strategies designed to enhance their bioaccessibility and bioavailability.

  • Enzymology in Drug Discovery

    • 1st Edition
    • Volume 747
    • English
    This volume is focused on the application of enzymology to drug discovery, with the overarching objective of introducing the general audience to the important role that enzymology plays in modern, molecular targeted drug discovery. The volume opens with a chapter on the role of enzymes in normal human physiology and the causal role played by aberrant enzyme activity in various disease state. A second chapter provides a comprehensive review of inhibition modalities for therapeutic enzyme inhibitors. From there the volume is composed of chapters that cover two general categories of information: (1) methodologies for studying enzyme-ligand interactions and (2) case studies of molecular targeted drug discovery against specific enzyme targets. Chapters within the first category cover methods such as assay design, the role of structural biology in drug optimization, analysis of slow and tight binding inhibitors, enzyme-inhibitor complex dynamics, and covalent enzyme inactivators. The second category includes case studies of therapeutic inhibitors of various enzyme target classes: proteases, methyltransferases, histone demethylases, helicases, nucleic acid processing enzymes, kinesin motor proteins, and cytochrome P450s. Finally, a chapter is also devoted to therapeutic replacement or repair of defective enzymes.

  • Sarcoma Immunology and Immunotherapy

    From Cellular Mechanisms to Clinical Translation
    • 1st Edition
    • Joseph Crompton
    • English
    Sarcoma Immunology and Immunotherapy offers a timely and comprehensive review of the rapidly evolving field of sarcoma immunology and immunotherapy. This book serves as an essential resource for healthcare professionals, scientists, and patients, providing insights into the immunologic features of sarcoma and the latest immune-based treatments. Focussing on the recent advances, the book discusses the sarcoma microenvironment and the development of innovative immunotherapies tailored for sarcoma patients. Readers will benefit from a thorough overview of existing knowledge, encompassing foundational concepts in sarcoma immunology, a detailed examination of laboratory research, and a complete summary of ongoing immunotherapy trials. This holistic approach ensures a robust understanding of the current landscape in sarcoma research and treatment. By equipping readers with essential background information and comprehensive reviews, this book fosters a deeper understanding of sarcoma immunology and therapeutic strategies. It empowers healthcare professionals and scientists to stay abreast of critical studies, ultimately enhancing patient care and outcomes in this challenging field.

  • Euphorbiaceae Family Oriented Drug Discovery

    Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family
    • 1st Edition
    • Bingjie Li + 1 more
    • English
    Euphorbiaceae Family Oriented Drug Discovery, Exploration of Isolation, Identification, Total Synthesis, and Drug Discovery Based on Natural Products from Euphorbiaceae Family, a volume in the Drug Discovery Opinions series, aims to comprehensively explore the isolation, identification, synthesis, and drug discovery based on natural products derived from the Euphorbiaceae family. Focused on the isolation, identification, synthesis of bioactive compounds, and drug discovery techniques, the contents of the book are organized into ten chapters. The book opens with an introduction to the Euphorbiaceae family, its botanical overview, medicinal significance, and the importance of exploring its natural products for drug discovery.The next chapters focus on specific techniques for identification and synthesis of natural products, cover the antitumor activities and mechanisms of action of natural products, and discuss the specific antimicrobial properties and mechanisms of action. Final sections discuss anti-inflammatory properties, pharmacology, drug discovery processes for Euphorbiaceae Natural Products, and describe challenges and future directions in research. The final chapter presents final considerations, summarizing key findings and insights from the book.

  • Enzymology for Biotechnologists

    • 1st Edition
    • Timir Tripathi + 1 more
    • English
    Enzymology for Biotechnologists provides a comprehensive introduction to enzymology with a strong focus on its applications in biotechnology. Chapters cover the fundamental principles of enzyme structure, function, kinetics, and assays, and extends into advanced topics such as enzyme production, immobilization, reactor design, process intensification, and the use of enzymes in low-water and green solvent systems. Special attention is given to industrial applications, grey and white biotechnology, and the integration of processes that highlight sustainability and innovation. The book presents enzymology from a perspective of biotechnology, and focuses on scale-up, process design, and industrial applications. This targeted approach makes sure that BTech, MTech, MSc, and PhD students, as well as researchers and professionals, gain not only a solid understanding of enzyme science but also its translation into real-world biotechnological processes.

  • RNA-Binding Proteins Part D

    • 1st Edition
    • Volume 746
    • English
    A central theme of this volume is the dynamic relationship between RNA structure, RNA-binding proteins, and cellular organization. The chapters integrate experimental, computational, biochemical, biophysical, imaging, and systems-level approaches to investigate how RNA–protein interactions regulate RNA processing, translation, localization, stability, phase separation, and cellular stress responses. As Volume 746 of the Methods in Enzymology series, the volume emphasizes the integration of methodological innovation with biological applications, providing researchers with practical approaches to dissect how RNA–protein interactions govern RNA fate and function, biomolecular condensate formation, and stress granule assembly.Overall, this collection highlights the transition of RNA biology from a primarily sequence-centered discipline toward a more dynamic view in which RNA structure, molecular interactions, phase separation, cellular organization, and signaling are intimately connected. It will therefore be a valuable resource for researchers and students seeking both practical methodologies and mechanistic insights into the rapidly expanding field of RNA biology.

  • Neonatal Surgery

    Techniques, Evidence and Outcomes
    • 1st Edition
    • David J. Hackam
    • English
    Neonatal Surgery: Techniques, Evidence, and Outcomes addresses the growing need for specialized surgical care in neonates, whose unique physiology demands distinct considerations from other surgical populations. Written by leaders in the field, this definitive textbook is the first devoted entirely to neonatal surgery, filling a vital gap in the literature with evidence-based guidance on timing, technique, and postoperative management for optimal outcomes. The book opens with the general care of the neonatal surgical patient, covering anatomy and physiology, preoperative workup, anesthesia, pain management, nursing, family experience, transport, nutrition, pharmacy, vascular access, and radiographic considerations. Subsequent sections address specialized areas including head and neck, thoracic, abdominal, urologic, orthopedic, neurosurgical, plastic and reconstructive, and congenital heart surgery, each offering detailed, evidence-based guidelines and techniques for managing specific conditions. The book concludes with a look at the future of neonatal surgery and considerations for surgery in low- and middle-income countries. An invaluable resource for clinical learners and practicing surgeons alike, it serves as a critical how-to guide for students and residents and an authoritative reference for practicing surgeons, including evidence-based management strategies. Researchers will find it indispensable for understanding the metabolic and physiological responses to neonatal surgery, adding translational relevance to their work. This textbook is essential for anyone involved in the surgical care of neonates, providing the knowledge needed to achieve the best possible outcomes

  • Sleep Neurology

    • 1st Edition
    • Anne Marie Morse
    • English
    Sleep Neurology explores the intricate relationship between sleep and neurological health, bridging the gap between theoretical knowledge and practical application. This comprehensive reference highlights the role of sleep in overall health and provides an examination of how sleep influences a wide range of neurological disorders. From neurodevelopmental issues to neurodegenerative diseases, this book offers a detailed review of how sleep science can be applied to improve patient outcomes in various neurological conditions. Structured around key neurological topics, the book offers insights into conditions such as epilepsy, stroke, and traumatic brain injury, emphasizing the importance of sleep management in their treatment. Each chapter not only discusses the scientific underpinnings of sleep but also provides tangible strategies for integrating sleep health into primary neurological care.

  • Next-Generation Food Bioactives

    Mechanisms, Technologies, and Translational Applications
    • 1st Edition
    • Karuppusamy Arunachalam + 3 more
    • English
    Next-Generation Food Bioactives: Mechanisms, Technologies, and Translational Applications offers a thorough examination of food-derived bioactive compounds such as polyphenols, flavonoids, polysaccharides, peptides, and saponins, and their significance in health promotion, disease prevention and the development of functional foods and nutraceutical products. Divided into six comprehensive sections, the book covers the fundamental properties of these compounds, advanced extraction and analysis methods, and explores their molecular mechanisms and interactions with the gut microbiome. Next-Generation Food Bioactives: Mechanisms, Technologies, and Translational Applications further discusses challenges related to bioavailability, safety, and regulatory considerations, while highlighting emerging trends such as the integration of artificial intelligence and omics technologies in bioactive discovery and functional food formulation. Designed for researchers, industry scientists, and healthcare professionals, this book provides valuable insights to support innovation and evidence-based development in the field of food bioactives.

  • Wearable Biosensors for Healthcare

    Techniques and Applications
    • 1st Edition
    • Vigneswaran Narayanamurthy + 2 more
    • English
    Wearable Biosensors for Healthcare: Techniques and Applications is a comprehensive exploration of the transformative role of wearable biosensors in modern healthcare. The book explains the integration of artificial intelligence in health monitoring, showcasing how AI enhances data analysis and personalized health insights. Through practical case studies, sections illustrate real-world implementations across various healthcare domains, including chronic disease management, fitness tracking, and mental health monitoring. Additionally, it emphasizes the importance of interdisciplinary design principles, highlighting the need for collaboration among engineering, medicine, and data science to develop effective wearable solutions. Addressing technical challenges and proposing future research directions, this book serves as a vital resource for anyone interested in the intersection of technology and healthcare, ultimately aiming to inspire further innovation in the field of wearable biosensing.

  • Legal Issues in Quality for Healthcare Institutions

    • 1st Edition
    • Ramesh Sachdeva
    • English
    Legal Issues in Quality for Healthcare Institutions provides the perspective of practicing physicians, lawyers, and academic legal scholars to comprehensively address the implications for quality of care and patient safety both from a legal, medical, and improvement science standpoint. Hospital administrators, physicians, nurses, researchers, legal scholars, as well as regulatory and compliance officers working in hospitals and acute care facilities will find this to be a helpful resource in understanding and addressing the many facets and issues in the field of medicine and law related to quality and patient safety.

  • Endometriosis and Associated Pain

    Bridging Theory and Practice
    • 1st Edition
    • Chi Chiu Wang
    • English
    Endometriosis and Associated Pain: Bridging Theory and Practice is a comprehensive professional resource comparing Eastern and Western perspectives on endometriosis-relate... pain and co-morbidities. It addresses a significant gap by summarizing clinical, pathological, and social aspects, highlighting strengths and weaknesses in both traditions synthesizing existing evidence. The book targets basic science researchers and clinicians in women’s health, reproductive biology, and pain medicine, providing detailed reviews, recent developments, and future directions. Structured into six sections covering clinical features, pathology assessments, treatments, alternative therapies, and global health guidelines, bringing together extensive expertise in reproductive medicine. This book is a vital, up-to-date reference for professionals seeking a cross-cultural understanding of endometriosis pain management.

  • Synthetic Biology in Medicine

    Tools and Transformative Therapies
    • 1st Edition
    • Xie Zhen
    • English
    Synthetic Biology in Medicine: Tools and Transformative Therapies covers the design and optimization of artificial biological components, gene editing systems, principles for designing and constructing artificial gene circuits, cell engineering, delivery systems of artificial biomolecules, and the prospects and challenges of synthetic biology technologies applied in drug development. The book contains many application cases related to clinical practice and industry, offering references for solving industrial pain points.

  • Drug Repurposing in Cancer Research

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    Drug Repurposing in Cancer Research investigates the innovative use of drug repurposing in oncology, focusing on emerging and re-emerging cancer types. The book provides a comprehensive yet concise overview of current trends, making it an essential resource for academics and professionals in the field. Structured into 21 chapters, the book presents foundational facts alongside practical and clinically relevant data. It covers topics ranging from market dynamics to AI-driven transformations in cancer treatment, highlighting the rapid advancements in oncology. This compilation ensures that readers are equipped with the latest information necessary for effective research and development. For pharmaceutical researchers, biomedical scientists, and clinicians, "Drug Repurposing in Cancer Research" offers valuable insights into the growing demand for innovative cancer treatments. It serves as a timely resource for understanding the potential of repurposed drugs, supporting efforts in cancer prevention and treatment strategies.

  • Urinary Incontinence

    Integrating Science and Clinical Practice
    • 1st Edition
    • Marcus Drake + 2 more
    • English
    Urinary Incontinence: Integrating Science and Clinical Practice succinctly describes the importance of lower urinary tract physiology to all for an understanding of urinary incontinence and its clinical treatment. World-leading contributors describe the key influences on mechanisms and therapies for proper understanding of the scientific basis of incontinence.The first part of the book is dedicated to System Physiology: Function and Adaptation. In this section, an anatomical sequence is followed for presenting the chapters, moving from the lower urinary tract organs upwards through the spinal centers to the brain. These chapters discuss what is known and unknown for crucial areas, such as neurological control and co-ordination, bladder fibrosis, bladder physiology and more.The second part is dedicated to Incontinence: Mechanism and Therapy. In this clinical application section, chapters derive from the clinical classification of incontinence and explore topics such as the role of urodynamics; mechanisms underpinning medical and interventional treatments; the sensations arising from the lower urinary tract; adverse effects of therapy and the considerable faced in managing incontinence.Written for researchers and clinicians, this book is a welcomed resource for those aiming to understand more about urinary incontinence.

  • Roles of the Cerebellum in Motor Control

    Foundations, Experimental Approaches and Clinical Applications
    • 1st Edition
    • Mario Manto + 2 more
    • English
    Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking, comprehensive reference on the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease.From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.

  • Plant Nutrient Strategies for Abiotic Stress Resilience

    • 1st Edition
    • Mamdouh A. Eissa
    • English
    Plant Nutrient Strategies for Abiotic Stress Resilience presents a cutting-edge exploration of how nutrient strategies can enhance crop resilience in the face of increasing abiotic stresses such as drought, salinity, heat, cold, and nutrient-poor soils. Through 18 comprehensive chapters authored by leading experts in plant nutrition and stress physiology, the book bridges fundamental scientific knowledge with practical agronomic applications. Maintaining crop productivity in the face of abiotic stressors such as drought, salinity, nutrient depletion, and climate variability continues to challenge crop producers around the world. At the same time, they need to ensure environmentally sustainable nutrient management in diverse and often fragile ecosystems. Many lack access to integrated, up-to-date knowledge that combines soil-plant nutrient dynamics with real-world strategies to combat stress in crops. From nutrient uptake mechanisms under stress conditions to advanced innovations such as nano-fertilizers and genetic approaches for nutrient efficiency, Plant Nutrient Strategies for Abiotic Stress Resilience offers an essential, science-based toolkit for researchers, students, consultants, and policymakers aiming to secure sustainable crop production in a changing climate.

  • Endovascular Therapy for Intracranial Atherosclerotic Stenosis

    • 1st Edition
    • Ning Ma + 1 more
    • English
    Endovascular Therapy for Intracranial Atherosclerotic Stenosis presents selected cases of endovascular treatment for intracranial atherosclerotic stenosis (ICAS), providing detailed information on periprocedural medical management, endovascular strategies, device selection, and follow-up outcomes. The book serves to improve understanding of ICAS and share clinical experiences from high-volume stroke intervention centres with neuro-interventional... The book reviews recent developments in ICAS management and presents evidence that appropriate patient selection and peri-operative planning may contribute to the effectiveness of endovascular therapy for ICAS

  • Current Approaches to Overcome Therapeutic Resistance of Leukemia

    • 1st Edition
    • Zhe-Sheng Chen + 2 more
    • English
    Current Approaches to Overcome Therapeutic Resistance of Leukemia presents a comprehensive academic resource addressing the persistent challenge of treatment resistance in leukemia. It explores biological, molecular, and clinical dimensions of resistance, bridging fundamental research with therapeutic innovation. The book examines key resistance mechanisms, including genetic mutations, leukemic stem cells, and tumor microenvironment interactions, alongside emerging insights such as epigenetic regulation, metabolic reprogramming, and immune evasion. It further highlights advanced therapeutic approaches, including immunotherapy, targeted therapies, combination strategies, and AI-driven tools for drug discovery and monitoring. This volume provides students, researchers, and clinicians with foundational and integrated knowledge essential for understanding resistance biology and translating discoveries into clinical practice. It supports evidence-based decision-making and promotes the development of innovative strategies to improve patient outcomes.

  • Cognitive Remediation in Psychiatric Disorders Part B

    Other Conditions, Contexts and Considerations
    • 1st Edition
    • Volume 307
    • English
    Cognitive Remediation in Psychiatric Disorders is a two-volume work comprising Part A: Core Psychiatric Conditions (Volume 306) and Part B: Other Conditions, Contexts and Considerations (Volume 307). Together, the volumes provide a comprehensive, contemporary account of cognitive remediation and related cognition-oriented interventions across psychiatric, neurodevelopmental, lifespan, and other clinical contexts. Part A establishes the historical, conceptual, and practical foundations of cognitive remediation and examines its application across psychosis, serious mental illness, depression, bipolar disorder, obsessive-compulsive disorder, substance use disorders, and trauma-related disorders. Part B extends the discussion to personality disorders, eating disorders, behavioral addictions, ADHD, autism spectrum disorder, intellectual and developmental disabilities, cognitive concerns in older adults, HIV-associated neurocognitive disorders, multiple sclerosis, cognitive difficulties following electroconvulsive therapy, and emerging technology-enabled approaches. Across both volumes, contributors address intervention principles and mechanisms, clinical integration, adaptation and accessibility, metacognition and subjective cognition, memory, real-world skill acquisition, and functional and vocational outcomes. Together, the volumes provide a broad, integrated framework for understanding how cognition-oriented interventions can support recovery, participation, and everyday functioning across diverse clinical populations.

  • AI and Global Health

    Unlocking Transformative Potential
    • 1st Edition
    • Adil Haider
    • English
    AI and Global Health: Unlocking Transformative Potential provides a roadmap for practitioners to apply and leverage artificial intelligence to strengthen health systems using the World Health Organization's health systems approach. The book's combination of case studies and secondary research inspires the possibility of what can happen using AI in healthcare, ensuring the use of robust, scientific evidence to draw conclusions. Additionally, readers will learn from others in settings where AI has been a tool for change, providing healthcare practitioners and policymakers with what they need to think through how it can be applied in resource limited settings.The book provides a strong call to action for policymakers and healthcare leaders of governments, international organizations, and healthcare institutions to take the lead in AI implementation as a key lever for advancing global health goals through a systems approach. As AI is a rapidly evolving field with significant investment made in this industry in recent years from government and the private sector, this book articulates how this growth can be harnessed for countries that need a different approach to addressing global health problems.

  • Molecular Chaperones in Neurodegenerative Diseases

    • 1st Edition
    • Volume 156
    • English
    Molecular Chaperones in Neurodegenerative Diseases explores the roles of molecular chaperones in maintaining protein homeostasis and their involvement in the onset and progression of neurodegenerative disorders. The book highlights current research on chaperone-mediated mechanisms, disease pathology, and emerging therapeutic approaches targeting protein misfolding and aggregation.

  • Childhood Disorders of Rickets and Osteomalacia

    A Comprehensive Review
    • 1st Edition
    • Suma Uday
    • English
    Childhood Disorders of Rickets: A Comprehensive Review defines the pathophysiology of rickets and the various genetic and acquired conditions that present with rickets in childhood. This comprehensive review details the various forms of rickets, the histopathology, recent advances leading to new therapeutic options in treating rickets, and the role of Vitamin D and calcium in nutritional rickets. Additionally, the authors explore future research in various areas of nutritional and non-nutritional forms of rickets.Written by global experts for clinicians and researchers treating and studying the various forms of rickets, the book will also be of interest to those working in public health and policy makers working on the prevention of nutritional rickets worldwide.

  • Operative Strategies in Pelvic Exenteration Surgery

    • 1st Edition
    • Michael E Kelly + 1 more
    • English
    Operative Strategies in Pelvic Exenteration Surgery is a reference for the surgical management of Pelvic Exenteration Surgery. It covers all aspects of surgery from the colorectal, urological, gynecological, and orthopedic point of view. Coverage consolidates the research of world-leaders and includes the history of exenterative study, outlining the current state and indicating future developments. The book also discusses the current surgical operative strategies for the management of locally advanced and recurrent pelvic neoplasms with illustrations, intra-op photos, and supplementary video material.Created from the experiences of an international collaboration of surgeons, this reference is the perfect reference for surgical oncologists, colorectal, gynecology, urology, and vascular surgeons as well as any group involved in complex pelvic surgery including complex open, laparoscopic, and robotic surgery.

  • Emergent Nanotherapeutics in Diabetic Complications

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Emergent Nanotherapeutics in Diabetic Complications explores how cutting-edge nanotechnology is transforming the treatment of diabetes-related disorders beyond glycemic control. This comprehensive volume examines targeted, multifunctional nanoplatforms designed to address the wide range of comorbidities linked to diabetes, including vascular complications, metabolic dysfunctions, and impaired wound healing. Structured in five parts, the book spans from current nanoformulation strategies to emerging innovations such as CRISPR-Cas9 delivery, AI-guided nanoparticles, and 3D/4D printed nanostructures.Bridg... the gap between preclinical research and clinical application, it offers valuable guidance on stimuli-responsive systems, biocompatible materials, and regulatory pathways. This is essential resource for medical professionals, biomedical engineers, and pharmaceutical scientists seeking scalable, next-generation solutions for managing diabetic complications through nanomedicine.

  • Nutritional and Health Aspects of Food in North Asia, Volume 1

    • 1st Edition
    • Lijing Ke + 2 more
    • English
    Nutritional and Health Aspects of Food in North Asia, Volume 1, is part of Elsevier's ongoing Traditional and Ethnic Food Series, complementing other volumes in the series by providing deeper scientific insight into traditional and ethnic foods from regions around the world. Supported by the Global Harmonization Initiative (GHI), an international, non-profit network of food scientists and organizations dedicated to achieving global consensus on the availability of safe, healthy food worldwide, this volume offers a representative, comprehensive, scientific review of the traditional and ethnic foods native to North Asia, specifically China, Korea, and Taiwan. It explores the history, cultural heritage, composition, preparation, nutritional value, and scientific understanding supported by modern scientific research and data, while highlighting the health-promoting properties of well-established iconic regional traditional foods such as kimchi, tea phenolics, soy-based products, fermented vegetables, and rice-based dishes, to name a few. Through contributions from leading local experts, Nutritional and Health Aspects of Food in North Asia, Volume 1, discusses the challenges and opportunities in harmonizing food regulations to facilitate the global availability of these culturally significant healthy foods. An essential resource for food and nutrition scientists, food industry professionals, policymakers, and regulators, this volume examines how traditional and historical eating habits continue to shape diets across North Asia.

  • Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities

    Evidence-Based Molecular Mechanisms and Clinical Outcomes
    • 1st Edition
    • Debidas Ghosh + 3 more
    • English
    Ethnopharmacological Strategies for Diabetes-Associated Reproductive Co-morbidities: Evidence-Based Molecular Mechanisms and Clinical Outcomes is a comprehensive, interdisciplinary reference addressing the complex link between diabetes mellitus and infertility in both men and women. This edited volume synthesizes molecular insights into diabetes-induced reproductive dysfunction—such as oxidative stress, inflammation, endocrine disruption, and tissue damage—with evidence-based evaluations of medicinal plants and their bioactive phytochemicals. It bridges laboratory research and clinical trials to highlight how plant-derived compounds can regulate glycemic control, restore hormonal balance, reduce oxidative damage, and improve gametogenesis. Targeting clinicians, researchers, and postgraduate students in biomedical and pharmaceutical sciences, the book offers detailed therapeutic profiles, safety assessments, and translational applications. By consolidating fragmented knowledge, it empowers healthcare professionals and scientists to develop integrative, cost-effective strategies for managing diabetes-related infertility.

  • Brain-Computer Interfaces (BCI)

    • 1st Edition
    • Volume 229
    • English
    Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Reasoning

    An Integrative Approach
    • 2nd Edition
    • Daniel Krawczyk
    • English
    Reasoning: An Integrative Approach, Second Edition provides an overview, summary, and synthesis of research approaches to the psychology of reasoning. Representing historical perspectives, state-of-the art research, and coverage of upcoming future directions, this volume offers an integrative approach including research on animal behavior, neuroscience, cognitive psychology, AI, development, medicine, and philosophy. The contents range from animal studies through applied situations, and present historical perspectives, discussion of both animal reasoning and human reasoning to provide a cross-species context, and an examination of human reasoning across the lifespan. Though intended primarily for neuroscientists, the book will provide an interdisciplinary examination of reasoning, synthesizing perspectives from neuroscience, cognitive psychology, animal behavior, development, and philosophy, to provide readers with a well-rounded understanding of what reasoning is, various types of reasoning, and its role in decision making and social interactions. New to this edition is research on the influence of technology throughout the book, as well as a greater emphasis on the way that cultural backgrounds and variations in our exposure to information influence our thinking. This will enhance the scope, relatability, and diversity of the book, making it more applicable to future practices and research.

  • Biopolymers for 3D Tissue Engineering

    Processing and Applications
    • 1st Edition
    • Narendra Reddy + 1 more
    • English
    Biopolymers for 3D Tissue Engineering: Processing and Applications explores the critical role of biopolymers in advancing tissue engineering and 3D cell culture—key technologies in drug discovery, personalized medicine, and disease treatment. The book provides a comprehensive overview of the structure, properties, and processability of biopolymers with a focus on innovative techniques for converting them into functional scaffolds suitable for 3D cell culture. Sections cover carbohydrates, proteins, and synthetic biopolymers in a single, authoritative source, making it invaluable for students, researchers, professionals, and industry stakeholders.As scaffolds form the foundation of these applications, current options—primarily synthetic polymers like polypropylene, polyethylene, or polystyrene, and some natural materials such as collagen and silk fibroin—are often expensive and lack optimal properties such as biocompatibility, biodegradability, and mechanical stability. This book addresses the global effort to develop next-generation scaffolds that overcome these limitations. As biopolymers offer a compelling solution, with inherent biodegradability, biocompatibility, and sustainability, this book guides on the latest technologies and innovations.

  • The Evolution of Artificial Intelligence in Healthcare and Medicine

    From Basic Methods to Clinical Practice
    • 1st Edition
    • Mario Cannataro
    • English
    The Evolution of Artificial Intelligence in Healthcare and Medicine: From Basic Methods to Clinical Practice explores revolutionary technological advancements in the medical and healthcare realms due to generative AI and Deep Learning. This comprehensive guide not only explores cutting-edge technologies such as transformers and large language models for newcomers but also demystifies advanced applications like sequential decoding techniques and segmentation algorithms rarely explored in other literature. Sections cover foundational concepts and terminologies, explore deep learning and generative AI, provide AI's role in biomedical research, examine its integration into clinical practice, scrutinize its applications in public health, and discuss challenges and future prospects.This is an indispensable resource for healthcare professionals, scientists, researchers, students, and enthusiasts seeking to deepen their understanding of this rapidly evolving field.

  • Current Research on Biofilm Mediated Chronic Diseases

    Immunological Background and Clinical Interpretations
    • 1st Edition
    • Dibyajit Lahiri + 3 more
    • English
    Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations is an in-depth exploration of the complex interplay between biofilms, the immune system, and chronic diseases. These microbial communities, encased in self-produced extracellular polymeric substances (EPS), adhere to surfaces and resist environmental stresses, including host immune responses and antimicrobial agents.This comprehensive book investigates the formation, characteristics, and profound impact of biofilms on human health. Coverage spans the fundamentals of biofilm formation, immune evasion, and antimicrobial resistance (AMR); the role of biofilms in chronic diseases including periodontal disease, chronic wounds, and respiratory and urinary tract infections; their involvement in cancer development and neural disorders via the gut-brain axis; emerging therapeutic strategies such as nanotechnology, phage therapy, and immunomodulatory approaches; and the growing application of artificial intelligence (AI) and machine learning to biofilm-immune interactions and personalized medicine.Current Research on Biofilm Mediated Chronic Diseases: Immunological Background and Clinical Interpretations provides essential insights for researchers, undergraduates, and postgraduates seeking to understand and combat the challenges posed by biofilms in chronic disease pathology. This book offers valuable knowledge on recent techniques for detecting and mitigating antimicrobial resistance (AMR) and biofilm formation, making it an indispensable resource for scientists and clinicians alike.

  • Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part B

    • 1st Edition
    • Volume 193
    • English
    Blood-Based Biomarkers for Alzheimer's and Parkinson's Disease – Part B, published as Volume 193 of the serial International Review of Neurobiology, provides a comprehensive examination of emerging blood-based biomarkers and related biological mechanisms relevant to Alzheimer's disease, Parkinson's disease, vascular cognitive impairment, stroke, and other neuropsychiatric disorders. The volume highlights advances in biomarker discovery, genetic and epigenetic determinants of neurodegeneration, extracellular vesicles and exosomes, protein misfolding, microRNA dysregulation, blood-brain barrier dysfunction, and biofluid-based biosensing technologies. It also explores the integration of artificial intelligence with multimodal biomarker datasets to improve diagnosis, prognosis, and precision medicine approaches. Bringing together contributions from international experts, this volume offers researchers and clinicians an up-to-date resource on translational developments that are shaping the future of neurodegenerative disease detection and management.

  • Application of Python in the Healthcare Technology

    Medical Data Analysis and Developing ML/AI Models
    • 1st Edition
    • Praveen Kumar M
    • English
    Application of Python in Healthcare Technology: Medical Data Analysis and Developing ML/AI Models provides comprehensive coverage of the Python programming language from a medical-based perspective. With a strong focus on utility-based learning rather than technical-based learning of Python, this title clarifies how the application of Python in the healthcare technology industry has a meaningful impact on patient care through the development of deep learning models for early prediction of diseases and the development of Clinical Decision Support System (CDS). In 13 chapters, an extensive range of topics pertaining to the intersection of Python and medical sciences is covered. Coverage defines how to set up an environment to work with python, describes Python class, methods, and functions, explains both basic and advanced statistical analysis in Python, and provides a tool to assist in the development of deep learning models such as API, Git, Github, NumPy, Pandas, and SciPy.

  • Current Advances in Cancer Stem Cells and Neoplasia Research

    • 1st Edition
    • Volume 8
    • Hirendra Banerjee
    • English
    Cancer, Volume 8 in the Stem Cell Innovation in Health and Disease series explores the rapidly evolving role of stem cells in cancer treatment. As cancer continues to impose a heavy global health burden, stem cell therapies are being recognized for their regenerative potential and ability to enhance recovery following aggressive therapies. Hematopoietic stem cell (HSC) transplantation is already a standard, FDA-approved treatment for hematologic cancers such as leukemia, myeloma, and lymphoma. These cells help regenerate healthy blood cells post-treatment. In addition, mesenchymal stem cells (MSCs) and neural stem cells (NSCs) are showing promise in preclinical models as therapeutic carriers, capable of homing to tumor sites and delivering anti-cancer agents such as nanoparticles, siRNAs, and small-molecule drugs. Recent clinical advancements include differentiation therapy, where stem cells are used to induce cancer cells to become non-cancerous. Two completed phase I clinical trials have demonstrated innovative applications: one using NSCs to convert a prodrug into a toxic compound within tumors, and another using MSCs engineered with viral enzymes to activate cytotoxic drugs directly at the tumor site. MSCs have also helped reduce graft-versus-host disease (GVHD), a major complication of stem cell transplants. This volume is divided into two main sections: understanding stem cell roles in cancer biology, and translating stem cell innovations into clinical practice. It features cutting-edge research, including organoid models, genetic editing, and iPSC technologies. Together, these insights offer a timely review of the field’s progress and its real-world potential to reshape cancer therapy.

  • Advances in Preservation and Packaging for Milk and Dairy Products

    • 1st Edition
    • Roji Waghmare + 1 more
    • English
    Preservation and shelf-life extension make food safe to eat and accessible to people all over the world, significantly reducing spoilage and waste. As a particularly perishable food group, milk and dairy products require highly effective methods of preservation and packaging in the ever-changing global food supply chain. Advances in Preservation and Packaging for Milk and Dairy Products provides in-depth knowledge of the methods and technologies used to ensure the safety, quality and shelf life of milk and dairy products. This book begins with an overview of the fundamental principles and challenges of preserving milk and dairy products. It progresses to discuss advances in both conventional and emerging preservation techniques, from thermal and fermentation methods to non-thermal technologies like high-pressure processing, pulsed electric fields, and cold plasma. This book also provides a comprehensive overview of packaging innovations, including biodegradable and active packaging. Taking an interdisciplinary approach,Advances in Preservation and Packaging for Milk and Dairy Products is a comprehensive guide for food scientists, researchers, and industry professionals working to innovate in the dairy sector.

  • Trauma During Pregnancy

    • 1st Edition
    • Jorge Hidalgo + 2 more
    • English
    Surgical Care of the Critically Ill During Pregnancy, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women in all surgical aspects including trauma. The book's authors offer best practices and evidence-based material explicitly focused on the most common complications in pregnant patients that may occur to improve patient care. It not only covers critical care investigation from medical-surgical complications that any patient can present, but also how to prepare and anticipate complications in the critical care unit.

  • Laboratory Sleep Medicine

    Fundamentals of Sleep Technology
    • 1st Edition
    • Ravi Gupta + 2 more
    • English
    Laboratory Sleep Medicine: Fundamentals of Sleep Technology, is the second of the Fundamentals of Sleep Technology series, discusses balancing the fundamentals of sleep medicine with the newest innovations in the lab. High priority is given to practices that must be followed in sleep labs to guarantee the safety of patients and workers. To make information straightforward and easy to grasp, key events in each epoch of polysomnography are showcased. This serves to walk sleep professionals cogently through the history of sleep technology advancement.Laborato... Sleep Medicine: Fundamentals of Sleep Technology is keenly aware that manual titration with PAP is the gold standard treatment for sleep apnea. However, certain patients may require oxygen treatment, which is also covered in depth. In addition, case vignettes illustrate the development of a relevant report using the following: data from a sleep diary, actigraphy, and polysomnography. How to do sleep tests in unusual situations (such as at-home sleep apnea testing and testing in an intensive care unit) are also covered.

  • The Brain Histaminergic System in Health and Disease

    • 1st Edition
    • Zhong Chen + 2 more
    • English
    Histamines in Neurology and Psychiatry summarizes histamines and their impact on neuroinflammation and brain development in key neural circuits. This book presents the latest research on the physiological regulation of a neuroendocrine responses and releases, broadly discussing histamine receptor modulators and histamine effects in neurology and psychiatry, and also including clinical applications that will be of interest to practitioners.

  • Pain Conditions of the Head and Face

    A Practical Guide to Diagnosis and Management
    • 1st Edition
    • Anat Galor + 1 more
    • English
    Pain Conditions of the Head and Face: A Practical Guide to Diagnosis and Management provides a user-friendly guide on diagnosing and managing common head and facial pain conditions using new methods and therapies. The book contains practical information, reviewing epidemiology, presenting key features, contributing mechanisms, and including treatment algorithms for common pain conditions of the head and face. Focus is given to aspects of disease that are novel and evolving, and all conditions are discussed within the framework of the latest advances in research and patient care.Doctors seeking to ameliorate their patients’ pain from such maladies as (among many others) neuropathic ocular pain, trigeminal neuralgia, herpetic neuralgia, temporomandibular disorders, burning mouth disorder, and neuropathic ear pain will require no other book to identify their patients’ illnesses and make sure they receive the care they need.

  • Metagenomics in Biotechnology

    Environmental, Industrial, and Clinical Applications
    • 1st Edition
    • Abd El-Latif Hesham + 3 more
    • English
    Metagenomics in Biotechnology: Environmental, Industrial, and Clinical Applications provides a comprehensive understanding of metagenomic biotechnology, including its underlying principles, techniques, and tools used for data analysis. It explores how metagenomics plays a crucial role in environmental and industrial applications, such as the identification and quantification of microbial communities, the bioremediation of pollutants, biofuel development, and sustainable agriculture. The book also delves into the clinical implications of metagenomics, from technological advancements, pathogen identification, detection, drug discovery, and development. This understanding helps aid in the design and implementation of innovative solutions to environmental, industrial, and clinical challenges. With current trends, challenges, and solutions in metagenomics rounding out the coverage, this book is a valuable resource for researchers, students, and professionals looking to deepen their knowledge of the various techniques used for data analysis and further leverage the potential of metagenomic biotechnology.

  • Lightweight Secure and Intelligent Approaches for Medical Devices

    Trends and Future Frontiers
    • 1st Edition
    • R. Praveen + 1 more
    • English
    Lightweight Secure and Intelligent Approaches for Medical Devices: Trends and Future Frontiers addresses the rapidly evolving intersection of artificial intelligence, Internet of Medical Things (IoMT), and edge computing within healthcare. This reference meets the critical demand for resource-efficient, secure, and trustworthy AI models tailored specifically for embedded medical devices operating under stringent constraints. By integrating advances in lightweight AI, medical device security, and intelligent data processing, the book fills a vital gap in current literature, offering researchers, engineers, and healthcare professionals a comprehensive resource to develop next-generation medical technologies. The book is organized into four parts, beginning with foundational concepts including the evolution of AI in healthcare devices, lightweight model design, and medical device security standards. It progresses to predictive intelligence and reliability, covering AI techniques for disease monitoring, device calibration, and personalized medicine. The security and privacy section explores network architectures, privacy-preserving AI, lightweight cryptography, and defenses against adversarial attacks. The final part presents emerging trends such as edge AI, digital twins, explainable AI, augmented and virtual reality applications, and quantum-safe security protocols. Each chapter combines theoretical insights with practical case studies and research perspectives to guide real-world deployment. Lightweight Secure and Intelligent Approaches for Medical Devices: Trends and Future Frontiers serves as an essential reference for researchers, medical device developers, cybersecurity professionals, and graduate students aiming to innovate secure and intelligent healthcare solutions in resource-constrained environments.

  • Halal Meat Production

    Challenges and Innovations
    • 1st Edition
    • Awis Qurni Sazili + 2 more
    • English
    With approximately 25% of the world's population identifying as Muslim, halal food encompasses an important part of global food production. Halal meat poses particular challenges as production increasingly grows in scale while regulatory standards must be maintained to keep animal welfare, handling, and slaughter practices in accordance with Islamic law. Halal Meat Production: Challenges and Innovations aims to compile the latest research and key background information on this topic, promoting additional research and improving existing practices. It will comprehensively explore recent scientific advances in halal meat production, including the fundamental concept of halal, animal welfare, and proper handling and restraining techniques. It will also address key challenges and critical topics, such as the use of stunning in halal slaughter, industrial-scale production, and cultured meat products.Halal Meat Production: Challenges and Innovations is written and edited by experts from around the world. This book offers an ideal resource for meat and livestock scientists as well as food regulatory agencies.

  • Fundamentals of 3D Food Printing and Applications

    • 2nd Edition
    • Fernanda C. Godoi + 4 more
    • English
    Fundamentals of 3D Food Printing and Applications, Second Edition offers a broad overview of 3D printing technology applied to food. This new edition outlines emerging 3D food printing technologies and their working mechanisms across a wide range of application areas, including the development of soft foods and confectionary designs. Chapters cover new trends and demands, such as changes in consumer preferences, new regulations, and new applications of 3D printing technology in the food industry. It also explores the use of natural and organic materials as printing materials to address end-user concerns about artificial food.In addition, the book covers the use of automated systems and advanced technologies, such as machine learning and artificial intelligence, to improve efficiency and consistency in 3D food printing. Case studies and best practices from industry professionals who have successfully scaled up their 3D food printing operations are presented throughout. Edited and written by a team of worldwide experts in 3D food printing, this book is the best resource covering the latest developments in 3D printing technology.

  • Dry Eye Disease

    A Clinical Handbook
    • 1st Edition
    • James Stuart William Wolffsohn + 2 more
    • English
    Dry Eye Disease: A Clinical Handbook illuminates the translation of cutting-edge research on dry eye disease into practical situations, allowing clinical diagnosis and management of the condition using the latest evidence-based methods. It first presents research on the core pathophysiological features of dry eye disease, including tear film instability, hyperosmolarity, inflammation, and ocular surface damage. Thereafter, it champions a patient-centered approach to dry eye management, emphasizing the necessity of classifying the ocular surface disease(s) most relevant to each case. It discusses global disease distribution and the role of non-modifiable risk factors like age, sex, and ethnicity. Additionally, the book describes tools for monitoring symptoms over time and assessing subtle signs of the disease. Readers will find practical methods for improving patient outcomes both in clinical settings and at home.

  • Fungal Biodeterioration and Biodegradation

    Insights into Fungal Behaviour, Mechanisms, and Applications
    • 1st Edition
    • Adesh Kumar + 3 more
    • English
    Fungal Biodeterioration and Biodegradation: Insights into Fungal Behaviour, Mechanisms, and Applications offers a comprehensive, interdisciplinary overview of fungi’s dual roles in environmental processes and material deterioration. Fungi are Earth's main recyclers, capable of breaking down complex substances like lignin, plastics, and pollutants. However, they also cause biodeterioration of food, artworks, textiles, and infrastructure, posing challenges across industries and conservation efforts. This book bridges molecular mechanisms with practical applications, providing researchers, conservators, and industry professionals with essential knowledge on how fungi interact with materials, pollutants, and microbial communities. It covers foundational topics such as fungal biology, enzymatic pathways, and colonization processes. The volume explores fungi’s role in degrading natural and synthetic polymers, petroleum products, and environmental contaminants, supported by case studies on cultural heritage preservation, bioremediation, and industrial waste management. Cutting-edge omics, enzyme engineering, and scalable biotech solutions are highlighted, along with future directions in fungal biotechnology and genetic engineering.Fungal Biodeterioration and Biodegradation equips professionals with scientific insights and practical strategies to harness fungi’s power for environmental cleanup, sustainable industry practices, and cultural conservation.

  • Plant Tissue Culture

    Techniques and Experiments
    • 5th Edition
    • Sunghun Park
    • English
    Plant Tissue Culture, Fifth Edition offers a practice-driven introduction to one of the most influential experimental platforms in plant science. Combining established methodologies with contemporary advances in biotechnology, it demonstrates how cultured cells, tissues, and organs can be used to explore plant development and morphogenesis, propagate valuable germplasm, generate novel variation, and support crop trait enhancement.Structur... around a series of laboratory exercises, the book enables technical proficiency alongside an in-depth understanding of the biological principles that govern cellular growth, function, and regenerative responses. Readers are guided through the investigative techniques that have shaped the field, from micropropagation and embryo rescue to protoplast technologies and plant transformation, illustrating how in-vitro systems continue to serve as powerful tools for both discovery and application.This fully revised edition also discusses the expanding relationship between culture-based methods and molecular approaches, including genome editing and RNA interference. Building on decades of established principles and placing cutting-edge developments in the broader context of plant research and agricultural innovation, the volume highlights the continuing evolution of a discipline that remains central to unlocking and harnessing plant potential.

  • Omics Bioprospecting of Beneficial Microorganisms in Sustainable Agriculture

    • 1st Edition
    • Sergio de los Santos Villalobos + 2 more
    • English
    Advances in high-throughput sequencing, systems biology, and microbiome science reveal unprecedented opportunities to harness microbial diversity for crop productivity, soil health, nutrient management, and pest and disease control. These technologies are enabling researchers to move beyond the simple identification of useful microorganisms toward a mechanistic understanding of their functions, interactions, and uses in agricultural systems.Omics Bioprospecting of Beneficial Microorganisms for Sustainable Agriculture examines how genomic, transcriptomic, proteomic, metabolomic, metagenomic, and integrated multi-omics approaches are accelerating the discovery and development of agricultural biologicals. Chapters cover plant-growth-promoti... and nutrient-solubilizin... bacteria, mycorrhizal and endophytic fungi, insect-associated microorganisms, bacteriophages, and plant-associated viruses, highlighting their roles in supporting plant health and ecosystem resilience.In addition to discovery pipelines, the book addresses emerging tools for community profiling, activity characterization, microbial engineering, and precision agriculture. Real-world applications and case studies demonstrate how these approaches are being translated into reduced reliance on chemical inputs and suited to specific crops and growing conditions.The volume concludes with discussions on biosafety, regulatory frameworks, commercialization challenges, climate resilience, and future directions for microbiome-based innovations. Bringing together perspectives from leading scholars across disciplines, it provides a comprehensive reference for scientists, agronomists, microbiologists, biotechnology professionals, and graduate students committed to strengthening food security.

  • Quercetin in Drug Discovery

    • 1st Edition
    • Gautam Sethi + 2 more
    • English
    Quercetin in Drug Discovery is a detailed reference exploring the multifaceted pharmacological potential of quercetin, a naturally occurring flavonoid with significant therapeutic promise. Addressing the critical need for consolidated knowledge, this guide highlights quercetin’s diverse biological activities and the translational challenges limiting its clinical applications, making it essential for researchers and pharmaceutical scientists. The comprehensive table of contents covers quercetin’s pharmacological properties, molecular docking studies, and ADME profiles, alongside therapeutic applications in cardiovascular diseases, cancer, and other conditions. It further examines bioavailability enhancement strategies, drug formulation, innovative delivery systems, and clinical trial evidence. Contributions from leading experts provide detailed insights into signaling pathways, molecular targets, and synthetic derivatives. Quercetin in Drug Discovery equips pharmacologists, medicinal chemists, and pharmaceutical scientists with critical information to advance research and drug development. By addressing bioavailability issues and regulatory considerations, this reference supports the translation of quercetin from bench to bedside, fostering innovation in natural product-based therapeutics.

  • Metabolic Reprogramming in Breast Cancer: A New Frontier in Therapy

    • 1st Edition
    • Volume 408
    • English
    Metabolic Reprogramming in Breast Cancer: A New Frontier in Therapy explores how altered metabolic pathways drive breast cancer progression, survival, and treatment resistance. The book highlights emerging insights into tumor metabolism and discusses how these discoveries may open new avenues for targeted and more effective therapies.

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