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Elsevier

Structural Biology of Ubiquitination

From Mechanisms to Interventions

  • 1st Edition - November 25, 2026
  • Latest edition
  • Editors: Navaneet Chaturvedi, Vijay Kumar
  • Language: English

Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and th… Read more

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Description

Structural Biology of Ubiquitination: From Mechanisms to Interventions provides an in-depth exploration of the structural and biophysical principles governing ubiquitination and their implications in diseases such as cancer and neurodegeneration. The book seamlessly integrates experimental insights with advanced computational methods, including AI-driven drug discovery, molecular modeling, and biophysical simulations, offering a comprehensive toolkit for researchers and clinicians. By bridging fundamental science with translational applications, the book empowers readers to design targeted therapeutics, understand disease mechanisms at the molecular level, and accelerate progress toward personalized medicine.

Key features

  • Provides structural insights into ubiquitination pathways and their roles in diseases such as cancer and neurodegeneration
  • Utilizes computational and AI-driven approaches to advance drug discovery
  • Highlights the therapeutic relevance of the ubiquitin-proteasome system
  • Bridges experimental and computational research to support precision medicine

Readership

Structural biologists; biochemists; researchers in cancer biology, neuroscience, and molecular biophysics; computational biologists specializing in molecular modeling and AI-driven drug discovery; graduate students and faculty in biochemistry, computational biology, and cancer research

Table of contents

1. Introduction to Ubiquitination: Mechanisms, enzymes (E1, E2, E3), and biological significance

2. Structural level of Ubiquitination through the eyes of Cryo-EM, X-ray crystallography, and NMR

3. Structural biology of Ubiquitin ligases

4. Computational Biophysics in Ubiquitination Studies

5. Dysregulation of Ubiquitination in Cancer: Molecular mechanisms and oncogenic pathways

6. Deubiquitinases (DUBs) as Cancer Regulators: Structural and Computational Insights for targeted therapy

7. Dysregulation of Ubiquitination in Neurodegeneration: Molecular mechanisms and neurodegenerative pathways
8. Deubiquitinases (DUBs) in Amyotrophic Lateral Sclerosis (ALS): Mechanisms and therapeutic interventions

9. AI and Machine Learning in Ubiquitination and Drug Discovery

10. PROTACs and Targeted Protein Degradation Strategies in Ubiquitination-linked Disease Therapy

11. Challenges and Future Perspectives in Ubiquitination Research

12. Translational Research and Clinical Trials in Ubiquitination-Targeted Therapy

Product details

  • Edition: 1
  • Latest edition
  • Published: November 25, 2026
  • Language: English

About the editors

NC

Navaneet Chaturvedi

Navaneet Chaturvedi is an assistant professor at the Amity Institute of Biotechnology, Amity University, Noida, India. He has built a solid foundation and essential skills for a research-intensive role. With extensive experience, Dr. Chaturvedi is eager to contribute to the vibrant research community. His work spans institutions worldwide, including Tel Aviv University, IIT BHU, University of Information Science & Tech North Macedonia, University of Leicester, and PharmCADD in South Korea, enabling collaboration with multidisciplinary teams and fostering innovation. His expertise includes molecular dynamics simulation, molecular docking, free energy calculations, machine learning, protein folding, and computer-aided drug design. Dr. Chaturvedi has a growing portfolio of research and review articles and book chapters published in leading international journals and publishers.
Affiliations and expertise
Assistant Professor, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India

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Vijay Kumar

Prof. Vijay Kumar is a distinguished faculty member and researcher specializing in Structural biology, Protein chemistry and neurosciences. He holds the position of Professor of the Department of Biotechnology, Anand School of Engineering and Technology, Sharda University, Agra. Prof. Kumar is internationally recognized and ranks among the top 2% of most cited scientists according to the STANFORD list. He earned his PhD in Biophysics from AIIMS, New Delhi, and completed a postdoctoral fellowship at UMass Medical School, focusing on folding and aggregation of proteins such as SOD1 and TDP-43 implicated in motor neuron disease, ALS, and FTD. He also served as Principal Investigator under the DST-SERB Young Scientist Scheme at Jamia Millia Islamia. His current research focuses on protein folding, misfolding, and aggregation, and the role of toxic RNA species in neurodegenerative diseases. He is a member of the Protein Society, Indian Biophysical Society, Indian Academy of Neurosciences, and the International Society for Neurochemistry. He has held fellowships from CSIR, India and a DAAD fellowship in Germany.

Affiliations and expertise
Professor of the Department of Biotechnology, Anand School of Engineering and Technology, Sharda University, Agra.”