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Books in Nucleic acids

BooksJournals

    • Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

      • 1st Edition
      • Surendra Nimesh + 2 more
      • English
      Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc.

    • Purines, Pyrimidines and Nucleotides and the Chemistry of Nucleic Acids

      • 1st Edition
      • T. L. V. Ulbricht
      • Robert Robinson
      • English
      Purines, Pyrimidines and Nucleotides and the Chemistry of Nucleic Acids is a five-chapter text that presents a simple introduction to the basic chemistry of purines and pyrimidines and their derivatives. The opening chapters describe the general properties, reactions, and synthesis of purines and pyrimidines. The next chapter deals with the structure, synthesis, mechanism, and stereochemistry of nucleosides and their analogues. These topics are followed by a discussion on the reactions and biosynthesis of nucleotides. The final chapter focuses on the structure and biosynthesis of DNA, RNA, and other nucleic acids. This book is of value to organic chemists and biochemists, as well as researchers in the allied fields.

    • Dynamics of Proteins and Nucleic Acids

      • 1st Edition
      • Volume 92
      • English
      Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

    • The biochemistry of the Nucleic Acids

      • 1st Edition
      • J.N. Davidson
      • English
      The Biochemistry of the Nucleic Acids provides an elementary outline of the main biochemical features of nucleic acids and nucleoproteins. The book describes the occurrence and biological functions of nucleic acids, their chemical constituents, and catabolism. This text is organized into 14 chapters and begins with a historical overview, from the discovery of the nucleic acids to their isolation and characterization. The discussion then shifts to bacterial transforming factors and transduction phenomena, along with the genetic function and metabolic stability of DNA, the chemical composition of the cell nucleus, and the Feulgen nucleal reaction. The reader is methodically introduced to the structure and biosynthesis of RNA and DNA; nucleic acids found in viruses; and biosynthesis of mononucleotides. An account of nucleases and related enzymes is also given. A chapter on the precise mechanism by which nucleic acids are broken down in the cell concludes the book. This book is intended for students of biochemistry, chemists, and biologists.

    • The Nucleic Acids

      • 1st Edition
      • Erwin Chargaff
      • English
      The Nucleic Acids, Volume III covers the significant progress in understanding the chemistry and biological importance of the nucleic acids. This volume is composed of 12 chapters, and begins with an overview of the general principles of the determination of weight, shape, and dimension of large molecules in solution. These topics are followed by discussions on the photochemistry of nucleic acids and its constituents; chemical and enzymic synthesis of polynucleotides; and nucleic acid content and dynamics of bacterial viruses. The next chapters describe the biosynthesis of purine and pyrimidine nucleotides. A chapter examines the relationship of nucleic acid and protein synthesis through considering cell-free systems, particularly those derived from mammalian tissues. Another chapter looks into the protein biosynthesis in intact bacterial cells. The final chapters explore the nucleic acid metabolism, with a special emphasis on the effect of radiation on the process. This book is of value to organic chemists and biochemists.

    • microRNAs in Development

      • 1st Edition
      • Volume 99
      • English
      This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike.

    • Cellular RNA Interference Mechanisms

      • 1st Edition
      • Volume 102
      • English
      This volume explores some of the most exciting recent advances in basic research on cellular RNA interference mechanisms and how this knowledge is leading to advances in the various fields.

    • Progress in Nucleic Acid Research and Molecular Biology

      • 1st Edition
      • Volume 82
      • P. Michael Conn
      • English
      Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences, including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

    • Electrochemistry of Nucleic Acids and Proteins

      Towards Electrochemical Sensors for Genomics and Proteomics
      • 1st Edition
      • Volume 1
      • E. Palecek + 2 more
      • English
      DNA (sometimes referred to as the molecule of life), is the most interesting and most important of all molecules. Electrochemistry of Nucleic Acids and Proteins: Towards Electrochemical Sensors for Genomics and Proteomics is devoted to the electrochemistry of DNA and RNA and to the development of sensors for detecting DNA damage and DNA hybridization. Volume 1, in the brand new series Perspectives in Bioanalysis, looks at the electroanalytical chemistry of nucleic acids and proteins, development of electrochemical sensors and their application in biomedicine and in the new fields of genomics and proteomics. The authors have expertly formatted the information for a wide variety of readers, including new developments that will inspire students and young scientists to create new tools for science and medicine in the 21st century.