Principles of Nucleic Acid Structure
- 2nd Edition - October 14, 2021
- Imprint: Academic Press
- Authors: Stephen Neidle, Mark Sanderson
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 6 7 7 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 9 6 7 8 - 6
Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid struct… Read more
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Request a sales quotePrinciples of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).
This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
- Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge
- Defines technical terms for novices
- Includes a complete list of resources, including relevant online databases and software, as well as useful websites
Researchers in structural and molecular biology, biochemistry and drug discovery, chemistry, chemical biology, as well as advanced undergraduate and graduate students studying nucleic acid structure and function
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface to the second edition
- Preface from the first edition
- Chapter 1. Methods for studying nucleic acid structure
- 1.1. Introduction
- 1.2. X-ray diffraction methods for structural analysis
- 1.3. NMR methods for studying nucleic acid structure and dynamics
- 1.4. Cryo-EM methods for macromolecular complexes
- 1.5. Molecular modelling and simulation of nucleic acids
- 1.6. Chemical, enzymatic and biophysical probes of structure and dynamics
- 1.7. Sources of structural data
- 1.8. Visualisation of nucleic acid molecular structures
- Chapter 2. The building blocks of DNA and RNA
- 2.1. Introduction
- 2.2. Base pairing
- 2.3. Base and base pair flexibility
- 2.4. Sugar puckers
- 2.5. Conformations about the glycosidic bond
- 2.6. The backbone torsion angles and correlated flexibility
- Chapter 3. DNA structure as observed in fibres and crystals
- 3.1. Structural fundamentals
- 3.2. Polynucleotide structures from fibre diffraction studies
- 3.3. B-DNA oligonucleotide structure as seen in crystallographic analyses
- 3.4. A-DNA oligonucleotide crystal structures
- 3.5. Z-DNA – left-handed DNA
- 3.6. Bent DNA
- 3.7. Concluding remarks
- Chapter 4. Non-standard and higher-order DNA structures: DNA–DNA recognition
- 4.1. Mismatches in DNA
- 4.2. DNA triple helices
- 4.3. Guanine quadruplexes
- 4.4. The i-motif
- 4.5. DNA junctions
- 4.6. Unnatural DNA structures
- Chapter 5. Principles of small molecule–DNA recognition
- 5.1. Introduction
- 5.2. DNA–water interactions
- 5.3. General features of DNA–drug and small-molecule recognition
- 5.4. Intercalative binding
- 5.5. Intercalative-type binding to higher-order DNAs
- 5.6. Groove-binding molecules
- 5.7. Small-molecule covalent bonding to DNA
- Chapter 6. RNA structures and their diversity
- 6.1. Introduction
- 6.2. Fundamentals of RNA structure
- 6.3. Transfer RNA structures
- 6.4. Ribozymes
- 6.5. Riboswitches
- 6.6. The ribosome, a ribozyme machine
- 6.7. RNA-drug complexes
- 6.8. RNA motifs
- 6.9. RNA databases
- Chapter 7. Principles of protein–DNA recognition
- 7.1. Introduction
- 7.2. Direct protein–DNA contacts
- 7.3. Major groove interactions – the α-helix as the recognition element
- 7.4. Zinc finger recognition modes
- 7.5. Other major groove recognition motifs
- 7.6. Other DNA binding domains
- 7.7. Minor groove recognition
- 7.8. DNA bending and protein recognition
- 7.9. Protein–DNA small-molecule recognition
- 7.10. DNA-binding proteins and their role in genomics
- Chapter 8. RNA binding proteins
- 8.1. Aminoacyl synthetase–tRNA complexes
- 8.2. Structure of reverse transcriptases
- 8.3. snRPs (small nuclear ribonucleoproteins)
- 8.4. The ribosome
- Index
- Edition: 2
- Published: October 14, 2021
- No. of pages (Paperback): 454
- No. of pages (eBook): 454
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128196779
- eBook ISBN: 9780128196786
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Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.
Affiliations and expertise
Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UKMS
Mark Sanderson
Mark Sanderson is a Visiting Professor of Biophysics in the Dept of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London. Recent structural studies in his laboratory have centred on type-II topoisomerase–DNA–drug complexes in collaboration with Prof. Mark Fisher’s group at St. George’s University of London using cryo-EM and X-ray crystallography, and the study of novel nucleic acid–protein complexes.
Affiliations and expertise
Visiting Professor, Faculty of Medicine, Imperial College London, UKRead Principles of Nucleic Acid Structure on ScienceDirect