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Hypercortisolism: Diagnosis and Differential Diagnosis

  • 1st Edition, Volume 132 - June 1, 2026
  • Latest edition
  • Editor: Marta Araujo Castro
  • Language: English

Hypercortisolism: Diagnosis and Differential Diagnosis, Volume 132 presents a comprehensive series of chapters focused on the various aspects of endogenous hypercortisolism as con… Read more

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Description

Hypercortisolism: Diagnosis and Differential Diagnosis, Volume 132 presents a comprehensive series of chapters focused on the various aspects of endogenous hypercortisolism as contributed by an international team of specialists in endocrinology. Chapters in this new release include Cushing´s syndrome: Clinical presentation and associated comorbidities, Biochemical diagnosis of hypercortisolism: when and how?, ACTH independent Cushing syndrome: diagnosis and etiology, Bilateral macronodular and micronodular hyperplasia: biochemical, radiological and genetic diagnosis, Differential diagnosis between endogenous Cushing´s syndrome and pseudoCushing, and much more.

Additional chapters delve into Differential diagnosis of ACTH dependent Cushing´s syndrome: hormonal and radiological studies, Ectopic Cushing´s syndrome: clinical presentation and diagnosis, Cyclic Cushing´s syndrome, Mild autonomous cortisol secretion: diagnosis, Cushing´s syndrome and pregnancy: clinical presentation and diagnosis, Molecular profile of Cushing´s syndrome, Cardiometabolic comorbidities in overt Cushing´s syndrome, and New tools for the diagnosis of hypercortisolism.

Key features

  • Includes tactics on the proper diagnosis of hypercortisolism, a serious, multisystemic disease that, if left untreated, can lead to severe complications and increased mortality, including cardiovascular events, diabetes, and infections
  • Covers the diagnosis of hypercortisolism and how it is complex due to non-specific symptoms, the existence of multiple potential causes, and the variability of test results
  • Distinguishes between true hypercortisolism and conditions with similar symptoms, including their differences, especially in cases like subclinical, cyclic or pseudo-Cushing's syndrome

Readership

For the following medical specialties: Endocrinology, Internal Medicine, Clinical biochemical, Genetics; and Family Medicine

Table of contents

1. Cushing´s syndrome: Clinical presentation and associated comorbidities.
Alín Abreu Lomba

2. Biochemical diagnosis of hypercortisolism: when and how?
Anna Aulinas Masó

3. ACTH independent Cushing syndrome: diagnosis and etiology
Andres Ortiz

4. Bilateral macronodular and micronodular hyperplasia: biochemical, radiological and genetic diagnosis
Víctor Navas Moreno Sr., Mónica Marazuela, Carolina Sager La Ganga and María Sara Tapia Sanchiz

5. Differential diagnosis between endogenous Cushing´s syndrome and pseudoCushing
Ahmed Alaa Abdul-Aziz

6. Differential diagnosis of ACTH dependent Cushing´s syndrome: hormonal and radiological studies
Wilfredo Antonio Rivera Martín

7. Ectopic Cushing´s syndrome: clinical presentation and diagnosis
Valentina Morrelli and Antonio Musolino

8. Cyclic Cushing´s syndrome
Elisabeth Nowak

9. Mild autonomous cortisol secretion: diagnosis
Sara Donato

10. Cushing´s syndrome and pregnancy: clinical presentation and diagnosis
Betina Biagetti Sr.

11. Molecular profile of Cushing´s syndrome
Alejandro Ibáñez-Costa and Justo Castaño

12. Cardiometabolic comorbidities in overt Cushing´s syndrome
Laura Gonzalez

13. New tools for the diagnosis of hypercortisolism
Felicia A. Hanzu and Felicia Alexandfra Hanzu

Product details

  • Edition: 1
  • Latest edition
  • Volume: 132
  • Published: June 5, 2026
  • Language: English

About the editor

MC

Marta Araujo Castro

Marta Araujo-Castro, MD, PhD, is a Consultant Endocrinologist in the Neuroendocrinology and Adrenal Unit of the Department of Endocrinology and Nutrition at Ramón y Cajal University Hospital, Madrid, Spain, and a researcher at the Ramón y Cajal Institute for Health Research (IRYCIS). She obtained her PhD from the Alcalá de Henares University, where she received the Extraordinary Doctorate Award for her research on personalized medicine in adrenal tumors using metabolomics.

Dr. Araujo-Castro completed her residency in Endocrinology and Nutrition at Hospital Universitario Puerta de Hierro Majadahonda and has developed extensive clinical and research expertise in adrenal and pituitary disorders, hereditary endocrine neoplasia, neuroendocrine tumors, and endocrine oncology. She coordinates the Adrenal and Pituitary Units at her institution and actively participates in multidisciplinary endocrine tumor and hereditary cancer boards. Her research focuses on translational endocrinology, particularly the identification of diagnostic, prognostic, and predictive biomarkers in adrenal and pituitary diseases, precision medicine, endocrine tumor genetics, and optimization of the management of patients with adrenal tumors, Cushing syndrome, pheochromocytoma/paraganglioma, and primary aldosteronism. She has led and participated in numerous national and international collaborative studies and is actively involved in several Spanish and European endocrine registries and research networks.

She is committed to advancing evidence-based endocrine practice through multidisciplinary collaboration, clinical research, education, and mentorship, with a particular focus on improving the diagnosis and personalized management of patients with hereditary endocrine tumor syndromes.

Affiliations and expertise
1Neuroendocrinology and Adrenal Unit of the Endocrinology & Nutrition Department. Hospital Universitario Ramón y Cajal. Madrid. Spain 2Ramón y Cajal Research Institute (IRYCIS), Madrid, Spain

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