Hypercortisolism: Diagnosis and Differential Diagnosis
- 1st Edition, Volume 132 - June 1, 2026
- Latest edition
- Editor: Marta Araujo Castro
- Language: English
This volume outlines a comprehensive series of chapters focused on various aspects of endogenous hypercortisolism contributed by an international team of specialists in endocrinol… Read more
Purchase options
This volume outlines a comprehensive series of chapters focused on various aspects of endogenous hypercortisolism contributed by an international team of specialists in endocrinology. The following chapters are included in the volume: 1. Clinical presentation and comorbidities: Examines how Cushing's syndrome manifests and related health conditions; 2. Biochemical diagnosis of hypercortisolism: Details diagnostic approaches for hypercortisolism, including timing and methodology; 3. ACTH-independent Cushing syndrome: Focuses on diagnosis and causes of ACTH-independent forms; 4. Bilateral macronodular and micronodular hyperplasia: Covers biochemical, radiological, and genetic diagnosis; 5. Differential diagnosis between endogenous and pseudo-Cushing: Provides strategies to distinguish between true Cushing's and pseudoCushing; 6. Differential diagnosis of ACTH-dependent Cushing's syndrome: Discusses hormonal and imaging studies for distinguishing ACTH-dependent cases; 7. Ectopic Cushing's syndrome: Reviews clinical features and diagnosis of ectopic ACTH production; 8. Cyclic Cushing's syndrome: Presents the clinical course and diagnosis of cyclic forms; 9. Mild autonomous cortisol secretion: Explores diagnostic criteria for mild autonomous cortisol excess; 10.Cushing's syndrome in pregnancy: Describes presentation and diagnosis during pregnancy; 11.Molecular profile of Cushing's syndrome: Details genetic and molecular characteristics; 12. Cardiometabolic comorbidities in overt Cushing's syndrome: Discusses cardiovascular and metabolic risks associated with the syndrome; 13.New tools for diagnosis: Introduces innovative diagnostic methods for hypercortisolism.
Each chapter is written by experts from leading medical institutions across Europe and Latin America. The chapters collectively offer a broad, in-depth exploration of Cushing's syndrome—from clinical presentation and differential diagnosis to molecular profiling and advances in diagnostic technology.
Each chapter is written by experts from leading medical institutions across Europe and Latin America. The chapters collectively offer a broad, in-depth exploration of Cushing's syndrome—from clinical presentation and differential diagnosis to molecular profiling and advances in diagnostic technology.
- Proper diagnosis of hypercortisolism is crucial because it is a serious, multisystemic disease that, if left untreated, can lead to severe complications and increased mortality, including cardiovascular events, diabetes, and infections
- The diagnosis of hypercortisolism is complex due to non-specific symptoms, the existence of multiple potential causes, and the variability of test results.
- Distinguishing between true hypercortisolism and conditions with similar symptoms is challenging, especially in cases like subclinical, cyclic, or pseudo-Cushing's syndrome.
For the following medical specialties: Endocrinology, Internal Medicine, Clinical biochemical, Genetics; and Family Medicine.
1. Cushing´s syndrome: Clinical presentation and associated comorbidities.
Alín Abreu Lomba
2. Biochemical diagnosis of hypercortisolism: when and how?
Anna Aulinas Masó
3. ACTH independent Cushing syndrome: diagnosis and etiology
Andres Ortiz
4. Bilateral macronodular and micronodular hyperplasia: biochemical, radiological and genetic diagnosis
Víctor Navas Moreno Sr., Mónica Marazuela, Carolina Sager La Ganga and María Sara Tapia Sanchiz
5. Differential diagnosis between endogenous Cushing´s syndrome and pseudoCushing
Ahmed Alaa Abdul-Aziz
6. Differential diagnosis of ACTH dependent Cushing´s syndrome: hormonal and radiological studies
Wilfredo Antonio Rivera Martín
7. Ectopic Cushing´s syndrome: clinical presentation and diagnosis
Valentina Morrelli and Antonio Musolino
8. Cyclic Cushing´s syndrome
Elisabeth Nowak
9. Mild autonomous cortisol secretion: diagnosis
Sara Donato
10. Cushing´s syndrome and pregnancy: clinical presentation and diagnosis
Betina Biagetti Sr.
11. Molecular profile of Cushing´s syndrome
Alejandro Ibáñez-Costa and Justo Castaño
12. Cardiometabolic comorbidities in overt Cushing´s syndrome
Laura Gonzalez
13. New tools for the diagnosis of hypercortisolism
Felicia A. Hanzu and Felicia Alexandfra Hanzu
Alín Abreu Lomba
2. Biochemical diagnosis of hypercortisolism: when and how?
Anna Aulinas Masó
3. ACTH independent Cushing syndrome: diagnosis and etiology
Andres Ortiz
4. Bilateral macronodular and micronodular hyperplasia: biochemical, radiological and genetic diagnosis
Víctor Navas Moreno Sr., Mónica Marazuela, Carolina Sager La Ganga and María Sara Tapia Sanchiz
5. Differential diagnosis between endogenous Cushing´s syndrome and pseudoCushing
Ahmed Alaa Abdul-Aziz
6. Differential diagnosis of ACTH dependent Cushing´s syndrome: hormonal and radiological studies
Wilfredo Antonio Rivera Martín
7. Ectopic Cushing´s syndrome: clinical presentation and diagnosis
Valentina Morrelli and Antonio Musolino
8. Cyclic Cushing´s syndrome
Elisabeth Nowak
9. Mild autonomous cortisol secretion: diagnosis
Sara Donato
10. Cushing´s syndrome and pregnancy: clinical presentation and diagnosis
Betina Biagetti Sr.
11. Molecular profile of Cushing´s syndrome
Alejandro Ibáñez-Costa and Justo Castaño
12. Cardiometabolic comorbidities in overt Cushing´s syndrome
Laura Gonzalez
13. New tools for the diagnosis of hypercortisolism
Felicia A. Hanzu and Felicia Alexandfra Hanzu
- Edition: 1
- Latest edition
- Volume: 132
- Published: June 1, 2026
- Language: English
MC
Marta Araujo Castro
Marta Araujo-Castro, MD., PhD., is an endocrinologist of the Endocrinology and Nutrition Department of the Ramón y Cajal University Hospital in Madrid, Spain. She is the coordinator of the Neuroendocrinology & Adrenal Unit of the Endocrinology Department of her hospital. Her main clinical focus and research is on pituitary and adrenal gland disorders. She is the principal investigator and coordinator of the ACRO-SPAIN Registry, the SPAIN-ALDO Registry and the PHEO-PARA-RISK Study of the Spanish Society of Endocrinology & Nutrition (SEEN). Furthermore, in the last years she has received several awards related to adrenal and pituitary disorders (Cushing´s syndrome, acromegaly, adrenal incidentalomas, pheochromocytomas and so on). She is the current coordinator of the adrenal diseases group of the SEEN, a member of the scientific board of the working group of Aldosterone Producing Adenomas (APA) of ENSAT, coordinator of the Pituitary Committee of the Ramón y Cajal University Hospital and the principal investigator of the group of Endocrine-Metabolic, Digestive and Nutrition Surgery of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS).
She has more than 150 Medline listed manuscripts, cited >1000 times. More information
Dr. Araujo-Castro is a member of the SEEN, the European Endocrine Society (ESE), Spanish Group of Neuroendocrine Tumors (GETNE), European Network for the Study of Adrenal Tumors (ENSAT), Endocrine Society, SEEN and other many medical societies.
She actively participates in several national and international congresses with presentations related to adrenal pathology. Moreover, Dra. Araujo-Castro is a professor of the master’s degree in Endocrine Oncology Pathology at TECH University; she holds the title of master’s degree in research Methodology in Health Sciences of the Laboratory of Applied Statistics of the Autonomous University of Barcelona (UAB) (Spain) and the Diploma in Statistics in Health Sciences of the UAB.
about my professional profile below:
Researchgate: https://www.researchgate.net/profile/Marta-Araujo-Castro
Twitter: Marta_Araujo_C
ORCID: https://orcid.org/0000-0002-0519-0072
Affiliations and expertise
Ramón y Cajal University Hospital, Madrid, Spain