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Elsevier

Books in Clinical biochemistry

  • Lipid Analysis in Biology, Health, and Disease

    • 1st Edition
    • Sanjoy K. Bhattacharya
    • English
    Lipid Analysis in Biology, Health, and Disease bridges the gap between discovery science and clinical lipidology, empowering both scientific and medical communities to apply lipid analysis and understanding in new research, as well as diagnosis and management of diseases. Here, international experts in the field begin with the basic biology of the lipids, followed by methods and technology for study, and lipids in lab medicine and epidemiology. This book uniquely combines biology and analysis to drive healthcare advances, with a diverse range of technologies and analytic methods considered.Basic lipid biology chapters discuss membrane expansion, lysosomal positioning, mitochondrial biogenesis, lipid-protein interactions, molecular dynamics, cholesterol transport, immune activation and inflammation, lipid droplets, and gender differences in lipid metabolism. Each disease chapter incorporates basic lipid epidemiology, risk factors, and genetic associations.

  • Bioquimica clinica

    Texto y atlas a color
    • 7th Edition
    • Michael Murphy + 2 more
    • Spanish
    Nueva ed. de esta obra de bioquímica que constituye un texto único y singular en la materia dentro de nuestro portfolio y que siempre ha mantenido el mismo abordaje: una obra visual, concisa, práctica y con un enfoque clínico. Es de destacar también el especial énfasis que se hace en la importancia de los test de laboratorio, su correcto diseño e interpretación de resultados para un correcto diagnóstico. Se mantiene su organización en 4 grandes secciones: Capítulos introductorios: Repaso de métodos y técnicas de laboratorio,Bioquími... Conceptos “core”, cubre todo el “bulk” de las pruebas bioquímicas más rutinarias y su relevancia clínica, Endocrinología: Proporciona una cobertura exhaustiva de los test bioquímicos realizados en el caso de patologías relativas a tiroides, hipófisis, glándulas adrenales, así como a las que afectan a las gónadas, siempre enfatizando su relevancia en la clínica e Investigaciones específicas: aquí se incluyen otros aspectos de pruebas y aspectos metabólicos. Cada uno de los capítulos tiene un diseño a doble página, con gran cantidad de elementos visuales, cuadros clínicos, casos, esquemas a todo color que lo convierten en “unidades didácticas” que incluso pueden estudiarse de forma individual. Las principales novedades de esta edición son la incorporación de 3 nuevos capítulos: Trastornos del páncreas, Métodos de inmunoensayo (anticuerpos.) y Métodos para la separación e identificación de moléculas. Así mismo, se han actualizado y renovado gran parte de las ilustraciones y esquemas y el número de casos clínicos que acompañan a algunos capítulos se han visto reforzados La nueva edición incluye acceso a contenido online en inglés a través de e-book+

  • Ureases

    Functions, Classes, and Applications
    • 1st Edition
    • Rodrigo Ligabu Braun + 1 more
    • English
    Ureases: Foundations, Classes, and Applications provides a thorough, practical analysis of ureases—enzymes of growing relevance across a range of biotechnological applications and drug discovery. Unique in many aspects, ureases are one of the few enzymes to have nickel in their active sites. This book covers all aspects of this enzymatic class starting with foundational overview and then providing historical urease research and current state, from basic biochemistry to the use of ureases as hallmarks in enzymology, crystallography, and bioinorganic chemistry. The different classes of ureases, structurally diverse but chemically equivalent, are individually discussed.The multi-protein, multi-step activation of ureases (with chemical modification of residues, transport, and transfer of nickel ions) are examined in-depth, along with the catalytic mechanisms of ureolysis and its inhibitors. The final two sections of the book address multiple applications of ureases in health and biotechnology, respectively, going from gastric ulcer treatment to architectural uses in buildings and engineering. Future applications and next steps in research are also considered.

  • Biochemistry of Collagens, Laminins and Elastin

    Structure, Function and Biomarkers
    • 3rd Edition
    • Morten Karsdal
    • English
    Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease. This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens.

  • Sweet Biochemistry

    Remembering Structures, Cycles, and Pathways by Mnemonics
    • 2nd Edition
    • Asha Kumari
    • English
    Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity.

  • Sulfurtransferases

    Essential Enzymes for Life
    • 1st Edition
    • Noriyuki Nagahara
    • English
    Sulfurtransferases: Essential Enzymes for Life stands as the first comprehensive resource on this increasingly important class of enzymes. Following an introduction to the field from the Editors, each chapter covers a specific sulfurtransferase, including its basic biology and roles in healthy functioning, disease, drug discovery, and other biotechnological applications. The physiological function for each enzyme is considered in depth, along with regulation mechanisms, pharmacological inhibitors, and pathology and conditions related to altered enzymatic activity. Sulfurtransferases discussed include rhodanese, MST, thiosulfate-thiol sulfurtransferase, tRNA uracil 4-sulfurtransferase, thiosulfate-dithiol sulfurtransferases, biotin synthase, cysteine desulfurase, lipoyl synthase, molybdenum cofactor sulfurtransferase, thiazole synthase, molybdopterin synthase sulfurtransferase, molybdopterin synthase, tRNA-uridine 2-sulfurtransferase, tRNA-5-taurinomethyl... 2-sulfurtransferase, tRNA-5-methyluridine (54) 2-sulfurtransferase, and L-aspartate semialdehyde sulfurtransferase, among others. Here, researchers will discover key knowledge and recent advances to bring forward new studies on this increasingly relevant class of enzymes, while clinicians may apply new findings in medical practice.

  • Human Biochemistry

    • 2nd Edition
    • Gerald Litwack
    • English
    **Selected for Doody’s Core Titles® 2024 in Biochemistry**Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more.Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

  • Contemporary Practice in Clinical Chemistry

    • 4th Edition
    • William Clarke + 1 more
    • English
    Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry.

  • Proteomic and Metabolomic Approaches to Biomarker Discovery

    • 2nd Edition
    • Haleem J. Issaq + 1 more
    • English
    Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research.

  • Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

    • 2nd Edition
    • Volume 7
    • Georg Hempel
    • English
    Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs.