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GPCRs

Structure, Function, and Drug Discovery

1st Edition - September 11, 2019

Editors: Beata Jastrzebska, Paul S.-H. Park

Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 6 2 2 8 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 6 7 2 8 - 1

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiolog… Read more

GPCRs

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GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.