Biochemistry of Collagens, Laminins and Elastin
Structure, Function and Biomarkers
- 3rd Edition - November 7, 2023
- Author: Morten Karsdal
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 6 1 7 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 6 1 8 - 2
Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elast… Read more
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Request a sales quoteBiochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease.
This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens.
- Provides an updated, comprehensive discussion of collagen and related structural proteins
- Contains insights into biochemical interactions and changes to structural composition of proteins in disease states
- Proves the importance of proteins for collagen assembly, function and durability
- Examines details on how collagens play a key role in a range of chronic diseases
- Offers approaches for protein quantification and detection of collagen aging
Active researchers in biochemistry, molecular biology, cell biology, applied microbiology, structural biology and pathology, Students
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Foreword
- Preface
- Acknowledgments
- List of abbreviations
- Introduction
- Why are collagens and structural proteins important?
- Introduction to the matrix—Interstitial and basement membranes
- Overall structure of collagens
- Collagen synthesis and other essentials
- The origin of collagens—Collagen phylogenetics
- Collagen turnover as function of age
- Why laminins?
- Understanding the epitope of a protein
- Why do we need to quantify the ECM?
- Conclusion
- The collagen history
- The diversity of the collagen family: Beyond the 28 collagen types
- Molecular and supramolecular assembly of collagens
- Collagens: A networking family in various contexts
- Chapter 1. Type I collagen
- Chapter 2. Type II collagen
- Soluble biomarkers of type II collagen
- Chapter 3. Type III collagen
- Biomarkers of type III collagen
- Chapter 4. Type IV collagen
- Composition and structure of type IV collagen
- Type IV collagen diseases
- Matrikines from the NC1 domains
- Biomarkers of type IV collagen
- Chapter 5. Type V collagen
- Autoimmunity
- Cardiovasuclar disease
- Cancer
- Biomarkers of type V collagen
- Chapter 6. Type VI collagen
- Biomarkers of type VI collagen
- Chapter 7. Type VII collagen
- Expression and function
- The role of COLVII in pathologies
- Chapter 8. Type VIII collagen
- Type VIII collagen
- Biomarkers of type VIII collagen
- Chapter 9. Type IX collagen
- Soluble biomarkers of type IX collagen
- Chapter 10. Type X collagen
- Biomarkers of type X collagen
- Chapter 11. Type XI collagen
- Biomarkers of type XI collagen
- Chapter 12. Type XII collagen
- Chapter 13. Type XIII collagen
- Biomarkers of type XIII collagen
- Chapter 14. Type XIV collagen
- Chapter 15. Type XV collagen
- Chapter 16. Type XVI collagen
- Role in aging and disease
- Biomarkers of type XVI collagen
- Chapter 17. Type XVII collagen
- Chapter 18. Type XVIII collagen
- Text
- Tissue expression
- Functional role of type XVIII collagen in pathological conditions
- Hemophilia and the involvement of the short isoform of type XVIII collagen
- The short isoform of type XVIII collagen, a biomarker for hemophilia
- Role of endostatin in biology and pathology
- Biomarkers of endostatin
- Chapter 19. Type XIX collagen
- Biomarkers of type XIX collagen
- Chapter 20. Type XX collagen
- Chapter 21. Type XXI collagen
- Chapter 22. Type XXII collagen
- Biomarkers of type XXII collagen
- Chapter 23. Type XXIII collagen
- Biomarkers of type XXIII collagen
- Chapter 24. Type XXIV collagen
- Chapter 25. Type XXV collagen
- Chapter 26. Type XXVI collagen
- Chapter 27. Type XXVII collagen
- Chapter 28. Type XXVIII collagen
- Biomarkers of type XXVIII collagen
- Chapter 29. Laminins
- Summary
- Structure
- Nomenclature
- Interaction partners
- Signaling
- Laminin-111
- Laminin-211
- Laminin-121
- Laminin-221
- Laminin-332, -311, and -321
- Laminin-411
- Laminin-421
- Laminin-511
- Laminin-521
- Laminin-213
- Laminin-323, -423, and -523
- Laminin mutations and disease in humans
- Chapter 30. Elastin
- Biomarkers of elastin
- Chapter 31. Fibronectin
- Fibronectin
- Fibronectin as a biomarker
- Chapter 32. The extended family of collagens
- Introduction
- Chapter 33. Collagen receptors
- Introduction
- Integrins
- DDRs
- The immunoglobulin (Ig) receptor superfamily
- CD44
- Summary
- Chapter 34. Aging—the most important collagen neoepitope?
- Introduction
- PTMs related to aging
- Neoepitope identification
- Chapter 35. Collagen chaperones
- Chaperone introduction
- Chaperone activities of prolyl hydroxylases and peptidyl-prolyl isomerases
- HSP47
- HSP47 in disease and as a target for treatment
- SPARC
- Periostin
- COMP
- Chapter 36. Collagen diseases
- Osteogenesis imperfecta
- Ehlers–Danlos syndrome
- Alport syndrome
- Epidermolysis bullosa
- Stickler syndrome
- Collagen VI-related muscular dystrophies
- Chapter 37. The signals of the extracellular matrix
- Introduction
- Type IV collagen—arresten, canstatin, tumstatin, tetrastatin, pentastatin, and hexastatin
- Type VIII collagen—vastatin
- Collagen XV—restin
- Type XVIII collagen—endostatin
- Other extracellular matrix fragments
- Chapter 38. The roles of collagens and fibroblasts in cancer
- Tumor fibrosis and cancer-associated fibroblasts
- Collagens and immunotherapy
- Altered degradation of collagen in the tumor
- Collagen fragments as noninvasive biomarkers of tumor fibrosis
- Chapter 39. Use of extracellular matrix biomarkers in clinical research
- Biomarker terminology
- Extracellular matrix biomarkers as a translational tool in drug development
- Established use of ECM biomarkers in drug development and epidemiology
- Perspectives for collagen biomarkers in clinical research
- Chapter 40. Common confounders when evaluating noninvasive protein biomarkers
- Technical and analytical validation of novel noninvasive protein biomarkers
- Laboratory automation
- Clinical validation of novel noninvasive biomarkers
- Analyte features and impact on pathological/clinical relevance of noninvasive biomarker measurements
- Sample handling when evaluating novel noninvasive biomarkers
- Importance of patient cohort characteristics, sample size, and reporting guidelines
- Chapter 41. Extracellular matrix and endotypes
- The extracellular matrix
- Endotypes of the ECM
- Clinical application of endotyping
- Clustering of biochemical markers as indications of endotypes
- PRO-C2 as a biomarker of the low cartilage repair endotype in osteoarthritis patients
- Chapter 42. The extracellular matrix of the skin: systemic diseases with local manifestations
- Introduction
- Chapter 43. The basement membrane and its role in pulmonary disease
- Assembly, composition and function
- Localization, remodeling and repair
- Pathological changes in basement membranes
- Chapter 44. Collagen remodeling in inflammatory bowel disease
- Collagen remodeling and intestinal fibrosis
- Biomarkers of intestinal fibrosis and mucosal damage
- Antifibrotic treatments for IBD
- Chapter 45. ECM biomarkers in population-based cohorts
- Key features of population-based studies
- Endotrophin, a marker of disease severity
- Genome-wide association studies
- The importance of a balanced ECM
- Chapter 46. Collagen biomarkers of chronic diseases
- Index
- No. of pages: 584
- Language: English
- Edition: 3
- Published: November 7, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780443156175
- eBook ISBN: 9780443156182
MK
Morten Karsdal
Morten Karsdal has been CEO of Nordic Bioscience A/S since June 2010.
Since 2002, Morten Karsdal has focused his research on the discovery and development of novel biochemical markers. This has resulted in the development of more than 15 ELISA assays for detecting biomarkers that have been used for research in the fields of fibrosis, osteoporosis and osteoarthritis. One of these assays has been 510(k) approved by the Food and Drug Administration (FDA) in the USA.
Affiliations and expertise
CEO, Nordic Bioscience A/S, Herlev, DenmarkRead Biochemistry of Collagens, Laminins and Elastin on ScienceDirect