Sweet Biochemistry
Remembering Structures, Cycles, and Pathways by Mnemonics
- 2nd Edition - July 25, 2023
- Latest edition
- Author: Asha Kumari
- Language: English
Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images… Read more
Sweet Biochemistry: Remembering Structures, Cycles, and Pathways by Mnemonics, Second Edition makes biochemistry lively, interesting and memorable by connecting objects, images and stories to biochemistry concepts. Here, Dr. Asha Kumari has converted cycles and difficult pathways into very simple formula and short stories and images to help readers see things in complicated cycles and better visualize biochemistry. As biochemistry is evolving steadily, with new and impactful topics, this new edition has been fully updated to include mnemonics on timely topics in biochemistry such as DNA replication, RNA, transcription, translation, and CRISPR technology, as well as fundamentals of immunity.
- Provides quick, indigenous formula, mnemonics, figures, poems and short stories to absorb key concepts in biochemistry
- Presents original diagrams that are easy to recall
- Features simplified tables for remembering distinguishing features
- Updated to address evolving topics in basic and medical biochemistry, including DNA replication, RNA transcription and translation and immunity fundamentals
(Post) graduate students and scientists in biochemistry, Medical students, practitioners and students across nursing and Allied Health Professions
List of figures
List of tables
Preface
Acknowledgements
1. Glycolysis
Microview
Importance of glucose phosphorylation
Role of magnesium for kinases
Critical isomerisation to fructose
Second phosphorylation
Reason of DHAP conversion to Gly-3-P?
Conversion of Gly-3-P to 1,3-bisphosphoglycerate
Reaction of phosphoglycerate kinase: the heroic step
PG isomerises to 2-PG: the role
Importance of enolase reaction
2. Citric acid cycle
First have a look at the quick view of pathway
Now let us observe the reactions in detail
3. Electron transport chain
Microview
The special electron transporters: NADH and FADH2
The story of electron transport chain
What relates to electron transport chain in the story?
4. Beta oxidation of fatty acids
Importance of beta oxidation of fatty acids
Carnitine: prominent molecule of beta oxidation
5. Fatty acid biosynthesis
Traditional recap
Microview
Relation of beta oxidation and synthesis of fatty acids synthesis
6. Cholesterol structure
Role of cholesterol
Lipid rafts and cholesterol
What relates to cholesterol in honeycomb house?
7. Cholesterol synthesis
Traditional recap
Microview
First enzyme thiolase
3-Hydroxy-3-methylglutaryl-CoA synthase
3-Hydroxy-3-methylglutaryl-CoA reductase
Story of queen bee’s honeycomb house
8. Haem synthesis
Rate-limiting step of haem synthesis: aminolevulinic acid formation
Regulation of aminolevulinic acid synthase
Aminolevulinic acid synthase activity in liver can be induced by steroids and some drugs by promoting ALAS1 gene expression
9. Porphyrias
Traditional recap
Manifestations of porphyria
Why photosensitivity and neuropsychiatric symptoms are observed in porphyrias?
Pain is reported by patients with porphyrias even within minutes of visible light or neon light exposure
Neuropsychiatric features
High ALAS1 activity may deplete pyridoxal phosphate, adding further to secondary sensory axonal neuropathy
10. Urea cycle
Carbamoyl phosphate synthetase 1: an unique enzyme
Are there other modulators also for carbamoyl phosphate synthetase 1?
11. Urea cycle disorders
But why ammonia is so toxic to brain?
12. Glycogen storage disorders
Glycogen storage diseases
Mechanisms for features of glycogen storage disorders
Story mnemonic of glycogen storage disorders
13. Mucopolysaccharidoses
Hurler disease
Scheie syndrome: Mucopolysaccharidoses I
Hunter syndrome: Mucopolysaccharidoses II
Sanfilippo syndrome: Mucopolysaccharidoses III
Morquio syndrome: Mucopolysaccharidoses IV
MaroteauxLamy syndrome: Mucopolysaccharidoses VI
Sly syndrome: Mucopolysaccharidoses VII
14. Lipid storage disorders/sphingolipidoses
Tay-Sach’s disease and Sandoff’s disease
Gaucher disease
NiemannPick disease
Farber’s disease
Fabry’s disease
Metachromatic leukodystrophy
15. Ceramide structure and derivatives
What are ceramides doing in our body
16. Prostaglandin synthesis
Biological actions of prostaglandins
Cyclooxygenase is the controller of rate-limiting step
17. Purine structure
Chemically
Here are some interesting purines
18. Purine synthesis de novo
A brief view of reactions
Amido phosphoribosyl transferase (Atase) rate-limiting
enzyme with a unique ammonia channel
Interesting regulation of purines
19. Pyrimidine structure-2
Uracil
Thymine
Cytosine
20. Pyrimidine de novo .
21. DNA structure and DNA replication
Alternative DNA structures
Here is a brief summary of steps of DNA replication
22. Differences in eukaryotic and prokaryotic replication
23. Transcription
Let us see the steps of transcription
24. Translation
Chain termination
25. Inhibitors of translation
Antibiotics and the mechanism of action
Toxins that disturb protein synthesis
Lectins
26. Operon
The lac Operon
27. Various types of RNA
Messenger RNA
Small-nuclear RNA
MicroRNA
Small-interfering RNA
Ribozyme
28. Antibody
29. Class switching
When is class switching required?
Mechanism of class switching
30. Antigen
Hapten
Superantigens
Neoantigens
Autoantigen
Adjuvants
31. Major histocompatibility complex
The categorisation of human leucocyte antigen forms three classes I, II and III
32. Vaccines
Whole pathogen vaccines
Subunit vaccine
Recombinant protein vaccine
Toxoid vaccine
Conjugate vaccine
Virus-like particles
Outer membrane vesicle vaccines
Nucleic acid vaccines
Viral-vectored vaccines
Exercises
Further reading
Index
- Edition: 2
- Latest edition
- Published: July 25, 2023
- Language: English
AK
Asha Kumari
Dr. Asha Kumari is a young medical biochemist. Her parent institute is Pt. BD Sharma PGIMS, Rohtak, from where she completed her MBBS and MD in biochemistry in 2014. She is presently working as an assistant professor at the Department of Biochemistry, SHKM GMC, Nalhar, Nuh, Mewat, Haryana, India. She is a member of the Association of Medical Biochemists of India. She is actively involved in medical research and has written papers in international and national journals. Dr. Asha has a deep interest in improving the teaching methods in the medical field.
Affiliations and expertise
Assistant Professor, Department of Biochemistry, Shaheed Hasan Khan Mewati, Government Medical College, University of Health Sciences, Nuh, Mewat, Haryana, IndiaRead Sweet Biochemistry on ScienceDirect