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Chromatin Signaling and Diseases

2nd Edition - January 1, 2024

Editors: Olivier Binda, Martin Ernesto Fernandez-Zapico, Ana Sevilla Hernandez

Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 9 0 0 1 - 8

Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which govern… Read more

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Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is considered in-depth in Chromatin Signaling and Diseases, Second Edition as well as the impact of gene expression defects associated with malfunctioning chromatin signaling. In addition, this new edition has been fully updated to address recent developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinisation of naked foreign DNA and cancer evolution as regulated by chromatin signaling.