Chromatin Signaling and Diseases
- 2nd Edition - October 6, 2026
- Latest edition
- Editors: Olivier Binda, Martin Ernesto Fernandez-Zapico, Ana Sevilla Hernandez
- Language: English
Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which govern… Read more
Description
Description
Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.
Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.
Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.
Key features
Key features
- Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology
- Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling
- Addresses new and evolving topics in the field, including the chromatinization of naked foreign DNA, phase separation and chromatin, and chromatin signaling and cancer evolution
- Includes chapter contributions from leading international researchers in the field
Readership
Readership
Geneticists, clinical researchers, developmental biologists, life science researchers, cell biologists, molecular biologists, and biochemists
Table of contents
Table of contents
I: Transcription, gene expression, and chromatin
Clean text format without contributor names
I: Transcription, gene expression, and chromatin
- Basics of polymerase II gene transcription
Kayla C. LaRue-Nolan, Maria C. Pierpauli, Martin E. Fernandez-Zapico [FRONTMATTE...0443190018 | PDF] - From mRNA to protein: Translation as a key layer of gene expression
Mehdi Liauzun, Jacobo Solorzano, Morgane Le Bras, Corinne Bousquet, Yvan Martineau [FRONTMATTE...0443190018 | PDF]
- Histone acetyltransferases, key writers of the epigenetic language
X.-J. Yang [FRONTMATTE...0443190018 | PDF] - Histone lysine methylation
- The role of histone mark writers in chromatin signaling―Protein arginine methyltransferases
Olivier Binda, Jocelyn Côté [FRONTMATTE...0443190018 | PDF] - Histone kinases and phosphatases
Mahsa Azizyan, Nikolaus A. Watson, Jonathan M.G. Higgins [FRONTMATTE...0443190018 | PDF] - Regulation of chromatin structure and function by adenosine diphosphate (ADP)-Ribosylation
Dan Huang, Andrea D. Edwards, W. Lee Kraus [FRONTMATTE...0443190018 | PDF]
- The bromodomain and its contribution to human health
Naomie Linteau, Jean-Philippe Lambert [FRONTMATTE...0443190018 | PDF] - Chromo domain proteins: Forms and functions
Joel C. Eissenberg [FRONTMATTE...0443190018 | PDF] - The role of PHD fingers in chromatin signaling
E.A. Morrison, C.A. Musselman [FRONTMATTE...0443190018 | PDF] - Structures and functional interactions of tudor domains
Maria Victoria Botuyan, Georges Mer [FRONTMATTE...0443190018 | PDF]
- Histone deacetylases, the erasers of the code
M.J. Lamberti, R.E. Vera, F.M. Mentucci, N.B. Rumie Vittar, G. Schneider [FRONTMATTE...0443190018 | PDF] - Lysine demethylases
M.A. García, R. Fueyo, M.A. Martínez-Balbás [FRONTMATTE...0443190018 | PDF]
- Variation, modification, and reorganization of broken chromatin
T.C. Humphrey, J.A. Downs, A.L. Chambers [FRONTMATTE...0443190018 | PDF] - Crosstalk between histone modifications integrates various signaling inputs to fine tune transcriptional output
Kayla LaRue-Nolan, David Pease, Glancis Luzeena Raja Arul, Brooke Tader, Sankari Nagarajan, Steven A. Johnsen [FRONTMATTE...0443190018 | PDF] - Crosstalk between DNA methylation and chromatin structure
V. Ferrero, T. Mazo, N.N. Barotto, M. Roqué, L. Vargas-Roig, M.E. Pasqualini [FRONTMATTE...0443190018 | PDF]
- Epigenetic regulation of endoplasmic reticulum stress
M.F. Rodriguez-Quevedo, M. Toruner, A. Levenik, K. Barroso, E. Chevet [FRONTMATTE...0443190018 | PDF] - Chromatin signaling in aging and cellular senescence
Laurence M. Gagné, Florence Couteau, Frédérick A. Mallette [FRONTMATTE...0443190018 | PDF] - Phase separation and chromatin
Lannah S. Abasi, Galia T. Debelouchina [FRONTMATTE...0443190018 | PDF] - Histone variants and their chaperones, in health and disease
Alejandro Saettone, Shahir M. Morcos, Eric I. Campos [FRONTMATTE...0443190018 | PDF] - 3D chromatin physiology in mammalian genomes
Amaury Aguilar-Lomas, Sherlyn Claudio-Galeana, Mayra Furlan-Magaril [FRONTMATTE...0443190018 | PDF]
- Transcriptional regulation of autophagy
Maria Noé Garcia, Maximiliano A. Diaz, Daniel Grasso [FRONTMATTE...0443190018 | PDF] - Stem cells and stem-like cancer cells chromatin dynamics
Niuska Alvarez, Carlos Mateos-Sánchez, Maria Manterola, Ana Sevilla [FRONTMATTE...0443190018 | PDF] - Altered chromatin signaling in cancer
Andrew S. Liss, Yusuke Okuda [FRONTMATTE...0443190018 | PDF] - Chromatin remodeling and epigenetic reprogramming in chronic disease and cancer in the liver and pancreas
Ateka Saleh, Karam Ghazal-Aswad, M.G. Fernandez-Barrena, C.L. Pin [FRONTMATTE...0443190018 | PDF]
- Emerging epigenetic therapies
Piotr K. Kopinski, Ignacio J. Magi, Lauren A. Dalvin [FRONTMATTE...0443190018 | PDF] - Use of chromatin changes as biomarkers
R.A. Hlady, K.D. Robertson [FRONTMATTE...0443190018 | PDF] - Chromatin organization and microRNAs in heart disease and programming of disease susceptibility
Jielin Yang, Adar Aharon-Yariv, Amalia Caballero, Paul Delgado-Olguin [FRONTMATTE...0443190018 | PDF]
- Impact of chromatin changes in pathogenesis of infectious diseases: A pathogen view
A. Ropolo, M.C. Touz, C. Feliziani, M.R. Rivero [FRONTMATTE...0443190018 | PDF] - Chromatinization of naked foreign DNA: The example of HSV-1
Franceline Juillard, Rémi Lebon, Patrick Lomonte [FRONTMATTE...0443190018 | PDF] - Regulation of host chromatin by bacterial metabolites
Wilhelm E. Sjöland, Kimberly A. Krautkramer [FRONTMATTE...0443190018 | PDF]
Clean text format without contributor names
I: Transcription, gene expression, and chromatin
- Basics of polymerase II gene transcription
- From mRNA to protein: Translation as a key layer of gene expression
- Histone acetyltransferases, key writers of the epigenetic language
- Histone lysine methylation
- The role of histone mark writers in chromatin signaling―Protein arginine methyltransferases
- Histone kinases and phosphatases
- Regulation of chromatin structure and function by adenosine diphosphate (ADP)-Ribosylation
- The bromodomain and its contribution to human health
- Chromo domain proteins: Forms and functions
- The role of PHD fingers in chromatin signaling
- Structures and functional interactions of tudor domains
- Histone deacetylases, the erasers of the code
- Lysine demethylases
- Variation, modification, and reorganization of broken chromatin
- Crosstalk between histone modifications integrates various signaling inputs to fine tune transcriptional output
- Crosstalk between DNA methylation and chromatin structure
- Epigenetic regulation of endoplasmic reticulum stress
- Chromatin signaling in aging and cellular senescence
- Phase separation and chromatin
- Histone variants and their chaperones, in health and disease
- 3D chromatin physiology in mammalian genomes
- Transcriptional regulation of autophagy
- Stem cells and stem-like cancer cells chromatin dynamics
- Altered chromatin signaling in cancer
- Chromatin remodeling and epigenetic reprogramming in chronic disease and cancer in the liver and pancreas
- Emerging epigenetic therapies
- Use of chromatin changes as biomarkers
- Chromatin organization and microRNAs in heart disease and programming of disease susceptibility
- Impact of chromatin changes in pathogenesis of infectious diseases: A pathogen view
- Chromatinization of naked foreign DNA: The example of HSV-1
- Regulation of host chromatin by bacterial metabolites
Product details
Product details
- Edition: 2
- Latest edition
- Published: October 6, 2026
- Language: English
About the editors
About the editors
Olivier Binda
Editor
Dr. Olivier Binda is a Researcher at the University of Ottawa, specializing in epigenetics and gene expression as it relates to human diseases. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier’s Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Molecular Cell, Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.
Affiliations and expertise
University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, CANADA.
Affiliations and expertise
Principal Investigator, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UKMartin Ernesto Fernandez-Zapico
Editor
The research program of Martin E. Fernandez-Zapico, M.D., focuses on the cellular and molecular characterization of epigenetic pathways regulating pancreatic carcinogenesis, a dismal disease with one of the poorest prognoses among all neoplasms. Specifically, Dr. Fernandez-Zapico and his team study the modulation of chromatin and nuclear dynamics by oncogenic cascades and its impact in gene expression regulation, a critical step during pancreatic neoplastic transformation.
Dr. Fernandez-Zapico and his team are confident that the knowledge derived from his studies will help with the understanding of the contribution of these epigenetic events to the initiation and/or progression of pancreatic carcinogenesis as well as serve as a foundation for the development of new therapeutic approaches.
Dr. Fernandez-Zapico's program is affiliated with the Mayo Clinic Cancer Center, Department of Oncology, Division of Gastroenterology and Hepatology, and the Center for Cell Signaling in Gastroenterology. His research is supported by the National Institutes of Health (NIH), the NIH-funded Mayo Clinic Pancreatic Cancer Specialized Program of Research Excellence (SPORE), the NIH-funded Mayo Clinic Center for Cell Signaling in Gastroenterology, and the Leukemia and Lymphoma Foundation.
Affiliations and expertise
Associate Professor of Medicine, Associate Professor Pharmacology, Mayo Institute, Rochester, MN, USAAna Sevilla Hernandez
Editor
Ana Sevilla Hernandez is Head of the Stem Cells in the Development and Disease Lab, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Barcelona University, Spain.
Affiliations and expertise
Head of the Stem Cells, Development and Disease Lab, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Barcelona University, SpainView book on ScienceDirect
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