Books in Molecular biology cellular biology and genetics

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An Introduction to Artificial Intelligence for Clinicians

• 1st Edition
• December 1, 2099
• Pearse A Keane + 4 more
• English

An Introduction to Artificial Intelligence for Clinicians: A Practical Guide to Clinical AI for Healthcare Professionals addresses the rapidly expanding field of clinical artificial intelligence and the potential it holds for healthcare professionals and their patients. It enables readers to create their own deep learning project and build a model using code-free deep learning. It also provides them with a comprehensive overview of the statistics used in clinical AI and methods to critically appraise clinical AI papers. By equipping clinicians with education and skills they can use in the present world of clinical AI, they are better positioned for the future arrival of artificial intelligence into day-to-day patient care. To ensure the broad relevance of this book, the editors also draw on a yet unpublished qualitative evidence synthesis of stakeholder experiences of AI implementation across all healthcare contexts worldwide, which empowers readers to see how clinical AI could benefit patients in their own context and to inspire others to affect change. It is a valuable resource for clinicians, students, researchers, healthcare professionals and members of medical and biomedical fields who are interested to learn more about artificial intelligence applied to clinical setting and healthcare.

NMR in the Cloud

• 1st Edition
• March 1, 2099
• Jeffrey Hoch
• English

NMR in the Cloud: Resources for Moving Biomolecular NMR Research to the cloud is the ideal reference for Biomolecular researchers to explore and incorporate cloud-based tools to increase productivity of their projects. The COVID-19 pandemic, by forcing social distancing and work-from-home, has accelerated these trends and increased the demand for online resources for data processing and analysis, data storage, and remote collaboration and training tools. The trend toward online research will continue well after the pandemic subsides, because online resources remain valuable even in the absence of restrictions on in-person work. They increase the efficiency of the research enterprise and make it more robust in the face of disruptions of all sorts, environmental as well as public health. The book is structured around four parts. The first introduces reproducible computing for Bio-NMR, and collaborative computing tools. Part two presents online NMR platforms, including WeNMR, SB Grid, BMBR, Scientific Cloud Computing tools, and data Stewardship. The third part covers NMR specific online tools, including NMRfx, NMRPipe, NMRFAM-SPARKY, MNova, Chemical Shift Prediction, Peak Assignment, SPINACH, GISSMO, CSRosetta, NMR Metabolomics, Protein Structure Prediction, and reproducibility in the cloud environment. Part four presents case studies that help researchers envision how to select and deploy these tools to make their biological quest more productive and impactful. Biomolecular researchers will benefit from this book by gaining insights into selecting and using these analytical tools in the most productive way. Core Bio-NMR Managers may as well benefit from offering the book as reference for their customers.

Cell Culture Techniques

• 1st Edition
• January 1, 2099
• Shailendra Singh Shera
• English

Cell Culture Techniques: Protocols, Methods, Tools and Processes is the ideal laboratory reference to execute animal cell culture assays. Based on the author’s experience and practice, the selected methods represent the current status of the field. Cell culture practices covered in this book include the ones used both in academic and corporate lab setting. The initial part of the book guides the reader through the key decisions and challenges involved with setting up a cell culture laboratory. Serum-free media is then discussed as the way to provide cells the requirements for their growth.The next group of chapters cover the general procedures for cell culture, including selection of media, preparation and sterilization of equipment, tissue extraction or dissociation and initiation of the cell culture.The chapters that follow discuss authentication, contamination detection by microbes and viruses. The next chapters cover stem cells, organoids, and spheroid cells. The last part of the book provides methods for cell separation, high-speed cell sorting, detection of cell cycle stages and then finally discusses biosafety aspects of cell culture.

Essential Genetics

• 1st Edition
• August 1, 2030
• John Jenkins
• English

Gene Expressions

• 1st Edition
• March 1, 2030
• Emanuel Goldman
• English

This book discusses the mechanisms by which genetic information is expressed in bacteria, with comparison to eukaryotic gene expression. Coverage includes description of molecular components involved in gene expression (RNA polymerases, messenger RNA, transfer RNA, ribosomes), how the genetic code functions, and processes and regulatory features of transcription and translation. Major areas of bacterial genetics are also reviewed, to help the reader understand how regulatory features were discovered, as well as some classic historical experiments. Gene regulation in some bacterial pathogens and in some human viral pathogens is also described.

Fibroblast Biology

• 1st Edition
• January 1, 2030
• Nicholas Kurniawan + 1 more
• English

Fibroblast Biology: Development, Differentiation, and Mechanical Regulation in Health and Disease offers a comprehensive treatment of fibroblast biology to cell biologists, biomedical engineers, and research physicians interested in understanding the role these cells play in maintaining organismal homeostasis. Conditions covered include keloid fibroblasts, cancer, neurological diseases, rheumatoid arthritis, diseases in the lungs, kidney, and muscular tissue, including the cardiac muscle. This book is a complete reference that serves as perfect entry-pint for researchers new to this field. Research physicians can benefit from the connections established between cell biology and specific disease states covered.Comprised of three parts, the book opens with an introduction to fibroblasts, covering their roles in the human body, their heterogeneity, profiling, and interactions with the extracellular matrix. The initial part is concluded with an overview of cell mechanics and mechanobiology. Part two delves into the biology of fibroblasts, including signaling networks, activation, proliferation and differentiation, migration, their role in normal wound healing, interactions with other cell types, and the changes in fibroblasts across the organismal lifespan. The final part is dedicated to fibroblasts roles in disease states and therapeutic opportunities.

Cellular Processes in the Aging Brain

• 1st Edition
• September 1, 2029
• Claudio Torres
• English

Cellular Processes in the Aging Brain provides an exploration of the cellular and molecular processes underlying aging in the context of the brain. Aging is the greatest risk factor for the development of most of neurodegenerative disorders; however, the aspects of the aging process that predispose us to the development of brain pathology are largely unknown. The senescence process is an irreversible growth arrest triggered by various events including telomere dysfunction, DNA damage, oncogene activation, oxidative stress and proteasome inhibition. The presence of senescent cells in the human brain could be critical because they display an altered pattern of secretion known as the senescence-associated secretory phenotype (SASP), a complex mixture of factors that profoundly affect neighboring cells and tissues by creating a pro-inflammatory microenvironment. This book is split into three parts, the first covers the physiological background, the second part covers basic mechanisms of cellular processes impacting the aging brain, and the third part introduces novel interventions, allowing for an understanding of the situation and paths to move forward. Cellular Processes in the Aging Brain is the first book to look specifically at the cellular process of aging in the brain, and it will be of great use to researchers in the field of cellular senescence and neuroscience, researchers with interest in basic science and novel translational approaches and advanced students as well as research-focused clinicians.

Atlas of Chick Development

• 4th Edition
• June 1, 2029
• Pamela Lear + 1 more
• English

The Atlas of Chick Development, Fourth Edition, is a classic work covering all major event of chick development. It remains the established standard; the only book providing a comprehensive description of chick development from fertilization to hatching. This work has extensive and detailed photographs, enlargements showing regions of special-interest and complexity, and illustrations. The revised text and expanded illustrative material describe the intricate changes that take place during development. Updates also include accounts of recent experimental and molecular research that has transformed our understanding of morphogenesis as well as overviews of functional techniques and imaging and analytical techniques. These wide-ranging updates make this book an essential resource for developmental biologists, geneticists, molecular biologists, poultry scientists, biochemists, immunologists, and other life scientists who use the chick embryo as their research model. Individuals joining this burgeoning area, ignited by the increased insight into events surrounding organ and tissue differentiation, will find this a valuable tool to help grow a basic knowledge of morphogenesis.

Spatial Omics

• 1st Edition
• June 1, 2029
• Kieran Mcgourty
• English

Spatial Omics: Methods for Reconstructing the Spatial Heterogeneity of Biological Tissue is a complete and detailed reference on research methods that combine the in-depth analysis at single cell level with context provided by tissue positioning. The methods covered in the book include Methods that require the mechanical tissue retrieval, digestion and enrichment, Methods based on in situ hybridization and imaging, Methods reliant on next generation sequencing and hybrid techniques, and Computational based methods to determine spatial relatedness of cells. Technologies are focused on the balance between sensitivity, accuracy, and extent of features through which single cells can be evaluated, and more.Cellular and molecular biologists will benefit from the detailed experimental setup information included in this comprehensive book. Computational biologists and computer scientists involved in biological visualization problems can also use this book as a guide to interpret and analyze experimental data.

Precision Medicine and Wellness Science

• 1st Edition
• June 1, 2029
• Vincent Henrich
• English

Precision Medicine and Wellness Science: Genes, Environment, and Pathways to Chronic Disease explores key principles and practical examples of gene-environment relationships and how they affect the health status of individuals. Carefully crafted chapters analyze— drawing on both research and clinical perspectives—how genetic and environmental factors interact at the cellular level to raise an individual’s chronic disease risk, dissecting the complex genotype-phenotype relationships of several common chronic diseases and how they manifest in patients. The book provides illustrative examples from recent literature that offer scientifically based strategies for analyzing chronic disease risk and prolonging wellness. The book also discusses new and future technologies that will be important for developing and applying wellness science (i.e., lifestyle or environmental changes) and precision medicine-based approaches in the next decade, along with the feasibility and potential of recent discoveries and proposed technologies. Throughout, the book features case studies of actual chronic disease patients whose presentation involves genetic and familial concerns, demonstrating how genetic, lifestyle, and environmental factors may be assessed when diagnosing an individual’s disease risk.