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Books in Molecular biology

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    • Cryo-EM Methods and Management

      • 1st Edition
      • Edward T. Eng + 2 more
      • English
      Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern cryo-EM facility. The book consists of four parts, beginning with an overview of cryo-EM. It then moves on to discuss Cryo-EM workflows, with chapters focusing on sample handling and preparation, data collection and hardware, and data procession and visualization. The third part centers on aspects of cryo-EM infrastructure and community building, considering facility set-up and management, monitoring facility performance, instrumentation monitoring , data sharing and standards, and training and development standards. The book then closes with a section looking towards future prospects for cryo-EM. This is an ideal reference for cryo-EM facility and lab managers, providing guidance to the often-overlooked aspect of facility building and management. Additionally researchers working with cryo-EM across molecular biology, structural biology, cell biology and biochemistry will benefit from this book.

    • Computational Approaches to Natural Products Discovery

      • 1st Edition
      • Volume 730
      • English
      Computational Approaches to Natural Products Discovery, Volume 720 provides descriptions of the latest techniques in computational methods for the study of natural products. Techniques covered are related to genome mining, natural product biosynthesis, natural product evolution, and natural product structure. Chapters in this new release cover Prediction of natural product bioactivity from BGC sequence to guide genome mining efforts, Genome mining for resistance genes to identify bioactive natural products with ARTS, Predicting lasso peptide structure with LassoPred, Predicting lanthipeptide structure with Rosetta, Using lsaBGC to investigate BGC Evolution, and an Analysis of BGC evolution with CORASON.

    • RNases in Health and Diseases

      From Housekeeping Enzymes to Moonlight Proteins
      • 1st Edition
      • Ester Boix
      • English
      RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins presents a comprehensive exploration of the structural and functional properties of RNases, revealing their importance well beyond basic cellular maintenance. The book introduces readers to the evolving landscape of RNase research, including their multifaceted roles and newly discovered capabilities. Particularly notable are their contributions to the generation of non-coding signaling RNAs and their emerging potential as tools for diagnostics and therapy. The content is organized into three distinct sections, beginning with RNase structure and continuing with research methods and advanced tools for studying these enzymes.In addition to foundational knowledge, the final section investigates the connections between RNases and various diseases, illustrating their clinical relevance. This resource offers both researchers and students a broad perspective, making it valuable for anyone seeking a solid background in RNase biology. Readers will gain insights into recent breakthroughs, research techniques, and the therapeutic possibilities that position RNases at the forefront of biomedical innovation.

    • Cell Death Part A

      • 1st Edition
      • Volume 205
      • English
      This comprehensive volume explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. The book brings together leading experts to discuss both established and emerging approaches for studying cell death, with a strong emphasis on practical laboratory techniques and their applications in disease research and drug discovery.

    • Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

      • 1st Edition
      • Ramesh Kumar Ahirwar + 4 more
      • English
      Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control presents an in-depth overview of innovative approaches in plant metabolomics, focusing on their practical integration into industry. The book examines advanced techniques such as metabolic engineering, metabolite imaging, NMR analysis, microfluidics, and computational bioinformatics. These methods are crucial for identifying and optimizing bioactive compounds in plants, reflecting the growing demand for natural products and plant-derived therapeutics. Through detailed case studies, readers gain insight into real-world applications and scenarios, making this resource invaluable for professionals aiming to enhance accuracy and efficiency in metabolite profiling.In addition to pharmaceutical applications, the book explores the use of plant metabolomics in crop improvement, archaeological studies, cosmetic development, and food quality assurance. It offers a multidisciplinary perspective, highlighting the significant impact of plant metabolites across sectors such as molecular and cellular biology, biotechnology, and biochemistry. Specialists in pharmaceuticals, nutraceuticals, cosmetics, and agriculture will find this comprehensive guide essential for staying abreast of the latest advances and understanding the broad implications of plant metabolite research.

    • 2D and 3D Cellular Screening Models and AI Guided Analysis

      • 1st Edition
      • Volume 204
      • English
      This book provides a comprehensive overview of the latest advancements in cellular screening models, with a particular focus on both 2D and 3D systems. It explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery.

    • Animal Models of Disease Part E

      • 1st Edition
      • Volume 203
      • English
      Animal Models of Disease, Part E, Volume 203 in the Methods in Cell Biology series presents significant advancements in understanding disease mechanisms through animal models. This volume features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

    • Cerebellum Development and Disease

      • 1st Edition
      • Volume 167
      • English
      Cerebellum Development and Disease offers a comprehensive overview of the intricate processes underlying the formation, maturation, and function of the cerebellum, as well as the wide spectrum of disorders that can affect this essential brain region. The book brings together leading experts in neurodevelopment, neurobiology, genetics, and clinical neurosciences to explore the molecular and cellular mechanisms guiding cerebellar development, from embryogenesis to adulthood.

    • Artificial Intelligence for Multi-omics Analysis Part A

      • 1st Edition
      • Volume 221
      • English
      Artificial Intelligence for Multi-omics Analysis, Part A, Volume 221 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as an Introduction to Artificial Intelligence in Multi-omics Analysis, Multi‐omics application in health and diseases, Artificial Intelligence in Genomics Analysis, Artificial Intelligence in Single-cell and Spatial Transcriptomics Data, Artificial Intelligence in the prediction of 3D chromatin structure and gene regulation, Artificial intelligence in Mass Spectrometry-based Proteomics, Integrating Artificial Intelligence into Metabolomics for Predicting Diseases, and more.Additional chapters cover Artificial Intelligence in Microbial Metagenomics, Artificial Intelligence in Interactomics, Artificial Intelligence Integration in Medical Imaging Data, AI in biomolecular structural data analysis, Artificial intelligence in Cryo-Electron Microscope data, Explainable artificial intelligence for multi-omics data, and Multi-Omics Cancer Stratification: from Statistical to Deep Learning Perspective.

    • Live Biotherapeutics: Advancing Microbial Medicine

      • 1st Edition
      • Volume 220
      • English
      Microbial therapeutics are rapidly reshaping modern medicine, with live biotherapeutics emerging as a promising frontier. By harnessing the power of beneficial microbes, these innovative treatments offer new hope for conditions that resist conventional drugs, including metabolic disorders and antimicrobial-resist... infections. As the demand for safer, more effective alternatives grows, understanding this field becomes increasingly vital. The upcoming book, Live Biotherapeutics: Advancing Microbial Medicine, will provide a comprehensive and accessible overview of the science, applications, and future potential of live biotherapeutics in transforming healthcare.