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Books in Molecular biology

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Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

  • 1st Edition
  • July 1, 2025
  • Theresa Coetzer
  • English
  • Paperback
    9 7 8 - 0 - 3 2 3 - 9 1 8 0 1 - 5
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 7 2 0 4 - 8
Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

Methods for Monitoring Mitochondrial Functions During Pathogen Infection

  • 1st Edition
  • Volume 194
  • June 1, 2025
  • Saverio Marchi + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 9 2 1 9 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 9 2 2 0 - 6
Methods for Monitoring Mitochondrial Functions During Pathogen Infection, Volume 188 in the Methods in Cell Biology series highlights advances in the field, with this new volume presenting interesting chapters on timely topics, including Mitochondrial Labeling with Fluorescent Proteins for Enhanced Morphological Characterization and Visualization of Intercellular Mitochondrial Transfer, Visualizing mitochondrial electron transport chain complexes and super-complexes during infection of human macrophages with Legionella pneumophila, Quantitative assessment of mitochondrial membrane potential in macrophages in sepsis, Quantification of mitochondrial reactive oxygen species in macrophages during sepsis, and much more.Additional chapters cover Quantification of intracellular and mitochondrial ATP content in macrophages during lipopolysaccharide-induced inflammatory response, Analysis of cytosolic mtDNA release during Staphylococcus Aureus infection, Monitoring mitochondria dynamics upon infection using a tomographic approach, A screening system to determine bacterial effects on MADCAM1 expression by high endothelial venule cells, Isolation of mitochondria from Mycobacteria infected cells, Monitoring mitochondrial localization of Mycobacterial proteins, and more.

Techniques and Protocols in Molecular Biology

  • 1st Edition
  • May 1, 2025
  • Buddhi Prakash Jain
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 4 1 6 0 - 7
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 4 1 6 1 - 4
Techniques and Protocols in Molecular Biology delivers detailed practical guidance for a variety of molecular techniques and procedures. Each chapter focuses on a different technique, including isolation techniques for DNA and RNA, gene cloning, PCR, DNA sequencing, ELISA and cell culture. These protocols all includes a detailed description of the technique along with the main principles, required equipment, and comprehensive steps to assist researchers with replicating the protocol and performing the techniques themselves.This foundational reference is essential for students and researchers looking to enhance their understanding of key molecular techniques and reproduce them successfully in their own laboratory work.

Handbook of Translational Transcriptomics

  • 1st Edition
  • April 22, 2025
  • Anton Buzdin
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 9 1 1 0 - 7
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 3 7 6 8 - 3
Handbook of Translational Transcriptomics: Research, Protocols and Applications provides a comprehensive overview to the field of transcriptomics. With an emphasis on the various protocols and techniques available for investigation, it acts as a practical guide to researchers for implementing their own investigations in the field.The book begins with an overview of the past, present, and potential approaches in the field of transcriptomics, with discussion of choosing the correct approach based on the research needed, it also highlighting the pros and cons of each approach. Following this it explores techniques and protocols for investigating specific approaches focusing on RNA sequencing, expression arrays, and gene expression, providing detailed. It then delves into data analysis and offers recommendations, guidelines, and approaches related to data interpretation. The book also considers the translation of transcriptomics to clinical application and applications in molecular diagnostics, biomarkers in medicine, and personalized medicine specific to oncology, as well as biotechnology for pharmaceutical research.Handbook of Translational Transcriptomics is a detailed reference that provides a complete view of transcriptomics, ranging from methods to handling data and medical applications.

Retinoids in Development and Disease

  • 1st Edition
  • Volume 161
  • March 1, 2025
  • Norbert Ghyselinck + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 1 7 0 0 - 1
  • eBook
    9 7 8 - 0 - 3 2 3 - 9 1 7 0 1 - 8
Retinoids in Development and Disease, Volume 161 in the Current Topics in Developmental Biology series focuses on the role of retinoids during development and disease. Topics covered include Retinoids, Retinol-Binding Protein 2 (RBP2), Retinol-Binding Protein 4 (RBP4): Obesity and Metabolic Disease, Early Retinoic Acid Signaling Organizes the Body Axis and Defines Domains for the Forelimb and Eye, Rethinking Retinoic Acid Self-Regulation: A Signaling Robustness Network Approach, Meiotic initiation in the fetal ovary without retinoic acid receptors: an unforeseen twist, Action of retinoic acid on progenitor cells in the testis, amongst many other topics.Additional sections cover Retinoic acid homeostasis and disease, Redefining the roles of endogenously produced retinoic acid in heart development and regeneration: lessons from genetic models, The Multifaceted Roles of Retinoids in Vision, Eye Development, and Retinal Degenerative Diseases, Essential roles for retinoid signaling in craniofacial development, and much more.

Molecular Medicine and Biomedical Research in the Era of Precision Medicine

  • 1st Edition
  • March 1, 2025
  • Ranbir Chander Sobti + 4 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 2 3 0 0 - 6
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 3 0 1 - 3
Molecular Medicine and Biomedical Research in the Era of Precision Medicine: New Technologies and Personalized Drug Therapies for Patient Care provides researchers with an extensive overview of recent advances in molecular biology impacting the development of targeted therapies. The book delivers insights into the pathobiological and pathogenetic mechanisms of various diseases, providing a detailed study of the latest personalized interventions to be implemented across such conditions. It covers a range of technologies, including RNA-sequencing, AI, Machine Learning, gene therapy, omics and nanotechnology, delving into their clinical applications across various diseases.The book also tackles targeted treatments of different disease types, including acute, chronic, infectious and noncommunicable diseases. Future perspectives are also covered, providing an in-depth study across molecular medicine, drug discovery and delivery, disease diagnosis and prevention, and therapeutic interventions, and acting as an invaluable interdisciplinary reference for researchers across the biomedical sciences.

Biotechnology

  • 3rd Edition
  • January 31, 2025
  • David P. Clark + 3 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 1 8 4 8 4 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 8 4 8 5 - 7
Biotechnology: The Technological Applications of Genetics and Genomics, Third Edition, approaches modern biotechnology from a molecular basis, discussing how the fields of genetics, molecular biology, microbiology, and biochemistry are merging their respective discoveries into the expanding applied field of biotechnology. Each chapter starts with basic concepts that develop into more specific and detailed applications, providing readers with a good image of possibilities and current limitations in the field and future research directions.This new edition has been fully revised and updated to include research advances, and has new chapters on artificial intelligence, genome editing, precision and personalized medicine, and more. This book is an invaluable resource to anyone interested in understanding what molecular biotechnology is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future.

Immuno-oncology and immunotherapy Part C

  • 1st Edition
  • Volume 191
  • January 15, 2025
  • Lorenzo Galluzzi + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 0 - 8
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 1 - 5
Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Artificial Intelligence in Microbiology: Scope and Challenges volume-II

  • 1st Edition
  • Volume 56
  • January 15, 2025
  • Akanksha Srivastava + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 6 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 7 - 7
Artificial Intelligence in Microbiology: Scope and Challenges, Volume-II, Volume 56 covers changes due to the emergence of Artificial Intelligence (AI). AI is being used to analyze massive data in a predictable form, about the behavior of microorganisms, to solve microbial classification-related problems, and more. Chapters include Taking on the resistance: AI and battle against antimicrobial resistance, AI-powered insights into microbial communities for bioremediation strategies, Efficient and cost-effective production of viral vaccines via AI, Production and development of novel drug targets through AI, Use of AI in neuroscience, Role of Artificial Intelligence in studying metagenomics of Microbes: Decoding the microbial Sphere, and more.Other chapters explore Exploring the functional role of bacterial proteins via AI, Application of AI in Aquaculture/Fisheries: Disease identification, detection, diagnosis, drug development, Artificial Intelligence in drug discovery & development; scope and challenges, Production of bacteriocins by AI: as food preservative, Exploring the Role of Artificial Intelligence in the Microbial remediation of heavy metals, Uses of Artificial Intelligence in the Agricultural Pest Management, Microbial fermentation processes using Artificial Intelligence, and more.

Paper-Based Optical Chemosensors

  • 1st Edition
  • November 13, 2024
  • Liang Feng
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 3 3 5 6 - 5
  • eBook
    9 7 8 - 0 - 4 4 3 - 1 3 3 5 7 - 2
Paper-based Optical Chemosensors comprehensively discusses the origin, development, and current state-of-the-art in paper-based sensors. With a focus on the principles, classifications, methodology, design, and application of paper-based sensors, this book represents a developing research field with recent innovative applications resulting in a comprehensive presentation of the different physico-chemical techniques using paper sensors. It discloses underlying rules and factors in paper-based sensors and discusses intricate sensing systems and working environments by ways of chemistry and physics for a variety of application scenarios such as environmental protection, food safety, public safety, and clinical diagnosis.This is a valuable resource for researchers who major in analytical chemistry, or for those who are interested in the development of methods or devices for rapid analysis/monitoring based on paper/membrane-based sensors who wish to broaden their knowledge in the allied field.