
RNases in Health and Diseases
From Housekeeping Enzymes to Moonlight Proteins
- 1st Edition - April 15, 2026
- Latest edition
- Editor: Ester Boix
- Language: English
RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins presents a comprehensive exploration of the structural and functional properties of RNases, revealing… Read more

RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins presents a comprehensive exploration of the structural and functional properties of RNases, revealing their importance well beyond basic cellular maintenance. The book introduces readers to the evolving landscape of RNase research, including their multifaceted roles and newly discovered capabilities. Particularly notable are their contributions to the generation of non-coding signaling RNAs and their emerging potential as tools for diagnostics and therapy. The content is organized into three distinct sections, beginning with RNase structure and continuing with research methods and advanced tools for studying these enzymes.
In addition to foundational knowledge, the final section investigates the connections between RNases and various diseases, illustrating their clinical relevance. This resource offers both researchers and students a broad perspective, making it valuable for anyone seeking a solid background in RNase biology. Readers will gain insights into recent breakthroughs, research techniques, and the therapeutic possibilities that position RNases at the forefront of biomedical innovation.
- Covers basic theoretical information, methodological tools, and potential therapeutic applications in the RNase field
- Introduces new concepts to the RNase field
- Includes both the historical background in the field and the most recent advances
- Contains contributions from international experts in the field
Early career and consolidated researchers working either in the RNases field or in a more general context on protein structure-function, Advanced undergraduate students and Master students within the Biochemistry, Enzymology, Structural Biology and Biomedicine areas
1. Overview. RNases, a family of multifaceted proteins
2. Catalytic mechanism of action: mechanism, exonucleases vs endonucleases, single stranded vs double stranded.
3. RNases diversity: vertebrate RNase A superfamily, RNase T2, RNase L, RNase kappa, plant RNase S, bacterial RNases
4. RNase in evolution: RNAs and RNases
5. RNA subsite binding sites
6. From monomers to multimers
7. RNases cellular traffic
8. RNases and tyrosine kinase receptors
9. RNases and posttranscriptional modifications
10. RNases targeting non-coding RNAs
11. RNase Inhibitors
Section II: Research Methods
12. Tools to study RNases:
a) labelled probes
b) HPLC product analysis,
c) Cp-RNAseq…
13. RNase-based tools: RNaseH, RNAse4 for RNA analysis,…CRISPR/Cas9
Section III: Diseases
14. RNases in infectious diseases
15. RNases in inflammatory disorders
16. RNases in cancer
17. Human Natural Variants
18. RNases as diagnostic tools
19. RNases as therapeutic targets
20. RNases and drug design: antitumoral, anti-inflammatory or antimicrobial agents
- Edition: 1
- Latest edition
- Published: April 15, 2026
- Language: English
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