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Books in Developmental biology

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    • Immuno-oncology and Immunotherapy Part G

      • 1st Edition
      • Volume 202
      • English
      Immuno-oncology and Immunotherapy, Part G, Volume 202 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including In situ imaging of pulmonary invariant Natural Killer T cells in precision cut lung slices, Immunofluorescent microscopy to quantify and characterize chromosomal instability, Spatial techniques for understanding the tumor microenvironment, Very high-flex immunophenotyping using co-linear cytofluorometric evaluation, Large-scale CRISPR-Cas9 screens to define regulators of immune checkpoint biology, Assessment of cytoplasmic dsDNA for cellular immunogenicty, and much more.Additional sections cover Harmonization of a multiparametric flow cytometry panel for immunological monitoring on PBMC and whole blood samples: a real-life example, Quantitative assessment of arterial remodeling from confocal microscopy image analysis of the mid-gestation mouse decidua, Phenotypic characterization and function of tumor infiltrating and peripheral B cells in cancer patients, Methodological Advances to analyze Cancer-Associated Fibroblast-derived ECM effects on Macrophage Polarization, and many other topics that will be of interest to readers.

    • γδ T Cells in Health and Disease Part B

      • 1st Edition
      • Volume 398
      • English
      γδ T Cells in Health and Disease, Part B provides a comprehensive and up-to-date overview of the diverse roles that γδ T cells play in human physiology and pathology. This volume builds on foundational knowledge to explore advanced topics and recent discoveries in γδ T cell biology, with a particular focus on their mechanisms of action, functional diversity, and implications for clinical practice. Chapters in this new release cover Development of gd T cells, Human T-cell receptor inborn errors of immunity shed light on the real-life role of γδ vs αβ T lymphocytes, and much more.Other sections explore Deciphering the Role of γδ T cells in Skin Inflammatory Diseases: Insights from Psoriasis, Atopic Dermatitis, and Alopecia Areata, Role of gd T cells in zoonosis infection, γδ T cells in Escherichia coli infection and Gamma-delta T cells in breast cancer: dual role in tumor immunity and emerging therapeutic approaches.

    • γδ T Cells in Health and Disease Part A

      • 1st Edition
      • Volume 397
      • English
      γδ T Cells in Health and Disease, Part A, provides a comprehensive overview of the biology, function, and clinical significance of γδ T cells, a unique subset of T lymphocytes with distinct roles in immune responses. This volume brings together leading experts to explore the fundamental aspects of γδ T cell development, activation, and regulation, as well as their involvement in maintaining health and contributing to disease.

    • Animal Models of Disease Part D

      • 1st Edition
      • Volume 197
      • English
      Animal Models of Disease, Part D, Volume 197 in the Methods in Cell Biology series presents significant advancements in understanding disease mechanisms through animal models. This volume features chapters on timely topics such as characterizing tumor-infiltrating group 1 innate lymphoid cells in PyMT breast tumors and using zebrafish to unravel the molecular mechanisms of Alzheimer’s disease. The book also covers colitis mouse models and appropriate models for studying diabetes pathophysiology, demonstrating its comprehensive approach to current research.Additional sections cover evaluating polyglutamine protein aggregation in transgenic Caenorhabditis elegans models of Huntington's disease and studying tumor responses to radioimmunotherapy in ovarian cancer models. It also highlights the antimicrobial regime for gut microbiota depletion in mice and the biodistribution of metallic nanoparticles for lymphoma studies. This book is an essential resource for researchers seeking to explore disease mechanisms and therapeutic approaches through animal models.

    • The Emerging Genomic Landscape of Complex Immune-Mediated Traits

      • 1st Edition
      • Volume 114
      • English
      The Emerging Genomic Landscape of Complex Immune-Mediated Traits, Volume 114 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Unraveling the Interplay of Genetic Variants and Epigenetic Signatures in Complex traits, Crosstalk between T Cell Gene Regulation and Intestinal Epithelial Cells: Insights into Mucosal Immunity, Understanding the link between regulatory RNA regions and genomic variation with coeliac disease, Interplay Between the Host Genome, Autoimmune Disease and Infection, and Organoids and gut-on-chip as powerful tools to model the genetics of intestinal mucosal inflammation.

    • Cytokine-Based Immunotherapy - Part A

      • 1st Edition
      • Volume 396
      • English
      Cytokine-Based immunotherapy, Volume 396, Part A delves into the intricate world of cytokines, vital signaling proteins that orchestrate the immune response and their pivotal role in modulating various immune functions. From their fundamental mechanisms to their therapeutic applications, this book offers a thorough examination of the latest trends and developments in leveraging cytokines for immunotherapy. The book includes chapters such as Cytokine-driven cancer immune evasion mechanisms, which explores how cytokines contribute to cancer cells' ability to evade the immune system. Cytokine-based immunotherapy in hematolymphoid malignancies is also explored, discussing the use of cytokines in treating blood cancers.Targeting TNF-alpha examines the immunotherapeutic approach for alleviating neuropathic pain. The key role of immunomodulatory cytokines for the development of novel nk cell-based cancer therapies focuses on the importance of cytokines in developing new cancer treatments. Finally, complexities in the clinical development of TGFβ inhibitors covers the challenges in creating inhibitors for TGFβ.

    • The Microbiome in Cancer and Autoimmunity - Part B

      • 1st Edition
      • Volume 395
      • English
      Microbiome in Cancer and Autoimmunity - Part B, Volume 395 offers a comprehensive exploration of the intricate relationship between the human microbiome and the development of cancer and autoimmune diseases. Delving into cutting-edge research and clinical insights, this groundbreaking work elucidates the role of microbial communities in influencing immune responses, disease pathways, and therapeutic outcomes. Specific chapters cover the Effect of Microbial Dysbiosis on Autoimmune-Associate... Inflammation, Gut Microbiota and Systemic Immune Responses in Cancer, The role of microbiome in gastrointestinal cancer, Cancer and Microbiome-Targeted Therapies, Autoimmune disease and Microbiome Targeted Therapies, and the Effect of Diet and Lifestyle on Microbiome Composition.

    • The Microbiome in Cancer and Autoimmunity - Part A

      • 1st Edition
      • Volume 394
      • English
      Microbiome in Cancer and Autoimmunity - Part A, Volume 394 offers a comprehensive exploration of the intricate relationship between the human microbiome and the development of cancer and autoimmune diseases. Delving into cutting-edge research and clinical insights, this groundbreaking work elucidates the role of microbial communities in influencing immune responses, disease pathways, and therapeutic outcomes. From deciphering the molecular mechanisms underlying microbiome-host interactions to unraveling the impact of dysbiosis on disease progression, the book provides a multifaceted analysis of the microbiome's pivotal role in cancer and autoimmunity.With contributions from leading experts in the field, this book serves as a pivotal resource for researchers, clinicians, and healthcare professionals seeking to understand and harness the therapeutic potential of the microbiome in combating cancer and autoimmune conditions.

    • Novel Genetic Pathways Associated to Energy Homeostasis Impairments

      • 1st Edition
      • Volume 113
      • English
      Novel Genetic Pathways Associated to Energy Homeostasis Impairments, Volume 113 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Advances in Metabolism: Energy Balance Circuitry, Advances in Metabolism: Diabetic Retinopathy, From Metabolomics to Energy Balance Physiology, Advances in Metabolism: Prader-Willi Syndrome, Neural Mechanisms and Health Implications of Food Cravings During Pregnancy, Advances in Metabolism: Diabetes, Advances in Metabolism: Cachexi, and Parkinson’s Disease and Metabolic Disorders: Understanding Their Shared Co-Morbidity Through the Autonomic Nervous System.

    • Circadian Rhythms in Health and Disease

      • 1st Edition
      • Volume 393
      • English
      Circadian Rhythms in Health and Disease, Volume 393 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Circadian Rhythms in Cardiac Health and Disease, Liver as a nexus of daily metabolic cross talk, Non-rhythmic modulators of the circadian system: A new class of circadian modulators, The emerging role of circadian rhythms in exosome-mediated cellular crosstalk, Circadian rhythms and muscle health, and Output circuits from the suprachiasmatic nucleus controlling diverse physiological functions.