Skip to main content
Elsevier
View Cart
Your Account

Books in Molecular genetics

BooksJournals

The Chromosome 22q11.2 Deletion Syndrome

  • 1st Edition
  • August 19, 2022
  • Donna M. McDonald-McGinn
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 6 0 4 7 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 6 0 4 8 - 0
The Chromosome 22q11.2 Deletion Syndrome: A Multidisciplinary Approach to Diagnosis and Treatment serves as the first comprehensive, user-friendly resource on the etiology, prognosis, and recurrence risk associated with the chromosome 22q11.2 deletion syndrome. Leading international contributors cover the background, genetics, testing methods, and pathophysiology of 22q11.2DS, placing emphasis on a strong foundation for multidisciplinary treatment strategies. Written by specialists in every applicable subspecialty, such as, cardiology, immunology, endocrinology, gastroenterology, hematology, ophthalmology, neurology, and psychiatry, among other fields. This book presents an authoritative resource with full color images that enhance concept illustration and aid in real-time decision-making. As 22q11.2 deletion syndrome has become a model for understanding rare and frequent anomalies, numerous medical issues, cognitive and behavioral phenotypes, and later onset conditions, this text will become the go to resource for clinicians, researchers, trainees, and motivated family members, in gaining a full understanding of this complex chromosomal disorder.

Prenatal Genetic Counseling

  • 1st Edition
  • October 20, 2021
  • Sam Riedijk + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 3 3 2 9 - 0
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 3 3 3 1 - 3
**Selected for Doody’s Core Titles® 2024 in Clinical Genetics**Prenatal Genetic Counseling: Practical Support for Prenatal Diagnostics, Decision-Making, and Dealing with Uncertainty provides a foundation for new research and a one-stop source for physicians, genetic counselors, psychologists, social workers, general practitioners, grief workers, translational researchers, and administrators seeking to work in the field of clinical genomics ethically and in full consideration of patients’ psychological well-being. Here, an international team of experienced counselors and clinician-scientists lay out the range of methods and technologies applied in prenatal decision-making, including NIPT; invasive testing with microarray analysis or whole genome sequencing; ultrasound screening; and prenatal diagnosis for known hereditary conditions, among others. From here, they examine specific challenges in the clinical translation. In a field where decisions about life or death of a child are made, professionals are bound to encounter uncertainty. This book was co-created by health care practitioners, scientists, patients and students to provide insights and direction for offering support straight from the heart to couples faced with fetal anomalies. To make this possible for all couples, diversity in prenatal genetic counseling is also addressed. Finally, next steps in prenatal genetic counseling research and clinical implementation are discussed. As we are challenged by the rapid advances in prenatal genomics, so are our patients. Learning from our patients with every encounter, this book aims to offer access to the insights we gathered as well as to stimulate lifelong learning.

Diagnosis and Management of Hereditary Cancer

  • 1st Edition
  • March 20, 2021
  • John W. Henson + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 9 0 7 4 6 - 0
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 8 5 8 2 - 9
Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families.

Clinical DNA Variant Interpretation

  • 1st Edition
  • February 27, 2021
  • George P. Patrinos + 3 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 2 0 5 1 9 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 2 0 5 2 0 - 4
Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practical chapters discuss genomic variant interpretation, terminology and nomenclature, international consensus guidelines, population allele frequency, functional evidence transcripts for RNA, proteins, and enzymes, somatic mutations, somatic profiling, and much more.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

  • 1st Edition
  • August 15, 2019
  • Loutfy H. Madkour
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 9 7 7 7 - 6
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 9 7 7 8 - 3
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

Introductory Review on Sirtuins in Biology, Aging, and Disease

  • 1st Edition
  • April 20, 2018
  • Leonard Guarente + 2 more
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 1 3 4 9 9 - 3
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 3 5 0 0 - 6
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration.

Molecular Pathology

  • 2nd Edition
  • November 1, 2017
  • William B. Coleman + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 2 7 6 1 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 2 7 8 7 - 5
As the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine.  The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states.

Endocrine Biomarkers

  • 1st Edition
  • September 25, 2017
  • Hossein Sadrzadeh + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 3 4 1 2 - 5
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 3 4 1 8 - 7
Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.

Translational Bioinformatics and Systems Biology Methods for Personalized Medicine

  • 1st Edition
  • April 18, 2017
  • Qing Yan
  • English
  • Paperback
    9 7 8 - 0 - 1 2 - 8 0 4 3 2 8 - 8
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 4 3 8 8 - 2
Translational Bioinformatics and Systems Biology Methods for Personalized Medicine introduces integrative approaches in translational bioinformatics and systems biology to support the practice of personalized, precision, predictive, preventive, and participatory medicine. Through the description of important cutting-edge technologies in bioinformatics and systems biology, readers may gain an essential understanding of state-of-the-art methodologies. The book discusses topics such as the challenges and tasks in translational bioinformatics; pharmacogenomics, systems biology, and personalized medicine; and the applicability of translational bioinformatics for biomarker discovery, epigenomics, and molecular dynamics. It also discusses data integration and mining, immunoinformatics, and neuroinformatics. With broad coverage of both basic scientific and clinical applications, this book is suitable for a wide range of readers who may not be scientists but who are also interested in the practice of personalized medicine.

Advances in Genetics

  • 1st Edition
  • Volume 96
  • October 26, 2016
  • Theodore Friedmann + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 0 9 6 7 2 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 0 9 7 8 4 - 7
Advances in Genetics provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, critically analyzing future directions.