Diagnosis and Management of Hereditary Cancer
Tabular-Based Clinical and Genetic Aspects
- 1st Edition - March 20, 2021
- Imprint: Academic Press
- Authors: John W. Henson, Robert G Resta
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 7 4 6 - 0
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 8 5 8 2 - 9
Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for pa… Read more
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Request a sales quoteMany hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families.
- Unique table-based presentation of 50 key aspects of hereditary cancer
- Clinical features, genetics, genetic testing, diagnosis, counseling, and management of multiple hereditary cancer syndromes
- Table-based format to inter-relate clinical and scientific information
- Landscape layout for easier viewing of tabular information
Clinicians, oncologists, cancer researchers, geneticists, researchers with an interest in hereditary cancer and cancer genetics, genetic counselors, cancer surgeons, neuro-oncologists, gastroenterologists, internists, and family practitioners
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedications
- Foreword
- Abbreviations
- Introduction
- Section A: Genetics
- Table 1. Concepts in hereditary cancer genetics
- Abstract
- Table 2. Genetic alterations in hereditary cancer
- Section B: Genetics testing
- Table 3. Genetic counseling considerations
- Abstract
- Table 4. Genetic testing—constitutional
- Table 5. Genetic testing—tumor
- Table 6. DNA sources for genetic testing
- Table 7. Variant annotation
- Table 8. Analysis of a detected alteration
- Table 9. ACMG evidence of pathogenicity
- Table 10. ACMG rules for variant classification
- Table 11. Oncogenes in hereditary cancers
- Table 12. Autosomal recessive hereditary cancers
- Table 13. Autosomal recessive, nonneoplastic hereditary conditions from cancer genes
- Table 14. Digenic modifiers, contiguous genes, and phenocopies
- Table 15. Mechanisms of phenotypic variability
- Table 16. Pseudogenes of cancer susceptibility genes
- Section C: Clinical features
- Table 17. Red flags suggesting hereditary cancer
- Abstract
- Table 18. Key issues in eliciting and evaluating family histories
- Table 19. Pedigree symbols—Common symbols and definitions
- Table 20. Pedigree symbols—Line definitions
- Table 21. Pedigree symbols—evaluation and testing information
- Table 22. Physical examination—body region (Cephalad to Caudad)
- Table 23. Physical examination—syndrome
- Table 24. Risk estimation models
- Table 25. Screening, surveillance, and diagnostic tests for cancer
- Table 26. Physiologic imaging tests for PCC/PGL/neuroendocrine tumors
- Table 27. Management of known alterations
- Section D: Tumors—Syndromes—Genes
- Table 28. Tumors, syndromes, genes
- Abstract
- Table 29. Syndromes, tumors, genes
- Table 30. Genes, tumors, syndromes
- Table 31. Colorectal polyp types with associated syndromes
- Table 32. Genes—reference data
- Section E: Classic hereditary cancer syndromes
- Table 33. APC-associated polyposis hereditary conditions
- Abstract
- Table 34. Birt–Hogg–Dubé syndrome
- Table 35. Cowden syndrome/PHTS
- Table 36. Gorlin syndrome (Nevoid basal cell carcinoma syndrome)
- Table 37. Hereditary breast and ovarian cancers
- Table 38. Hereditary leiomyoma and renal cell carcinoma (HLRCC)
- Table 39. Hereditary pheochromocytoma/paraganglioma (PCC/PGL; HNPGL)
- Table 40. Li–Fraumeni syndrome
- Table 41. Lynch syndrome
- Table 42. Multiple endocrine neoplasia type 1
- Table 43. Multiple endocrine neoplasia type 2
- Table 44. MUTYH-associated polyposis (MAP)
- Table 45. Neurofibromatosis type 1
- Table 46. Neurofibromatosis type 2
- Table 47. Peutz–Jeghers syndrome
- Table 48. Retinoblastoma
- Table 49. Tuberous sclerosis complex
- Table 50. Von Hippel–Lindau syndrome
- Patient care plans
- Information sources
- Acknowledgments
- References
- Index
- Index of Genes
- Edition: 1
- Published: March 20, 2021
- Imprint: Academic Press
- No. of pages: 384
- Language: English
- Hardback ISBN: 9780323907460
- eBook ISBN: 9780323885829
JH
John W. Henson
Dr. Henson is director of the Hereditary Cancer Clinic at the Georgia Cancer Center, Medical College of Georgia, Augusta University, in Augusta, Georgia, USA. He has practiced neuro-oncology for over 25 years and is a well-published leader in several related fields, with over 125 papers and book chapters. He attended the Intensive Course in Cancer Genomic Risk Assessment at City of Hope in 2018. He was previously Chief of Oncology Services at Piedmont Healthcare and on the staff of Massachusetts General Hospital and the faculty of Harvard Medical School for 17 years. Dr. Henson is a member of numerous societies, including as an affiliate member of the American College of Medical Genetics.
Affiliations and expertise
Hereditary Cancer Clinic, Georgia Cancer Center, Augusta, GA,USA.RR
Robert G Resta
Mr. Resta is a retired cancer genetic counselor with 37 years of experience in the Swedish Hereditary Cancer Clinic. He is a well-known expert in this field with over 60 publications. He has published extensively on the historical, ethical, and psychological aspects of genetic counseling. He is a former Editor-in-Chief of the Journal of Genetic Counseling and a frequent contributor to The DNA Exchange, the most widely read genetic counseling blog. He is the 2013 recipient of the Natalie Weissberger Paul National Achievement Award, the most distinguished honor within the National Society of Genetic Counselors.
Affiliations and expertise
Genetic Counselor, Swedish Hereditary Cancer Clinic, Seattle, Washington, USARead Diagnosis and Management of Hereditary Cancer on ScienceDirect