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Elsevier

Books in Carcinogenesis

  • Lanzkowsky's Manual of Pediatric Hematology and Oncology

    • 8th Edition
    • Jonathan D. Fish + 2 more
    • English
    Lanzkowsky's Manual of Pediatric Hematology and Oncology, 8th Edition remains an essential resource for clinicians specializing in pediatric hematology and oncology, as well as other healthcare professionals dedicated to caring for children with blood disorders and cancers. This comprehensive text covers a wide array of topics, from molecular and genomic methodologies to specific hematologic disorders and various types of cancer, along with supportive care strategies. Such breadth equips readers with a deep understanding of the complexities inherent in pediatric hematology and oncology. Each chapter is authored by leading experts who provide the latest evidence-based practices, diagnostic techniques, and treatment modalities, ensuring that practitioners have access to authoritative insights for informed clinical decision-making. This manual offers the tools and strategies necessary for delivering high-quality, evidence-based care, ultimately enhancing patient outcomes and improving the quality of life for young patients. Whether you are a trainee, an early-career physician, or a seasoned practitioner, this manual is an indispensable reference that will support your journey in pediatric hematology and oncology.

  • Proteomics: A Promising Approach for Cancer Research

    Proteome Signaling Dysregulation in Cancer, Therapeutic Interventions, and Future Perspectives, Volume 2
    • 1st Edition
    • Muneeb U Rehman + 3 more
    • English
    Proteomics: A Promising Approach for Cancer Research Volume 2 Proteome signaling dysregulation in cancer, therapeutic interventions, and future perspectives provides an updated overview of scientific knowledge, achievements, and findings in the field of cancer proteomics. The field of cancer proteomics is very dynamic, with emerging trends specifically related to clinical solutions. The book content was developed to help readers get up to speed on the topic and easily apply learnings into research or clinical practice.Volume 2 covers proteome signaling, their dysregulation to therapeutics options and future prospects in 17 different signaling pathways. It capitalizes the enormous interest in proteomics among academics and gives new viewpoints on this topic in cancer treatment. It is a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment.

  • Principles of Immunotherapy in Breast and Gastrointestinal Cancers

    Activity, Mechanisms of Resistance and New Sensitization Strategies
    • 1st Edition
    • Michele Ghidini
    • English
    Principles of Immunotherapy in Breast and Gastrointestinal Cancers: Activity, Mechanisms of Resistance, and New Sensitization Strategies presents updated research findings on immunotherapy, with a special focus on the mechanisms of resistance of those cancer types and how to overcome them.The book discusses topics such as tumor cell-intrinsic and -extrinsic mechanisms of cancer resistance to immunotherapy; the role of currently available biomarkers; strategies to overcome therapeutic resistance; sensitizing agents for cancer resistance to cell-mediated immunotherapy; and immunotherapeutic approaches, mechanisms of resistance, and sensitizing strategies in gastroesophageal and biliopancreatic tumors and colorectal cancer.It is a valuable resource for researchers, students, and members of the biomedical and medical fields who want to learn more about resistance to immunotherapy and how to overcome it.

  • Onco-Palliative Care Essentials

    • 1st Edition
    • Azar Naveen Saleem + 2 more
    • English
    **Selected for 2026 Doody's Core Titles in Oncology**Onco-Palli... Care Essentials gives insight into the much-needed specialty to improve the quality of life of cancer patients. With a strong focus on the fundamental essentials of onco-palliative care, this book covers real-life cases with challenging cultural, existential, and social aspects.This book introduces the field of onco-palliative care to the reader, focusing on managing complex aspects associated with cancer and its treatment. It also helps the reader regarding approaches for “end of life care and discussion.” This book concludes with challenging care scenarios.Onco-Palli... Care Essentials is a very useful reference for all who are involved in cancer and palliative care, as well as those who care for cancer and terminally ill patients.

  • Functionalized Nanomaterials for Cancer Research

    Applications in Treatments, Tools and Devices
    • 1st Edition
    • Hamed Barabadi + 2 more
    • English
    Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step-by-step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients’ overall outcomes. The book discusses functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The book's chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. This is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment.

  • Treatment Landscape of Targeted Therapies in Oncology

    Challenges and Opportunities
    • 1st Edition
    • Pawan Kumar Maurya + 1 more
    • English
    Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help those who are new to the field (beginners) and various specialized scientists and researchers involved in cancer research. For decades, the hallmark of cancer treatment has been conventional chemotherapy. But with the rapid increase in our understanding of the immune system, more and more small molecules, peptides, recombinant antibodies, vaccines and cellular therapeutic modalities are being applied to manipulate the immune response for cancer treatment.

  • Epigenetic Cancer Therapy

    • 2nd Edition
    • Steven Gray
    • English
    Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use. Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

  • Proteomics

    A Promising Approach for Cancer Research
    • 1st Edition
    • Shafat Ali + 2 more
    • English
    Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment. The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book's content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice.

  • Lanzkowsky's Manual of Pediatric Hematology and Oncology

    • 7th Edition
    • Jonathan D. Fish + 2 more
    • English
    Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks.

  • Diagnosis and Management of Hereditary Cancer

    Tabular-Based Clinical and Genetic Aspects
    • 1st Edition
    • John W. Henson + 1 more
    • English
    Many hereditary cancer syndromes are linked to alterations in single genes. Detection and clinical interpretation of these alterations can guide cancer risk reduction for patients and their families through screening, prophylactic measures, and other strategies. Diagnosis and Management of Hereditary Cancer summarizes hereditary syndromes and their associated cancers and genes. The information is presented in 50 practice-enhancing tables that relate clinical, genetic, diagnostic, and management aspects in a manner that has previously not been available in a single reference. Intended to guide the specialist as well the novice, this volume will elevate the care of hereditary cancer patients and their families.

  • Cancers in the Urban Environment

    How Malignant Diseases Are Caused and Distributed among the Diverse People and Neighborhoods of a Major Global Metropolis
    • 2nd Edition
    • Thomas M. Mack
    • English
    Cancers in the Urban Environment: How Malignant Diseases Are Caused and Distributed among the Diverse People and Neighborhoods of a Major Global Metropolis, Second Edition, provides a detailed description of the occurrence of common forms of cancer in the ethnically, socially and environmentally complex milieu of a modern urban complex. The location is Los Angeles County, and the patterns of 72 different malignancies are described according to race, age, sex, social class calendar time (since 1972) and most notably, individual neighborhood, using detailed maps of high risk. This second edition uses twice as many cases and more demographic diversity. Physicians and scientific investigators in California and elsewhere can use the material provided to counsel patients and evaluate the consistency of any specific pattern of occurrence with each specific causal hypothesis. A detailed appendix describes the source of data, provides the basis for the choices made in the production of the volume, and gives a perspective on the search for "clusters" of malignancy.

  • Strategies for Curative Fluorescence-Guided Surgery of Cancer

    • 1st Edition
    • Robert Hoffman + 1 more
    • English
    Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique.

  • An Evidence-Based Approach to the Management of Nasopharyngeal Cancer

    From Basic Science to Clinical Presentation and Treatment
    • 1st Edition
    • Baharudin Abdullah + 2 more
    • English
    An Evidence-Based Approach to the Management of Nasopharyngeal Cancer: From Basic Science to Clinical Presentation and Treatment provides a comprehensive overview with updated management procedures for nasopharyngeal carcinoma. Written by experts on the subject, it is organized in a simple yet comprehensive manner to aid in the understanding of this complex condition. The book discusses several topics related to NPC, including epidemiology, pathophysiology, risk factors and treatment (surgical and non-surgical). Additionally, it discusses key features of clinical presentation of NPC, recent advances and promising new therapies. This will be a valuable source for clinicians, graduate students, oncologists and several members of the biomedical field who are interested in understanding nasopharyngeal cancer in a practical and applicable way.

  • Cellular Signalling in Cancer Metastasis

    • 1st Edition
    • English
    Cellular Signalling in Cancer Metastasis provides the reader with in-depth information on the cellular signaling mechanisms responsible for cancer metastasis. While significant progress has been made in understanding the mechanisms responsible for metastasis, the lack of a comprehensive book compiling these aspects was necessary, hence the development of this timely resource. This book is intended to help entry level researchers, from graduate students, postdocs and early career scientists, but is detailed enough to be considered by seasoned scientists. It provides the reader with the current knowledge available on the subject and stimulates others to take up investigations on understanding cancer metastasis.

  • Comprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors

    • 1st Edition
    • Kaisorn Chaichana + 1 more
    • English
    Comprehensive Overview of Modern Surgical Approaches to Intrinsic Brain Tumors addresses limitations in the scientific literature by focusing primarily on surgical approaches to various intrinsic neoplasms using diagrams and step-by-step instructions. It provides the advantages and disadvantages of these approaches, controversies, and technical considerations and discusses topics such as anatomy, pathology and animal models, imaging, open brain tumor approaches and minimally invasive approaches. Additionally, it discusses controversial treatments and the pros and cons of each. This book is a valuable source for medical students, neurosurgeons and any healthcare provider who has an interest in brain tumors and techniques to treat them.

  • Malignant Pleural Mesothelioma

    A Guide for Clinicians
    • 1st Edition
    • Antonio Giordano + 1 more
    • English
    Malignant Pleural Mesothelioma: A Guide for Clinicians is a practical book developed to assist clinicians, pathologist and molecular biologist in the management of malignant pleural mesothelioma (MPM). MPM represents a challenge in terms of diagnosis, staging and treatment, and to date, the optimal management of MPM patients has not yet been clearly defined – and this book is intended to be an efficient tool for these cases. The book encompasses topics such as epidemiology and surveillance evidence, multimodality imaging assessment of MPM, pathology, molecular mechanisms and treatment of such disease. Additionally, it discusses the standard operative procedures and the future directions for the management of MPM from experts’ experiences. Malignant Pleural Mesothelioma: A Guide for Clinicians is a valuable source for oncologists, pathologist, cancer researchers, thoracic specialists and several members of biomedical field who needs to learn more from experts about the diagnosis, operative procedures and treatment of malignant pleural mesothelioma.

  • Computational Epigenetics and Diseases

    • 1st Edition
    • Volume 9
    • English
    Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research.

  • Oncogenomics

    From Basic Research to Precision Medicine
    • 1st Edition
    • Franco Dammacco + 1 more
    • English
    Oncogenomics: From Basic Research to Precision Medicine offers a thorough survey of precision medicine and its diagnostic and therapeutic applications in oncology. Gathering contributions from leading international researchers in the field, chapters examine recent translational advances in oncogenomic methods and technologies, detailing novel molecular classifications of tumors as well as diagnostic and prognostic biomarkers for various types of cancers including pancreatic, gastrointestinal, breast, hematological, lung, osteotropic, genitourinary, and skin cancers. This book provides a foundation for clinical oncologists, human geneticists, and physicians to develop new targeted cancer treatments and incorporate genomic medicine into clinical practice, with particular attention paid to noninvasive diagnostic techniques such as the liquid biopsy and molecular characterization of solid malignancies.

  • Novel Designs of Early Phase Trials for Cancer Therapeutics

    • 1st Edition
    • Shivaani Kummar + 1 more
    • English
    Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials.

  • Systems Biology and Its Application in TCM Formulas Research

    • 1st Edition
    • Weidong Zhang
    • English
    Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine.

  • Advances in Cell and Molecular Diagnostics

    • 1st Edition
    • P.B. Raghavendra + 1 more
    • English
    Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare.

  • Cutaneous Melanoma

    A Pocket Guide for Diagnosis and Management
    • 1st Edition
    • Giuseppe Argenziano + 5 more
    • English
    Cutaneous Melanoma: A Pocket Guide for Diagnosis and Management serves as an easy-to-consult, short, and schematic reference providing guidelines for diagnosing and managing melanoma in the context of various clinical scenarios. In the daily routine of a busy clinician, there is a need for schematic reference tools that allow quick consultation for immediate decisions. Melanoma is a deadly disease that should be promptly managed following precise and evidence-based guidelines. The guide contains many schematics and figures, vastly outnumbering the pages dedicated to text. This guide follows the sequence of a real clinical setting, going from the first screening visit to the final stages of terminal patients.

  • Ethical Challenges in Oncology

    Patient Care, Research, Education, and Economics
    • 1st Edition
    • Colleen Gallagher + 1 more
    • English
    Ethical Challenges in Oncology: Patient Care, Research, Education, and Economics covers a wide variety of topics and viewpoints about ethical issues that arise in oncology throughout the full cancer care continuum. This book provides a holistic view on oncology ethics, incorporating the knowledge and expertise of authors from various departments and oncology specialties within the University of Texas MD Anderson Cancer Center. The first section focuses on the ethical issues associated with treating cancer patients. Next, the ethical challenges associated with oncology research, including funding, regulation, subject selection and the big picture are explored. The third section covers ethical issues associated with education in oncology as it reflects both past and future trends in developing proficient health care providers, patients and even executives. Final sections concentrate on the ethical dilemmas associated with the economic repercussions of oncology, offering thoughts on how to alleviate the ethical consequences that can arise from the global effects of cancer and cancer treatment. Each chapter includes discussion topics, answers pertinent questions and provides an ethical framework for problem- solving in each scenario. The topics uncover the ethical apprehensions and problems associated with oncology research and practice in order to determine best practices as well as provide guidance for all parties involved.

  • Molecular Approach to Cancer Management

    • 1st Edition
    • Gajanan V. Sherbet
    • English
    Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.

  • Thyroid Cancer and Nuclear Accidents

    Long-Term Aftereffects of Chernobyl and Fukushima
    • 1st Edition
    • Shunichi Yamashita + 1 more
    • English
    Thyroid Cancer and Nuclear Accidents: Long-Term Aftereffects of Chernobyl and Fukushima discusses the radiobiological effects of the release of radioiodine from two nuclear power plant accidents and appropriate interpretation of the results of thyroid ultrasound examination. The book pulls together expert opinion on radiation related thyroid cancer in an understandable manner, even for non thyroidologists. The book explains what has been learned from both accidents in relation to prevention of thyroid cancer following nuclear power plant accidents. The book encompasses topics such as risk estimations of thyroid cancer following nuclear accidents and clinical aspects after those specific situations. Additionally, it discusses in detail the reports from Fukushima related to thyroid cancer in the population. This book is a valuable resource for oncologists and biomedical researchers with interest in nuclear accidents and cancer cases.

  • Applications of Mass Spectrometry Imaging to Cancer

    • 1st Edition
    • Volume 134
    • English
    Applications of Mass Spectrometry Imaging to Cancer, the latest volume in the Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on applications of mass spectrometry imaging to cancer.

  • Cancer Disparities

    • 1st Edition
    • Volume 133
    • English
    Cancer Disparities, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This latest volume presents a broad introduction to a spectrum of factors contributing to cancer disparities that include ancestral informative markers’ role in properly identifying race based on genetic ancestry, basic biological pathways contributing to cancer disparities, epidemiological factors linked to cancer disparities, and social/behavioral factors influencing cancer disparities.

  • Handbook of Supportive and Palliative Radiation Oncology

    • 1st Edition
    • Monica S Krishnan + 2 more
    • English
    Handbook of Supportive and Palliative Radiation Oncology serves as a practical tool and rapid reference to assist radiation oncology practitioners in direct patient care with common palliative care issues. Containing the most recent advances in translational palliative care research, each chapter is organized in a succinct fashion to discuss major symptom burdens, suggested assessment, and various management options. Each symptom and disease section is written to be a rapid, practical guide for clinicians on the floor. The book starts with general approaches in palliative radiation oncology that are followed by a section that focuses on common symptoms in palliative care and their management. The next section of the book is devoted to site and disease-specific evaluation, intervention, and management. This handbook provides general guidelines and management recommendations for common clinical vignettes encountered by palliative radiation oncology practitioners and supported by palliative radiation oncology research. Concise references are cited to support treatment recommendation.

  • Anti-Angiogenesis Strategies in Cancer Therapies

    • 1st Edition
    • Shaker Mousa + 1 more
    • English
    Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences.

  • Cancer Stem Cells

    Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance
    • 1st Edition
    • Huiping Liu + 1 more
    • English
    Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies.

  • Conquering RAS

    From Biology to Cancer Therapy
    • 1st Edition
    • Asfar Azmi
    • English
    Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient’s bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 131
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

  • Informed and Healthy

    Theoretical and Applied Perspectives on the Value of Information to Health Care
    • 1st Edition
    • Maria G. N. Musoke
    • English
    Informed and Healthy: Theoretical and Applied Perspectives on the Value of Information to Health Care focuses on two major issues: the value attributed to information by users and its effect on health care; and, a new model of information behavior in which the value of information drives various information activities (unlike many information models which tend to give prominence to information needs). The inductive development of the model is explained, with associated implications for theory and transferability or applicability elsewhere. The book uses a case study of the health information system in Uganda and expands the analysis by comparing it to other systems utilized by different countries in diverse levels of development. Topics such as access and use of information; value attribution and effect on health outcomes; and modelling information behavior and its implications on health informatics are discussed in detail. This book is a valuable resource for health professionals, planners, and policy makers, as well as researchers interested in health information systems and their applicability in different environments.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 10
    • 1st Edition
    • M. A. Hayat
    • English
    Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy.

  • DNA Repair in Cancer Therapy

    Molecular Targets and Clinical Applications
    • 2nd Edition
    • Mark R. Kelley + 1 more
    • English
    DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.

  • Lanzkowsky's Manual of Pediatric Hematology and Oncology

    • 6th Edition
    • Jonathan D. Fish + 2 more
    • English
    Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Sixth Edition, is a comprehensive book on patient management, replete with algorithms and flow diagrams on diagnosis and management. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the sixth edition of this successful clinical manual has been entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format will enable readers to make accurate diagnoses and permit them to treat patients without having to reference larger medical textbooks. Based on the new standards of genetic classification and prognostic information that have arisen in the past five years, the sixth edition includes two new chapters (Diagnostic, Molecular, and Genomic Methodologies for the Hematologist, Transfusion Medicine) and several new expanded chapters that were previously sections in consolidated chapters (Myelodysplasia, Myeloid Leukemias, Lymphoid Leukemias, Hemolytic Anemia, and Disorders of Coagulation).

  • Advances in Cancer Research

    • 1st Edition
    • Volume 130
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research, presenting outstanding and original reviews on a variety of topics.

  • Breast Cancer Screening

    Making Sense of Complex and Evolving Evidence
    • 1st Edition
    • Nehmat Houssami + 1 more
    • English
    Breast Cancer Screening: Making Sense of Complex and Evolving Evidence covers broad aspects of breast cancer screening specifically focusing on current evidence, emerging evidence, and issues that will be critical for future breast screening practice such as tailored screening and shared decision-making in breast screening. The scope of the book is relevant to a global audience. This book provides balanced perspectives on this increasingly controversial topic, using scientific evidence to explain the evolution of knowledge relating to breast cancer screening. Breast Cancer Screening covers the key points related to this debate including the context of increasingly complex and conflicting evidence, divergent opinions on the benefits and harms of breast screening, and variability in screening practice and outcomes across settings around the world.

  • Hsp90 in Cancer: Beyond the Usual Suspects

    • 1st Edition
    • Volume 129
    • English
    Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 8- Human Diseases
    • 1st Edition
    • M. A. Hayat
    • English
    Volume 8 Autophagy and Human Diseases, concentrates on the role of Autophagy in human diseases, including tumorigenesis. The diseases discussed include melanoma, liver cancer, pancreatic cancer, and neurodegenerative disorders. Loss of autophagy in the central nervous system causes neurodegeneration (Alzheimers disease, Huntington’s disease, Parkin’s disease, and Amyotrophic Lateral Sclerosis). Melanoma is one of the most serious diseases in humans. Autophagy plays a key role in the anticancer response to Chemotherapy. However, autophagy can increase or decrease the effectiveness of chemotherapy. The reasons for these contradictory effects are explained. Autophagy also plays a role in idiopathic inflammatory diseases, infection, and immunity. An explanation is given how autophagy is closely linked to control of innate and adaptive immune responses in host defense in part by regulating cytokine production. The role of autophagy in cutaneous malignant melanoma is discussed in detail and expression of Beclin 1 and LC3 autophagic genes in melanoma is included to explain the molecular mechanisms underlying this very serious disease, which tends to metastasize to the brain. The effect of the treatment of this disease using Terfenadine through the induction of autophagy and apoptosis is also included. Autophagy and apoptosis are two main mechanisms involved in programmed cell death.

  • Prostate Cancer

    Science and Clinical Practice
    • 2nd Edition
    • Jack H. Mydlo + 1 more
    • English
    Prostate Cancer, Science and Clinical Practice, Second Edition, continues to be an important translational reference that bridges the gap between science and clinical medicine. It reviews the biological processes that can be implicated in the disease, reviews current treatments, highlights the pitfalls where relevant, and examines the scientific developments that might result in future treatments. Key chapters from the previous edition have been updated, and a plethora of new chapters describe new concepts of prostate cancer biology and newly developed therapeutics. Each chapter has been written by internationally recognized specialists on prostate cancer epidemiology, genetic susceptibility, cancer metastases, prostate physiology, proteomics, new therapeutics, and clinical trials.

  • Principles of Tumors

    • 1st Edition
    • Leon P. Bignold
    • English
    Principles of Tumors covers all of the fundamental aspects of tumors, including their definitions, incidences, causation, pathogenesis, treatments, and prevention. The book provides a unique approach, integrating a wide range of basic bioscience findings with clinico-pathological observations and phenomena encountered in their treatment. As tumors are studied in fairly separate, broad areas, such as basic biological sciences, pathology, oncology, and epidemiology, this book brings together these perspectives, providing an all-inclusive text that benefits all researchers, while also providing an avenue for translational research.

  • Cancer Treatment and the Ovary

    Clinical and Laboratory Analysis of Ovarian Toxicity
    • 1st Edition
    • Richard A Anderson + 1 more
    • English
    Cancer Treatment and the Ovary: Clinical and Laboratory Analysis of Ovarian Toxicity provides the reader with a basic understanding on how the ovary is adversely impacted by cancer treatment, an essential foundational knowledge for this rapidly-developing field. The book describes both the clinical and laboratory approaches to discovering the potentially adverse effects of cancer treatment on the ovary, also laying out possible preventative approaches and future directions for the field. Clinicians working in the field of reproductive biology and oncology will find an essential reference that provides the necessary tools to assess the reproductive toxicological effects of cancer treatments.

  • Immunotherapy of Cancer

    • 1st Edition
    • Volume 128
    • English
    Immunotherapy of Cancer provides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.

  • Epigenetic Cancer Therapy

    • 1st Edition
    • Steven Gray
    • English
    Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 127
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including taxane-anti-androgen... cross-resistance in advanced prostate cancer and proteasome inhibitors in the treatment of multiple myeloma.

  • Glycosylation and Cancer

    • 1st Edition
    • Volume 126
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

  • Brain Metastases from Primary Tumors, Volume 2

    Epidemiology, Biology, and Therapy
    • 1st Edition
    • M. A. Hayat
    • English
    Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.

  • Craniopharyngiomas

    Comprehensive Diagnosis, Treatment and Outcome
    • 1st Edition
    • James J. Evans + 1 more
    • English
    Craniopharyngiomas: A Comprehensive Guide to Diagnosis, Treatment and Outcome is a comprehensive guide to the science, diagnosis and treatment of craniopharyngiomas, rare brain tumors that grow near the pituitary gland. Even though these tumors are generally benign, due to the location, prognosis was often bleak. This reference provides a resource for specialists requiring a comprehensive overview of this rare form of tumor, outlining new diagnostic, imaging and surgical techniques, including endoscopic endonasal cranial base surgery, which enable successful neurosurgical intervention. With a better prognosis, patients require multidisciplinary management from neurology, otolaryngology, radiation oncology, endocrinology, and neuropathology.

  • Emerging Applications of Molecular Imaging to Oncology

    • 1st Edition
    • Volume 124
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, including molecular-genetic imaging, imaging the tumor microenvironment, tracking cells and vaccines in vivo, and more.