
Functionalized Nanomaterials for Cancer Research
Applications in Treatments, Tools and Devices
- 1st Edition - March 21, 2024
- Editors: Hamed Barabadi, Ebrahim Mostafavi, Chaudhery Mustansar Hussain
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 1 8 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 5 1 9 - 2
Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step-by-step description of knowledge on functiona… Read more

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Request a sales quoteFunctionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step-by-step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients’ overall outcomes. The book discusses functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The book's chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. This is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment.
- Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments
- Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities
- Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Part I: Introduction: Functionalized nanomaterials for cancer therapy research and new perspectives
- Chapter 1. Cancer theranostics: recent global advances
- Abstract
- 1.1 An introduction to cancer
- 1.2 An overview of theranostics
- 1.3 FDA-approved theranostic agents
- 1.4 Toxicity assessment of theranostics
- 1.5 Challenges
- Acknowledgment
- References
- Chapter 2. Cancer nanotechnology: a new approach to upgrade cancer diagnosis and therapy
- Abstract
- 2.1 Introduction
- 2.2 Nanotechnologies in cancer diagnosis
- 2.3 Nanotechnologies and cancer therapy
- 2.4 Cancer theragnostic
- 2.5 Nanotechnology clinical trials for cancer treatment
- 2.6 Challenges and future remarks
- 2.7 Conclusion
- Acknowledgment
- Conflict of interest
- References
- Chapter 3. Functionalized nanobiomaterials for cancer-targeted therapy: an overview
- Abstract
- 3.1 Introduction
- 3.2 Classification
- 3.3 Nanobiomaterials’ generations
- 3.4 Nanobiomaterials characteristics need to be considered in therapeutic applications
- 3.5 Therapeutic applications of nanobiomaterials
- 3.6 Functionalized nanobiomaterials used in cancer therapy
- 3.7 Challenges to overcome for clinical translation
- 3.8 Concluding remarks
- Acknowledgement
- References
- Part II: Functionalized nanomaterials for cancer therapy research: synthesis, manufacturing, and functionalization
- Chapter 4. Recent innovations of nanomaterials in manufacturing processes
- Abstract
- 4.1 The importance of nanotechnology
- 4.2 Nanotechnology in the pharmaceutical industry
- 4.3 Batch versus continuous manufacturing processes
- 4.4 Continuous manufacturing methodologies
- 4.5 Drug formulation using nanomaterials
- 4.6 Additive manufacturing in pharmaceuticals
- 4.7 Electrohydrodynamic atomization
- 4.8 Process analytical technology (PAT)
- 4.9 Conclusion
- References
- Chapter 5. Novel surface functionalization techniques for designing smart nanomaterials for cancer treatment
- Abstract
- 5.1 Introduction
- 5.2 Surface functionalization of the nanomaterials
- 5.3 Nanomaterial fabrication/functionalization technique
- 5.4 Surface functionalization techniques
- 5.5 Surface functionalized smart nanoparticle techniques for cancer treatment
- 5.6 Conclusions
- References
- Part III: Functionalized nanomaterials for cancer research: applications
- Chapter 6. Hybrid multifunctional nanomaterials for cancer diagnostics and therapeutics
- Abstract
- 6.1 Introduction
- 6.2 Classification of hybrid nanomaterials
- 6.3 Synthesis of hybrid multifunctional nanomaterials
- 6.4 Hybrid nanomaterials in codelivery of combination treatments
- 6.5 Hybrid nanomaterial-based cancer imaging
- 6.6 Hybrid nanomaterials in photodynamic therapy and photodynamic diagnosis
- 6.7 Immune system stimulation by a multifunctional biomimetic platform
- 6.8 Hybrid multifunctional nanomaterials in cancer precision medicine
- 6.9 Conclusion and future perspectives
- References
- Chapter 7. Functionalized lipoplexes and polyplexes for cancer therapy
- Abstract
- 7.1 Introduction
- 7.2 Choosing vector for gene therapy
- 7.3 Lipoplexes
- 7.4 Polyplexes
- 7.5 Lectin functionalized nanocarriers for gene delivery
- 7.6 Nanovectors for systemic siRNA transport
- 7.7 Future prospects and conclusion
- References
- Chapter 8. Functionalized exosomes for cancer therapy
- Abstract
- 8.1 Introduction
- 8.2 Synthesis of functionalized exosome
- 8.3 Effect of functionalized exosome on immune cells
- 8.4 Targeting cellular signaling through functionalized exosome
- 8.5 Exosome as prognostic marker
- 8.6 Exosomal proteins as potential biomarkers for cancers
- 8.7 Challenges
- 8.8 Conclusion
- References
- Chapter 9. Functionalized Archaeosomes for Cancer Therapy
- Abstract
- 9.1 Introduction
- 9.2 Nanoliposomes
- 9.3 Different types of liposomes, preparation methods, and their new generations
- 9.4 Application of liposomes
- 9.5 Structural properties and biosynthesis of archaeal lipids
- 9.6 Archaeal lipids: unusual physical properties and biomedical applications
- 9.7 Archaeosomes for targeted drug delivery: An insight
- 9.8 Surface modification of liposomes for targeted drug delivery
- 9.9 Functionalized archaeosomes as biological nanocarriers for anti-cancer agents
- 9.10 Challenges and limitations of archaeosomes for cancer therapy
- 9.11 Future perspective
- References
- Chapter 10. Functionalized bilosomes for cancer therapy
- Abstract
- 10.1 Introduction
- 10.2 Photochemical nanosystems for cancer therapy
- 10.3 Properties of the bilosomes
- 10.4 Studies on the use of bilosomes as nanocarriers
- 10.5 Studies on the use of bilosomes in cancer therapy applications
- 10.6 Future perspectives and concluding remarks
- 10.7 Conclusion
- References
- Chapter 11. Functionalized bioengineered metal-based nanomaterials for cancer therapy
- Abstract
- 11.1 Cancer: a global threat
- 11.2 Current cancer therapeutics: challenges and limitations
- 11.3 Nanotechnology: an overview
- 11.4 Unique properties of nanomaterials
- 11.5 Metal-based nanomaterials: properties and biomedical applications
- 11.6 Bioengineering of metal-based nanoparticles: an insight
- 11.7 Anticancer properties of bioengineered metal-based nanoparticles
- 11.8 Conclusions and future outlook
- References
- Chapter 12. Functionalized peptide and protein-based nanomaterials for cancer therapy
- Abstract
- 12.1 Introduction
- 12.2 Types of protein and peptide nanocarriers
- 12.3 Synthesis strategies of peptide and protein-based nanocarriers
- 12.4 Functionalized nanoparticles
- 12.5 Applications of protein/peptide nanoparticles as delivery systems in cancer therapy
- 12.6 Outlooks
- References
- Chapter 13. Functionalized nanobody-based delivery systems for cancer diagnosis and therapeutic applications
- Abstract
- 13.1 Introduction
- 13.2 Physical and biochemical characteristics of nanobody
- 13.3 Nanobody and cancer therapeutic strategies
- 13.4 Nanobody conjugates in cancer diagnosis
- 13.5 Nanobody and cancer therapy
- 13.6 Conclusion and future perspectives
- References
- Chapter 14. Functionalized phytosomes for cancer therapy
- Abstract
- 14.1 Introduction
- 14.2 Phytosomes as drug delivery systems
- 14.3 Preparation of phytosome-based delivery systems
- 14.4 Targeted drug delivery of phytosomes
- 14.5 Effects of phytosomes on pharmacokinetic features
- 14.6 Application of phytosomes in cancer therapy
- 14.7 Conclusion
- References
- Chapter 15. Functionalized porphysomes and porphyrin-based nanomaterials for cancer therapy
- Abstract
- 15.1 Introduction
- 15.2 Cancer theranostics using porphyrin-based nanomaterials
- 15.3 Different porphyrin-based nanoparticles cancer theranostic
- 15.4 Conclusion and future directions
- Acknowledgment
- References
- Chapter 16. Functionalized liposomes and niosomes for cancer therapy
- Abstract
- 16.1 Structure and properties of liposomes and niosomes
- 16.2 Preparation methods
- 16.3 Surface functionalized liposome/niosome
- 16.4 Targeting cancer cells with different surface functionalization
- 16.5 Smart responsive liposomes/niosomes and cancer therapy
- 16.6 Conclusion
- References
- Chapter 17. Functionalized dendrimers for cancer therapy
- Abstract
- 17.1 Introduction
- 17.2 Dendrimers and their advantages and disadvantages
- 17.3 Brief history of dendrimers production
- 17.4 Dendrimers in drug delivery systems
- 17.5 Functionalized dendrimers
- 17.6 In vitro and in vivo studies
- 17.7 Preclinical and clinical trials
- 17.8 Prospects for the use of functionalized dendrimers in diseases, including cancer
- 17.9 Current status and prediction
- 17.10 Conclusion and future perspectives
- References
- Chapter 18. Functionalized polymersomes for cancer therapy
- Abstract
- 18.1 Introduction
- 18.2 Design and preparation of polymersomes
- 18.3 Drug encapsulation in polymersomes
- 18.4 Mechanisms of drug release from polymersomes
- 18.5 Polymersomes in various cancer therapy
- 18.6 Theranostic application of polymersomes in cancer
- 18.7 Conclusion and future perspectives
- References
- Chapter 19. Functionalized quantum dot–based nanomaterials for cancer therapy
- Abstract
- 19.1 Introduction
- 19.2 Synthesis of functionalized quantum dots
- 19.3 General anticancer mechanism of functionalized quantum dots
- 19.4 Anticancer activity of functionalized carbon-based quantum dots
- 19.5 Anticancer activity of functionalized Cd-based quantum dots
- 19.6 Anticancer activity of functionalized Zn-based quantum dots
- 19.7 Theranostics applications of functionalized quantum dots
- 19.8 Biosafety of functionalized quantum dots
- 19.9 Conclusion
- References
- Chapter 20. Functionalized magnetic nanoparticles for cancer therapy
- Abstract
- 20.1 Introduction
- 20.2 Magnetic nanoparticles, their advantages, and disadvantages
- 20.3 Types of magnetic nanoparticles
- 20.4 A brief history of magnetic nanoparticles production
- 20.5 Magnetic nanoparticles in drug delivery systems
- 20.6 Functionalized magnetic nanoparticles
- 20.7 Current status and prediction
- 20.8 Conclusion and future perspectives
- References
- Chapter 21. Functionalized carbon-based nanomaterials for cancer therapy
- Abstract
- Graphical abstract
- 21.1 Introduction
- 21.2 Why carbon nanomaterials are suitable for biomedical applications, especially for cancer therapy?
- 21.3 Functionalization of carbon-based nanomaterials for cancer therapy
- 21.4 Cancer therapy methods by carbon-based nanocarriers
- 21.5 Types of carbon-based nanomaterials used in cancer treatment
- 21.6 Conclusions and perspectives
- References
- Chapter 22. Functionalized nanofibers for cancer therapy
- Abstract
- 22.1 Introduction
- 22.2 Encapsulated cargoes for cancer therapy
- 22.3 Different release profiles in nanofibers
- 22.4 Functionalization approaches
- 22.5 Novel forms of functionalized nanofibers
- 22.6 Conclusion
- References
- Chapter 23. Applications of liposomes for overcoming cancer drug resistance
- Abstract
- Abbreviations
- 23.1 Introduction
- 23.2 Codelivery systems
- 23.3 Actively targeted systems
- 23.4 Trigger-responsive systems
- 23.5 Combinational and miscellaneous strategies
- 23.6 Conclusion and future directions
- References
- Chapter 24. New generation of composite carbon quantum dots for imaging, diagnosing, and treatment of cancer
- Abstract
- 24.1 Introduction
- 24.2 New generation of composite carbon quantum dots
- 24.3 Nano and subnanoparticles for the cancer treatment
- 24.4 Problems and hurdles with quantum dots
- 24.5 Conclusion
- References
- Part IV: Functionalized nanomaterials: other aspects
- Chapter 25. Functionalized nanomaterials: health and safety
- Abstract
- 25.1 Introduction
- 25.2 Functionalized nanomaterials in vivo
- 25.3 Toxicity and safety concerns of functionalized nanomaterials
- 25.4 Developing sustainable nanomaterials for effective healthcare system
- 25.5 Conclusion and future perspective
- References
- Chapter 26. Commercial and regulatory challenges in cancer nanomedicine
- Abstract
- 26.1 Introduction
- 26.2 Different aspects of cancer treatment and limitations of current methods
- 26.3 Rationale for the development of nanomedicines for cancer treatment: commercialization values
- 26.4 Nanomedicine global market and cancers currently diagnosed and treated using commercialized nanomedicines
- 26.5 Ecosystem of cancer nanomedicines and nanodiagnostics industry: the role of players and their share for existing challenges
- 26.6 The workflow from bench to bedside
- 26.7 Challenges in translation, commercialization, and regulations
- 26.8 Case studies
- 26.9 Future perspective
- 26.10 Conclusion
- References
- Chapter 27. Biocompatibility and toxicity challenges of nanomaterials
- Abstract
- Abbreviations
- 27.1 Introduction
- 27.2 What are biocompatibility and toxicity?
- 27.3 Types of nanomaterials for cancer therapy
- 27.4 Physicochemical parameters influencing biocompatibility and toxicity of nanomaterials
- 27.5 Cellular mechanisms of nanomaterial toxicity
- 27.6 Long-term risk assessment of nanomaterials
- 27.7 Conclusion and future perspective
- Acknowledgements
- References
- Chapter 28. Functionalized nanomaterials and sustainable development
- Abstract
- 28.1 Introduction
- 28.2 Green nanotechnology used to treat cancer
- 28.3 Nanomaterials’ functionalization
- 28.4 Methods for functionalizing nanoparticles
- 28.5 Green synthesis of modified nanomaterials
- 28.6 Design strategies and mechanisms of drug release
- 28.7 Approaches to functional nanomaterials in cancer therapy
- 28.8 Conclusion
- Acknowledgements
- References
- Chapter 29. Cancer nanoimmunotherapy in the present scenario
- Abstract
- 29.1 Introduction
- 29.2 Immune system (general aspects)
- 29.3 Immunotherapy
- 29.4 Nanomedicine
- 29.5 Nanoimmunotherapy
- 29.6 Clinical studies
- 29.7 Limitations
- 29.8 Perspectives
- 29.9 Conclusions
- Acknowledgments
- References
- Chapter 30. Protein corona: challenges and opportunities for cancer therapy
- Abstract
- 30.1 Introduction
- 30.2 Basis and theories of protein corona formation
- 30.3 Protein corona affects the therapeutic functions of nanoparticles
- 30.4 Several parameters are determinative in protein corona formation and its composition
- 30.5 Protein corona challenges the cancer nanomedicine performance
- 30.6 Protein corona affects the biosafety of nanoparticles
- 30.7 Protein corona: opportunities for cancer nanomedicine
- 30.8 Future perspective
- 30.9 Conclusion
- References
- Chapter 31. Nanomaterials affecting cellular metabolism: opportunities and challenges for cancer therapy
- Abstract
- 31.1 Introduction
- 31.2 Metabolism of cancer cells in brief
- 31.3 Nanomaterials as metabolic stress and their effects on bioenergetics
- 31.4 Nanomaterials and upstream regulators of cellular metabolism
- 31.5 Effect of nanomaterials on lipid metabolism
- 31.6 Effect of nanomaterials on protein, peptide, and amino acid metabolism
- 31.7 Effect of nanomaterials on carbohydrate metabolism
- 31.8 Effect of nanomaterials on nucleic acid metabolism
- 31.9 Mechanisms and factors involved in nanomaterials’ effects on cellular metabolism: physiochemical properties of nanomaterials determine their effects on cellular metabolism
- 31.10 The effects of nanomaterials on cellular metabolism and treatment of cancer
- 31.11 Metabolomics as a tool to assess the effects of nanomaterials
- 31.12 Conclusion
- References
- Index
- No. of pages: 762
- Language: English
- Edition: 1
- Published: March 21, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780443155185
- eBook ISBN: 9780443155192
HB
Hamed Barabadi
EM
Ebrahim Mostafavi
CM
Chaudhery Mustansar Hussain
Dr. Chaudhery Mustansar Hussain, PhD, is an Adjunct Professor and Director of Laboratories in the Department of Chemistry & Environmental Sciences at the New Jersey Institute of Technology (NJIT), Newark, New Jersey, United States. His research is focused on the applications of nanotechnology and advanced materials, environmental management, analytical chemistry, and other various industries. Dr. Hussain is the author of numerous papers in peer-reviewed journals as well as a prolific author and editor of around One hundred and fifty (150) books, including scientific monographs and handbooks in his research areas. He has published with ELSEVIER, American Chemical Society, Royal Society of Chemistry, John Wiley & Sons, CRC Press, and Springer.