Proteomics
A Promising Approach for Cancer Research
- 1st Edition - February 14, 2023
- Imprint: Academic Press
- Editors: Shafat Ali, Sabhiya Majid, Muneeb U Rehman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 5 0 7 2 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 0 7 3 - 2
Proteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book… Read more
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Request a sales quoteProteomics: A Promising Approach for Cancer Research provides an updated overview of scientific knowledge, achievements and findings in the field of cancer proteomics. The book discusses topics such as the use of proteomics in cancer biology and drug discovery, its role in surgical oncology, applications of mass spectrometry, target proteomics, single-cell proteomics, and next-generation proteomics. In addition, it discusses proteomics and phosphor-proteomics in cancer precision medicine; translation of proteomics research into clinical application; and challenges and future developments of the field. This will be a valuable resource for cancer researchers, oncologists, graduate students, and members of biomedical field who are interested in the potential of proteomics in cancer research and treatment.
The field of cancer proteomics is very dynamic, with emerging trends related to clinical solutions developed in recent years, therefore this book's content helps readers get up-to-speed on the topic to easily apply learnings into their research or clinical practice.
- Provides up-to-date information on current cancer proteomics research developed globally
- Presents basic research aspects to clinical implications of proteomics on cancer diagnosis and potential treatments
- Discusses challenges and future developments of the field to leverage further research and applicability in clinical setting
Researchers and graduate students on cancer research and bioinformatics; oncologists, Clinical researchers
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Cancer proteomics: An overview
- Abstract
- 1: Introduction
- 2: Definition and goals of proteomics
- 3: Methods of protein measurement and biomarker identification
- 4: Biomedical applications
- 5: Mechanisms of proteomic changes in cancer
- 6: Cancer biomarker applications
- 7: Protocols for developing tumor biomarkers
- 8: General guidelines for a good study design for biomarker discovery
- 9: Applications of proteomics research in various cancers
- 10: Can proteomics research findings in cancer be translated into clinically oriented research?
- 11: Conclusion
- References
- Further reading
- Chapter 2: Proteomics: A groundbreaking development in cancer biology
- Abstract
- 1: Introduction
- 2: Why proteomics?
- 3: Types of proteomics
- 4: Proteomics: Analytical approaches
- 5: Conventional techniques
- 6: Advanced techniques
- 7: Gel-based approaches
- 8: Quantitative techniques
- 9: High-throughput techniques
- 10: Proteomics: A breakthrough in cancer
- 11: Oncoproteomics
- 12: Proteomic variations in cancer
- 13: Necessity of proteomics in cancer
- 14: Heterogeneity in cancer
- 15: Detecting tumor aggressiveness
- 16: Personalized cancer treatment
- References
- Chapter 3: Proteomics: Application of next-generation proteomics in cancer research
- Abstract
- 1: Introduction
- 2: What is proteomics?
- 3: Techniques in proteomics
- 4: Proteomics in cancer research
- 5: What is next-generation proteomics?
- 6: Edman sequencing
- 7: Protein microarray
- 8: Functional protein microarray
- 9: Analytical protein microarray
- 10: Reverse-phase protein microarray
- 11: Mass spectrometry-based proteomics
- 12: Advancements of MS technique in cancer research
- 13: Applications of MS in cancer research
- References
- Chapter 4: Proteomics approaches in the identification of cancer biomarkers and drug discovery
- Abstract
- 1: Introduction
- 2: Proteomics and cancer biomarkers
- 3: Proteomics and drug discovery
- 4: Current techniques and advancements in proteomics
- 5: Challenges in proteomics
- 6: Conclusion
- References
- Chapter 5: Proteomic profiling and its applications in cancer research
- Abstract
- 1: Introduction
- 2: Proteomic alterations in cancer
- 3: Analytical approaches of proteomics
- 4: Applications of proteomics in cancer
- 5: Applications of cancer biomarkers
- 6: Tumor aggressiveness detection
- 7: Lung cancer
- 8: Breast cancer
- 9: Ovarian cancer
- 10: Established biomarker panels: Their usefulness, challenges, and emerging potential
- 11: Prostate cancer
- 12: Conclusion
- References
- Further reading
- Chapter 6: Role of proteomics in surgical oncology
- Abstract
- Consent for publication
- Conflict of interest
- Author contributions
- 1: Introduction
- 2: Surgical oncology
- 3: Proteomic techniques in surgical oncology
- 4: Mass spectrometry
- 5: MALDI MSI (matrix aided laser desorption ionization mass spectrometry imaging)
- 6: SELDI-TOF MS
- 7: Laser capture microdissection (LCM)
- 8: Proteomics techniques used cancer biomarkers with special reference to surgical oncology
- 9: Gastrointestinal cancer biomarker and proteomics
- 10: Lung cancer biomarker and proteomics
- 11: Bladder cancer and renal cancer
- 12: Prostate cancer biomarker and proteomics
- 13: Brain cancer and proteomics
- 14: Leukemia and proteomics
- 15: Conclusion
- References
- Further reading
- Chapter 7: Applications of mass spectroscopy in understanding cancer proteomics
- Abstract
- 1: Introduction
- 2: Mass spectrometry‐based diagnostics
- 3: Mass spectroscopy imaging
- 4: Protein MSI in cancer research
- 5: Drug imaging in cancer research
- 6: Application of MS in cancer biomarker discovery
- 7: Conclusion and future perspectives
- References
- Chapter 8: Proteomic approaches in the study of cancers
- Abstract
- 1: Introduction
- 2: Proteomic approaches in cancer therapy
- 3: Proteomic approach in brain cancers
- 4: Proteomic approach in ovarian cancers
- 5: Proteomics approach in gastrointestinal cancer
- 6: Proteomics approach in lung cancer
- 7: Conclusion
- References
- Chapter 9: Cancer proteomics: Application of case studies in diverse cancers
- Abstract
- Consent for publication
- Conflict of interest
- Author contributions
- 1: Introduction
- 2: Proteome study of gastric cancer
- 3: Proteome study of esophageal cancer
- 4: Proteome study of lung cancer
- 5: Proteome study of genitourinary cancer
- 6: Proteome study of breast cancer
- 7: Proteome study of ovarian cancer
- 8: Conclusion
- References
- Chapter 10: The enduring interdependence of shotgun and targeted proteomics in cancer research
- Abstract
- 1: Introduction
- 2: Epidemiology of cancer
- 3: Hallmarks of cancer
- 4: Alterations in metabolism in cancer cells
- 5: Genomic studies maybe insufficient to study cancer cell behaviors
- 6: Traditional vs proteomic technologies
- 7: Shotgun proteomics approach
- 8: Targeted proteomics
- 9: Relevance of targeted proteomics in cancer
- 10: Advanced targeted methods
- 11: Sample sources for biomarker research
- 12: Applications of TP to major individual tumor types
- 13: Concluding remarks
- References
- Chapter 11: Applications of proteomics in cancer diagnosis
- Abstract
- Consent for publication
- Funding
- Conflict of interest
- Author contributions
- 1: Introduction to the mechanisms of proteomic changes in cancers
- 2: Proteomics techniques in cancer research: New and emerging methods, including prognostic methods
- 3: Proteomics research applications in various cancers
- 4: Conclusion
- References
- Chapter 12: Application of plasma membrane proteomics to identify cancer biomarkers
- Abstract
- Consent for publication
- Conflict of interest
- Author contributions
- 1: Introduction to plasma membrane and plasma membrane proteomics
- 2: Plasma membrane protein alterations associated with cancers
- 3: Membrane proteins as tumor targets and biomarkers
- 4: Proteomics methods for study of plasma membrane proteins
- 5: Role of protein markers in cancer diagnosis
- 6: Membrane proteomics and biomarker discovery in various cancers
- 7: Conclusion
- References
- Chapter 13: Utility of proteomics and phosphoproteomics in the tailored medication of cancer
- Abstract
- 1: Introduction
- 2: Precision biomarkers based on proteomics
- 3: Pathway and network analysis in proteomics
- 4: Integrated data approaches
- 5: Utility of proteomics and phosphoproteomics in commonly found cancers
- 6: Conclusion
- References
- Further reading
- Chapter 14: Proteomics: A modern tool for identifying therapeutic targets in different types of carcinomas
- Abstract
- 1: An overview of proteomics
- 2: Types of proteomics
- 3: Applications of proteomics
- 4: Fundamental applications of proteomics
- 5: Practical applications of proteomics
- 6: Proteomics in cancer
- 7: Analytical strategies of proteomics used in cancer research
- 8: Application of proteomics in understanding cancer growth and metastasis
- 9: Application of proteomics in cancer drug resistance
- 10: Application of proteomics in cancer treatment using immunotherapy
- 11: Proteomics in cancer biomarker identification
- 12: Creation of proteomics-based cancer databases
- References
- Chapter 15: Cancer proteomics, current status, challenges, and future outlook
- Abstract
- 1: Introduction
- 2: Cancer proteomics
- 3: Cancer growth
- 4: Metastasis
- 5: Drug resistance
- 6: Proteomics approach in brain cancer
- 7: Extracellular vesicles as brain cancer biomarkers
- 8: Construction of cancer databases
- 9: Recent trends in proteomics
- 10: Challenges
- 11: Future prospective
- References
- Index
- Edition: 1
- Published: February 14, 2023
- No. of pages (Paperback): 412
- No. of pages (eBook): 412
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323950725
- eBook ISBN: 9780323950732
SA
Shafat Ali
Shafat Ali (Ph.D.) pursued his BSc. from University of Kashmir and Masters in Zoology from Barkatullah Vishwavidyalaya, India. Currently he is engaged in research work for last 5 years at Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Department of Biochemistry, Government Medical College, Srinagar, Jammu and Kashmir, and ICMR funded Multidisciplinary Research Unit, Government Medical College, Srinagar, Jammu and Kashmir, India, with specialization in the field of reproductive immunogenetics, cytokine biology, gynaecology and obstetrics, molecular biology, cancer biology and cytogenetics. He has 5 years of research experience and 5 years of teaching experience. He has more than 20 book chapters, several edited books and numerous peer-reviewed, international research publications to his credit. Mr. Ali is also the reviewer of many reputed international journals. Presently, Mr. Ali is involved in studying immunogenetic mechanisms involved in recurrent pregnancy loss
Affiliations and expertise
Cytogenetics and Molecular Biology Laboratory, Centre of Research for Development, University of Kashmir, Jammu and Kashmir, IndiaSM
Sabhiya Majid
Sabhiya Majid, Ph.D. is a Professor and Chairperson of the Department of Biochemistry, Govt. Medical College Srinagar (GMC Sgr.), J&K, India. Prof. Majid has 30 years of experience in teaching, research and diagnostic biochemistry, having published around 100 research papers in journals of repute, many books and 12 book chapters. She has been the recipient of several fellowships, awards and grants from various reputed funding agencies. She has been the nodal officer and implemented various research and infrastructure development schemes including Fund for Improvement of Science & Technology Infrastructure, Department of Science & Technology, Govt. of India. She is a member of several scientific associations and boards of undergraduate, postgraduate and research studies. She is on the reviewer panel of a number of online peer-reviewed journals. Having moved on from her doctoral work on nutritional modulation of carcinogenesis to understanding the molecular basis of various disease processes, her current research focuses on non invasive cancer markers.
Affiliations and expertise
Professor and Chairperson, Department of Biochemistry, Government Medical College, Srinagar, IndiaMU
Muneeb U Rehman
Muneeb U Rehman (Ph.D.) is a Faculty member at College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. He holds a doctorate in Toxicology (specialization in cancer biology and natural product research) from Jamia Hamdard, New Delhi, India. Dr. Rehman has more than 10 years of research and teaching experience in the field of toxicology, cancer biology, natural product pharmacology and pharmacogenomics. He is the recipient of several national and international fellowships and awards. He has published more than 100 research papers in peer-reviewed, international journals, and has 5 edited books and 30 book chapters. Dr. Rehman is on the editorial boards and is a reviewer of several high-impact, international scientific journals. He is also a life member of various international societies and organizations. Currently, Dr. Rehman is engaged in studying the molecular mechanisms of cancer prevention by natural products and the role of pharmacogenomics and toxicogenomics in evaluating the effectiveness and safety of drugs.
Affiliations and expertise
College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaRead Proteomics on ScienceDirect