Lanzkowsky's Manual of Pediatric Hematology and Oncology
- 7th Edition - June 1, 2021
- Editors: Jonathan D. Fish, Jeffrey M. Lipton, Philip Lanzkowsky
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 6 7 1 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 7 6 0 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 3 6 1 - 3
Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood dis… Read more
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Request a sales quoteLanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks.
- Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures
- New chapter on Pediatric Vascular Anomalies
- New content on ‘blood avoidance’ programs to honor religious preferences
- Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders
- Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases
Fellows and residents in pediatric hematology/oncology; pediatric hematologists, pediatric oncologists, pediatricians; clinical researchers in pediatric hematology/oncology
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- About the Editors
- Philip Lanzkowsky Founding Author and Editor
- Jonathan D. Fish Managing Editor
- Jeffrey M. Lipton
- Preface to the seventh edition
- Preface to the sixth edition
- Preface to the fifth edition
- Preface to the fourth edition
- Preface to the third edition
- Preface to the second edition
- Preface to the first edition
- Introduction: Historic perspective (1955–2015)
- Reflection on 60 years of progress in pediatric hematology/oncology
- Chapter 1. Molecular and genomic methodologies for clinicians
- Abstract
- Clinical molecular and genomic methodologies: goals
- Methods of genetic analysis
- Interpretation of genetic variants obtained from next-generation sequencing
- Applications of next-generation sequencing to oncology
- Interpreting and evaluating the results from clinical genetic testing
- Further reading and references
- Chapter 2. Hematologic manifestations of systemic illness
- Abstract
- Alterations to red blood cells related to organ-specific pathologies
- Alterations to white blood cells related to organ-specific pathologies
- Alterations to platelets and coagulation related to organ-specific pathologies
- General considerations for the hematologic sequelae of infection
- Viral and bacterial illnesses associated with marked hematologic sequelae
- Parasitic illnesses associated with marked hematologic sequelae
- Hemolytic uremic syndrome
- Autoimmune disease
- Anemia of inflammation
- Nutritional deficiencies and environmental exposures
- Marrow infiltrative disorders
- Further reading and references
- Chapter 3. Classification and diagnosis of anemia in children and neonates
- Abstract
- Classification and diagnosis
- Neonatal anemia
- Further reading and references
- Chapter 4. Nutritional anemias
- Abstract
- Overview
- Iron-deficiency anemia
- Megaloblastic anemia
- Further reading and references
- Chapter 5. Lymphadenopathy and diseases of the spleen
- Abstract
- Lymphadenopathy
- Diseases of the spleen
- Further reading and references
- Chapter 6. Bone marrow failure
- Abstract
- Aplastic anemia
- Inherited bone marrow failure syndromes
- Further reading and references
- Chapter 7. General considerations of hemolytic diseases, red cell membrane, and enzyme defects
- Abstract
- Clinical features of hemolytic disease
- Laboratory findings
- Membrane defects
- Paroxysmal nocturnal hemoglobinuria
- Enzyme defects
- Further reading and references
- Chapter 8. Extracorpuscular hemolytic anemia
- Abstract
- Immune hemolytic anemia
- Nonimmune hemolytic anemia
- Further reading and references
- Chapter 9. Hemoglobinopathies
- Abstract
- Sickle cell disease
- Sickle cell trait (heterozygous form, AS)
- Hemoglobin C
- Hemoglobin E
- Unstable hemoglobins
- Thalassemias
- Further reading and references
- Chapter 10. Primary and secondary erythrocytosis
- Abstract
- Erythrocytosis or polycythemia
- Primary erythrocytosis
- Secondary erythrocytosis
- Diagnostic approach to erythrocytosis
- Further reading and references
- Chapter 11. Disorders of white blood cells
- Abstract
- Leukocytosis
- Leukopenia
- Neutrophil disorders
- Monocytes disorders
- Eosinophil disorders
- Basophil disorders
- Lymphocyte disorders
- Dedication
- Further reading and references
- Chapter 12. Disorders of platelets
- Abstract
- Thrombocytopenia in the newborn
- Inherited thrombocytopenias
- Immune thrombocytopenic purpura
- Other causes of thrombocytopenia
- Thrombocytosis
- Qualitative platelet disorders
- Inherited vascular and connective tissue disorders
- Nonthrombocytopenic purpura
- Laboratory evaluation of platelets and platelet function
- Further reading and references
- Chapter 13. Disorders of coagulation
- Abstract
- Hemostatic disorders
- Acquired coagulation factor disorders
- Inherited coagulation factor disorders
- Thrombotic disorders
- Antithrombotic therapy
- Further reading and references
- Chapter 14. Vascular anomalies
- Abstract
- Introduction
- Vascular tumors
- Simple vascular malformations
- Diagnostic work-up for vascular lesions
- Management
- Evaluation and monitoring of a vascular hepatic tumor
- Vascular anomaly syndromes
- Further reading and references
- Chapter 15. Histiocytic disorders
- Abstract
- Introduction
- Langerhans cell histiocytosis
- Other histiocytic disorders
- Hemophagocytic lymphohistiocytosis (hemophagocytic syndromes)
- Further reading and references
- Chapter 16. Lymphoproliferative disorders
- Abstract
- Angioimmunoblastic lymphadenopathy with dysproteinemia
- Small lymphocytic infiltrates of the orbit and conjunctiva (ocular adnexal lymphoid proliferation, pseudolymphoma, benign lymphoma, atypical lymphocytic infiltrates)
- Angiocentric immunolymphoproliferative disorders
- Castleman disease (angiofollicular lymph node hyperplasia, benign giant lymph node hyperplasia, angiomatous lymphoid hamartoma)
- Epstein–Barr virus-associated Lymphoproliferative disorders in immunocompromised individuals
- X-linked lymphoproliferative syndrome
- Autoimmune lymphoproliferative syndrome
- Lymphomatoid papulosis in children
- Further reading and references
- Chapter 17. Myelodysplastic syndromes and myeloproliferative disorders
- Abstract
- Myelodysplastic syndromes
- Myeloid proliferations in children with Down syndrome (DS)
- Juvenile myelomonocytic leukemia
- Myeloproliferative neoplasms
- Further reading and references
- Chapter 18. Acute lymphoblastic leukemia
- Abstract
- Incidence of ALL
- Etiology
- Clinical features of ALL
- Diagnosis
- Classification
- Cytogenetics and molecular genetics of ALL
- Prognostic factors
- Treatment
- Infant leukemia
- Philadelphia-positive ALL
- Ph-like ALL
- Down syndrome and ALL
- Relapse in children with ALL
- Immunotherapy for ALL
- Central nervous system relapse
- Long-term effects of ALL therapy
- Future drugs in ALL therapy
- Further reading and references
- Chapter 19. Acute myeloid leukemia
- Abstract
- Incidence and epidemiology
- Etiology and predisposing conditions
- Clinical features
- Diagnostic and monitoring studies
- Classification of AML
- Supportive care
- The treatment of newly diagnosed AML
- Prognosis of newly diagnosed AML
- Relapsed and refractory AML
- Novel therapeutic approaches
- Acute promyelocytic leukemia
- AML special subgroups
- Further reading and references
- Chapter 20. Hodgkin lymphoma
- Abstract
- Etiology and epidemiology
- Risk factors
- Biology
- Pathology
- Clinical presentation
- Diagnostic evaluation and staging
- Prognostic factors
- Treatment
- Follow-up evaluations
- Further reading and references
- Web resources
- Chapter 21. Non-Hodgkin lymphoma
- Abstract
- Introduction
- Incidence and epidemiology
- Pathologic classification
- Clinical features
- Diagnosis
- Staging
- Prognosis
- Management
- Non-Hodgkin Lymphoma Subtypes
- Further reading and references
- Chapter 22. Central nervous system tumors
- Abstract
- Pathology
- Clinical manifestations
- Diagnostic evaluation
- Treatment
- Specific CNS tumors
- Genetic syndromes related to brain tumors
- Further reading and references
- Chapter 23. Neuroblastoma
- Abstract
- Epidemiology
- Predisposition
- Pathology and biology
- Clinical features
- Diagnosis and staging
- Treatment modalities
- Prognosis, risk stratification, and therapy
- Neuroblastoma in the adolescent and young adult
- Further reading and references
- Chapter 24. Renal tumors
- Abstract
- Wilms tumor
- Nephroblastomatosis
- Congenital mesoblastic nephroma
- Clear cell sarcoma of the kidney
- Rhabdoid tumor of the kidney
- Renal cell carcinoma
- Further reading and references
- Chapter 25. Rhabdomyosarcoma and other soft-tissue sarcomas
- Abstract
- Incidence and epidemiology
- Pathologic and genetic classification
- Clinical features
- Diagnostic evaluation
- Staging
- Prognosis
- Treatment
- Follow-up after completion of therapy
- Recurrent disease
- Future perspectives
- Further reading and references
- Chapter 26. Malignant bone tumors
- Abstract
- Osteosarcoma
- Ewing sarcoma family of tumors
- Other bone tumors
- Further reading and references
- Chapter 27. Retinoblastoma
- Abstract
- Incidence
- Classification
- Risk for second malignant neoplasms
- Pathology
- Clinical features
- Differential diagnosis
- Patterns of spread
- Diagnostic procedures
- Classification
- Treatment
- Treatment of intraocular RB
- Treatment of recurrent RB
- Treatment of extraocular RB
- Posttreatment management
- Further reading and references
- Chapter 28. Extracranial germ cell tumors
- Abstract
- Epidemiology
- Biology
- Histology
- Molecular characteristics
- Clinical features
- Diagnostic evaluation
- Staging and risk stratification
- Treatment
- Risk-stratified therapeutic approaches
- Relapsed and resistant germ cell tumors
- Further reading and references
- Chapter 29. Hepatic tumors
- Abstract
- Incidence
- Epidemiology
- Pathology
- Clinical features
- Diagnostic evaluation
- Staging and risk stratification
- Treatment
- Further reading and references
- Chapter 30. Hematopoietic stem cell transplantation and cellular therapy
- Abstract
- Allogeneic stem cell transplantation
- HSC sources, collection, and manipulation
- Graft manipulation postcollection
- Medical evaluation of HSC donors
- Pretransplantation preparative regimens (conditioning)
- Engraftment
- Complications of HSCT
- Recent advances in HSCT
- Outcomes
- Further reading and references
- Chapter 31. Management of oncologic emergencies
- Abstract
- Metabolic emergencies
- Cardiothoracic emergencies
- Abdominal emergencies
- Renal emergencies
- Neurologic emergencies
- Endocrine emergencies
- Treatment-associated emergencies
- Further reading and references
- Chapter 32. Supportive care of patients with cancer
- Abstract
- Management of infectious complications
- Recognition and management of nausea and vomiting
- Mucositis
- Pain management
- Nutritional status of the oncology patient
- Utilization of hematopoietic growth factors
- Management of acute radiation side effects
- Management of CVCs
- Posttreatment immunizations
- Palliative care
- Further reading and references
- Chapter 33. Evaluation, investigations, and management of late effects of childhood cancer
- Abstract
- Models of survivorship care
- Interventions and screening guidelines
- Organ system–specific late effects
- Future considerations
- Further reading and references
- Chapter 34. Psychosocial factors impacting children with cancer and their families
- Abstract
- Time of diagnosis
- Treatment initiation
- Illness stabilization
- During relapses and recurrences
- Treatment outcomes: the unsuccessful course
- Treatment outcomes: the successful course
- Conclusion
- Further reading and references
- Chapter 35. Pediatric blood banking principles and transfusion medicine practices
- Abstract
- Introduction
- Immunohematology
- Donor recruitment and testing
- Blood collection and processing
- Blood products
- Blood component modification and administration
- Transfusion reactions
- Special populations
- Therapeutic apheresis
- Patient blood management
- Further reading and references
- Appendix 1. Hematological reference values
- Fetal and cord blood hematologic value
- Red cell values and related serum values
- White cell values
- Platelet values
- Coagulation values
- Bone marrow cells
- Index
- No. of pages: 834
- Language: English
- Edition: 7
- Published: June 1, 2021
- Imprint: Academic Press
- Hardback ISBN: 9780128216712
- eBook ISBN: 9780323997607
- eBook ISBN: 9780323853613
JF
Jonathan D. Fish
Jonathan D. Fish, MD is Assistant Professor of Pediatrics at the Hofstra Northwell School of Medicine. He is Director of the Survivors Facing Forward Program, a long-term follow-up program for survivors of childhood cancer, in the division of Pediatric Hematology/Oncology and Stem Cell Transplantation at the Steven and Alexandra Cohen Children’s Medical Center of New York. He holds a B.A., with distinction, from the University of Western Ontario and received his M.D. degree, magna cum laude, from the Upstate Medical Center of the State University of New York. He did his Pediatric training at the the Schneider Children’s Hospital, New Hyde Park, NY ( Presently known as the Steven and Alexandra Children’s Medical Center of New York) and completed his Pediatric Hematology-Oncology fellowship training at the Children’s Hospital of Philadelphia. Dr. Fish received the American Society of Pediatric Hematology-Oncology Young Investigator Award in 2008. His clinical and research interest is on the late effects of childhood cancer treatment and survivorship care.
Affiliations and expertise
Assistant Professor of Pediatrics, Hofstra Northwell School of Medicine, Hempstead, NY, USAJL
Jeffrey M. Lipton
Jeffrey M. Lipton, MD, PhD is the Chief of Hematology/Oncology and Stem Cell Transplantation at the Steven and Alexandra Cohen Children’s Medical Center of New York and Center Head, Patient Oriented Research, The Feinstein Institute for Medical Research. He is Professor, Elmezzi Graduate School of Molecular Medicine, The Feinstein Institute for Medical Research and Professor of Pediatrics and Molecular Medicine at the Hofstra North Shore – LIJ School of Medicine. He holds a B.A. from Queens College, City University of New York, a Ph.D in Chemistry from Syracuse University and an M.D. degree, magna cum laude, from Saint Louis University Medical School. He did his Pediatric residency training at the Children’s Hospital, Boston, MA and his Pediatric Hematology/Oncology fellowship training at the Children’s Hospital and the Sidney Farber Cancer Institute (now DFCI) in Boston. Dr. Lipton is a Past-President of the American Society of Pediatric Hematology/Oncology (ASPHO). His main interest is bone marrow failure.
Affiliations and expertise
Professor of Pediatrics and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USAPL
Philip Lanzkowsky
Dr. Philip Lanzkowsky was born in Cape Town on March 17, 1932 and graduated high school from the South African College and obtained his MB ChB degree from the University of Cape Town School of Medicine in 1954 and his Doctorate degree in 1959 for his thesis on Iron Deficiency Anemia In Children. He completed a pediatric residency at the Red Cross War Memorial Children’s Hospital in Cape Town in 1960. After working in Pediatrics at the University of Edinburgh and at St Mary’s Hospital of the University of London, Dr. Lanzkowsky did a pediatric Hematology-Oncology fellowship at Duke University School of Medicine and at the University of Utah.
In 1963 he was appointed Consultant Pediatrician and Pediatric Hematologist to the Red Cross War Memorial Children’s Hospital at the University of Cape Town and introduced Pediatric Hematology and Oncology as a distinct discipline. In 1965 he was appointed Director of Pediatric Hematology and Associate Professor of Pediatrics at the New York Hospital-Cornell University School of Medicine.
In 1970 he was appointed Professor of Pediatrics and Chairman of Pediatrics at Long Island Jewish Medical Center and established a division of Pediatric Hematology-Oncology which he directed until 2000. He was the founder of the Schneider Children’s Hospital, which he developed, planned, and was the hospital’s Executive Director and Chief of Staff from its inception in 1983 until 2010.
Dr. Lanzkowsky has received numerous honors and awards and has lectured extensively at various institutions and medical schools in the United States and around the world. In addition to having been the author of five editions of the Manual of Pediatric Hematology and Oncology used by clinicians worldwide, he is the author of How It All Began: The History of a Children’s Hospital and over 280 scientific papers, abstracts, monographs, and book chapters.
Dr. Lanzkowsky’s medical writings have been prodigious. His seminal contributions to the medical literature have included the first description of the relationship of pica to iron-deficiency anemia (Arch. Dis Child., 1959), Effects of timing of clamping of umbilical cord on infant’s hemoglobin level (Br. Med. J., 1960), Normal oral D-xylose test values in children (New Engl. J. Med., 1963), Normal coagulation factors in women in labor and in the newborn (Thromboses at Diath. Hemorr., 1966), Erythrocyte abnormalities induced by malnutrition (Br. J. Haemat., 1967), Radiologic features in iron deficiency anemia (Am. J. Dis. Child., 1968), Isolated defect of folic acid absorption associated with mental retardation (Blood, 1969; Am. J. Med, 1970), Disaccharidase levels in iron deficiency (J. Pediat., 1981) and Hexokinase “New Hyde Park” in a Chinese kindred (Am. J. Hematol., 1981).
Affiliations and expertise
North Shore-Long Island Jewish Health System, Consultant, Steven and Alexandra Cohen Children's Medical Center of New York, Professor of Pediatrics, Hofstra Northwell School of Medicine, Hempstead, NY, USARead Lanzkowsky's Manual of Pediatric Hematology and Oncology on ScienceDirect