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Books in Cellular biology

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Flow Cytometry in Immuno-oncology

  • 1st Edition
  • Volume 195
  • July 1, 2025
  • Marcello Pinti + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 3 2 3 - 8 9 8 8 3 - 6
  • eBook
    9 7 8 - 0 - 3 2 3 - 8 9 8 8 4 - 3
Flow Cytometry in Immuno-oncology, Volume 173 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics, Basic principles of Flow cytometry in immuno-oncology, Good practice and methods for flow cytometry in immuno-oncology, Automated flow cytometry in immuno-oncology, Flow cytometric analysis of Tregs in solid tumors, Multiparametric analysis of Tumor infiltrating lymphocytes in solid tumors, Analysis of tumor-infiltrating immune cells in intracranial glioblastoma, Assessing chromosomal abnormalities in leukemias by Imaging flow cytometry, Flow cytometric analysis of cellular alkaline phosphatase in acute myeloid leukemia, and much more.

Cholecystokinin

  • 1st Edition
  • April 7, 2025
  • Christine Feinle-Bisset + 1 more
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 3 7 2 0 - 1
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 3 7 2 1 - 8
Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology and pathophysiological roles of cholecystokinin (CCK) peptides. It begins with a historical overview before providing in-depth chapters into the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, and the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function. Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.Cholecystokinin: From Gallbladder to Cognition and Beyond acts as a fundamental reference on all biological and clinical aspects of CCK. This volume is ideal for researchers interested in gaining in-depth knowledge about the physiological roles of CCK and its impact across health and disease.

The Immunological Synapse Part C

  • 1st Edition
  • Volume 193
  • April 1, 2025
  • Clément Thomas + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 1 8 6 8 - 2
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 1 8 6 9 - 9
The Immunological Synapse - Part C, Volume 193 in the Methods in Cell Biology series provides state-of-the-art and detailed methods for the study of the T cell, natural killer (NK) cell and B cell immunological synapses. Topics covered in this third volume include tau-STED microscopy for 3D-quantitative colocalization of lytic granule markers, image processing approaches for 3D-analysis of markers and for microtubule remodeling quantification at the immunological synapse, flow cytometry to analyze NK cell-target cell conjugation, imaging flow cytometry to quantify a range of different subcellular processes at the immunological synapse, imaging techniques aimed at quantitatively analyzing B cell immunological synapse formation, quantification of force-mediated antigen extraction in the B cell immune synapse using DNA-based tension sensors, measuring interaction forces between T lymphocytes and their target cells using live microscopy and laminar shear flow chambers, measuring interaction kinetics between T cells and their target tumor cells with optical tweezers, and gauging antigen recognition by human primary T-cells featuring orthotopically exchanged TCRs of choice. Additionally, this volume includes methods to isolate and characterize primary NK cells and enrich the KIR2DL1+ population, and to expand γδ T cells and evaluate their cytotoxicity.

Cell Physiology Source Book

  • 5th Edition
  • March 1, 2025
  • F. Javier Alvarez-Leefmans + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 1 2 - 8 1 1 1 1 4 - 7
  • eBook
    9 7 8 - 0 - 1 2 - 8 1 1 1 1 5 - 4
Cell Physiology Source Book, Fifth Edition covers a broad range of topics in cell physiology. The book discusses research areas that have become active since the last edition (e.g., aquaporins, apicoplast and other organelles) and broadens its scope to include chronobiology, expansion of receptor/sensory physiology, endocrinology, and other topics such as quorum sensing and taxis. As methods or approaches on performing experiments appear to be very valuable parts of books to which readers tend to frequently refer, expansion of these types of chapters and/or appendices are included in this edition. Applicable to scientists, researchers, postdocs and graduate students across physiological, biochemical, biological and biomedical backgrounds, cell physiology is important for understanding larger organisms and potential advances in biomedicine.

Animal Models of Disease Part C

  • 1st Edition
  • Volume 192
  • February 1, 2025
  • Lorenzo Galluzzi + 3 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 2 2 4 2 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 2 4 3 - 6
Animal Models of Disease, Part C, Volume 192 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Using C. Elegans as a model for Neurodegenerative disease: Methodology and Evaluation, Modelo Animal de Esclerosis Multiple: Encefalomielitis Autoimmune Experimental (EAE, New mouse model to study aneurysm development, Spinal Nerve Ligation: An Experimental Neuropathic Pain Model in Rats and Mice, Identifying therapeutic compounds for Autosomal Dominant Optic Atrophy (ADOA) through screening in the nematode C. elegans, Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, and much more.Other chapters cover Purification and characterization of kidney-infiltrating leukocytes in a mouse model of lupus nephritis, Differences in intratumor innate lymphoid cell composition between orthotopic and spontaneous pancreatic mouse models, Assessing motor development and function in mouse models of neurodevelopmental disorders, Analysis of Gut Microbiota profile targeted to multi hypervariable regions of 16S rRNA in hypertensive heart failure rat model, and more.

Mitophagy in Health and Disease

  • 1st Edition
  • November 28, 2024
  • John J. Lemasters
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 1 5 2 6 0 - 3
Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.

Nongenetic Information and Evolution

  • 1st Edition
  • November 6, 2024
  • Nelson R Cabej
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 2 1 5 9 - 0
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 1 6 0 - 6
Nongenetic Information and Evolution investigates the origin and nature of nongenetic information and its role in the mechanisms of evolutionary change. This book opens with an introduction to the theoretical background and forms of nongenetic information, alongside its relationship with genetic information. It then explores nongenetic information across the biological kingdoms, including animals, nonneural organisms, plants, and unicellulars.It also covers epigenetics as a form of nongenetic information, exploring DNA methylation, histone modifications, chromatin remodeling, and miRNA expression in this context. This book closes with a discussion of nongenetic information in evolution, considering evidence demonstrating its inheritance and hereditary impact.This book provides a detailed overview of the origin and evolutionary impact of nongenetic inheritance, delivering a basis for further understanding the occurrence of hereditary phenomena and transgenerational phenotypic changes that do not involve genes. This is a useful reference for researchers in the field of epigenetics, evolutionary biology, developmental biology, and cellular and molecular biology.

Substance P

  • 1st Edition
  • November 6, 2024
  • Robert Vink
  • English
  • Paperback
    9 7 8 - 0 - 4 4 3 - 2 2 1 9 4 - 1
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 1 9 5 - 8
Substance P: From Pain to Cancer, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, provides a complete discussion of substance P biology, its role in normal physiology and a variety of diseases.The volume provides an introduction to substance P and its pharmacology, followed by exploring its role across the human body including cardiovascular function, micturition, learning and memory, emesis, respiration and sleep. It then discusses the critical role of substance P in several disease states including acute brain injury, neurodegeneration, seizures, depression and anxiety, cancer, musculoskeletal disorders, and viral infection, including COVID-19. The book closes with a look towards future perspectives for substance P.Substance P: From Pain to Cancer is an ideal reference for researchers across the life sciences interested in understanding the role of this multi-functioning mediator and its biological significance.

Immuno-oncology and immunotherapy Part A

  • 1st Edition
  • Volume 189
  • October 9, 2024
  • Lorenzo Galluzzi + 2 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 2 - 2
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 9 6 2 3 - 9
Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Chemokine Receptors in Health and Disease

  • 1st Edition
  • Volume 388
  • September 10, 2024
  • Rodney Macedo Gonzales + 1 more
  • English
  • Hardback
    9 7 8 - 0 - 4 4 3 - 2 2 1 7 2 - 9
  • eBook
    9 7 8 - 0 - 4 4 3 - 2 2 1 7 3 - 6
This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.