Extracellular Vesicles and Nanoscale Biomaterials as Therapeutics of Human Diseases
- 1st Edition - February 1, 2026
- Editors: Massimo Conese, Sante Di Gioia, Annalucia Carbone
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 5 3 3 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 5 3 4 - 7
Extracellular Vesicles and Nanoscale Biomaterials as Therapeutics of Human Diseases considers the potential clinical application of extracellular vesicles (EVs) and nanoscale… Read more
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Extracellular Vesicles and Nanoscale Biomaterials as Therapeutics of Human Diseases considers the potential clinical application of extracellular vesicles (EVs) and nanoscale biomaterials in the treatment of a variety of conditions.
The book begins with an overview of EVs and biomaterials, covering the fundamental characteristics of each and how they can be implemented to work together in disease treatment. It then moves on to discussion of specific application in wound healing, cancer, neurodegenerative diseases, bone and tissue regeneration, cardiovascular disease, and liver disease. The book closes with discussion of future perspectives regarding EVs and biomaterials in diagnosis and therapeutic application.
In its exploration of the combination of EVs and nanoscale biomaterials in therapeutic intervention, this book sets a strong basis for future developments in this area and acts as a useful reference for researchers working in the areas of cell biology, drug delivery, regenerative medicine and related fields.
- Includes an overview of the fundamentals of extracellular vesicles (EVs) and nanoscale biomaterials
- Brings together EVs and biomaterials in a comprehensive study on their clinical potential
- Explores specific therapeutic applications relative to a variety of conditions, including cancers, neurological diseases and cardiometabolic diseases
- Discusses both naturally occurring and engineered EVs
Researchers and clinicians in cell biology, molecular biology, biochemistry, drug delivery, regenerative medicine and related fields.Postgraduate students in related areas
Part I: Overview
1. An overview of Extracellular Vesicles
2. Nanoscale Biomaterials at the forefront of human disease treatment
3. Bioengineered extracellular vesicle-loaded bioscaffolds for therapeutic applications in regenerative medicine
4. Extracellular vesicles and biomaterials: from animal models to clinical trials
Part II: Extracellular vesicles and biomaterials in cutaneous wound healing
5. Recent advances on EV-based therapeutics for the regeneration of chronic wounds
6. The amniotic membrane as a scaffold for EVs in wound healing
7. Nerve regeneration in wound healing by EVs and biomaterials
8. miRNA loading of EVs and biomaterials in wound healing
Part III: Extracellular vesicles and biomaterials in cancer
9. A current view on biomaterials and EVs in cancer therapy
10. Application of engineered extracellular vesicles for targeted tumor therapy
11. EV-mediated nucleic acid delivery for cancer therapy
12. Application of EV-based immunotherapy to cancer
13. Polymer-Coated Extracellular Vesicles for Selective Codelivery of Chemotherapeutics and siRNA to Cancer Cells
14. Hybrid inorganic/organic nanoparticles with EVs for cancer treatment
15. Improving Tumor Targeting of Exosomal Membrane-Coated Polymeric Nanoparticles by Conjugation with Aptamers
Part IV: Extracellular vesicles and biomaterials in Neurological Diseases
16. An overview of biomaterials and EVs in neurodegenerative diseases
17. EVs hydrogel for spinal cord injury
18. Naturally occurring and engineered EVs in the treatment of Parkinson Disease
19. Biomaterials and stem cells as drug/gene-delivery vehicles for Parkinson's treatment
20. Self-oriented nanocarriers for EV delivery to neurodegenerative diseases
Part V: Extracellular vesicles and biomaterials in bone and cartilage regeneration
21. Current view on EVs in cell-free therapy for bone and cartilage repair and regeneration
22. The Delivery of Extracellular Vesicles Loaded in Biomaterial Scaffolds for Bone Regeneration
23. Hydrogels to Promote the Therapeutic Efficacy of Extracellular Vesicles for Bone Regeneration
24. Bioactive Scaffolds Integrated with Liposomes or Extracellular Vesicles for Bone Regeneration
25. Human Oral Stem Cells, Biomaterials and Extracellular Vesicles: A Promising Tool in Bone Tissue Repair
26. Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics
27. Polycaprolactone-based Scaffolds and Extracellular Vesicles to Promote Osteoblastic Differentiation and Mineralization
28. New advancements in the cartilage repair by the combination of extracellular vesicles and biomaterials
Part VI. Extracellular vesicles and biomaterials in Cardiometabolic Diseases
29. Extracellular vesicles in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
30. Cardiac repair by human umbilical cord mesenchymal stem cell derived exosomes encapsulated in hydrogels
31. Restoring Cardiac Functions after Myocardial Infarction-Ischemia/Reperfusion via an Extracellular Vesicles-Conductive Hydrogel
32. Cardiac recovery via extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells
33. Immunomodulatory capacity of alginate microcapsule and MSC-derived extracellular vesicles in diabetic mice post islet xenotransplantation
34. Therapeutic Role of EVs in Pancreas and Islet β-Cell Transplantation
Part VII: Extracellular vesicles and biomaterials in Liver Diseases
35. Engineered extracellular vesicle-based therapeutics for non-alcoholic fatty liver disease and alcoholic liver disease – An overview
36. Hydrogel-Mediated Sustained Systemic Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improves Hepatic Regeneration in Chronic Liver Failure
37. Mesenchymal stromal cells (MSCs) and their secretome in acute liver failure (ALF): A comprehensive review
38. Biomaterial-based cell and extracellular vesicles delivery strategies to promote liver regeneration
Part VIII: Concluding Perspectives
39. Perspectives in clinical translation of MSC extracellular vesicles and biomaterials
40. Prospective advances in extracellular vesicles and biomaterials in theranostics
1. An overview of Extracellular Vesicles
2. Nanoscale Biomaterials at the forefront of human disease treatment
3. Bioengineered extracellular vesicle-loaded bioscaffolds for therapeutic applications in regenerative medicine
4. Extracellular vesicles and biomaterials: from animal models to clinical trials
Part II: Extracellular vesicles and biomaterials in cutaneous wound healing
5. Recent advances on EV-based therapeutics for the regeneration of chronic wounds
6. The amniotic membrane as a scaffold for EVs in wound healing
7. Nerve regeneration in wound healing by EVs and biomaterials
8. miRNA loading of EVs and biomaterials in wound healing
Part III: Extracellular vesicles and biomaterials in cancer
9. A current view on biomaterials and EVs in cancer therapy
10. Application of engineered extracellular vesicles for targeted tumor therapy
11. EV-mediated nucleic acid delivery for cancer therapy
12. Application of EV-based immunotherapy to cancer
13. Polymer-Coated Extracellular Vesicles for Selective Codelivery of Chemotherapeutics and siRNA to Cancer Cells
14. Hybrid inorganic/organic nanoparticles with EVs for cancer treatment
15. Improving Tumor Targeting of Exosomal Membrane-Coated Polymeric Nanoparticles by Conjugation with Aptamers
Part IV: Extracellular vesicles and biomaterials in Neurological Diseases
16. An overview of biomaterials and EVs in neurodegenerative diseases
17. EVs hydrogel for spinal cord injury
18. Naturally occurring and engineered EVs in the treatment of Parkinson Disease
19. Biomaterials and stem cells as drug/gene-delivery vehicles for Parkinson's treatment
20. Self-oriented nanocarriers for EV delivery to neurodegenerative diseases
Part V: Extracellular vesicles and biomaterials in bone and cartilage regeneration
21. Current view on EVs in cell-free therapy for bone and cartilage repair and regeneration
22. The Delivery of Extracellular Vesicles Loaded in Biomaterial Scaffolds for Bone Regeneration
23. Hydrogels to Promote the Therapeutic Efficacy of Extracellular Vesicles for Bone Regeneration
24. Bioactive Scaffolds Integrated with Liposomes or Extracellular Vesicles for Bone Regeneration
25. Human Oral Stem Cells, Biomaterials and Extracellular Vesicles: A Promising Tool in Bone Tissue Repair
26. Harnessing Tissue-derived Extracellular Vesicles for Osteoarthritis Theranostics
27. Polycaprolactone-based Scaffolds and Extracellular Vesicles to Promote Osteoblastic Differentiation and Mineralization
28. New advancements in the cartilage repair by the combination of extracellular vesicles and biomaterials
Part VI. Extracellular vesicles and biomaterials in Cardiometabolic Diseases
29. Extracellular vesicles in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
30. Cardiac repair by human umbilical cord mesenchymal stem cell derived exosomes encapsulated in hydrogels
31. Restoring Cardiac Functions after Myocardial Infarction-Ischemia/Reperfusion via an Extracellular Vesicles-Conductive Hydrogel
32. Cardiac recovery via extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells
33. Immunomodulatory capacity of alginate microcapsule and MSC-derived extracellular vesicles in diabetic mice post islet xenotransplantation
34. Therapeutic Role of EVs in Pancreas and Islet β-Cell Transplantation
Part VII: Extracellular vesicles and biomaterials in Liver Diseases
35. Engineered extracellular vesicle-based therapeutics for non-alcoholic fatty liver disease and alcoholic liver disease – An overview
36. Hydrogel-Mediated Sustained Systemic Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improves Hepatic Regeneration in Chronic Liver Failure
37. Mesenchymal stromal cells (MSCs) and their secretome in acute liver failure (ALF): A comprehensive review
38. Biomaterial-based cell and extracellular vesicles delivery strategies to promote liver regeneration
Part VIII: Concluding Perspectives
39. Perspectives in clinical translation of MSC extracellular vesicles and biomaterials
40. Prospective advances in extracellular vesicles and biomaterials in theranostics
- Edition: 1
- Published: February 1, 2026
- Language: English
MC
Massimo Conese
Dr. Massimo Conese is Full Professor in General Pathology, Immunology and Pathophysiology at Università degli Studi di Foggia, Italy. He is Associate Editor of the Journal of Molecular Sciences, and editorial board member of Cells, Current Stem Cell Research & Therapy, Pathophysiology and Journal of Respiration. He is the author or co-author of over 150 scientific articles in various journals. Dr Conese’s major research interest is studying the use of mesenchymal stem cells and exosomes derived thereof as therapeutic interventions in cystic fibrosis airway epithelium for correction of basic defects and in skin repair to treat chronic and hard-to-heal wounds. He is also currently working on dopamine-loaded nanoparticles for a nose-to-brain delivery approach to treat Parkinson’s disease.
Affiliations and expertise
Professor in General Pathology, Immunology and Pathophysiology Dipartimento di Medicina Clinica e Sperimentale Università degli Studi di Foggia, ItalySG
Sante Di Gioia
Dr. Sante Di Gioia is Assistant Professor in General Pathology at Università degli Studi di Foggia, Italy. He is editorial board member of Pathophysiology and Journal of Respiration. He is the author or co-author of over 60 scientific articles in various journals.. Dr. Di Gioia’s main interest is studying the application of nanoparticles for the delivery of anti-inflammatory molecules into several cell types such as respiratory epithelial cells, intestinal epithelial cells and neuroblastoma cells. Recently his research interests are centered around the biological properties and therapeutic effects of plant-derived nanovesicles.
Affiliations and expertise
Assistant Professor in General Pathology Dipartimento di Medicina Clinica e Sperimentale Università degli Studi di Foggia, ItalyAC
Annalucia Carbone
Annalucia Carbone works in the Department of Clinical and Experimental Medicine, at the University of Foggia, Foggia, Italy.
Affiliations and expertise
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy