Skip to main content
Elsevier

Books in Genetics

  • The Phylogenetic Pathways

    Research, Protocols and Applications
    • 1st Edition
    • Muzafar Riyaz + 1 more
    • English
    The Phylogenetic Pathways: Tracing Evolution Across Time and Species embarks on a captivating journey that unveils the mysteries of evolutionary history and genetic ancestry. Delve into the fascinating realm of molecular phylogenetics and phylogenomics, where cutting-edge research and ancient genetic clues converge. Unravelling the enigmatic paradoxes that lie at the heart of the evolutionary process, this book takes readers on an exploration of genetic relationships spanning millions of years. From the origins of life to the branching paths of diverse species, readers will discover how scientists reconstruct the evolutionary tree of life using DNA. Through compelling storytelling and accessible explanations, the book introduces readers to the revolutionary field of phylogenetics, showcasing the powerful tools and methodologies used to decipher evolutionary patterns. It explores the frontiers of phylogenomics, where state-of-the-art genomic technologies illuminate the intricate tapestry of life's history. The book inspires curiosity, deepens the understanding of life's connections, and sheds light on the mysteries of the phylogenetic paradox, making it a must-read for anyone interested in the living world.

  • Non-Invasive Prenatal Screening of Rare Fetal Genetic Diseases

    • 1st Edition
    • Riyaz Ahmad Rather
    • English
    Non-Invasive Prenatal Screening of Rare Fetal Genetic Diseases offers a comprehensive exploration of the latest advancements in non-invasive prenatal screening (NIPS) technologies and their application in detecting rare fetal genetic disorders. It provides a detailed overview of current methods in NIPS technology, the application of NIPS in detecting rare genetic disorders, and ethical considerations. Sections cover advanced genomic methods such as Next-Generation Sequencing, Single-Nucleotide Polymorphism analysis, and Comparative Genomic Hybridization, highlighting their impact on the accuracy and scope of NIPS, while also exploring specific genetic disorders, including Trisomy 18, Trisomy 13, Duchenne Muscular Dystrophy, Angelman Syndrome, Turner Syndrome, and Cri du Chat Syndrome.Researchers will find this to be a valuable resource for understanding and applying NIPS protocols in their work, while clinicians will benefit from practical insights on appropriate screening methods, interpreting NIPS results, and counseling expectant parents. This book is an essential resource for researchers in obstetrics and gynecology, genetic counselors, and professionals in the biotechnology and pharmaceutical industries. It equips readers with the knowledge and tools needed to advance their work and improve prenatal care practices.

  • Microbial Biofilms and Cancer

    • 1st Edition
    • Volume 224
    • English
    Microbial Biofilms and Cancer series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Gene Therapy in Neurodegenerative Disorders

    From Bench to Bedside
    • 1st Edition
    • Vahid Mansouri + 1 more
    • English
    Gene Therapy in Neurodegenerative Disorders: From Bench to Bedside offers a comprehensive review of gene therapy modalities and their applications in treating neurodegenerative disorders. Initial chapters focus on the fundamentals of gene therapy strategies, including gene delivery methods and CNS-targeted gene delivery. Subsequent chapters delve into specific neurodegenerative disorders such as Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD), and Alzheimer's Disease (AD), highlighting the latest gene therapy approaches for each condition. Each chapter provides a detailed introduction to the relevant field before exploring specific tools and applications.With contributions from leading experts, the book addresses current and ongoing clinical trials, potential challenges, and promising advances in gene therapy for neurodegenerative disorders. It also discusses regulatory and ethical considerations in translating research from bench to bedside. This book is an essential resource for basic science researchers in gene therapy, geneticists, biotechnologists, and clinical researchers seeking new and effective treatments for neurodegenerative diseases. It equips readers with the knowledge and tools needed to advance their work and drive innovation in gene therapy.

  • miRNA in Human Disease

    From Biomarkers to Therapeutics
    • 1st Edition
    • Parul Gupta + 6 more
    • English
    miRNA in Human Disease: From Biomarkers to Therapeutics explores the critical role of microRNAs (miRNAs) in the development and progression of various diseases, emphasizing their significance as biomarkers and therapeutic targets. Sections provide a comprehensive overview of the biogenesis, function, and regulation of miRNAs, offering insights into how these small noncoding RNA molecules influence gene expression and contribute to disease development and progression. The book covers traditional and advanced methods for miRNA extraction, the role of miRNAs in infectious diseases, cancer, neurological disorders, cardiovascular disease, hemoglobinopathies, pregnancy complications, and metabolic disorders.Sections also discuss the latest research on miRNA-based therapies, including the design and delivery of miRNA mimics and inhibitors and their potential applications in personalized medicine. With a strong focus on practical implementation, the book includes detailed case studies and real-world examples that demonstrate the clinical relevance of miRNA research. It addresses the challenges and future directions in the field, providing a roadmap for researchers, clinicians, and industry professionals to harness the potential of miRNAs for disease diagnosis, treatment, and prevention.

  • Apolipoprotein E in Health and Disease

    Unravelling its Intricate Roles
    • 1st Edition
    • Dileep Kumar + 2 more
    • English
    Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles delves into the multifaceted functions of Apolipoprotein E (ApoE) across various health conditions and diseases. This comprehensive volume offers an in-depth exploration of ApoE, illuminating its structural insights, functional significance, and genetic variability. Each chapter examines the role of ApoE in different disease contexts, including cardiovascular diseases, Alzheimer's disease, neurological disorders, metabolic syndrome, liver health, cancer, and inflammatory disorders. Key chapters investigate ApoE's impact on lipid metabolism, atherosclerosis, and heart health while also probing its involvement in genetic predispositions and mechanistic implications in Alzheimer's disease. In addition, the book extends its exploration to the broader influence of ApoE on cognitive decline and other neurological conditions, metabolic health, liver function, cancer risk, and immune modulation. With a strong focus on the pharmacogenetics of ApoE, the book paves the way for precision medicine, offering insights into how ApoE genotypes influence medication responses and therapeutic strategies. Future prospects and challenges in harnessing ApoE for disease management are discussed, alongside its role in infectious diseases, genetic engineering innovations, and targeted drug delivery systems.

  • Cellular Communication in Development

    • 1st Edition
    • Volume 169
    • English
    Cellular Communication in Development, Volume 169 provides a comprehensive overview of the intricate signaling pathways and molecular mechanisms that govern how cells communicate during the development of multicellular organisms. This volume explores the essential roles of cell-to-cell communication in processes such as embryogenesis, tissue patterning, organ formation, and differentiation. Specific chapters include Specification of pgcs, Establishing and maintaining gonadal cell fate, Role of retinoic acid in meiosis, Assembly of primordial follicles, Activation of primordial follicles, Mechanisms of germ-soma communication during follicular growth, Somatic regulation of oocyte meiotic arrest and resumption, Ovarian stroma/function/role in aging, and much more.Additional sections explore New approaches to supporting follicle growth/ovarian function in vitro, Cancer therapy - effects on survival/development of oocyte/follicle, Female germ cells from somatic cells, Spermatogenic stem cell niche, Role of macrophages in testis function, Male germ cells from somatic cells, and more.

  • DNA in Health, Identity, and Ancestry

    • 1st Edition
    • Hisham Atan Edinur + 2 more
    • English
    DNA in Health, Identity and Ancestry examines the human genome and advances in molecular techniques in relation to their value in health, genetic ancestry, and forensic DNA. This book systematically presents these three areas, providing new insights into recent developments in these fields, including gene editing, ancestral fraction determination, and DNA profiling. It covers the latest advances in molecular biology to understand the pertinent issues in these areas. DNA in Health, Identity and Ancestry provides an introduction to human genomes, and then delves into health, forensics and ancestry across 36 chapters. Each section is concluded with practical case studies to demonstrate the application of the principles discussed in each respective section. This book is a valuable resource for researchers, practitioners, and postgraduate students in biochemistry, molecular biology and genetics. It not only provides them with fundamental knowledge on genetics, diseases, population genetics and forensic DNA, but also presents advances, technical operational standards, analytical tools and recent developments in these respective areas.

  • Frontiers of Cancer Biology

    Current Trends in Cancer Research
    • 1st Edition
    • Devavarapu Kasi Viswa Prasad + 1 more
    • English
    Frontiers of Cancer Biology: Current Trends in Cancer Research presents the latest research in cancer, which is advancing day by day. This book provides an introduction to cancer genetics, as well as the roles of genomic instability, oncogenes, proto-oncogenes, tumor suppressor genes, and DNA damage and repair in relation to cancer. It then goes on to discuss viral genomics and cancer, epigenetics and cancer, cancer genetics, gene therapy in precision medicine. Finally, this book reviews the future direction of cancer genetics. Frontiers of Cancer Biology: Current Trends in Cancer Research is a valuable resource for researchers and professionals working in cancer biology, as well as academics that want to keep up to date with the field.

  • Nanomedicine and Nutrigenomics

    Pioneering the Future of Health
    • 1st Edition
    • Yugal Kishore Mohanta + 2 more
    • English
    Nanomedicine and Nutrigenomics: Pioneering the Future of Health offers a comprehensive introduction to nanomedicine and nutrigenomics, ensuring readers grasp the fundamental concepts, techniques, and applications. The book provides an overview of nanotechnology, nanomaterials, and gene-nutrient interactions, paving the way for understanding the potential healthcare applications of these groundbreaking methodologies. It emphasizes the synergy between nanomedicine and nutrigenomics, showcasing how they can optimize health outcomes and delving into nanotechnology's role in enhancing drug delivery systems, diagnostics, and therapeutics, while also highlighting personalized nutrition interventions based on genetic makeup. The book addresses future advancements, ethical implications, and challenges, presenting a holistic view.