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Elsevier

Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders

  • 1st Edition - October 1, 2026
  • Latest edition
  • Author: Moyra Smith
  • Language: English

Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders explores the latest breakthroughs in genomics and neurosciences, providing essential insights for un… Read more

Description

Advances in Genomics and Neurosciences for Neurologic and Behavioral Disorders explores the latest breakthroughs in genomics and neurosciences, providing essential insights for understanding, diagnosing, and managing neurodevelopmental, psychiatric, and neurodegenerative disorders. The book highlights the intersection of genetic and genomic diagnostic techniques with brain function and structure analysis to enhance therapeutic strategies. Sections cover a wide range of topics, including the analysis of brain circuits, synapses, and neural activity, as well as the role of ion channels and neurotrophins in brain function. It examines advanced genetic and genomic diagnostic methods such as chromosome studies, gene sequencing, RNA analysis, and metabolite profiling.

The book also addresses neurodevelopmental disorders like cerebral palsy, epilepsy, and autism, psychiatric disorders such as schizophrenia and thought disorders, and the molecular biology of memory and age-related cognitive decline. Organized into five sections, the book includes chapters on the latest techniques for brain analysis, genetic diagnostics, neurodevelopmental and psychiatric disorders, aging-related impairments, and new therapeutic approaches. Key topics include brain regions and circuits, new methods for studying these areas, and the relevance of this information for accurate diagnosis and patient care.

Key features

  • Explores advances in genomics and neurosciences relevant to neurodevelopmental, psychiatric, and neurodegenerative disorders
  • Discusses cutting-edge genetic and genomic diagnostic techniques for accurate diagnosis and personalized treatment
  • Analyzes brain circuits, synapses, and dendrites to enhance understanding of brain-related disorders and diagnostic methods
  • Reviews therapeutic targets and pharmacological advances, including gene and RNA-directed therapies and optogenetic therapies
  • Provides real-world applications and case studies to bridge the gap between research and patient care

Readership

Neurologists, psychiatrists, geneticists, clinical researchers, neuroscientists, biomedical researchers, medical professionals specializing in genetics, academic faculty in genetics, postgraduate students in related fields

Table of contents

Section 1: Advances in Analyses of Structures and Functions in Brain

1. Electrophysiology and key discoveries

2. Ion channels and brain activity

3. Cortical Circuits structures and analyses

4. Neurotrophins

Section 2: Genetic and Genomic Diagnostic Techniques

5. Chromosome studies and microarrays

6. Gene sequencing exome sequencing genomic sequencing

7. RNA and transcription analyses 8. Metabolite analyses

Section 3: Neurodevelopmental Disorders

9. Neurodevelopmental defects

10. Cerebral Palsy and Movement disorders

11. Epilepsy

12. Developmental delay

13. Behavioral disorders including autism and attention deficit hyperactivity disorders

Section 4: Psychiatric Disorders

14. Transdiagnostic dimensions, maladaptive behaviors, distress

15. Thought disorders

16. Cross-disorder psychiatry

17. Schizophrenia

18. Genetics and Genomics in Psychiatry

Section 5: Impaired Function in Aging

19. Molecular biology of memory

20. Age related memory decline hippocampus and synaptic impairment and high risk genes

21. Mitochondrial functional impairment in aging

22. Alzheimer disease and risk loci

23. Epigenetic and transcription changes in aging

24. Dementia and neuropathology

25. Gene defects leading to abnormal protein aggregates

26. Fronto-temporal dementia

27. Vascular dementia

28. Parkinsonism and related gene defects

29. Amyotrophic lateral sclerosis

30. Vascular dementia

31. Macular degenerations and advances in therapy

Product details

  • Edition: 1
  • Latest edition
  • Published: October 1, 2026
  • Language: English

About the author

MS

Moyra Smith

Dr. Moyra Smith is a Professor Emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded Dr. Smith the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, strong record of publications, active engagement with programs in the Department of Pediatrics, mentoring of graduate students, and involvement with the CART Autism Center at UCI. Dr. Moyra Smith has published more than 100 scientific articles in peer-reviewed journals such as Frontiers in Molecular Biosciences, Molecular Psychiatry, the Journal of Medical Genetics (JMG), and Cytogenetics Cell Genetics.

Affiliations and expertise
Professor Emerita, Department of Pediatrics and Human Genetics, College of Health Sciences, University of California, Irvine, CA, USA