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Elsevier

Books in Life sciences general

Providing a broad overview of biological systems, ecology, evolution, and molecular biology, this selection supports researchers, educators, and students across life sciences. It features foundational concepts, recent advances, and interdisciplinary approaches that promote comprehensive understanding and innovative research in the biological sciences.

  • GANs in Medical Diagnostics and Classification

    • 1st Edition
    • Abhishek Kumar + 1 more
    • English
    GANs in Medical Diagnostics and Classification explores the role of Generative Adversarial Networks (GANs) in addressing underdiagnosed and overlooked health challenges. The book bridges cutting-edge AI research with real-world medical applications, presenting interdisciplinary insights into how GANs enhance diagnostics, treatment precision, and disease surveillance across domains such as antimicrobial resistance, rare genetic disorders, and environmental health risks. It also examines ethical, policy, and accessibility dimensions of AI in healthcare. By combining technical depth with practical case studies, this volume equips medical researchers, AI engineers, and healthcare professionals with actionable knowledge to tackle silent epidemics using GAN-based tools.

  • Gallin and Ognibene's Principles and Practice of Clinical Research

    • 5th Edition
    • John I. Gallin + 2 more
    • English
    Gallin and Ognibene’s Principles and Practice of Clinical Research, Fifth Edition provides the definitive text on clinical research as written by internationally recognized experts from the National Institutes of Health, the US Food and Drug Administration, academia, and global researchers. This new edition contains more than 30 new authors and 9 new chapters. Topics covered emphasize the role of informatics in clinical research, incorporating clinical outcome assessment into endpoints for decision-making, inclusion of diverse and vulnerable research subjects, patient advocacy groups, rare disease research, preparing research for pandemics, public health emergencies, research opportunities for surgeons, and content on preclinical animal studies.For the international researcher, two new chapters detail international clinical research experiences in South Africa, India, and Pakistan. As with the previous edition, the new release provides readers with summary questions and answers after each chapter.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • Glial Mechanisms in Sleep and Circadian Biology

    • 1st Edition
    • Marcos G. Frank
    • English
    Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

  • Dissolvable Microneedles (DMNS) For Cancer Diagnosis And Treatment

    • 1st Edition
    • Neetu Talreja + 3 more
    • English
    Dissolvable Microneedles as Multifunctional Platforms for Cancer Management presents a comprehensive, lab‑to‑clinic overview of dissolving microneedles (DMNs) for cancer diagnosis and therapy, emphasizing painless, minimally invasive delivery and localized treatment. The book details DMN materials, design, and fabrication—includin... AI‑enabled and 3D‑printed approaches—then advances to theranostic applications such as immunotherapy, photodynamic therapy, exosome‑loaded systems, and stimulus‑responsive platforms. Translation topics cover regulation, scale‑up, and CMC, alongside supportive strategies during chemotherapy. Academic readers gain a structured synthesis of recent advances, practical methods, and clinical outlooks, positioning DMNs as patient‑friendly, cost‑effective tools with significant potential to revolutionize cancer care.

  • The Role of Machine Learning and Artificial Intelligence in Revolutionizing Healthcare

    • 1st Edition
    • Prashant Kesharwani + 1 more
    • English
    Revolutionizing Healthcare: The Role of Machine Learning and Artificial Intelligence describes the complexity of healthcare data that necessitates the expanding use of artificial intelligence (AI). This book offers an explicit accounting of vital aspects on artificial intelligence in healthcare, discussing perspectives of the technologies explored based on findings outlined in highly organized tables, illustrative figures, and flow charts. It brings together novel applications of artificial intelligence in healthcare and helps readers define major gaps in knowledge that can lead to significant scientific discoveries.In addition, the book covers computational drug design, genomic data mining, nanomedicines, medical devices, cosmeceuticals, biosensors, genome counseling, quality control, clinical trials, and cybersecurity. Researchers, students, and scientists will find the book provides foundational and practical knowledge, along with the most advanced AI applications in healthcare.

  • Empowering Health through Lifestyle Medicine

    The Essential Guide for Preventing and Managing Chronic Disease
    • 1st Edition
    • John Anthony Stevens
    • English
    Empowering Health through Lifestyle Medicine: The Essential Guide for Preventing and Managing Chronic Disease combines the most updated and available research with personal insights and experience, using the Lifestyle Medicine 6 pillar framework. The book engages readers not only in the description and efficacy of LM but also in its knowledge and discussions on concepts and behaviors for managing nutrition, physical activity, stress, mental health, and how our interactions with the environment can create a healthier, happier life. It will encourage clinicians to engage their patients more often, and more practically, with lifestyle medicine, while also helping consumers engage with their clinicians.With a goal of helping clinicians and healthcare related professionals prevent and manage lifestyle-related illnesses for life, this evidenced-based book can be used by anyone in healthcare. It is also ideal for those researching illness prevention and chronic disease management to improve health research practice and patient outcomes.

  • Geographic Atrophy in Age-related Macular Degeneration

    • 1st Edition
    • Jay Chhablani + 1 more
    • English
    Geographic Atrophy in Age-related Macular Degeneration provides a comprehensive resource on this flourishing discipline, focusing on accurate diagnosis, imaging features, clinical trials, differential diagnoses, and both established and emerging treatment options. The book details diagnostic processes using techniques such as visual acuity tests, dilated eye exams, fundus photography, optical coherence tomography (OCT), and fluorescein angiography, emphasizing the importance of early detection. It also differentiates geographic atrophy from other retinal conditions with similar symptoms, such as dystrophies, equipping practitioners with the knowledge for accurate diagnosis.Additional... it explores traditional management approaches like antioxidant supplements, lifestyle changes, and low vision aids, alongside novel treatments such as complement inhibitors, cell-based therapies, and gene therapy, to inform clinicians about the latest advancements and research in patient care. With the recent FDA approval for GA treatment, there has been significant interest in the retina community. This rapidly growing field necessitates a new book on geographic atrophy in age-related macular degeneration to address gaps in existing literature and provide up-to-date, comprehensive information.

  • Fluid Dynamics of Viral Transmission

    • 1st Edition
    • Mehrzad Shams + 1 more
    • English
    Fluid Dynamics of Viral Transmission is an essential exploration into the transmission dynamics of COVID-19, focusing specifically on the airborne spread of respiratory aerosols carrying infectious viruses. In light of the recent global pandemic, it offers crucial insights into the complex interaction between fluid dynamics and viral transmission and provides practical solutions for minimizing risks in indoor environments. The book delves into CFD simulations, optimizing ventilation systems, air filtration strategies, and spatial layout modifications. It evaluates mitigation measures such as mask-wearing, physical distancing, and occupancy limits, aiming to equip readers with the knowledge to create safer indoor spaces. This book is ideal for public health officials, policymakers, healthcare professionals, engineers, researchers, and academics in fluid mechanics, computational fluid dynamics, epidemiology, and virology.

  • Current Advances in Cancer Stem Cells and Neoplasia Research

    • 1st Edition
    • Hirendra Banerjee
    • English
    "Cancer, Volume 8" in the "Stem Cell Innovation in Health and Disease" series explores the rapidly evolving role of stem cells in cancer treatment. As cancer continues to impose a heavy global health burden, stem cell therapies are being recognized for their regenerative potential and ability to enhance recovery following aggressive therapies. Hematopoietic stem cell (HSC) transplantation is already a standard, FDA-approved treatment for hematologic cancers such as leukemia, myeloma, and lymphoma. These cells help regenerate healthy blood cells post-treatment. In addition, mesenchymal stem cells (MSCs) and neural stem cells (NSCs) are showing promise in preclinical models as therapeutic carriers, capable of homing to tumor sites and delivering anti-cancer agents such as nanoparticles, siRNAs, and small-molecule drugs. Recent clinical advancements include differentiation therapy, where stem cells are used to induce cancer cells to become non-cancerous. Two completed phase I clinical trials have demonstrated innovative applications: one using NSCs to convert a prodrug into a toxic compound within tumors, and another using MSCs engineered with viral enzymes to activate cytotoxic drugs directly at the tumor site. MSCs have also helped reduce graft-versus-host disease (GVHD), a major complication of stem cell transplants. This volume is divided into two main sections: understanding stem cell roles in cancer biology, and translating stem cell innovations into clinical practice. It features cutting-edge research, including organoid models, genetic editing, and iPSC technologies. Together, these insights offer a timely review of the field’s progress and its real-world potential to reshape cancer therapy.

  • Human Reproduction

    From basics to Biotechnology
    • 1st Edition
    • Marc yeste
    • English
    Human Reproduction: From Basics to Biotechnology is a complete reference for anyone in the field of life, health, and biomedical sciences. The book provides an overview of basics in human reproduction to advanced knowledge of the field, including some evidence from other mammalian species that complement our current knowledge on the anatomy and physiology of the male and female reproductive tract and gametes. This resource covers the most used assisted reproductive techniques and technical advances, human reproduction and infertility disorders, their diagnosis and available treatment options.

  • Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine

    • 1st Edition
    • Cheng Xue + 3 more
    • English
    Molecular Insights for Harnessing Urine Biomarkers in Precision Medicine provides a comprehensive exploration into the molecular signatures and clinical implications of urine biomarkers, providing invaluable insights for clinicians, researchers, and healthcare professionals. From historical perspectives to cutting-edge technologies, this reference presents an updated understanding of urine biomarkers' role across diverse bodily systems. With sections devoted to fundamental concepts, molecular signatures, and clinical applications, readers gain a deep understanding of urine biomarkers' significance in disease diagnosis and personalized medicine.Each chapter explores specific body systems, including renal, urological, cardiovascular, and respiratory, uncovering the diagnostic potential of urine biomarkers in various conditions like cancer, cardiovascular diseases, and neurological disorders. Highlighted are the latest advances in technology, challenges, and future directions, keeping readers abreast of the rapidly evolving landscape of urine biomarker research. Real-world case studies illustrate practical applications, enhancing comprehension and facilitating knowledge transfer to clinical practice.

  • Morbidity Prevention in Aging

    The Role of Salutogenesis Amidst Crises
    • 1st Edition
    • Nestor Asiamah + 3 more
    • English
    Morbidity Prevention in Aging: The Role of Salutogenesis Amidst Crises addresses the urgent need to rethink disease prevention strategies for an aging population. The book begins by exploring how age-friendly environments support health-seeking behaviors. The next section focuses on developing personal skills such as resilience and self-efficacy for maintaining health during crises. Section III examines the reorientation of health services to support preventive care, including community care and diet promotion, while Section IV addresses the creation of policies that facilitate health-promoting interventions and integrate prevention strategies. Community engagement and empowerment in promoting health is emphasized in the fifth section.The book concludes by providing a framework for understanding disease prevention amidst crises, focusing on diverse racial, cultural, and socioeconomic experiences and ensuring equitable opportunities for lifelong disease prevention. This groundbreaking book emphasizes a salutogenic approach that focuses on factors promoting health rather than merely treating diseases. It provides a comprehensive framework for understanding how to maintain health and prevent diseases across the lifespan, even amidst challenges such as wars, climate change, and industrial hazards.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Andrew Vinard + 2 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Perianal Crohn’s Disease

    Diagnosis and Treatment
    • 1st Edition
    • Bolin Yang + 2 more
    • English
    Perianal Crohn’s Disease: Diagnosis and Treatment includes the latest knowledge, concepts, first-hand theoretical views, and clinical experience of clinical frontline experts in the field of inflammatory bowel disease. The book systematically describes disease phenotypes, clinical features, examination methods, diagnoses, and treatments. It takes a scientific, practical, and systematic account of both common and rare conditions associated with Perianal Crohn’s Disease, offering informative content, clinical case information, cutting-edge viewpoints, and current, authoritative research findings. The book contains a depth of current clinical experience, including the use of photographs to support examples of conditions, methods, and techniques. In addition, it provides clear ideas and a wealth of clinical information for the clinical diagnosis and management of perianal Crohn's disease.

  • Biosimilars in Cancer

    • 1st Edition
    • Ranjita Shegokar + 1 more
    • English
    Biosimilars in Cancer is a comprehensive resource on the role of biosimilars in treating various cancer types. The book offers a succinct yet thorough overview of current trends in oncology, covering 21 different cancers from liver to breast cancer. Chapters provide detailed insights into trends, fundamental facts, and practical and clinical data, making it an invaluable tool for academics and practitioners. The book empowers researchers and clinicians to enhance understanding and improve patient outcomes through the effective use of biosimilars in oncology. Targeted primarily at pharmaceutical researchers, biomedical scientists, and clinicians, it supports the growing oncology biosimilars market.In addition, the book provides critical insights for those involved in cancer diagnostics and clinical trials, helping them stay ahead in this rapidly progressing field.

  • Geostatistical Approaches to Environmental and Public Health Issues

    • 1st Edition
    • Deepak Kumar + 4 more
    • English
    Geostatistical Approaches to Environmental and Public Health Issues discusses how geostatistical techniques can be leveraged to better understand and respond to pressing environmental and public health challenges. The book showcases how techniques like kriging, spatial regression, Bayesian modeling, and space-time analysis offer powerful, nuanced insights into these issues. Emphasizing stochastic, non-deterministic approaches, it highlights the importance of modeling uncertainty in both environmental and health domains. Through case studies and research-driven chapters, sections demonstrate how integrating geospatial and statistical methods can enhance our understanding of where, why, and how events occur—ultimately improving the precision of health interventions and environmental policies.By aligning cutting-edge statistical approaches with the geospatial dimensions of health and environmental data, this book fills a critical gap in the literature and supports more targeted, data-driven decision-making in the face of global uncertainty. It bridges methodological innovation with applied research, making it an essential resource for scientists, policymakers, and public health practitioners.

  • Electrocardiography of Laboratory Animals

    • 3rd Edition
    • Meg M. Sleeper + 1 more
    • English
    Electrocardiography of Laboratory Animals, Third Edition, provides the latest information on critical topics such as safety electrocardiography, toxicology, safety pharmacology, and telemetry, ensuring that readers are well-equipped with the knowledge required for accurate ECG interpretation in preclinical studies. The book begins with the fundamental principles of electrocardiography and its applications in drug safety evaluation but then covers electrocardiography in a wide range of laboratory animals, including rodents, guinea pigs, rabbits, cats, dogs, and various non-human primates such as marmosets, cynomolgus monkeys, rhesus monkeys, baboons, and chimpanzees.Addition... it reviews the ECG characteristics of minipigs, nanopigs, and micropigs. The text also includes chapters on telemetry and echocardiography in preclinical safety studies, as well as discussions on important parameters like PR (PQ), QRS, and QT intervals. The book concludes with chapters on cardiac assays, biomarkers, stem cells, and cardiovascular medical devices, providing a holistic view of cardiovascular research. It is an essential resource for biological and medical researchers, veterinarians, zoologists, and students.

  • Molecular Tools and Infectious Disease Epidemiology

    • 2nd Edition
    • Betsy Foxman + 1 more
    • English
    Molecular Tools and Infectious Disease Epidemiology, Second Edition examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology.Section... discuss how using molecular tools in epidemiologic research affects program design and conduct, consider the ethical concerns that arise in molecular epidemiologic studies, and provide a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory, and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into their studies.

  • Clinical Atlas of Gonioscopy

    • 1st Edition
    • Chunyan Qiao + 3 more
    • English
    Clinical Atlas of Gonioscopy comprehensively and systematically covers all aspects of gonioscopy: from basic knowledge and common manifestations to characteristic signs of different diseases, and the application of gonioscopy in the laser and surgical treatment of glaucoma. Including over a thousand high-quality images, it helps clinicians explore the diverse and fascinating world of the anterior chamber angle, and deepens their understanding of the pathogenesis, classification, diagnosis, differential diagnosis, treatment and follow-ups of glaucoma.

  • Gestational Diabetes Mellitus

    Epidemiology, Clinical Practice and Evidence-Based Guidelines
    • 1st Edition
    • Moshe Hod + 6 more
    • English
    Gestational Diabetes Mellitus: Epidemiology, Clinical Practice and Evidence-Based Guidelines is an invaluable resource for healthcare professionals seeking to understand the latest developments in GDM. Over the past 20 years, significant progress has been made in the study of its epidemiology, mechanisms, diagnosis, management, and prevention. This book delves into these advancements, offering insights that are crucial for both researchers and clinicians. It explores potential therapeutic solutions to enhance patient care, and is essential reading for obstetricians, endocrinologists, diabetes researchers, maternal health specialists, and pediatric endocrinologists, as well as specialty fellows, residents, postdoctoral fellows, and graduate students in these fields.

  • Capsule Endoscopy in Pediatric Patients from Theory to Practice

    • 1st Edition
    • Thomas M. Attard
    • English
    Capsule Endoscopy in Pediatric Patients from Theory to Practice is a practical and authoritative guide that empowers pediatric gastroenterologists, physicians, and trainees to navigate the complexities of Video Capsule Endoscopy (VCE) in children. With a focus on bridging knowledge gaps and providing practical insights, this book offers updated information on understanding and utilizing VCE in the pediatric population. The book covers the background and technical aspects of VCE, including guidance on setting up a pediatric VCE service and an overview of indications and limitations. It delves into practical aspects such as preprocedural preparation, artifact reduction techniques, and management of capsule retention. By exploring VCE in various disease conditions such as inflammatory bowel disease, gastrointestinal bleeding, hereditary polyposis syndromes, and chronic abdominal pain, readers gain a comprehensive understanding of diagnosis, surveillance, and management. Special content elements, including key terms, case studies, and a timeline of recent advances, enhance the learning experience. This essential resource empowers readers to optimize patient care, make informed decisions, and confidently navigate the realm of VCE in children.

  • Dry Eye Disease

    A Clinical Handbook
    • 1st Edition
    • James Stuart William Wolffsohn + 2 more
    • English
    Dry Eye Disease: A Clinical Handbook illuminates the translation of cutting-edge research on dry eye disease into practical situations, allowing clinical diagnosis and management of the condition using the latest evidence-based methods. It first presents research on the core pathophysiological features of dry eye disease, including tear film instability, hyperosmolarity, inflammation, and ocular surface damage. Thereafter, it champions a patient-centered approach to dry eye management, emphasizing the necessity of classifying the ocular surface disease(s) most relevant to each case. It discusses global disease distribution and the role of non-modifiable risk factors like age, sex, and ethnicity. Additionally, the book describes tools for monitoring symptoms over time and assessing subtle signs of the disease. Readers will find practical methods for improving patient outcomes both in clinical settings and at home.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 135
    • English
    Advances in Clinical Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Value-Based Healthcare in the Digital Age

    Economic Efficiency and Transformation
    • 1st Edition
    • Miltiadis Lytras + 2 more
    • English
    Value-Based Healthcare in the Digital Age: Economic Efficiency and Transformation addresses the transformation in global healthcare that has been driven by digital innovation, economic efficiency, and value-based care. The book provides comprehensive frameworks that integrate health economics, digital transformation, and patient-centered value delivery. Facing rising costs, aging populations, and chronic diseases, the healthcare sector also sees opportunities in AI, machine learning, blockchain, and IoT for smarter, more efficient delivery. Users will find an exploration of the economic implications of these technologies, offering strategies to align them with value-based care principles, optimize resources, and improve patient outcomes.For academics, policymakers, and healthcare professionals, this book bridges theory and practice with cutting-edge research and real-world case studies. It equips readers with the knowledge and frameworks to navigate the evolving healthcare landscape, emphasizing global perspectives and diverse technological applications, ultimately driving innovation and economic sustainability in healthcare delivery.

  • COVID-19 in New York City

    Public Health Crisis and its Aftermath
    • 1st Edition
    • Rainer W.G. Gruessner
    • English
    COVID-19 in New York City: A Five-Year Account presents a comprehensive account of the pandemic, from how events unfolded, how circumstances were handled, and how New Yorkers learned to better manage a similarly deadly pandemic in the future. The book documents the period from when the first case was diagnosed in New York City, addressing the medical, political, social, psychological, business, and environmental aspects, as well as the changes in behavior and lifestyle. The author shares his birds eye view of the city through a comprehensive investigation of the events, and the impact of the current and future implications for all readers.This book serves as a guide for anyone interested in how to handle and cope with a future deadly pandemic or similar disaster and is written by a physician and advocate for science who was living in New York City during the pandemic.

  • The Matrix Metalloproteinases

    • 1st Edition
    • Volume 60
    • English
    The Matrix Metalloproteinases, Volume 60 in The Enzymes series, explores recent advances in the study of matrix metalloproteinases (MMPs), a critical family of enzymes involved in extracellular matrix remodeling and numerous physiological and pathological processes. This volume presents a comprehensive collection of chapters covering key aspects of MMP biology, including their structure, function, regulation, and detection through activity-based probes.Chapters in this release examine classical and selective MMP inhibitors, including specific targeting strategies for MMP-13, as well as the role of endogenous tissue inhibitors of metalloproteinases. Additional contributions explore the involvement of MMPs in various biological and disease contexts, including oral diseases, neurodegenerative disorders, neutrophil biology, and cancer progression.The volume also addresses current challenges and opportunities in the design of MMP-targeted therapeutics, highlighting advances in drug development and pharmacological applications. Together, these chapters provide valuable insights into the biochemical, physiological, and clinical significance of MMPs, making this volume an essential reference for researchers in enzymology, biochemistry, molecular biology, and biomedical sciences.

  • Acute Myocardial Infarction in Young Women

    Understanding its Mechanisms and Management
    • 1st Edition
    • Stéphane Peggy Manzo-Silberman
    • English
    Acute Myocardial Infarction in Young Women: Understanding its Mechanisms and Management serves as a seminal reference for understanding the current landscape of cardiovascular health in young women, highlighting clinical areas that require focused attention. By customizing the information to their unique physiological and clinical differences, more precise and effective interventions will lead to improved outcomes. The information is meticulously updated to address the specific cardiovascular health issues encountered by young women with myocardial infarction. This ensures that each stage of care—from cardiovascular risk assessment and symptom-recognition to the acute myocardial infarction (AMI) pathway, and rehabilitation follow-up—is optimized.Ultimately... this book equips health professionals with the most current and evidence-based information, enabling them to deliver the highest standard of care for young women with myocardial infarction. It will enhance quality of care, and contribute to improved health outcomes for young women across all stages of the cardiovascular healthcare continuum.

  • A Comprehensive Guide to Dorsal Root Ganglion Stimulation for Pain Management

    • 1st Edition
    • Scott G. Pritzlaff + 4 more
    • English
    A Comprehensive Guide to Dorsal Root Ganglion Stimulation for Pain Management explores the theoretical foundations, clinical applications, and technical nuances of DRG stimulation, providing a robust framework for understanding and implementing this advanced pain management technique. The book consolidates current best practices, novel technical considerations, and emerging research into a single, authoritative volume. Main themes include the anatomical and physiological basis of DRG stimulation, clinical indications, patient selection, surgical techniques, device programming, and long-term patient outcomes. By integrating insights from leading experts in the field, the book provides a comprehensive and practical guide for clinicians, researchers, and students. Distinct from existing titles that merely touch upon the subject, this book offers a detailed and specialized focus on DRG stimulation, including up-to-date evidence, clinical guidelines, and case studies. The book also features pedagogical elements such as learning objectives, review questions, and case studies to enhance understanding and application.

  • Multiple Faces of Takotsubo Syndrome

    Clinical Presentations, Mechanisms and Advanced Diagnostic Insights
    • 1st Edition
    • Luca Saba + 1 more
    • English
    Multiple Faces of Takotsubo Syndrome: Clinical Presentations, Mechanisms and Advanced Diagnostic Insights offers a thorough review of Takotsubo syndrome and the role of advanced imaging techniques in improving diagnosis, monitoring, and management of this complex cardiac condition. The book begins with an introduction to Takotsubo syndrome, covering its historical background, prevalence, and key clinical characteristics. Subsequent chapters delve into epidemiology, risk factors, and psychological aspects, including the impact of COVID-19 and other viral infections. Then, clinical manifestations, management, prevention, and treatments are thoroughly discussed, along with complications and prognosis. The basic science section explores the pathophysiological mechanisms, the heart-brain axis, and multi-organ involvement.A significant focus throughout is placed on invasive and non-invasive imaging modalities, including angiography, echocardiography, cardiac MRI, computed tomography, and nuclear imaging. Future directions highlight emerging biomarkers and imaging techniques for personalized medicine, and real-world case studies provide practical insights for clinicians. The book offers invaluable benefits to scientists, researchers, and clinicians alike.

  • Trauma During Pregnancy

    • 1st Edition
    • Jorge Hidalgo + 2 more
    • English
    Trauma During Pregnancy, a volume in the Critical Care Obstetrics series, is a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women experiencing trauma. The book's authors offer best practices and evidence-based material explicitly focused on the most common complications in pregnant patients that may occur to improve patient care. It not only covers critical care investigation from medical-surgical complications that any patient can present, but also how to prepare and anticipate complications in the critical care unit.

  • Precision Oncology in Liver Cancer

    Genomics, Infection, and the Exposome in African and Global Contexts
    • 1st Edition
    • Zodwa Dlamini
    • English
    Precision Oncology in Liver Cancer: Genomics, Infection, and the Exposome in African and Global Contexts explores liver cancer through the lens of precision medicine, integrating molecular profiling, environmental exposures, and targeted therapies. The book presents a multidisciplinary approach, covering infectious drivers like HBV/HCV, environmental carcinogens such as aflatoxins, and emerging tools including genomics, AI, and liquid biopsies. It emphasizes African-specific challenges and innovations, with case studies and comparative global insights. This volume equips researchers, clinicians, and policymakers with evidence-based strategies to address liver cancer disparities, offering a forward-looking framework for equitable cancer care and research in Africa and globally.

  • Pediatric Substance Exposure

    • 1st Edition
    • Ju Lee Oei
    • English
    Pediatric Substance Exposure is a crucial resource for medical practitioners focusing on the long-term management of children exposed to addictive substances during pregnancy. It provides guidance on supporting families affected by substance abuse, starting with a comprehensive overview of epidemiology and global policy. The book examines various substances and their impact on children, discussing fetal management, infant and child care, and addressing family needs as the child grows. Beyond the basics, the book reviews social aspects, future research, and policy needs. Clinicians and researchers will find it invaluable for evidence-based decision-making and optimal treatment strategies.

  • Emerging Technologies in Bioengineering for Oncology

    Fundamentals, Research, and Future Prospects
    • 1st Edition
    • Saikat Das + 2 more
    • English
    Emerging Technologies in Bioengineering for Oncology: Fundamentals, Research, and Future Prospects explores the integration of engineering, biology, and medicine to tackle challenges in developing innovative tools for cancer diagnosis and treatment. This comprehensive resource addresses the evolving landscape of bioengineering in oncology, highlighting the intersection of various disciplines to drive advancements in diagnostic and therapeutic approaches. The book explores a range of cutting-edge technologies such as lab-on-chip devices, wearable biosensors, 3D bioprinting, and targeted nanomedicine, offering promising avenues for enhanced diagnostic precision, treatment effectiveness, and personalized healthcare.Geared towards medical students and professionals, the book provides detailed insights into the latest developments, practical applications, and future research directions in the field. By offering a deep dive into the realm of bioengineering for oncology, it serves as a valuable asset for those seeking to advance cancer care through interdisciplinary collaboration and innovation.

  • Pioneering Precision in Cancer Treatment through 3D Bioprinting

    • 1st Edition
    • Anand Krishnan + 3 more
    • English
    Pioneering Precision in Cancer Treatment through 3D Bioprinting explores the transformative impact of 3D bioprinting on cancer therapy. This groundbreaking book examines innovative techniques revolutionizing cancer care, from creating patient-specific tumor models to accelerating drug discovery and enabling personalized treatments. It offers a comprehensive look at how 3D bioprinting is reshaping oncology. The book details the creation of intricate tumor models that mimic the in vivo environment, enabling precise drug testing and individualized treatment plans. It highlights 3D bioprinting's role in drug screening, tumor modeling, and creating implantable scaffolds for cancer treatment.By manipulating cell arrangements and microenvironments, 3D bioprinting produces accurate cancer models. For the academic audience, this book blends bioengineering, medical insights, and real-world applications. It provides valuable case studies and developments in 3D cancer model creation, enhancing the understanding of oncogenesis, tumor progression, and therapy responses.

  • AI and Precision Oncology

    Innovations in Diagnosis and Drug Development
    • 1st Edition
    • Arun Kumar Singh + 2 more
    • English
    AI and Precision Oncology: Innovations in Diagnosis and Drug Development examines the transformative role of artificial intelligence and machine learning in oncology. The book addresses the urgent need for early cancer diagnosis and effective therapeutic treatments, highlighting how technological advancements enable rapid analysis of large datasets to enhance patient outcomes. The content explores clinical applications of next-generation sequencing (NGS) integrated with AI technologies, covering risk prediction, disease detection, biomarker identification, and therapeutic target discovery. The book emphasizes the importance of bioinformatics tools in analyzing NGS data and showcases AI-powered applications that improve cancer diagnosis and prognostication.For the academic audience, this book provides valuable insights into the latest advancements in AI and precision oncology. It equips researchers and clinicians with knowledge on personalized treatment strategies and recent clinical studies, ultimately enhancing understanding of how AI can revolutionize cancer care and improve patient management.

  • The Hormonal Treatment of Endometriosis and Adenomyosis

    A Comprehensive Review of the Role of Hormonal Treatments in the Management of Pain and Infertility in Patients with Endometriosis and Adenomyosis
    • 1st Edition
    • Antoine Naem + 1 more
    • English
    The Hormonal Treatment of Endometriosis and Adenomyosis: A Comprehensive Review of the Role of Hormonal Treatments in the Management of Pain and Infertility in Patients with Endometriosis and Adenomyosis is a comprehensive and practical reference on the effects of various hormonal treatments on endometriosis and adenomyosis lesions. The book summarizes the latest evidence regarding the safety and efficacy of these treatments in managing pain associated with these conditions. Additionally, the book explores the evidence-based benefits of hormonal therapies in improving fertility chances for patients, both through natural conception and assisted reproductive technologies.The book helps readers grasp the generalizability of current research findings and identifies existing research gaps, shedding light on new perspectives for future investigation. Through this comprehensive approach, the book serves as an invaluable resource for healthcare professionals, researchers, and patients alike.

  • Pediatric Pulmonology

    A Global Handbook for Clinical Care Providers
    • 1st Edition
    • Allen J. Dozor
    • English
    Pediatric Pulmonology: A Global Handbook for Clinical Care Providers provides an in-depth exploration of pediatric respiratory diseases, offering a detailed examination of various conditions, diagnostic techniques, and treatment protocols. The book covers a wide range of topics, from the assessment of children with respiratory diseases to specific conditions such as asthma, cystic fibrosis, and bronchopulmonary dysplasia. Each chapter is contributed to by leading experts in the field, ensuring that the content is both authoritative and up-to-date. These crucial, practical skills are essential when a pediatric patient's first point-of-care is not a respiratory specialist.This is especially true of medical treatment in resource-poor areas. The book includes "how to guides" on vital procedures such as spirometry, chest imaging, and the management of respiratory emergencies. It also addresses respiratory diseases in newborns, the impact of environmental factors on children's respiratory health, and the unique challenges faced by children with neurologic and neuromuscular diseases. This comprehensive approach ensures that non-specialists gain a holistic understanding of pediatric respiratory diseases and their management.

  • Signal Processing-Driven AI for Healthcare

    • 1st Edition
    • Ildar Rakhmatulin + 1 more
    • English
    Signal Processing-Driven AI for Healthcare examines how AI techniques can be applied across four major biosignals—EEG, EMG, EOG, and ECG—to derive clinically meaningful insights. As biomedical data becomes increasingly multimodal, there is a rising need for integrated methodologies that unite these signals within robust, explainable AI pipelines suitable for healthcare environments. This book provides a unified framework that spans data acquisition, preprocessing, feature extraction, modeling, evaluation, and deployment, with an emphasis on reproducibility, practical Python-based implementations, and real-world translation to clinical workflows.

  • Epidemic Modeling

    Principles, Algorithms, and Applications
    • 1st Edition
    • Teddy Lazebnik
    • English
    Epidemic Modeling: Principles, Algorithms, and Applications is a comprehensive introduction and practical guide to building, understanding, and applying epidemiological models in real-world contexts. Bridging theory and practice, the book walks readers through the full modelling pipeline from the biological, social, and political drivers of disease spread to classical compartmental models such as SIR, and onward to modern computational techniques including agent-based simulation, machine learning, and optimization under uncertainty. Each chapter builds progressively, pairing clear conceptual explanations with hands-on code, real data examples, and step-by-step methods that readers can adapt to new challenges. Drawing on extensive academic and industry experience, the text emphasizes how modelling decisions are made in practice addressing real-world complications such as incomplete data, reporting delays, and measurement error. Designed as both a learning resource and long-term reference, the book equips readers to move beyond running existing models to designing, evaluating, and communicating their own. It also fosters a shared language across disciplines, helping technical and non-technical audiences engage meaningfully with modelling insights. Timely and practical, this book empowers the next generation of modelers and decision-makers to respond effectively to an increasingly complex epidemic landscape.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 134
    • English
    Advances in Clinical Chemistry, Volume 134 in this ongoing series, examines physiologic and pathophysiologic biochemistry and impacts on Clinical Chemistry testing and design. Sections cover Molecular mechanisms of disease and advances in the development of improved diagnostic and predictive biomarkers. Specific chapters in this new release include Biomarkers in Heart Failure, RNA biomarkers in antidoping, Cardiovascular disease and miRNA, Chronic low-grade inflammation in vegetarians and vegans: biomarker evidence and methodological considerations, Advances in microfluidic extracellular vesicle technology, and Biomarkers for Assessing Magnesium Status.As these evolving technologies and analytic strategies have become increasing relevant given the healthcare and socioeconomic impact worldwide, this book provides an essential reference.

  • Advancing Body Fluid Diagnostics with Flow Cytometry

    A Comprehensive Guide to Effusions and CSF
    • 1st Edition
    • Namrata P. Awasthi
    • English
    Advancements in Pathological Diagnosis: Harnessing Flow Cytometry for Detection of Malignant Epithelial Cells in Body Fluids is an invaluable resource for anyone involved in cytology and pathology, especially those interested in leveraging flow cytometry for diagnostic purposes. The book offers a comprehensive understanding of how flow cytometry can enhance the detection of malignant epithelial cells in body fluids, providing both theoretical knowledge and practical guidance. Flow cytometry's ability to rapidly analyze individual cells based on their properties is truly remarkable, and its application in detecting early-stage malignancies and screening large numbers of cells efficiently is invaluable. The book bridges the gap between traditional cytological diagnostics and the evolving landscape of technological advancements in pathology. Moreover, the inclusion of detailed chapters on flow cytometry and its applications in cytological diagnostics for effusion samples suggests that the book caters to both beginners in the field and seasoned professionals seeking to expand their knowledge base. The endorsement from medical professionals such as medical oncologists, surgical oncologists, gastroenterologists, and general surgeons further underscores the relevance and practicality of the book in enhancing diagnostics and patient care across various medical specialties. "Advancements in Pathological Diagnosis" is a timely and essential contribution to the field of cytology and pathology, offering a comprehensive guide to leveraging flow cytometry for improved diagnostics in the context of malignant epithelial cells in body fluids.

  • Digital Transformation in Healthcare

    Innovations in Hospital and Medical Services
    • 1st Edition
    • Patricia Ordonez de Pablos + 1 more
    • English
    Digital Transformation in Healthcare: Innovations in Hospital and Medical Services explores the digital revolution in healthcare, addressing the challenges and opportunities faced by hospitals, medical faculties, and research institutions. The book highlights the role of advanced information technologies in providing innovative solutions for an ageing population's well-being. It covers critical areas such as hospital management, adapting medical education to digital advancements, and emerging IT tools in healthcare. The book features contributions from leading academics and practitioners worldwide, discussing topics like 5G, AI, big data, blockchain, and digital tools for citizen empowerment, supported by real-world case studies. This resource is invaluable for academics, offering new insights to shape innovative policies in healthcare, education, and information technologies. It fosters dialogue among managers, students, policymakers, and healthcare professionals, contributing to the global advancement of digital healthcare practices.

  • Vertebrate Carbonic Anhydrases

    • 1st Edition
    • Volume 59
    • English
    Vertebrate Carbonic Anhydrases, Volume 59 in The Enzymes series, explores recent advances in the study of carbonic anhydrases (CAs) in vertebrate systems. This volume presents a comprehensive collection of chapters examining the diversity, structure, function, and physiological roles of vertebrate CA isoforms across multiple tissues and cellular compartments. Chapters include discussions on the phylogenetic relationships of vertebrate carbonic anhydrases and detailed examinations of several important isoforms, including carbonic anhydrases I, II, and III, as well as membrane-associated enzymes such as CA IV and XV. Additional contributions explore mitochondrial carbonic anhydrases (CA VA and VB), secreted isoforms such as CA VI, and more.The volume also examines acatalytic carbonic anhydrases and tumor-associated isoforms, providing insights into their structural characteristics and biological significance. A concluding chapter addresses current challenges and opportunities in the development of selective inhibitors and activators targeting vertebrate carbonic anhydrase isoforms, highlighting their potential therapeutic applications.

  • Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture

    • 1st Edition
    • Douglas P. Beall
    • English
    Worldwide, vertebral compression fractures (VCFs) continue to be the most common major fragility fracture, affecting patients over the age of 50, and osteoporosis is the most prevalent condition associated with VCFs. Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture provides treatment and management guidance of the osteoporosis disease process in patients who have had a VCF. This book opens with a foundation of osteoporosis and VCF and then reviews clinical and radiological assessment approaches, evaluation, treatment, and ongoing management options. Subsequent chapters cover the efficacy of the different vertebral augmentation types on patient outcomes, optimization methods, decisions for osteoporosis treatment in these patients, and recommendations to improve patient outcomes. Special attention is paid to the treatment sequence and objectives following an osteoporotic VCF. This book concludes with coverage of insightful developments in clinical management and current research and features targeted case studies representing common patient characteristics that showcase varying aspects of different VCFs and the underlying osteoporosis that gives rise to these fractures. This title serves as an invaluable resource for any practitioner managing fragility fractures in older patients as well as treating their underlying osteoporosis.

  • Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B

    • 1st Edition
    • Lung-Yi Loey Mak + 1 more
    • English
    Therapeutic Potentials of Tenofovir Alafenamide in Hepatitis B offers a comprehensive examination of the therapeutic potentials of Tenofovir Alafenamide (TAF) in hepatitis B, providing a succinct and up-to-date summary of all relevant evidence for this first-line oral antiviral agent. The text delves into key topics such as the pharmacological profile of TAF, its comparative efficacy against traditional antiviral agents, safety and tolerability, and the impact of TAF on drug resistance. Additionally, it explores the use of TAF in special populations, including pediatrics, the elderly, and individuals with renal impairment, as well as future directions in hepatitis B treatment strategies.Readers will discover the diverse potential applications of TAF in chronic hepatitis B, informed by valuable lessons learned from HIV treatment while also gaining insights into future therapeutic possibilities. Authored by leading experts in the field, each chapter presents focused and insightful perspectives, making this book an indispensable resource for practitioners and researchers alike. Serving as a critical resource for physicians, researchers, pharmacologists, and biomedical scientists, this book highlights the core knowledge necessary for understanding TAF and its clinical applications.

  • Advances in Transfusion Medicine

    A Practical Handbook
    • 1st Edition
    • Parmatma Prasad Tripathi
    • English
    Advances in Transfusion Medicine: A Practical Handbook presents a detailed overview of transfusion medicine, beginning with blood components and derivatives therapy, including RBC, platelet, and plasma transfusions, as well as hematopoietic stem cell therapy. The book addresses patient blood management, focusing on practical applications and specific considerations in various populations. Safety practices in transfusion, including blood donation strategies and reactions are also covered. In addition, emerging therapies and technologies, such as artificial red blood cells and gene therapy are explored alongside global health challenges related to blood safety and shortages.The role of immunohematology and genomics is highlighted, along with cellular therapy applications, ethical considerations, and a discussion on pediatric transfusions and guidelines for managing transfusions in children. Miscellaneous topics like emerging infections and pathogen reduction technologies complete the overview, emphasizing current practices and future directions in the field.

  • Intelligence-Based Healthcare

    Artificial Intelligence Concepts with Real‑World Applications for Healthcare Leaders and Providers
    • 1st Edition
    • Anthony Chang + 2 more
    • English
    Intelligence-Based Healthcare: An Essential Guide with Case Studies of Artificial Intelligence for the Healthcare Leader and Provider is an essential guide with an introduction to data science and artificial intelligence to provide the reader with a quick orientation and education on AI in healthcare. This book also offers a framework for success in planning, deployment, implementation, and evaluation of AI models in healthcare. In 25 chapters, Intelligence-Based Healthcare: An Essential Guide with Case Studies of Artificial Intelligence for the Healthcare Leader and Provider both introduces the reader to artificial in medicine and healthcare, and AI concepts. To render AI more understandable and relatable to the reader, case studies are used as a learning strategy to illustrate the aforementioned AI concepts. The cases implement AI in solving a very specific problem, clinical or operational, in clinical medicine or healthcare. Both cases that illustrate successful implementation of AI as unsuccessful application cases with important lessons learned are included. Each chapter can be read independently and therefore the book is a valuable resource for researchers, health professionals, postgraduate students, post doc researchers and faculty members in the fields of artificial intelligence in medicine and healthcare, and all those who wish to broaden their knowledge in the allied field.

  • Signaling Pathways in Breast Cancer

    Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance
    • 1st Edition
    • Sumel Ashique + 3 more
    • English
    Signaling Pathways in Breast Cancer: Molecular Mechanisms, Therapeutic Strategies, and Multidrug Resistance provides an in-depth exploration of the complex molecular mechanisms that drive breast cancer progression. The book focuses on critical signaling pathways, including PI3K/Akt/mTOR, MAPK/ERK, JAK/STAT, Wnt/β-catenin, and Notch, elucidating their roles in tumor development, survival, and therapeutic resistance. The content offers a comprehensive overview of these pathways, detailing their dysregulation in breast cancer and implications for targeted therapeutic strategies. It discusses FDA-approved treatments, emerging therapies, and the mechanisms behind drug resistance, integrating recent research findings to highlight novel molecular targets and biomarker discovery. This book serves as a valuable resource for researchers, clinicians, and students, bridging the gap between basic molecular biology and clinical applications. By providing structured insights into complex signaling networks and therapeutic interventions, it equips readers with essential knowledge for developing innovative approaches to breast cancer management and improving patient outcomes.

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