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Elsevier

Books in Geriatrics and gerontology

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Cultural Dimensions of Ageism

    East Meets West Toward an Age-inclusive Society
    • 1st Edition
    • Takashi Yamashita + 1 more
    • English
    Cultural Dimensions of Ageism: East Meets West Toward an Age-Inclusive Society explores ageism in two contrasting nations—Japan and the United States—and their respective approaches to addressing it. Despite its longstanding presence, ageism remains an underrecognized form of discrimination and stereotyping. As populations age rapidly worldwide, ageism manifests with striking similarities and profound differences across cultures, significantly shaping the lives of older adults. Drawing on these cross-cultural perspectives, the book offers strategic solutions for combatting ageism in a transcultural context, providing valuable insights for building a more inclusive, respectful global society. This groundbreaking contribution integrates novel, critical cross-national insights from two distinct cultural zones: Japan, a super-aged society with the world's highest life expectancy, and the United States, an economically developed nation with demographically and culturally diverse populations. Readers will find comprehensive coverage of ageism, cross-cultural comparison, and global aging in one succinct resource. For scientists and researchers, the book offers cross-cultural observations of ageism research from East/Japan and West/North America, with reflective questions and key takeaways to facilitate engagement. Clinicians will benefit from increased knowledge about ageism in diverse global communities, enriched by case studies and personal stories that bring a human element to the research. This is an essential resource for anyone dedicated to understanding and addressing ageism in our rapidly aging world.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • Morbidity Prevention in Aging

    The Role of Salutogenesis Amidst Crises
    • 1st Edition
    • Nestor Asiamah + 3 more
    • English
    Morbidity Prevention in Aging: The Role of Salutogenesis Amidst Crises addresses the urgent need to rethink disease prevention strategies for an aging population. The book begins by exploring how age-friendly environments support health-seeking behaviors. The next section focuses on developing personal skills such as resilience and self-efficacy for maintaining health during crises. Section III examines the reorientation of health services to support preventive care, including community care and diet promotion, while Section IV addresses the creation of policies that facilitate health-promoting interventions and integrate prevention strategies. Community engagement and empowerment in promoting health is emphasized in the fifth section.The book concludes by providing a framework for understanding disease prevention amidst crises, focusing on diverse racial, cultural, and socioeconomic experiences and ensuring equitable opportunities for lifelong disease prevention. This groundbreaking book emphasizes a salutogenic approach that focuses on factors promoting health rather than merely treating diseases. It provides a comprehensive framework for understanding how to maintain health and prevent diseases across the lifespan, even amidst challenges such as wars, climate change, and industrial hazards.

  • Geriatric Neurosurgery in Clinical Practice

    • 1st Edition
    • Joe M. Das
    • English
    Geriatric Neurosurgery in Clinical Practice is an essential resource that provides a thorough and modern overview of geriatric neurosurgery. This volume compiles the latest research and clinical practice guidelines, offering practical advice for clinicians caring for elderly patients. It delves into a range of topics, including the management of common neurosurgical conditions in elderly patients, surgical techniques, postoperative care, and the integration of multidisciplinary approaches to enhance patient outcomes. Users will find this to be an invaluable reference for practicing neurosurgeons, neurosurgery residents, neurologists, geriatric physicians, and researchers seeking clear and concise information on current treatments and procedures for geriatric neurosurgery.

  • Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture

    • 1st Edition
    • Douglas P. Beall
    • English
    Worldwide, vertebral compression fractures (VCFs) continue to be the most common major fragility fracture, affecting patients over the age of 50, and osteoporosis is the most prevalent condition associated with VCFs. Patient Treatment and Management Following an Osteoporotic Vertebral Compression Fracture provides treatment and management guidance of the osteoporosis disease process in patients who have had a VCF. This book opens with a foundation of osteoporosis and VCF and then reviews clinical and radiological assessment approaches, evaluation, treatment, and ongoing management options. Subsequent chapters cover the efficacy of the different vertebral augmentation types on patient outcomes, optimization methods, decisions for osteoporosis treatment in these patients, and recommendations to improve patient outcomes. Special attention is paid to the treatment sequence and objectives following an osteoporotic VCF. This book concludes with coverage of insightful developments in clinical management and current research and features targeted case studies representing common patient characteristics that showcase varying aspects of different VCFs and the underlying osteoporosis that gives rise to these fractures. This title serves as an invaluable resource for any practitioner managing fragility fractures in older patients as well as treating their underlying osteoporosis.

  • Aging and the Kidney

    Mechanisms, Consequences, and Management Strategies
    • 1st Edition
    • Stephen Fadem + 2 more
    • English
    Aging and the Kidney: Possible Mechanisms, Consequences, and Management Strategies explores the connection between kidney health and overall well-being with increasing age and longevity. The first part examines histological, structural, physiological, and functional changes that contribute to age-related declines in kidney function. The role of nutrition and proteomics is also discussed. The second part examines the functional decline in elderly patients and includes subparts on impaired quality of life, sleep quality, fall risk, frailty, depression, and sarcopenia. It also considers unique features of hypertension, diabetes, glomerulonephritis, and peripheral vascular disease.The final part focuses on diagnostic, management, and prevention strategies. Common myths about chronic kidney disease in the elderly are addressed, with particular attention to how a solitary kidney in living donors ages over time. In addition, kidney function and its relationship to neurologic complications, cancers, and cardiovascular disease are explained, along with current treatment approaches, medications, and future directions in the care of elderly patients.

  • Microglial Aging

    Basic, Translational and Clinical Advances
    • 1st Edition
    • Marie-Eve Tremblay
    • English
    Microglial Aging: Basic, Translational, and Clinical Advances explores groundbreaking research on microglial function in the context of aging. This comprehensive resource delves into the physiological roles of microglia, the effects of aging on their structure and activity, and their significance in age-related neurodegenerative diseases. With insights from basic, translational, and clinical studies, it provides a thorough understanding of microglial health and its impact on aging. The book discusses how lifestyle choices can enhance microglial functions and prevent neurodegenerative diseases. It covers both pharmacological and non-pharmacological approaches, such as the ketogenic diet, cannabinoids, psychedelics, and non-invasive vagal nerve stimulation.This text is invaluable for researchers and clinicians focused on improving the quality of life for an aging population.

  • The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics

    • 1st Edition
    • Abhishek Kumar Singh + 2 more
    • English
    The Potential of Intermittent Fasting in Age-related Diseases and Precision Anti-aging Therapeutics takes an in-depth look at the beneficial and efficacious role of Intermittent Fasting (IF) in a wide array of aging-associated diseases. It provides a comprehensive resource that not only outlines the potential benefits and future research directions but also delves into the limitations and nuances of IF in managing these conditions. The book is divided sections and begins by covering the fundamentals of aging and the effects of IF. Subsequent sections examine the physiological impact IF has on aging; its potential influence on stress resistance, heart, gut, and overall health optimization; social and ethical considerations as a therapeutic strategy; bridging IF research findings and clinical practice; and the potential integration and application of IF into age-related diseases treatment. Offering a consolidated and scientifically grounded perspective aimed at equipping readers with a balanced understanding, this book serves as a go-to reference for researchers and clinicians alike seeking clear and accurate insights into how IF can positively influence the health and longevity of the aging population.

  • Role of Sex and Gender in Aging and Longevity

    • 1st Edition
    • Calogero Caruso
    • English
    Role of Sex and Gender in Aging and Longevity aims to shed light on the complex interplay between sex and gender differences in the aging process and longevity of individuals. While biological sex differences have long been recognized as influencing various aspects of aging, this book includes how gender also plays a significant role in shaping these processes, accelerating aging, or favoring longevity. By acknowledging the influence of both biological and socially constructed factors, this book offers a comprehensive understanding of why individuals may experience different aging trajectories and have divergent longevity outcomes. This book explores the intricate ways in which gender norms, roles, and expectations shape individual experiences of aging and delves into the social determinants of health that can interact with biological factors to influence the aging process and longevity outcomes. By examining these interactions, this book aims to provide a nuanced understanding of the multifaceted nature of aging and longevity and how sex and gender contribute to these complex phenomena, laying the groundwork for future aging research and providing significant implications for disease prevention, screening, diagnosis, and treatment of age-related conditions.

  • Geriatric Surgery and Perioperative Care

    • 1st Edition
    • Gabriella Bettelli + 1 more
    • English
    Geriatric Surgery and Perioperative Care presents clear evidence to support regulatory and financial decisions in the light of the value-based care principles. The book outlines standards of care for elderly patients undergoing surgery as well as minimal requirements for modern management aimed at delivering cost-effective healthcare. It opens with the epidemiology and patho-physiological changes of aging and their impact on anesthesia and surgery. Subsequent chapters guide readers through the surgical process, addressing preoperative optimization, intraoperative procedures and management, and postoperative principles, including ICU care.The book concludes with ethical principles, care models, and hospital design to support a golden silver surgery using a team-based approach. This title is an important resource for healthcare professionals, practitioners, and others pursuing current strategies and methods for successful perioperative care of the elderly.

  • Early Vascular Aging (EVA)

    New Directions in Cardiovascular Protection
    • 2nd Edition
    • Pedro Guimarães Cunha + 4 more
    • English
    Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA.

  • Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

    • 1st Edition
    • Sandeep Kumar Singh + 2 more
    • English
    Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

  • The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

    • 1st Edition
    • Elizabeth Head + 1 more
    • English
    The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena.

  • Encyclopedia of Biomedical Gerontology

    • 1st Edition
    • Suresh Rattan
    • English
    Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention.

  • The Science of Hormesis in Health and Longevity

    • 1st Edition
    • Suresh Rattan + 1 more
    • English
    The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

  • The End of Alzheimer’s

    The Brain and Beyond
    • 2nd Edition
    • Thomas J. Lewis + 1 more
    • English
    The End of Alzheimer’s: The Brain and Beyond, Second Edition is the first comprehensive overview on the molecular basis of Alzheimer’s outside of the brain, merging the most recent findings within the field into a single book. It aims to educate the reader on the many overlooked aspects of Alzheimer’s disease that occur outside the brain. This book uniquely provides step-by-step, peer-reviewed evidence that the current research model may be misguided and that a new and emerging model is more accurate. It carefully outlines the molecular research in Alzheimer’s outside the brain and argues that a more thorough, whole-body diagnosis will provide better answers about its causes and lead to new treatments. It is beneficial to researchers who need to be apprised of the emerging science on the causes of Alzheimer’s, and will hopefully redirect many into new avenues of cellular research and discovery.

  • Nutritional Modulators of Pain in the Aging Population

    • 1st Edition
    • Ronald Ross Watson + 1 more
    • English
    Nutritional Modulators of Pain in the Aging Population provides an overview on the role of foods, dietary supplements, obesity, and nutrients in the prevention and amelioration of pain in various diseases in the aging population. Headaches, fibromyalgia, joint pain, arthritis pain, back pain, and stomach pain are discussed. In addition, the potential health risks of using foods to reduce symptoms is evaluated. Each chapter reviews pain causing conditions before reviewing the role of food or exercise. Both researchers and physicians will learn about dietary approaches that may benefit or harm people with various types of pain. Chapters include current research on the actions of nutrients in pain treatment, the effects of lifestyle and exercise on pain management, and discussions of dietary supplements that provide pain relief from chronic conditions like arthritis.

  • Sleep and Neurologic Disease

    • 1st Edition
    • Mitchell G. Miglis
    • English
    Sleep and Neurologic Disease reviews how common neurologic illnesses, such as Parkinson’s Disease and Alzheimer’s dementia impact sleep. In addition, the book discusses how common primary sleep disorders influence neurologic diseases, such as the relationship between obstructive sleep apnea and stroke, as well as their association with various primary headache disorders and epilepsy syndromes. The utilization of sleep technology, such as polysomnography, multiple sleep latency testing, actigraphy, laboratory and CSF testing is also covered. The book is written for the practicing neurologist, sleep physician, neuroscientist, and epidemiologist studying sleep.

  • Parkinson's Disease

    Molecular Mechanisms Underlying Pathology
    • 1st Edition
    • Patrik Verstreken
    • English
    Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.

  • Physical Activity and the Aging Brain

    Effects of Exercise on Neurological Function
    • 1st Edition
    • Ronald Ross Watson
    • English
    Physical Activity and the Aging Brain: Effects of Exercise on Neurological Function is a complete guide to the manifold effects of exercise and physical activity on the aging brain. Cognitive decline and motor impairment, onset of diseases and disorders, and even changes in family structure and social settings that occur as we age can all impact activity levels, yet continued physical activity is crucial for successful neurological functioning. This book examines the role that exercise and physical activity play in halting or modulating the deleterious effects of these numerous aging concerns by first examining the current state of research into how exercise manifests physical changes in the brain. It then discuss how physical activity combines with other lifestyle factors to benefit the aging brain, including nutrition, computerized brain training, and social engagement. Most significantly, it also covers how physical activity can serve as therapy to help alleviate the symptoms of various neurological diseases impacting aging populations, with particular emphasis on Alzheimer’s disease and age-related cognitive decline. The book provides broad coverage of the effects of exercise and physical activity on the aging brain, its therapeutic effects, and the many factors that influence the aging process.

  • Ambient Assisted Living and Enhanced Living Environments

    Principles, Technologies and Control
    • 1st Edition
    • Ciprian Dobre + 4 more
    • English
    Ambient Assisted Living and Enhanced Living Environments: Principles, Technologies and Control separates the theoretical concepts concerning the design of such systems from their real-world implementations. For each important topic, the book bridges theory and practice, introducing the instruments needed by professionals in their activities. To this aim, topics are presented in a logical sequence, with the introduction of each topic motivated by the need to respond to claims and requirements from a wide range of AAL/ELE applications. The advantages and limitations of each model or technology are presented through concrete case studies for AAL/ELE systems. The book also presents up-to-date technological solutions to the main aspects regarding AAL/ELE systems and applications, a highly dynamic scientific domain that has gained much interest in the world of IT in the last decade. In addition, readers will find discussions on recent AAL/ELE technologies that were designed to solve some of the thorniest business problems that affect applications in areas such as health and medical supply, smart city and smart housing, Big Data and Internet of Things, and many more.

  • Women and Positive Aging

    An International Perspective
    • 1st Edition
    • Lisa Hollis-Sawyer + 1 more
    • English
    Women and Positive Aging: An International Perspective presents the noted research in the fields of psychology, gerontology, and gender studies, reflecting the increasingly popular and pervasive positive aging issues of women in today’s society from different cohorts, backgrounds, and life situations. Each section describes a bridge between the theoretical aspects and practical applications of the theory that is consistent with the scientist-practition... training model in psychology, including case studies and associated intervention strategies with older women in each chapter. In addition to incorporating current research on aging women’s issues, each section provides the reader with background about the topic to give context and perspective.

  • Handbook of the Biology of Aging

    • 8th Edition
    • Nicolas Musi + 1 more
    • English
    Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

  • Person-Centered Communication with Older Adults

    The Professional Provider's Guide
    • 1st Edition
    • Timothy A. Storlie
    • English
    Providers serving older adults face a growing problem. Older adults are becoming increasingly dissatisfied with service quality citing deficits in provider communication and relationship skills. The author argues this dissatisfaction is largely related to three widespread issues: ageism, use of professional jargon, and age-related changes in the older adult. To address these concerns, Dr. Storlie advocates adoption of an evidence-based, person-centered approach to communication. The benefits of person-centered communication are many. They can increase older adult satisfaction with provider services, enhance mutual respect and understanding, improve accuracy of information exchanged, positively impact service outcomes, increase compliance with provider recommendations, and reduce the frustration and stress often experienced by both provider and older adult. Rare to this genre, readers are introduced to several under-explored topics within the field of communication, along with methods for applying concepts from research findings into these topics to enhance the quality of interpersonal communication. Topics include the role of mental imagery in the communication process, the influence of neurocardiology on relationships, and controversial findings from research into quantum physics. The book concludes by highlighting progress made in narrowing the interpersonal communication gap and forecasts how communications-orien... technological advances might improve quality of life for 21st century older adults and the providers who serve them. Utilizing interdisciplinary case studies to illustrate common problematic situations, this book provides detailed exercises that explain how providers can integrate person-centered communication into their practices to improve provider-older adult interactions. Written in a style designed to maximize learning, it helps providers find the information they need, understand what they read, and apply what they’ve learned to improve professional communication. Person-Centered Communication with Older Adults is an essential guide for today’s healthcare professionals and other aging-services providers, and also for the educators who help to prepare the providers of tomorrow.

  • Family Caregiving in the New Normal

    • 1st Edition
    • Joseph E. Gaugler + 1 more
    • English
    Family Caregiving in the New Normal discusses how the drastic economic changes that have occurred over the past few years have precipitated a new conversation on how family care for older adults will evolve in the future. This text summarizes the challenges and potential solutions scientists, policy makers, and clinical providers must address as they grapple with these changes, with a primary focus given to the elements that may impact how family caregiving is organized and addressed in subsequent decades, including sociodemographic trends like divorce, increased participation of women in the workforce, geographic mobility, fewer children in post-baby boom families, chronic illness trends, economic stressors, and the current policy environment. A section on the support of caregivers includes technology-based solutions that examine existing models, personal health records, and mobile applications, big data issues, decision-making support, person-centered approaches, crowd-sourced caregiving such as blogs and personal websites that have galvanized caregivers, and new methods to combine paid and unpaid forms of care.

  • Aging and Decision Making

    Empirical and Applied Perspectives
    • 1st Edition
    • Thomas M. Hess + 2 more
    • English
    Decisions large and small play a fundamental role in shaping life course trajectories of health and well-being: decisions draw upon an individual's capacity for self-regulation and self-control, their ability to keep long-term goals in mind, and their willingness to place appropriate value on their future well-being. Aging and Decision Making addresses the specific cognitive and affective processes that account for age-related changes in decision making, targeting interventions to compensate for vulnerabilities and leverage strengths in the aging individual. This book focuses on four dominant approaches that characterize the current state of decision-making science and aging - neuroscience, behavioral mechanisms, competence models, and applied perspectives. Underscoring that choice is a ubiquitous component of everyday functioning, Aging and Decision Making examines the implications of how we invest our limited social, temporal, psychological, financial, and physical resources, and lays essential groundwork for the design of decision supportive interventions for adaptive aging that take into account individual capacities and context variables.

  • Diet and Nutrition in Dementia and Cognitive Decline

    • 1st Edition
    • Colin R. Martin + 1 more
    • English
    Diet and Nutrition in Dementia and Cognitive Decline offers researchers and clinicians a single authoritative source which outlines the complex interrelationships between cognitive decline, dementia and the way diet can be modified to improve outcomes. In a cross-disciplinary field like dementia research and practice, clinicians and researchers need a comprehensive resource which will quickly help them identify a range of nutritional components and how they affect cognitive decline and the development of dementia. While the focus is on clinical applications, the book also features landmark and innovative preclinical studies that have served as the foundation of rigorous trials. Chapters explore the evidence of how nutritional components, either in the diet or supplements, can either impede the development to, or progression from, the onset of dementia. Authors investigate how conditions and processes overlap between defined conditions and present studies which show that dietary components may be equally effective in a number of conditions characterized by declining cognition or dementia. This book represents essential reading for researchers and practicing clinicians in nutrition, dietetics, geriatrics, nursing, neurology, and psychology, as well as researchers, such as neuroscientists, molecular and cellular biochemists, interested in dementia. http://www.acnr.co.u...

  • Inflammation, Advancing Age and Nutrition

    Research and Clinical Interventions
    • 1st Edition
    • Irfan Rahman + 1 more
    • English
    The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.

  • Handbook of the Biology of Aging

    • 7th Edition
    • Edward J. Masoro + 1 more
    • English
    Handbook of the Biology of Aging, Seventh Edition, reviews and synthesizes recent findings and discoveries in the field. This volume is part of The Handbooks of Aging series, which also includes The Handbook of the Psychology of Aging and The Handbook of Aging and the Social Sciences. The book is organized into two parts. Part 1 covers basic aging processes. It covers concepts relevant to clinical research, such as muscle, adipose tissue, and stem cells. It discusses research on how dietary restriction can slow down the aging process and extend life in a wide range of species. Part 2 deals with the medical physiology of aging. It contains several chapters on the aging of the human brain. These chapters deal not only with diseases but also with normal aging changes to cerebral vasculature and myelination as well as the clinical implications of those changes. Additional chapters cover how aging affects central features of human health such as insulin secretion, pulmonary and cardiac function, and the ability to maintain body weight and body temperature. The volume is primarily directed at basic researchers who wish to keep abreast of new research outside their own subdiscipline. It will also be useful to medical, behavioral, and social gerontologists who want to learn about the discoveries of basic scientists and clinicians.

  • Handbook of Aging and the Social Sciences

    • 7th Edition
    • Linda George
    • English
    Handbook of Aging and the Social Sciences, Seventh Edition, provides extensive reviews and critical evaluations of research on the social aspects of aging. It also makes available major references and identifies high-priority topics for future research. The book is organized into four parts. Part 1 reviews developments in the field of age and the life course (ALC) studies and presents guidelines on conducting cohort analysis. Part 2 covers the demographic aspects of aging; longevity trends; disability and aging; and stratification and inequality research. Part 3 includes chapters that examine socioeconomic position and racial/ethnic disparities in health at older ages; the role of social factors in the distribution, antecedents, and consequences of depression; and aspects of private wealth transfers and the changing nature of family gift-giving. Part 4 deals with pension reform in Europe; the political activities of older Americans; the future of retirement security; and gender differences in old age. The Handbook is intended for researchers, professional practitioners, and students in the field of aging. It can also serve as a basic reference tool for scholars, professionals, and others who are not presently engaged in research and practice directly focused on aging and the aged.

  • Handbook of the Psychology of Aging

    • 7th Edition
    • K Warner Schaie + 1 more
    • English
    The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals. It also provides perspectives on the behavioral science of aging for researchers and professionals from other disciplines. The book is organized into four parts. Part 1 reviews key methodological and analytical issues in aging research. It examines some of the major historical influences that might provide explanatory mechanisms for a better understanding of cohort and period differences in psychological aging processes. Part 2 includes chapters that discuss the basics and nuances of executive function; the history of the morphometric research on normal brain aging; and the neural changes that occur in the brain with aging. Part 3 deals with the social and health aspects of aging. It covers the beliefs that individuals have about how much they can control various outcomes in their life; the impact of stress on health and aging; and the interrelationships between health disparities, social class, and aging. Part 4 discusses the emotional aspects of aging; family caregiving; and mental disorders and legal capacities in older adults.

  • Handbook of Assessment in Clinical Gerontology

    • 2nd Edition
    • Peter A. Lichtenberg
    • English
    New trends in mental healthcare practice and a rapid increase in the aged population are causing an explosion in the fields of clinical gerontology and geropsychology today. This comprehensive second edition handbook offers clinicians and graduate students clear guidelines and reliable tools for assessing general mental health, cognitive functioning, functional age, psychosocial health, comorbidity, behavior deficits, and more. Psychopathology, behavioral disorders, changes in cognition, and changes in everyday functioning are addressed in full, and a wide range of conditions and disorders common to this patient population are covered. Each chapter provides an empirical review of assessment instruments, assessment scales in their totality, a review of how these instruments are used with and adapted for different cultural groups, illustration of assessments through case studies, and information on how to utilize ongoing assessment in treatment and/or treatment planning. This combination of elements will make the volume the definitive assessment source for clinicians working with elderly patients.

  • Handbook of Models for Human Aging

    • 1st Edition
    • Stephen A. Benjamin + 7 more
    • English
    The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advant... of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.

  • Handbook of Aging and the Social Sciences

    • 6th Edition
    • Robert H. Binstock + 4 more
    • English
    The Handbook of Aging and the Social Sciences, Sixth Edition provides a comprehensive summary and evaluation of recent research on the social aspects of aging. The 25 chapters are divided into four sections discussing Aging and Time, Aging and Social Structure, Social Factors and Social Institutions, and Aging and Society. Within this context, aging is examined from the perspectives of many disciplines and professions including anthropology, bioethics, demography, economics, epidemiology, law, political science, psychology, and sociology.The Sixth Edition of the Handbook is virtually 100% new material. Seventeen chapters are on subjects not carried in the previous edition. Seven topics were carried over from the previous edition but written by new authors with fresh perspectives and brought up to date. Some of the exciting new topics include social relationships in late life, technological change and aging, religion and aging, lifestyle and aging, perceived quality of life, economic security in retirement, and aging and the law. There is also a greater emphasis on international perspectives, particularly in chapters on aging and politics, diversity and aging, and immigration.The Handbook will be of use to researchers and professional practitioners working with the aged. It is also suitable for use as a course text for graduate and advanced undergraduate courses on aging and the social sciences.

  • Handbook of the Psychology of Aging

    • 6th Edition
    • James E. Birren + 1 more
    • English
    Handbook of the Psychology of Aging, 6e provides a comprehensive summary and evaluation of recent research on the psychological aspects of aging. The 22 chapters are organized into four divisions: Concepts, Theories, and Methods in the Psychology of Aging; Biological and Social Influences on Aging; Behavioral Processes and Aging; and Complex Behavioral Concepts and Processes in Aging. The 6th edition of the Handbook is considerably changed from the previous edition. Half of the chapters are on new topics and the remaining half are on returning subjects that are entirely new presentations by different authors of new material. Some of the exciting new topics include Contributions of Cognitive Neuroscience to Understanding Behavior and Aging, Everyday Problem Solving and Decision Making, Autobiographical Memory, and Religion and Health Late in Life.The Handbook will be of use to researchers and professional practitioners working with the aged. It is also suitable for use as a textbook for graduate and advanced undergraduate courses on the psychology of aging.The Handbook of the Psycology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Biology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.

  • Sleep and Aging

    • 1st Edition
    • Volume 17
    • English
    Alterations in sleep are common manifestations of aging that can lead to significant health problems and contribute to behavioural problems associated with age-related neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Recent advances have revealed key cellular and molecular mechanisms involved in sleep regulation, and this knowledge is helping to advance an understanding of both the normal functions of sleep and the mechanisms responsible for abnormalities in sleep in various neurological conditions and during normal aging. This volume of Advances in Cell Aging and Gerontology brings together chapters by leaders in the fields of sleep research and the neurobiology of aging. The book starts with chapters describing fundamental aspects of the neurocircuitry involved in sleep, patterns of brain activity during the different stages of sleep and disturbances of sleep during aging. The links between depression, anxiety and insomnia are reviewed in regards to the underlying neurochemical alterations that appear to involve abnormalities in neurotransmitter and neurotrophic factor signalling. The evolutionary basis of sleep is reviewed and the emerging evidence supporting a major role for sleep in learning and memory is described. The bulk of the book focuses on specific sleep disorders associated with aging and age-related neurodegenerative disorders. A comprehensive consideration of this topic is woven through a number of chapters that address both basic research and clinical aspects of sleep abnormalities during aging and in disease. The impact of sleep on the immune system is described. The articles are written in a high level of detail and are comprehensive, thus providing valuable information for a range of scientists and other well-educated people. In particular, the book will be a valuable resource for graduate students, postdoctoral and senior scientists in the fields of sleep, aging, neurodegenerative disorders and learning and memory. In addition, clinicians will find this book valuable as it provides a bridge between basic research and the treatment of the patients with sleep disorders.

  • Protein Phosphorylation in Aging and Age-Related Disease

    • 1st Edition
    • Volume 16
    • Paul Mark Mattson
    • English
    It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

  • Energy Metabolism and Lifespan Determination

    • 1st Edition
    • Volume 14
    • M.P. Mattson
    • English
    Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production. During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

  • Caloric Restriction: A Key to Understanding and Modulating Aging

    • 1st Edition
    • Volume 1
    • E.J. Masoro
    • English
    For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages. What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

  • Mechanisms of Cardiovascular Aging

    • 1st Edition
    • Volume 11
    • T. Hagen
    • English
    This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression. This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

  • Calcium Homeostasis and Signaling in Aging

    • 1st Edition
    • Volume 10
    • M.P. Mattson
    • English
    This volume of Advances in Cell Aging and Gerontology reviews the mechanisms that regulate cellular calcium homeostasis in various tissues throughout the body and how these systems change during aging. Normal functions of calcium in regulating various physiological processes are considered and the evidence supporting roles for perturbed calcium regulation in the pathogenesis of several prominent age-related disorders are detailed.The cross-disciplinary approach used to organize this book should provide readers interested in a specific area of calcium regulation with a broader perspective and a framework for which to shape future studies in their laboratories.

  • Aging with HIV

    Psychological, Social, and Health Issues
    • 1st Edition
    • Janice E. Nichols + 6 more
    • English
    In 1998, approximately 30 million people worldwide were living with HIV/AIDS, about 5 million of whom became infected that year. The epidemic continues to expand, with an estimated doubling time of 10 years, making AIDS the leading infectious cause of death ahead of tuberculosis and malaria. Even in the U.S.A. where the death rate from AIDS is declining as a result of effective drug therapies, HIV infection rates continue to climb in several population groups. The prevalence of AIDS among people over the age of 50 is steadily increasing, and most older people are unprepared to address it for a number of reasons, including the widespread discomfort with matters sexual and homosexual and the belief that elderly people are not sexually active and therefore not at risk.This guide for care providers seeks to educate and inform readers about the difficulties and complications that accompany the disease in older people. Thus, while the appendix includes technical descriptions of methodology, data, and results, the narratives in the chapters describing the findings and their practical implications are written in layman's language. Topics covered include biomedical aspects, demographics, sexuality, stressors, mental health, older women, and patient care, all of which are supported by case studies.

  • Handbook of the Psychology of Aging

    • 5th Edition
    • James E. Birren + 1 more
    • English
    The Handbook of the Psychology of Aging has become the definitive reference source for information on the psychology of adult development and aging. The Fifth Edition provides comprehensive reviews of research on biological and social influences on behavior and age-related changes in psychological function. In addition to covering environmental influences on behavior and aging and gender differences in aging, new chapters in the Fifth Edition discuss wisdom, creativity, and technological change and the older worker. This handbook is an essential reference for researchers in adult development and gerontology and suitable as an advanced textbook for courses on the psychology of aging.

  • Programmed Cell Death, Volume II

    Role in Disease, Pathogenesis & Prevention
    • 1st Edition
    • Volume 6
    • S. Estus + 2 more
    • English
    This volume provides the most recent insight into how abnormalities in the regulation of cell death lead to a variety of diseases. Each chapter in this book is written by an internationally recognized expert on the role of aberrant cell death in the pathogenesis of a particular disease. In addition to various types of cancer and neurodegenerative disorders, this book covers diseases ranging from arthritis to cardiovascular disease to diabetes. The chapters each integrate information obtained from patients with data obtained in experimental models of the disease to arrive at an emerging view of the pathogenic mechanisms of the disease. Applications of this fundamental knowledge to prevention and treatment of the diseases are considered. When taken together with http://www.elsevier.... Cell Death, Volume 1, this title will provide graduate students, postdocs and senior investigators in an array of biomedical disciplines invaluable resource for their pursuit of the causes and cures of many different human diseases.

  • Neuropsychological Evaluation of the Older Adult

    A Clinician's Guidebook
    • 1st Edition
    • Joanne Green
    • English
    One of the largest patient populations seen by neuropsychologists are older adults suffering from problems associated with aging. Further, the proportion of the population aged 65 and above is rising rapidly. This book provides a guide to neuropsychological clinicians increasingly called upon to assess this population. The book details in a step-by-step fashion the phases and considerations in performing a neuropsychological assessment of an older patient. It covers procedural details including review of patient's medical records, clinical interview, formal testing, interpretation of test scores, addressing referral questions, and preparing an evaluation report.

  • The Aging Brain

    • 1st Edition
    • Volume 2
    • J.W. Geddes + 1 more
    • English
    The brain is the most complex organ system in the human, both in the intricacy of its cellular architecture and in the extent of its repertoire of macromolecules. The Aging Brain presents the current state of understanding of molecular, cellular, and functional changes that occur in normal brain aging, and compares and contrasts those changes with events occurring in age-related neurodegenerative disorders. The chapters, written by world leaders in the field of brain aging, provide a timely and comprehensive consideration of key areas of this rapidly growing field of aging research. The topics covered include structural, functional, biochemical and molecular changes that occur during usual aging and in age-related neurological disorders. An emphasis is placed on emerging findings at the cellular and molecular levels. The roles of oxidative stress and perturbed energy metabolism in aging and neurodegenrative disorders are covered in considerable detail. In addition, the impact of aging and disease on specific neurotransmitter, neurotrophic factor and cytokine signaling pathways is reviewed. Finally, recent findings concerning possible approaches to reduce risk for age-related neurodegenerative disorders, such as caloric restriction, are presented. The collective body of information presented in The Aging Brain will provide those stepping into the field of brain aging with an overview of our current understanding of fundamental changes that occur in the aging brain, and their molecular and cellular underpinnings. At the same time, the book delves deeply into critical mechanistic details of brain aging that should prove valuable to experts in the field.

  • Encyclopedia of Gerontology

    Age, Aging, and the Aged
    • 1st Edition
    • James E. Birren + 7 more
    • English
    Edited by James Birren, one of the world's leading researchers in gerontology, this two-volume work is the most comprehensive work on age, aging, and the aged available. This entirely new encyclopedia covers the latest research on the biology, psychology, and sociology of aging in addition to covering how aging is depicted in the humanities. This dynamic field has grown over the years to encompass fascinating studies of development and change with age. This encyclopedia provides a reference source for identifying major areas of investigation and our knowledge to date. Prepared for a college- and professional-level readership, each article provides depth and breadth of coverage, including theory and summaries of empirical findings. Every article contains a definition paragraph, describing the subject at hand, a glossary of unfamiliar terms, and a bibliography of suggested readings. The set is fully cross-referenced and contains a complete subject index.

  • Handbook of the Psychology of Aging

    • 4th Edition
    • English
    The Handbook of the Psychology of Aging has become the definitive reference source for information on the psychology of adult development and aging. This new edition reviews recent developments in research on such topics as social and biological influences on behavior, cognitive functions in the aging individual, and motivational and personality changes with age. The Handbook features a strong emphasis on systematic explanation and covers important theoretical and methodological issues that form the basis for research on adult development and aging.

  • Changes in Sensory Motor Behavior in Aging

    • 1st Edition
    • Volume 114
    • A.-M. Ferrandez + 1 more
    • English
    Recently, studies on aging processes and age-related changes in behavior have been expanding considerably, probably due to the dramatic changes observed in the demographics. This increase in the overall age and proportion of elderly people has heightened the severity of problems associated with the safety and well-being of elderly persons in everyday life. Many researchers working on motor control have thus focused more intensely on the effects of age on motor control. This new avenue of research has led to programs for alleviating or delaying the specific sensory-motor limitations encountered by the elderly (e.g. falls) in an attempt to make the elderly more autonomous.The aggregation of studies from different perspectives is often fascinating, especially when the same field can serve as a common ground between researchers. Nearly all contributors to this book work on sensory-motor aging; they represent a large range of affiliations and backgrounds including psychology, neurobiology, cognitive sciences, kinesiology, neuropsychology, neuropharmacology, motor performance, physical therapy, exercise science, and human development. Addressing age-related behavioral changes can also furnish some crucial reflections in the debate about motor coordination: aging is the product of both maturational and environmental processes, and studies on aging must determine how the intricate interrelationships between these processes evolve. The study of aging makes it possible to determine how compensatory mechanisms, operating on different subsystems and each aging at its own rate, compensate for biological degenerations and changing external demands. This volume will contribute to demonstrating that the study of the aging process raises important theoretical questions.