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Elsevier

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

  • 1st Edition - July 19, 2022
  • Latest edition
  • Editors: Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra
  • Language: English

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, founda… Read more

Description

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

Key features

  • Covers different aspects of anti-aging research, from foundational knowledge to future perspectives
  • Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs
  • Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Readership

Advanced undergraduate students and graduate students as well as researchers interested or working in various aspects of aging

Table of contents

1. The aging: introduction, theories, principles and future prospective
Shabnam Shabir, Mahendra Pratap Singh

2. Brief description of aging in different levels as cellular, tissues, and organs
Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Amit Singh

3. Brief about hallmarks of aging
Josephine Esposto and Vyshnavy Balendra

4. Overview of various anti-aging strategies
Dhiraj Kumar and Faiyaz Ahmad

5. Elimination of damaged cells-dependent anti-aging strategy
Rayees Ahmad Naik, Vinodinee Dubey, Roshni Rajpoot, Debabrata Dash, Nidhi Gupta and Raj Kumar Koiri

6. Telomerase reactivation for anti-aging
TS Gopenath, Shreya Shreshtha and Kanthesh M. Basalingapa

7. Epigenetic drugs based on anti-aging approach
Tarun Minocha, Namrata Dwivedi, Chetan Panda, Anamika Misra, Barsha Baisakhi Nayak, Sanjeev Kumar Yadav, Hareram Birla and Sandeep K. Singh

8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug development
Neha Gogia, Victor Olmos, Fatema Haidery, Kimberly Luttik, Leon Tejwani, Janghoo Lim

9. Dietary restriction and mTOR and IIS inhibition: the potential to anti-aging drug approach
Sing-Hua Tsou

10. Anti-Aging Drugs, Candidates, and Food Supplements- The journey so far
Yodhaanjali JR, Rithwick Surya, Sumukha KC, Harini G, Gouri Deshpande, Chandan S,Raghu Ram Achar

11. Role of AMPK and Sirtuins as anti-aging proteins
Manjula Ramu, Sonali Vishal and Neha Gogia

12. Mitophagy and Mitohormetics: promising anti- aging strategy
Chih Li Lin

13. Clearance of senescent cells: potent anti-aging approach
Jacques Ferreira and Alex Deamer

14. Stem cell-based therapy as antiaging prospective
Sumaira Yusuf, Mahendra P. Singh

15. Anti-inflammatory therapy as a game changer towards anti-aging
Dr. Naveen Shivavedi, Anshul Shakya, Bedanta Bhattacharjee and Bhargab Deka

16. Invertebrate model organisms for aging research
Arvind Kumar Shukla, Andrew Scott and Edward Giniger

Review quotes

"This is a highly useful book that describes the modern theories of the aging process and its impact at a cellular and organ level. The book provides comprehensive discussion on the different hallmarks of aging and the strategies of anti-aging drug development with a focus on recent advances that slow or reverse the aging process including telomerase reactivation, clearance of senescent cells, and stem cell-based therapy among others…. The book meets the objectives as it provides valuable information on anti-aging drug discovery on the basis of the hallmarks of aging…. [It] has several high-quality colored illustrations, which make the subject matter easy to understand and more enjoyable....This is an excellent book that discusses the modern theories of aging, the different hallmarks of aging, and the various anti-aging strategies…. I am quite hopeful this book will be of great value in supporting the multidisciplinary efforts to understand the aging process…. [A] unique [book] that addresses the hallmarks of aging on which anti-aging drug discovery is based."— ©Doody’s Review Service, 2022, Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)

Product details

  • Edition: 1
  • Latest edition
  • Published: July 29, 2022
  • Language: English

About the editors

SS

Sandeep Kumar Singh

Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.

Affiliations and expertise
Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India

CL

Chih Li Lin

Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimer’s disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimer’s dementia, particularly studying molecular mechanisms of amyloid beta (Aβ)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia.
Affiliations and expertise
Professor and Research Fellow, Institute of Medicine, Chung Shan Medical University and Hospital, Taiwan, Province of China

SM

Shailendra Kumar Mishra

Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.
Affiliations and expertise
Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh, India

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