Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

1st Edition - July 19, 2022
Editors: Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 2 3 5 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 2 3 6 - 6

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, founda… Read more

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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. The aging: introduction, theories, principles, and future prospective
Abstract
1.1 Introduction
1.2 Modern theories of aging in biology
1.3 Principles
1.4 Extrinsic and intrinsic factors on aging
1.5 Future perspective (aging therapies)
1.6 Summary
References
Chapter 2. Impact of aging at cellular and organ level
Abstract
2.1 Introduction
2.2 Multicellular organization: human body
2.3 Changes associated with aging
2.4 Aging in cells
2.5 Aging in tissue and organs
2.6 Models to study aging
2.7 Antiaging therapy/treatment
2.8 Conclusion
Competing interests
Declaration of interest
Financial support
Authors’ contributions
References
Chapter 3. Brief about hallmarks of aging
Graphical abstract
Abstract
3.1 The nine hallmarks of aging
3.2 Conclusions
References
Chapter 4. Overview of various antiaging strategies
Abstract
4.1 Introduction
4.2 Modulation of autophagy for successful aging
4.3 Elimination of senescent cells for successful aging
4.4 Plasma transfusion for successful aging
4.5 Intermittent fasting as a means for successful aging
4.6 Regular exercise for successful aging
4.7 Role of antioxidants for successful aging
4.8 Stem cell therapy for successful aging
4.9 Summary
References
Chapter 5. Elimination of damaged cells-dependent antiaging strategy
Abstract
5.1 Introduction
5.2 Aging-associated disease and physiological changes
5.3 Antiaging strategies
5.4 Hallmarks of aging
5.5 Cellular reprogramming
5.6 Models of premature aging based on cellular reprogramming
5.7 Cellular rejuvenation by partial reprogramming
5.8 Implications for regenerative medicine: successes and limitations of in vivo reprogramming
5.9 Conclusion
Acknowledgments
References
Chapter 6. Telomerase reactivation for anti-aging
Abstract
6.1 Introduction
6.2 Aging
6.3 Aging—a telomere–mitochondria relation
6.4 Telomerase and its possible role in antiaging therapies
6.5 Tapping the potential of telomerase
6.6 Stem cells and aging
6.7 Future aspects in antiaging
Acknowledgments
Competing interests
Funding
Authors’ contribution
References
Chapter 7. Epigenetic drugs based on antiaging approach: an overview
Abstract
7.1 Introduction
7.2 The first wave of epigenetic drugs
7.3 The second wave of epigenetic drugs
7.4 The third wave of epigenetic drugs
7.5 The fourth wave of epigenetic drugs
7.6 Conclusion
References
Chapter 8. Exploring the role of protein quality control in aging and age-associated neurodegenerative diseases
Abstract
8.1 Proteins misfolding in aging and diseases
8.2 Protein quality control
8.3 Altered protein quality control in aging and diseases: lessons learned from in vitro and in vivo models
8.4 Therapeutic perspectives
8.5 Emerging techniques
8.6 Conclusion
Acknowledgments
Conflict of interest
Author’s contributions
References
Chapter 9. Dietary restriction and mTOR and IIS inhibition: the potential to antiaging drug approach
Abstract
9.1 Introduction
9.2 The antiaging drug discovery
9.3 The mechanism of pharmacological strategies in antiaging process
9.4 Conclusion
References
Chapter 10. Antiaging drugs, candidates, and food supplements: the journey so far
Abstract
10.1 Introduction
10.2 Antiaging drugs
10.3 Aging—molecular and biochemical significance
10.4 Summary
References
Chapter 11. Role of AMP-activated protein kinase and sirtuins as antiaging proteins
Abstract
11.1 Introduction
11.2 AMP-activated protein kinase and its functions
11.3 Sirtuins: role of SIRT1
11.4 Correlation between AMP-activated protein kinase and sirtuins
11.5 Effect of AMP-activated protein kinase and sirtuins on calorie restriction and longevity
11.6 Role of AMP-activated protein kinase and sirtuins in mitochondrial homeostasis
11.7 AMP-activated protein kinase and sirtuins in age-associated neurodegenerative diseases
11.8 Modulation of AMP-activated protein kinase and sirtuins
11.9 Conclusion
Acknowledgments
Conflict of interest
Author’s contributions
References
Chapter 12. Mitophagy and mitohormetics: promising antiaging strategy
Abstract
12.1 Mitochondrial basis of aging
12.2 Age-associated changes in mitochondria
12.3 UPRmt and mitochondrial hormesis (mitohormesis)
12.4 Pathways involved in mitohormetic response
12.5 Mitohormetic pathways converge on the mitophagy
12.6 Antiaging strategies based on regulation of mitohormesis
12.7 Conclusion
References
Chapter 13. Clearance of senescent cells: potent anti-aging approach
Abstract
13.1 Introduction
13.2 SASP modulators
13.3 Immunotherapeutics
13.4 Senolytics
13.5 Senolytic clinical trials
13.6 Senescence reversal
13.7 Conclusion
References
Chapter 14. Stem cell-based therapy as an antiaging prospective
Abstract
14.1 Introduction
14.2 Classification of stem cells
14.3 Stem cell therapy
14.4 Mechanisms of stem cell therapy in age-related diseases and antiaging
14.5 Molecular mechanism of stem cell therapy from an antiaging perspective
14.6 Limitations of the stem cell therapies
References
Chapter 15. Antiinflammatory therapy as a game-changer toward antiaging
Abstract
15.1 Introduction
15.2 Characteristics of aging
15.3 Theories of aging
15.4 The free radical, oxidative, and mitochondrial theories of aging
15.5 The immune system as a homeostatic system
15.6 Oxidation and inflammation as related homeostatic mechanisms of the immune response
15.7 Conclusion and future perspectives
Conflict of interest
References
Chapter 16. Invertebrate model organisms for aging research
Abstract
16.1 Introduction
16.2 Invertebrate models for aging research
16.3 Caenorhabditis elegans model for aging research
16.4 Drosophila model for aging research
16.5 Drosophila melanogaster and Caenorhabditis elegans for aging research: similarities and contrasts
Acknowledgments
References
Index

Sandeep Kumar Singh

Assistant Professor in Department of Medical Biotechnology at the All India Institute of Medical Sciences, Nagpur. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. His research interests are in neurodegenerative diseases and has ~12 years of experience. He’s a member of editorial boards of several international journals related to neuroscience and member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad.

Affiliations and expertise

Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, India

Chih Li Lin

Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimer’s disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimer’s dementia, particularly studying molecular mechanisms of amyloid beta (Aβ)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia.

Affiliations and expertise

Professor and Research Fellow, Institute of Medicine, Chung Shan Medical University and Hospital, Taiwan, Province of China

Shailendra Kumar Mishra

Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.

Affiliations and expertise

Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh, India

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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

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Sandeep Kumar Singh

Chih Li Lin

Shailendra Kumar Mishra