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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging
- 1st Edition - July 19, 2022
- Editors: Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 2 3 5 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 0 2 3 6 - 6
Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, founda… Read more
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Request a sales quoteAnti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.
- Covers different aspects of anti-aging research, from foundational knowledge to future perspectives
- Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs
- Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others
Advanced undergraduate students and graduate students as well as researchers interested or working in various aspects of aging
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. The aging: introduction, theories, principles, and future prospective
- Abstract
- 1.1 Introduction
- 1.2 Modern theories of aging in biology
- 1.3 Principles
- 1.4 Extrinsic and intrinsic factors on aging
- 1.5 Future perspective (aging therapies)
- 1.6 Summary
- References
- Chapter 2. Impact of aging at cellular and organ level
- Abstract
- 2.1 Introduction
- 2.2 Multicellular organization: human body
- 2.3 Changes associated with aging
- 2.4 Aging in cells
- 2.5 Aging in tissue and organs
- 2.6 Models to study aging
- 2.7 Antiaging therapy/treatment
- 2.8 Conclusion
- Competing interests
- Declaration of interest
- Financial support
- Authors’ contributions
- References
- Chapter 3. Brief about hallmarks of aging
- Graphical abstract
- Abstract
- 3.1 The nine hallmarks of aging
- 3.2 Conclusions
- References
- Chapter 4. Overview of various antiaging strategies
- Abstract
- 4.1 Introduction
- 4.2 Modulation of autophagy for successful aging
- 4.3 Elimination of senescent cells for successful aging
- 4.4 Plasma transfusion for successful aging
- 4.5 Intermittent fasting as a means for successful aging
- 4.6 Regular exercise for successful aging
- 4.7 Role of antioxidants for successful aging
- 4.8 Stem cell therapy for successful aging
- 4.9 Summary
- References
- Chapter 5. Elimination of damaged cells-dependent antiaging strategy
- Abstract
- 5.1 Introduction
- 5.2 Aging-associated disease and physiological changes
- 5.3 Antiaging strategies
- 5.4 Hallmarks of aging
- 5.5 Cellular reprogramming
- 5.6 Models of premature aging based on cellular reprogramming
- 5.7 Cellular rejuvenation by partial reprogramming
- 5.8 Implications for regenerative medicine: successes and limitations of in vivo reprogramming
- 5.9 Conclusion
- Acknowledgments
- References
- Chapter 6. Telomerase reactivation for anti-aging
- Abstract
- 6.1 Introduction
- 6.2 Aging
- 6.3 Aging—a telomere–mitochondria relation
- 6.4 Telomerase and its possible role in antiaging therapies
- 6.5 Tapping the potential of telomerase
- 6.6 Stem cells and aging
- 6.7 Future aspects in antiaging
- Acknowledgments
- Competing interests
- Funding
- Authors’ contribution
- References
- Chapter 7. Epigenetic drugs based on antiaging approach: an overview
- Abstract
- 7.1 Introduction
- 7.2 The first wave of epigenetic drugs
- 7.3 The second wave of epigenetic drugs
- 7.4 The third wave of epigenetic drugs
- 7.5 The fourth wave of epigenetic drugs
- 7.6 Conclusion
- References
- Chapter 8. Exploring the role of protein quality control in aging and age-associated neurodegenerative diseases
- Abstract
- 8.1 Proteins misfolding in aging and diseases
- 8.2 Protein quality control
- 8.3 Altered protein quality control in aging and diseases: lessons learned from in vitro and in vivo models
- 8.4 Therapeutic perspectives
- 8.5 Emerging techniques
- 8.6 Conclusion
- Acknowledgments
- Conflict of interest
- Author’s contributions
- References
- Chapter 9. Dietary restriction and mTOR and IIS inhibition: the potential to antiaging drug approach
- Abstract
- 9.1 Introduction
- 9.2 The antiaging drug discovery
- 9.3 The mechanism of pharmacological strategies in antiaging process
- 9.4 Conclusion
- References
- Chapter 10. Antiaging drugs, candidates, and food supplements: the journey so far
- Abstract
- 10.1 Introduction
- 10.2 Antiaging drugs
- 10.3 Aging—molecular and biochemical significance
- 10.4 Summary
- References
- Chapter 11. Role of AMP-activated protein kinase and sirtuins as antiaging proteins
- Abstract
- 11.1 Introduction
- 11.2 AMP-activated protein kinase and its functions
- 11.3 Sirtuins: role of SIRT1
- 11.4 Correlation between AMP-activated protein kinase and sirtuins
- 11.5 Effect of AMP-activated protein kinase and sirtuins on calorie restriction and longevity
- 11.6 Role of AMP-activated protein kinase and sirtuins in mitochondrial homeostasis
- 11.7 AMP-activated protein kinase and sirtuins in age-associated neurodegenerative diseases
- 11.8 Modulation of AMP-activated protein kinase and sirtuins
- 11.9 Conclusion
- Acknowledgments
- Conflict of interest
- Author’s contributions
- References
- Chapter 12. Mitophagy and mitohormetics: promising antiaging strategy
- Abstract
- 12.1 Mitochondrial basis of aging
- 12.2 Age-associated changes in mitochondria
- 12.3 UPRmt and mitochondrial hormesis (mitohormesis)
- 12.4 Pathways involved in mitohormetic response
- 12.5 Mitohormetic pathways converge on the mitophagy
- 12.6 Antiaging strategies based on regulation of mitohormesis
- 12.7 Conclusion
- References
- Chapter 13. Clearance of senescent cells: potent anti-aging approach
- Abstract
- 13.1 Introduction
- 13.2 SASP modulators
- 13.3 Immunotherapeutics
- 13.4 Senolytics
- 13.5 Senolytic clinical trials
- 13.6 Senescence reversal
- 13.7 Conclusion
- References
- Chapter 14. Stem cell-based therapy as an antiaging prospective
- Abstract
- 14.1 Introduction
- 14.2 Classification of stem cells
- 14.3 Stem cell therapy
- 14.4 Mechanisms of stem cell therapy in age-related diseases and antiaging
- 14.5 Molecular mechanism of stem cell therapy from an antiaging perspective
- 14.6 Limitations of the stem cell therapies
- References
- Chapter 15. Antiinflammatory therapy as a game-changer toward antiaging
- Abstract
- 15.1 Introduction
- 15.2 Characteristics of aging
- 15.3 Theories of aging
- 15.4 The free radical, oxidative, and mitochondrial theories of aging
- 15.5 The immune system as a homeostatic system
- 15.6 Oxidation and inflammation as related homeostatic mechanisms of the immune response
- 15.7 Conclusion and future perspectives
- Conflict of interest
- References
- Chapter 16. Invertebrate model organisms for aging research
- Abstract
- 16.1 Introduction
- 16.2 Invertebrate models for aging research
- 16.3 Caenorhabditis elegans model for aging research
- 16.4 Drosophila model for aging research
- 16.5 Drosophila melanogaster and Caenorhabditis elegans for aging research: similarities and contrasts
- Acknowledgments
- References
- Index
- No. of pages: 410
- Language: English
- Edition: 1
- Published: July 19, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323902359
- eBook ISBN: 9780323902366
SS
Sandeep Kumar Singh
Assistant Professor in Department of Medical Biotechnology at the All India Institute of Medical Sciences, Nagpur. He is researcher and neuroscientist with a strong background in Biochemistry and Biomedicine. His research interests are in neurodegenerative diseases and has ~12 years of experience. He’s a member of editorial boards of several international journals related to neuroscience and member of several scientific societies. Dr. Singh has been appointed as Bentham Ambassador by Bentham Science Publisher (USA). He is a speaker at several scientific national and international conferences/symposium/workshops in India and abroad.
Affiliations and expertise
Department of Medical Biotechnology, All India Institute of Medical Sciences, Nagpur, MH, IndiaCL
Chih Li Lin
Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimer’s disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimer’s dementia, particularly studying molecular mechanisms of amyloid beta (Aβ)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia.
Affiliations and expertise
Professor and Research Fellow, Institute of Medicine, Chung Shan Medical University and Hospital, Taiwan, Province of ChinaSM
Shailendra Kumar Mishra
Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.
Affiliations and expertise
Indian Scientific Education and Technology Foundation, Lucknow, Uttar Pradesh, IndiaRead Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging on ScienceDirect