
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Seventh Edition
Volume 1
- 7th Edition, Volume 1 - September 27, 2024
- Imprint: Academic Press
- Editors: Roger N. Rosenberg, Juan M. Pascual
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 9 0 4 1 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 9 0 4 2 - 1
Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition, provides a comprehensive introduction and reference to the foundations and key pr… Read more
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Request a sales quoteRosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Seventh Edition, provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to neurologic and psychiatric disease. This volume has been thoroughly revised and includes newly commissioned chapters on ethics, genetic counselling and genet therapy for the central nervous system disorders. A favorite of over four generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the previous edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community at large.
- Both volumes combined provide a comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease
- This volume provides a detailed introduction on both the clinical and basic research implications of molecular and genetics surrounding the brain
- Includes new chapters on genomics of human neurological disorders, CRISPR and genome engineering
Practitioners including neurologists, psychiatrists and genetic counselors, trainee physicians and laboratory researchers interested in neurogenetics and molecular neuroscience
1. Mendelian, non-mendelian, multigenic inheritance and epigenetics
2. Precision medicine in neurology
3. Epigenomics of neurological disorders
4. What genes can and cannot do
5. Genotype-phenotype considerations in neurogenetic disease
6. Immunogenetics of neurological disease
7. Pharmacogenomic approaches to the treatment of sporadic alzheimer's disease
8. Application of mouse genetics to human disease: Generation and analysis of mouse models
9. DNA sequencing and other methods of exonic and genomic analyses
10. Association, cause and causal association. Revision 2: Playing the changes.
11. Adeno-associated virus-mediated gene therapy in central nervous system genetic disorders
12. Genomics of human neurological disorders
13. CRISPR/Cas9-based genetic engineering for translational research in neurological disorders
14. Neural cells derived from pluripotent stem cells and directly induced from somatic cells
15. Neuroimaging in dementia
16. Neuroethics
17. Genetic counseling
18. Antisense oligonucleotide drugs for neurological and neuromuscular diseases
19. Autophagy and neurological disorders
20. The aging brain
SECTION II. NEUROLOGIC DISEASES
21. Cerebral malformations
22. Global developmental delay and intellectual disability
23. Aging and dementia in down syndrome
24. An overview of rett syndrome
25. Fragile X clinical features and neurobiology
26. Neurological evaluation and management of autism spectrum disorder
27. Angelman syndrome
28. The prion diseases
29. Leptin-related disorders of the nervous system
30. Genetics of autonomic disorders
SECTION III. NEUROMETABOLIC DISORDERS
Mitochondrial Disorders
31. The mitochondrial genome
32. Mitochondrial disorders due to mutations in the mitochondrial genome
33. Mitochondrial disorders due to mutations in the nuclear genome
34. Pyruvate dehydrogenase, pyruvate carboxylase, krebs cycle and mitochondrial transport disorders
Lysosomal Disorders
35. Gaucher disease – neuronopathic forms
36. The Niemann-Pick diseases
37. GM2-gangliosidoses
38. Metachromatic leukodystrophy and multiple sulfatase deficiency
39. Krabbe disease: Globoid cell leukodystrophy
40. Leukodystrophies--an overview
41. The mucopolysaccharidoses
42. The mucolipidoses
43. Disorders of glycoprotein degradation: α-mannosidosis, β-mannosidosis, fucosidosis, sialidosis, and aspartylglycosaminuria
44. GM1 gangliosidosis, Morquio Disease, galactosialidosis and sialidosis
45. Acid ceramidase deficiency: Farber lipogranulomatosis, spinal muscular atrophy associated with progressive myoclonic epilepsy and peripheral osteolysis
46. Wolman disease
47. Lysosomal membrane disorders: lysosome-associated membrane protein-2 deficiency (Danon disease)
48. Fabry disease: α-galactosidase A deficiency
49. Schindler disease: deficient α -N-acetylgalactosaminidase activity
SECTION IV: METABOLIC DISORDERS
50. Organic acid disorders
51. Glycogen and polyglucosan storage diseases
52. Disorders of galactose metabolism
53. Inborn Errors of Amino Acid Metabolism
54. Urea cycle disorders
55. Glucose transporter type I deficiency and other glucose flux disorders
56. Maple syrup urine disease: biochemical, clinical and therapeutic considerations
57. Congenital disorders of N-linked glycosylation
58. Disorders of glutathione metabolism
59. Canavan disease
60. Neurotransmitter disorders
61. Peroxisomal disorders
62. Purines and pyrimidines
63. The acute porphyrias
- Edition: 7
- Volume: 1
- Published: September 27, 2024
- No. of pages (Hardback): 1006
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780443190414
- eBook ISBN: 9780443190421
RR
Roger N. Rosenberg
JP
Juan M. Pascual
Juan M. Pascual, M.D., Ph.D., is the inaugural holder of The Once Upon a Time Foundation Professorship in Pediatric Neurologic Diseases and also holds the Ed and Sue Rose Distinguished Professorship in Neurology. His laboratory research interests span virtually the entire field of neuroscience, including medical neuroscience, from molecular structure and function (including drug action), neural physiology and metabolism at the cellular, circuit and whole-brain level and neurogenetics, all of which is complemented with neurological patient care and clinical trials. Laboratory research greatly influences his clinical activities and patient observations guide his laboratory research direction. As a clinician, Dr. Pascual specializes in genetic and metabolic diseases of the nervous and neuromuscular systems of infants, children, and adults with a particular emphasis on complex diagnostic problems, second opinions for patients visiting from the rest of the U.S. and abroad, and in clinical trials. Dr. Pascual has special clinical research expertise in undiagnosed and rare diseases, glucose metabolism, mitochondrial, degenerative, and multi-organ disorders. Dr. Pascual is a tenured faculty member in four Departments at UT Southwestern Medical Center: Neurology and Neurotherapeutics, Physiology, Pediatrics, and the Eugene McDermott Center for Human Growth & Development / Center for Human Genetics. He is also Director of the Rare Brain Disorders Program (Clinic and Laboratory). He is also a member of the Division of Pediatric Neurology, of the graduate Ph.D. programs in Neuroscience and Integrative Biology, and of the postgraduate clinical training programs in Neurology, Pediatric Neurology, Pediatrics, and Medical Genetics. He teaches at UT Southwestern Medical School. In addition, Dr. Pascual is an adjunct professor in the Department of Biological Sciences at the School of Natural Sciences and Mathematics, The University of Texas at Dallas. Dr. Pascual directs a highly collaborative research laboratory and is credentialed campus-wide at Children's Medical Center Dallas, UT Southwestern University Hospitals and Clinics, and Parkland Memorial Hospital, where he consults on inpatients and outpatients with particularly complex or severe diseases. Much of his research is funded by the National Institutes of Health. Dr. Pascual received his M.D. degree with unique distinction from the Universidad de Granada, Spain, one of the oldest universities in the world, founded in 1349 by Yusuf I, Sultan of Granada and one of the builders of the Alhambra. He received his Ph.D. degree in Molecular Physiology and Biophysics from Baylor College of Medicine in Houston, Texas, under Arthur M. Brown, M.D., Ph.D., McCollum Professor and Chair. His postdoctoral research was conducted under Arthur Karlin, Ph.D., Higgins Professor and Director of the Center for Molecular Recognition, College of Physicians and Surgeons of Columbia University and, later, at the Colleen Giblin Research Laboratories for Pediatric Neurology at the same institution under a Neurological Sciences Academic Development Award from the National Institute of Neurological Disorders and Stroke. He also received residency training in Pediatrics at Washington University School of Medicine - St. Louis Children's Hospital and in Neurology and Pediatric Neurology at the Neurological Institute of New York - Columbia University Medical Center. He received certification in Neurology with Special Qualification in Child Neurology from the American Board of Psychiatry and Neurology.