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Books in Neuropathology

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A Review on Diverse Neurological Disorders

  • 1st Edition
  • June 5, 2024
  • Rameshwar Nath Chaurasia + 2 more
  • English
  • eBook
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A Review of Diverse Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics offers an unparalleled compilation of the current understanding of neurodegenerative disorders. This book investigates the origins of mental disorders, encompassing bacterial and fungal invasions, viral assaults, and genetic predispositions, providing readers with a thorough grasp of the neurological landscape. Each chapter dissects the intricacies of these incapacitating conditions, ranging from the pathogenesis of central nervous system tuberculosis to the involvement of endocannabinoids in rabies infection. Topics such as neuroinflammation, axonal pathology, and the intricate relationship between diet, gut microbiomes, and cognitive decline are also explored. This book conducts an extensive examination of neurodegeneration, incorporating discussions on the role of probiotics and natural bioactive compounds in preventing ailments such as Parkinson’s, Alzheimer’s, and amyotrophic lateral sclerosis (ALS). With meticulous analyses of vitamins, micronutrients, antioxidants, and nutraceuticals, this work offers a roadmap for promoting neuroprotection. A Review of Diverse Neurological Disorders serves as a resource that not only reviews the current understanding but also lays the groundwork for future treatments and innovations.

Neuroglia: Function and Pathology

  • 1st Edition
  • May 12, 2023
  • Alexej Verkhratsky + 1 more
  • English
  • Hardback
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  • eBook
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Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment. In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function. Neuroglia: Function and Pathology provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates.

Stereotaxic Brain Atlas of the Egyptian Fruit Bat

  • 1st Edition
  • January 5, 2022
  • Raya Eilam-Altstadter + 3 more
  • English
  • Hardback
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  • eBook
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The Stereotaxic Brain Atlas of the Egyptian Fruit Bat provides the first stereotaxic atlas of the brain of the Egyptian fruit bat (Rousettus aegyptiacus), an emerging model in neuroscience. This atlas contains coronal brain sections stained with cresyl violet (Nissl), AChE, and Parvalbumin – all stereotaxically calibrated. It will serve the needs of any neuroscientist who wishes to work with these bats – allowing to precisely target specific brain areas for electrophysiology, optogenetics, pharmacology, and lesioning. More broadly, this atlas will be useful to all neuroscientists working with bats, as it delineates many brain regions that were not delineated so far in any bat species. Finally, this atlas will provide a useful resource for researchers interested in comparative neuroanatomy of the mammalian brain.

The Human Hypothalamus

  • 1st Edition
  • Volume 182
  • July 7, 2021
  • Dick F. Swaab + 4 more
  • English
  • Hardback
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  • eBook
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The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more.

Diseases of the Nervous System

  • 2nd Edition
  • May 18, 2021
  • Harald Sontheimer
  • English
  • Hardback
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  • eBook
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The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations.

Epidemiology of Brain and Spinal Tumors

  • 1st Edition
  • April 9, 2021
  • Jahangir Moini + 2 more
  • English
  • Hardback
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  • eBook
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Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors.

Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates, Compact

  • 5th Edition
  • May 19, 2019
  • Keith B.J. Franklin + 1 more
  • English
  • formats.Other
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  • eBook
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Paxinos and Franklin's The Mouse Brain in Stereotaxic Coordinates, Compact Fifth Edition, is the compact version of the most widely used and cited atlas of the mouse brain in print. It emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience. The compact edition provides the coronal plates and diagrams of the full mouse atlas in a smaller, more convenient spiral format and at a student friendly price. High resolution digital photographs of the coronal plane of section from the full 5th edition complement the coronal drawings. Unique to the compact, it includes an introduction to the use of the atlas in stereotaxic surgery.

Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates

  • 5th Edition
  • April 6, 2019
  • George Paxinos + 1 more
  • English
  • Hardback
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  • eBook
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Paxinos and Franklin’s The Mouse Brain in Stereotaxic Coordinates, Fifth Edition, emulates in design and accuracy Paxinos and Watson’s The Rat Brain in Stereotaxic Coordinates, the most cited publication in neuroscience.

Atlas of the Developing Rat Nervous System

  • 4th Edition
  • February 9, 2018
  • George Paxinos + 1 more
  • English
  • Hardback
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  • eBook
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Paxinos and Ashwell's Atlas of the Developing Rat Nervous System, Fourth Edition, builds on the many excellent features of previous editions that have made this book the most cited atlas of the developing rat brain. It provides the most comprehensive depiction of not only the structures in the brain and spinal cord, but also of the peripheral nervous system and target organs that are important for developmental neurobiologists, allowing the user to follow neural structures through the developing embryo in both time and space. The nomenclature and identification of structures in this edition have been thoroughly updated to ensure accuracy and compatibility.

Fragile X Syndrome

  • 1st Edition
  • May 26, 2017
  • Rob Willemsen + 1 more
  • English
  • Hardback
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  • eBook
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Fragile X Syndrome: From Genetics to Targeted Treatment provides a structured overview of the molecular and clinical background of the disorder as well as treatment options. The book discusses the detailed molecular information on each of the pathways involved with sufficient details for all whose research touches this pathway. It provides a state-of-the-art update on all clinical aspects associated with this syndrome, including phenotype, diagnostics and epidemiology. It also includes an overview of the lessons learned from the preclinical research and pioneering trials on the fragile X syndrome for the investigators involved in clinical trials of neurodevelopmental disorders. This book is written for academic researchers, pharmaceutical investigators, and clinicians in the field who work on the disorder, and for researchers involved in clinical trials of the fragile X syndrome or related disorders. “This fascinating book, edited by Rob Willemsen and Frank Kooy, summarizes the current knowledge of the molecular aspects of fragile X syndrome (FXS), andthe potential for therapies resulting from this knowledge...Particularly interesting is a review “fragile X research from a parental perspective,” which summarizes the results of an international survey of the attitudes of families with FXS relatives towards research…This book is also an essential reference book for genetic counselors...The book provides counselors with the necessary biological background for proper explanations to the relatives of FXS patients. Many parents acquire a substantial knowledge of the conditions afflicting their children. The book will be helpful for both families and counselors to manage the expectations of families participating in clinical trials…In conclusion, this book is essential for everyone who is involved in the diagnosis and treatment of FXS patients.” - European Journal of Human Genetics (September 2018)