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Elsevier

Books in Neuroimmunology

This collection investigates genetic influences on neural development, function, and disease. Supporting geneticists, neuroscientists, and clinicians, it features breakthroughs in gene editing, hereditary disorders, and personalized treatments for neurological conditions.

  • Autoimmune Encephalitis and Paraneoplastic Syndrome

    Current Knowledge and Updates
    • 1st Edition
    • Shitiz Sriwastava
    • English
    Autoimmune Encephalitis and Paraneoplastic Syndrome: Current Knowledge and Updates provides an overview of the immune-driven disorders of the nervous system, particularly autoimmune encephalitis. By integrating case studies, flow charts, and clinical examples throughout, the book helps users navigate the complexities of autoimmune encephalitis. Sections also address demographic traits, tumor correlations, and outcomes, equipping readers with essential knowledge for diagnosis and management. With a strong focus on classifying these disorders, defining their pathogenesis and pathophysiology, and examining recent treatment guidelines, this book serves as a comprehensive guide for clinicians, neurologists, and researchers in neuroimmunology.

  • Mechanisms of Disease Pathogenesis in Multiple Sclerosis

    • 1st Edition
    • Francisco Javier Quintana
    • English
    Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.

  • Determinants of Addiction

    Neurobiological, Behavioral, Cognitive, and Sociocultural Factors
    • 1st Edition
    • Justin R. Yates
    • English
    Why can two people use a drug and one person becomes addicted while the other does not? Determinants of Addiction: Neurobiological, Behavioral, Cognitive, and Sociocultural Factors unravels the complexities underlying addiction to understand how individual factors at the genetic, cellular, anatomical, cognitive–behavioral... and sociocultural level can influence susceptibility to substance use disorders. The first section reviews the neurobiological determinants of addiction and examines how drugs hijack the reward pathway and alter numerous neurotransmitter systems such as dopamine. The second section covers the behavioral–cognitive determinants of addiction such a conditioning, memory processes, and decision-making. The final section examines individual differences in addiction vulnerability, with a focus on personality factors, sociocultural factors, sex/gender, and stress. The book references commonly used drugs such as nicotine, ethanol (alcohol), opioids, and cocaine.

  • Managing Treatment-Resistant Depression

    Road to Novel Therapeutics
    • 1st Edition
    • Joao L. de Quevedo + 2 more
    • English
    Managing Treatment-Resistant Depression: Road to Novel Therapeutics defines TRD for readers, discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered in this book, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants, including tricyclic antidepressants and monoamine oxidase inhibitors, augmentation strategies, and newer antidepressant treatments like ketamine and esketamine. In addition, evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed. Written by top experts in the field, this book is the first of its kind to review all methods of treatment for TRD.

  • The Molecular Immunology of Neurological Diseases

    • 1st Edition
    • Sunil Kumar
    • English
    The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches.

  • Origins of Human Socialization

    • 1st Edition
    • Donald W. Pfaff
    • English
    Origins of Human Socialization introduces a new concept on the origins of basic human instinct. The book combines the three disciplinary approaches, including neuroscience, paleoanthropology and developmental psychology as an intertwined foundation for prosocial behavior. It argues that humans have the basic brain mechanisms for prosocial activity, offering new insights into more sophisticated social behavior. It also examines both visual and auditory systems in both humans and animals to explain the evolution of social interactions. Written by world-renowned researcher Dr. Donald Pfaff, this book is the first to explore why we have basic social instinct and how it works. For centuries, researchers have argued over the foundations of human behavior in society. Anthropologists point to transitions from hunter/gathers to urban dwellers leading to human domestication. Developmental psychologists highlight social competences in babies. Neuroscientists focus on specific genetic and neurochemical mechanisms that attribute to social behavior. This book brings all of these important areas together in an interdisciplinary approach that helps readers understand how they are linked.

  • The Immune System and Mental Health

    • 1st Edition
    • Hymie Anisman + 2 more
    • English
    The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson’s and Alzheimer’s-like dementia are explored.

  • Inflammation and Immunity in Depression

    Basic Science and Clinical Applications
    • 1st Edition
    • Bernhard Baune
    • English
    Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression.

  • Insights to Neuroimmune Biology

    • 2nd Edition
    • Istvan Berczi
    • English
    Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms.

  • The Brain and Host Defense

    • 1st Edition
    • Volume 9
    • English
    It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems.Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system.