Mechanisms of Disease Pathogenesis in Multiple Sclerosis
- 1st Edition - June 11, 2024
- Editor: Francisco Javier Quintana
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 3 8 4 8 - 6
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 3 8 4 9 - 3
Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusi… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteMechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.
- Summarizes our current understanding of Multiple Sclerosis
- Discusses clinical features and available biomarker monitoring
- Focuses on mechanisms that drive disease pathogenesis
Neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1. Multiple sclerosis: Clinical course, open questions, unmet clinical needs
- Introduction
- Clinical course
- Open questions
- Unmet clinical needs
- Chapter 2. Novel imaging approaches in multiple sclerosis
- Introduction
- Use of MRI in pwMS
- Novel imaging techniques
- Artificial intelligence in MS
- Concluding remarks
- Chapter 3. Effect of infections on multiple sclerosis
- Introduction
- Infectious triggers linked to MS
- Risk of relapse during systemic infection
- The protective role of helminth infections against MS
- Chapter 4. T cells in multiple sclerosis
- Introduction: Why is multiple sclerosis a T cell mediated disease?
- Concepts of T cell mediated inflammatory lesion induction in MS
- Autoreactive T cell priming in lymph nodes draining peripheral sites
- Autoreactive T cell priming in lymph nodes draining the CNS
- Reactivation of T cells upon entry into the CNS compartment
- Regulatory T cells in CNS inflammation
- T cells in the systemic compartment of MS patients
- T cells in the CSF and the meningeal compartments
- T cells in the CNS parenchyma
- Tissue imprinting of T cells
- When systemic T cells might not be the major drivers of MS pathology any more
- Perspective
- Chapter 5. B cells in multiple sclerosis
- Introduction
- B cell biology in homeostasis and inflammation
- Evidence for B cell involvement in multiple sclerosis
- B cells in experimental autoimmune encephalomyelitis (EAE)
- Antibody-independent functions of B cells in MS/EAE
- Therapeutic directions targeting B cells in MS
- Chapter 6. Microglia in multiple sclerosis
- Introduction
- CNS resident myeloid cells during homeostasis
- CNS-resident myeloid cells during neuroinflammation
- Chapter 7. Monocytes in multiple sclerosis
- Introduction
- Monocytes
- The duelists: Microglia vs monocytes
- Pathogenesis of monocyte-derived cells in multiple sclerosis
- Current therapies, current and past trials
- Chapter 8. Antigen presenting cells in multiple sclerosis
- Antigen processing and presentation on major histocompatibility complexes
- Peripheral activation of autoreactive T cells
- T-cell reactivation in the central nervous system
- Chapter 9. Oligodendrocytes in multiple sclerosis
- Introduction
- Basic properties of OLs/myelin
- Structural properties
- Metabolic properties of OLs
- Heterogeneity of OLs
- Histopathology of OLs/myelin in MS
- Basis of OL injury
- Acute cytotoxicity
- Sublethal OL injury
- Delayed lethal injury of OLs
- Sources of OL injury
- Comparison of OPC versus mature OL direct injury
- Myelin injury and repair
- Chapter 10. Astrocytes in multiple sclerosis
- Introduction
- Homeostatic astrocytes
- Reactive astrocytes
- Astrocytes in multiple sclerosis
- Astrocytes in Parkinson's disease
- Conclusions and future directions
- Chapter 11. The blood-brain barrier in multiple sclerosis
- Short introduction - the importance of the blood-brain barrier in multiple sclerosis and addressed topics
- The BBB as part of the neurovascular unit, its entities and function
- Dysfunctional neurovascular coupling linked to gray matter atrophy in MS patients
- Chapter 12. Microbiome in multiple sclerosis
- Introduction
- A window into the environment
- Microbiome in brain development
- The role of serotonin
- The role of B cells
- Role of the microbiota in experimental autoimmune neuroinflammation
- Intestinal barrier dysfunction and microbial translocation in EAE and MS
- Dysbiosis in MS?
- From association to causation
- Consortia
- Microbiome and therapeutics
- Probiotics
- Short-chain fatty acids and other metabolites
- Fecal transplantation/rational microbiota replacement
- Concluding remarks
- Index
- No. of pages: 500
- Language: English
- Edition: 1
- Published: June 11, 2024
- Imprint: Academic Press
- Paperback ISBN: 9780128238486
- eBook ISBN: 9780128238493
FQ
Francisco Javier Quintana
Francisco J. Quintana, PhD, is an Associate Professor of Neurology at the Center for Neurologic Diseases, at Brigham and Women’s Hospital, Harvard Medical School, and an Associate Member at the Broad Institute of Harvard and MIT. Dr. Quintana’s research investigates signaling pathways that control the immune response and neurodegeneration, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders. Dr. Quintana has published over 140 peer reviewed articles and book chapters. He is the recipient of the Lady Anne Chain Prize for Academic Excellence and Scientific Achievements, the Junior Investigator Award from the National Multiple Sclerosis Society, the Pathway to Independence Award of the National Institute of Allergy and Infectious Diseases, the Award for Outstanding Research Achievement form Nature Biotechnology and the Tecan Award for Innovation, the Harry Weaver Award from the National Multiple Sclerosis Society, the Young Mentor Award from Harvard Medical School and the Milestones in MS research from the National MS Society.
Affiliations and expertise
Associate Scientist, Brigham and Women's Hospital; Professor of Neurology, Harvard Medical School; Brigham and Women's HospitalRead Mechanisms of Disease Pathogenesis in Multiple Sclerosis on ScienceDirect