Determinants of Addiction
Neurobiological, Behavioral, Cognitive, and Sociocultural Factors
- 1st Edition - December 3, 2022
- Imprint: Academic Press
- Author: Justin R. Yates
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 0 5 7 8 - 7
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 3 2 5 - 6
Why can two people use a drug and one person becomes addicted while the other does not? Determinants of Addiction: Neurobiological, Behavioral, Cognitive, and Sociocultural Facto… Read more
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Request a sales quoteWhy can two people use a drug and one person becomes addicted while the other does not? Determinants of Addiction: Neurobiological, Behavioral, Cognitive, and Sociocultural Factors unravels the complexities underlying addiction to understand how individual factors at the genetic, cellular, anatomical, cognitive–behavioral, and sociocultural level can influence susceptibility to substance use disorders. The first section reviews the neurobiological determinants of addiction and examines how drugs hijack the reward pathway and alter numerous neurotransmitter systems such as dopamine. The second section covers the behavioral–cognitive determinants of addiction such a conditioning, memory processes, and decision-making. The final section examines individual differences in addiction vulnerability, with a focus on personality factors, sociocultural factors, sex/gender, and stress. The book references commonly used drugs such as nicotine, ethanol (alcohol), opioids, and cocaine.
- Explores differentiating factors that influence why people develop a substance use disorder
- Introduces the cellular and anatomical pathways of addiction
- Identifies genes implicated in substance use disorders
- Reviews role of conditioning in the development of substance use disorders
- Includes personality, sex/gender and sociocultural factors in addiction
- Discusses the influence of peers and stress on addiction process
Researchers and graduate students in neuroscience, neurology, psychiatry, and addiction medicine
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Memoriam
- About the author
- Preface
- Acknowledgements
- Organization of book
- Section I. Prologue
- Chapter 1. Introduction to addiction: Substance use disorders
- Introduction
- Learning objectives
- Introduction to addiction and substance use disorders (SUDs)
- Key aspects of SUDs
- Commonly used drugs
- Quiz 1.1
- Drug combinations
- Prevalence of SUDs
- Health and economic impacts of SUDs
- Translational approach to studying addiction
- Quiz 1.2
- Chapter summary
- Glossary
- Section II. Neurobiological mechanisms of addiction
- Chapter 2. Pharmacological actions of commonly used drugs
- Introduction
- Learning objectives
- Introduction to the nervous system and neurotransmitters
- Neurons
- How neurons communicate with each other
- Glial cells
- Quiz 2.1
- Major neurotransmitters
- Quiz 2.2
- Drug mechanisms of action
- Pharmacological treatments for substance use disorders
- Quiz 2.3
- Chapter summary
- Glossary
- Chapter 3. Neuroanatomical and neurochemical substrates of addiction
- Introduction
- Learning objectives
- Primary brain structures of the mesocorticolimbic pathway
- Other brain regions involved in reward
- Paradigms to study addiction-like behaviors
- Quiz 3.1
- Neuroanatomical underpinnings of the addiction process: focus on dopaminergic signaling
- Quiz 3.2
- Contribution of other neurotransmitter systems to the addiction process
- Quiz 3.3
- Chapter summary
- Glossary
- Chapter 4. Molecular and cellular mechanisms of addiction
- Introduction
- Learning objectives
- Heritability of substance use disorders
- Genes associated with drug addiction in humans
- Quiz 4.1
- Genetic approaches to studying addiction in animals
- Epigenetics and addiction
- Pharmacogenetic approach to treating addiction
- Quiz 4.2
- Cellular changes following drug administration
- Astrocytes and addiction
- Quiz 4.3
- Chapter summary
- Glossary
- Section III. Behavioral and cognitive mechanisms of addiction
- Chapter 5. Learning mechanisms of addiction: operant conditioning
- Introduction
- Learning objectives
- Overview of operant conditioning
- Quiz 5.1
- Operant processes involved in addiction
- Using operant conditioning to study addiction
- Neurobiological differences across self-administration paradigms
- Quiz 5.2
- Chapter summary
- Glossary
- Chapter 6. Learning mechanisms of addiction: Pavlovian conditioning
- Introduction
- Learning objectives
- Overview of Pavlov's study
- Principles of Pavlovian conditioning
- Pavlovian processes involved in addiction
- Pavlovian-based theories of addiction
- Quiz 6.1
- Conditioned place preference
- Using Pavlovian concepts to treat addiction
- Quiz 6.2
- Chapter summary
- Glossary
- Chapter 7. Attentional and memory processes underlying addiction
- Introduction
- Learning objectives
- Cognitive model of addiction
- Drug effects on attention and automaticity
- Attention to drug warnings
- Quiz 7.1
- Drug effects on memory
- Cognitive impairments as a predictor of drug use problems
- Modeling relapse-like behavior
- Conditioned place preference revisited
- Quiz 7.2
- Neurobiology of attention and memory: relevance to addiction
- Cellular mechanisms of learning and addiction
- Glutamate homeostasis hypothesis of addiction
- Cognitive-based treatments for addiction
- Quiz 7.3
- Chapter summary
- Glossary
- Chapter 7: Exam answer key
- Chapter 8. Maladaptive decision making and addiction
- Introduction
- Learning objectives
- Overview of decision making
- Impulsive decision making
- Quiz 8.1
- Risky decision making
- Maladaptive decision making as a risk factor for substance use disorders
- Quiz 8.2
- Shared neuromechanisms of maladaptive decision making and addiction
- Metacognition, mindfulness, and addiction
- Treatments for improving drug-induced impairments in decision making
- Quiz 8.3
- Chapter summary
- Glossary
- Section IV. Individual and sociocultural factors linked to addiction
- Chapter 9. Individual differences in addiction: focus on personality traits
- Introduction
- Learning objectives
- Measuring personality traits
- Personality factors associated with drug use and addiction
- Quiz 9.1
- Impulsivity
- Attention deficit/hyperactivity disorder
- Quiz 9.2
- Chapter summary
- Glossary
- Chapter 10. Social and sociocultural factors associated with addiction
- Introduction
- Learning objectives
- Peer and familial influences on drug use
- Theories of social influence on drug use
- Social influences on drug use in animal models
- Quiz 10.1
- Socioeconomic status (SES)
- Racial and ethnic differences in addiction
- Religion/spirituality and addiction
- Socially based treatments for SUDs
- Quiz 10.2
- Chapter summary
- Glossary
- Chapter 11. Stress and addiction
- Introduction
- Learning objectives
- Neurobiology of stress
- Stress and drug use patterns in humans
- Animal models of stress
- Quiz 11.1
- Neuromechanisms mediating relationship between stress and addiction
- Hedonic allostasis model of addiction revisited
- Methods for reducing stress
- Quiz 11.2
- Chapter summary
- Glossary
- Chapter 12. Gender and sex differences in addiction
- Introduction
- Learning objectives
- Differentiating sex from gender
- Gender differences in drug use patterns
- Animal studies assessing sex differences in addiction-like behaviors
- Quiz 12.1
- Gender/sex as a moderating variable
- Potential causes of gender/sex differences in drug sensitivity
- Drug use in sexual/gender minority individuals
- Quiz 12.2
- Chapter summary
- Glossary
- Section V. Epilogue
- Chapter 13. Beyond substance use disorders: Behavioral addictions
- Introduction
- Learning objectives
- What's considered a behavioral addiction?
- Comorbid disorders observed in behavioral addictions
- Learning and cognitive mechanisms underlying behavioral addictions
- Quiz 13.1
- Risk factors associated with behavioral addictions
- Neurobiological underpinnings of behavioral addictions
- Treatment interventions for behavioral addictions
- Quiz 13.2
- Chapter summary
- Glossary
- Index
- Edition: 1
- Published: December 3, 2022
- No. of pages (Paperback): 598
- No. of pages (eBook): 598
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780323905787
- eBook ISBN: 9780323913256
JY
Justin R. Yates
Dr. Yates received his PhD in Experimental Psychology from the University of Kentucky in 2014. He is currently a Professor in Psychological Science at Northern Kentucky University. His research interests include elucidating the neurobehavioral mechanisms underlying drug addiction and studying the neural mechanisms of impulsive and risky decision-making. Dr. Yates’ research has been recognized at a national level, as he has received the American Psychological Association (APA) Division 25 B.F. Skinner Foundation New Researcher Award, the APA Division 28 Young Psychopharmacologist Award (both in 2018), and the APA Division 6 Early Career Award (2021). He has also received awards from Northern Kentucky University, including the 2019 Excellence in Undergraduate Research Mentoring Award and the 2020 Excellence in Research, Scholarship, and Creative Activity Award.
Affiliations and expertise
Associate Professor, Psychological Science, Northern Kentucky University, USARead Determinants of Addiction on ScienceDirect