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Epigenetic Mechanisms in Brain Physiology and Disorders

  • 1st Edition - July 1, 2026
  • Latest edition
  • Editors: Moshe Szyf, Zsofia Nemoda
  • Language: English

Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiolog… Read more

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Description

Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.

Key features

  • Summarizes the role of epigenetics in neurological and psychiatric disorders
  • Includes brain physiology and pathology
  • Covers epigenetic processes in memory, learning, sleep, and regulation of other body functions
  • Explores potential future roles in diagnostics and therapeutics

Readership

Researchers and practitioners in clinical neurology

Table of contents

1. Introduction. Epigenetic mechanisms in brain function.

2. Evolution of epigenetic landscapes during pre and postnatal brain development and aging.

3. The role of DNA methylation and stepwise oxidation of 5 methylcytosine in epigenetic regulation of gene expression in the brain.

4. Learning and memory.

5. Stress and the HPA axis

6. Metabolic homeostasis

7. Puberty and sexual behavior

8. Body Temperature and thermal regulation

9. The role of epigenetic mechanism in the neuroimmune axis

10. The impact of genetic alterations in epigenetic proteins on brain disorders.

11. Epigenetic processes in neurodevelopmental disorders (RETT syndrome, Autism)

12. Linking early adversity epigenetics and neuropsychiatric disorders (psychosis)

13. Epigenetic processes in substance abuse, and behavioral addictions

14. Epigenetic processes in neurological diseases Alzheimer, Parkinson disease, Parkinson, ALS

15. Epigenetic mechanisms in chronic pain

16. Early life adversity trauma and PTSD linked by epigenetic mechanisms

17. Epigenetic mechanisms in brain aging, cognitive decline and dementia

18. Methodological challenges in epigenome wide associations with neuropsychiatry and behavioraldisorders

19. Animal models with construct validity for studying epigenetic processes in neurobehavior

20. Using epigenetic editing and to examine the role of site specific DNA methylation and oxidationalterations in neuroepigenetics.

21. Methods for dissecting cell neuron/glia/astrocyte specific patterns of methylationIPSC stem cells derived neuronal precursor cells to model in vitro the role of DNA methylation in the nervous system and brain disorders

Product details

  • Edition: 1
  • Latest edition
  • Published: July 1, 2026
  • Language: English

About the editors

MS

Moshe Szyf

Dr. Szyf received his Ph.D. from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School, joined the McGill University in 1989 and currently holds a James McGill Professorship and GlaxoSmithKline-CIHR Chair in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program.  Dr. Szyf has been the founder of the first “Pharma” to develop epigenetic pharmacology “Methylgene Inc.” and the first journal in epigenetics “Epigenetics.”  Szyf lab has proposed two decades ago that DNA methylation is a prime therapeutic target in cancer and other diseases and has postulated and provided the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics.”
Affiliations and expertise
Department of Pharmacology and Therapeutics, McGill University Medical School, Montreal QC, Canada

ZN

Zsofia Nemoda

Zsofia Nemoda is an assistant professor at Semmelweis University in Budapest Hungary. She is a member of the Hungarian Biochemical Association, the International Society of Psychiatric Genetics, and the Hungarian Society of Human Genetics. She has 41 articles published in international journals with a cumulative impact factor of 168 and independent citations of 1139. In 2023 & 2024 she was affiliated the Douglas Mental Health University Institute, Montreal, Canada working with Dr. Linda Booij.
Affiliations and expertise
Assistant Professor, Semmelweis University, Budapest, Hungary