Epigenetic Mechanisms in Brain Physiology and Disorders
- 1st Edition - September 1, 2026
- Latest edition
- Editors: Moshe Szyf, Zsofia Nemoda
- Language: English
Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiolog… Read more
Description
Description
Epigenetic Mechanisms in Brain Physiology and Disorders provides a comprehensive summary of epigenetic mechanisms in brain development, from embryogenesis to aging, brain physiology and pathology. It discusses the role DNA methylation plays in regulating genomic functions, which in turn guide brain function. The book explores the epigenetic role in cell type differentiation, epigenetic processes in memory, learning, and neuronal functioning, the role of DNA methylation and other epigenetic mechanisms in sleep, feeding and metabolic control, sex, temperature regulation, and cardiovascular and blood pressure regulation. It further explores the role of epigenetic processes in neuropsychiatry disorders, neurological disease and behavioral disorders, as well as epigenetic diagnostics and therapeutics.
Key features
Key features
- Summarizes the role of epigenetics in neurological and psychiatric disorders
- Includes brain physiology and pathology
- Covers epigenetic processes in memory, learning, sleep, and regulation of other body functions
- Explores potential future roles in diagnostics and therapeutics
Readership
Readership
Researchers and practitioners in clinical neurology
Table of contents
Table of contents
Section I. Epigenetic mechanisms in the brain
1. Introduction to epigenetic mechanisms in the brain
2. The role of epigenetic DNA modifications in the brain: focus on cell specification, neuropathology and environmental influences
3. The role of histone modification in epigenetic regulation of gene expression and cell specification
4. Human Brain Evolution: Role of SVA Retrotransposons and SVA Long Non-coding RNA
Section 2. The role of epigenetic mechanisms in brain physiology
5. Epigenetic influences on affect and emotion regulation: Insights from the oxytocin system
6. Epigenetic mechanisms in Stress and the HPA axis
7. Central epigenetic mechanisms of overeating and thermal regulation
8. Gut Microbiota and Epigenetic Mechanisms in Brain Physiology and Disorders
Section 3. Epigenetic mechanisms in neuropsychiatric, neurological and behavioral disorders
9. The Impact of Genetic Mutations in Epigenetic Factors on Brain Development and Neurodevelopmental Disorders
10. Epigenetics processes involved in schizophrenia and antipsychotic treatment
11. Epigenetic processes in depressive and anxiety disorders
12. Epigenetic Factors in Eating Disorders: Clinical Correlates and Diagnostic Specificity
13. Linking early adversity epigenetics and neuropsychiatric disorders; interaction between environment epigenetics and inherited susceptibility variants
14. Epigenetic processes in substance abuse, and behavioral addictions: involvement of dopaminergic pathways
15. Epigenetic processes in Parkinson disease
16. Epigenetics and epilepsy
17. Epigenetic mechanisms in Alzheimer disease
18. DNA Methylation in Motor Neuron Biology and Epigeneticopathy in Amyotrophic Lateral Sclerosis
19. Epigenetic processes in neurodevelopmental disorders
20. Epigenetic mechanisms in neuroinflammatory disease of the brain: Multiple sclerosis
21. Epigenetic mechanisms involved in post traumatic stress disorder
22. Epigenetic mechanisms in brain aging and their role in cognitive decline and mental health disorders
23. The epigenetic mechanisms mediating the long-term impacts of environmental toxicants on brain functions and health
24. Epigenetic personalized medicine in glioblastoma
Section 4. Methods and methodological issues in unraveling the neurobehavioral methylome
25. METHODOLOGICAL CHALLENGES AND OPPORTUNITIES IN EPIGENOME-WIDE ASSOCIATION STUDIES FOR PSYCHIATRIC DISORDERS
26. Animal models with construct validity for studying epigenetic processes in neurobehavior
27. Single-Cell Approaches for Mapping Cell-Type-Specific Epigenetic Regulation
28. Measuring Histone Modifications Across Different Cell Types in the Central Nervous system
29. IPSC stem cells derived neuronal precursor cells to model in vitro the role of DNA methylation in the nervous system and brain disorders
30. Epigenetic Architecture of the Developing Brain
1. Introduction to epigenetic mechanisms in the brain
2. The role of epigenetic DNA modifications in the brain: focus on cell specification, neuropathology and environmental influences
3. The role of histone modification in epigenetic regulation of gene expression and cell specification
4. Human Brain Evolution: Role of SVA Retrotransposons and SVA Long Non-coding RNA
Section 2. The role of epigenetic mechanisms in brain physiology
5. Epigenetic influences on affect and emotion regulation: Insights from the oxytocin system
6. Epigenetic mechanisms in Stress and the HPA axis
7. Central epigenetic mechanisms of overeating and thermal regulation
8. Gut Microbiota and Epigenetic Mechanisms in Brain Physiology and Disorders
Section 3. Epigenetic mechanisms in neuropsychiatric, neurological and behavioral disorders
9. The Impact of Genetic Mutations in Epigenetic Factors on Brain Development and Neurodevelopmental Disorders
10. Epigenetics processes involved in schizophrenia and antipsychotic treatment
11. Epigenetic processes in depressive and anxiety disorders
12. Epigenetic Factors in Eating Disorders: Clinical Correlates and Diagnostic Specificity
13. Linking early adversity epigenetics and neuropsychiatric disorders; interaction between environment epigenetics and inherited susceptibility variants
14. Epigenetic processes in substance abuse, and behavioral addictions: involvement of dopaminergic pathways
15. Epigenetic processes in Parkinson disease
16. Epigenetics and epilepsy
17. Epigenetic mechanisms in Alzheimer disease
18. DNA Methylation in Motor Neuron Biology and Epigeneticopathy in Amyotrophic Lateral Sclerosis
19. Epigenetic processes in neurodevelopmental disorders
20. Epigenetic mechanisms in neuroinflammatory disease of the brain: Multiple sclerosis
21. Epigenetic mechanisms involved in post traumatic stress disorder
22. Epigenetic mechanisms in brain aging and their role in cognitive decline and mental health disorders
23. The epigenetic mechanisms mediating the long-term impacts of environmental toxicants on brain functions and health
24. Epigenetic personalized medicine in glioblastoma
Section 4. Methods and methodological issues in unraveling the neurobehavioral methylome
25. METHODOLOGICAL CHALLENGES AND OPPORTUNITIES IN EPIGENOME-WIDE ASSOCIATION STUDIES FOR PSYCHIATRIC DISORDERS
26. Animal models with construct validity for studying epigenetic processes in neurobehavior
27. Single-Cell Approaches for Mapping Cell-Type-Specific Epigenetic Regulation
28. Measuring Histone Modifications Across Different Cell Types in the Central Nervous system
29. IPSC stem cells derived neuronal precursor cells to model in vitro the role of DNA methylation in the nervous system and brain disorders
30. Epigenetic Architecture of the Developing Brain
Product details
Product details
- Edition: 1
- Latest edition
- Published: September 1, 2026
- Language: English
About the editors
About the editors
MS
Moshe Szyf
Dr. Szyf received his Ph.D. from the Hebrew University and did his postdoctoral fellowship in Genetics at Harvard Medical School, joined the McGill University in 1989 and currently holds a James McGill Professorship and GlaxoSmithKline-CIHR Chair in Pharmacology. He is the founding co-director of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Canadian Institute for Advanced Research Experience-based Brain and Biological Development program. Dr. Szyf has been the founder of the first “Pharma” to develop epigenetic pharmacology “Methylgene Inc.” and the first journal in epigenetics “Epigenetics.” Szyf lab has proposed two decades ago that DNA methylation is a prime therapeutic target in cancer and other diseases and has postulated and provided the first set of evidence that the “social environment” early in life can alter DNA methylation launching the emerging field of “social epigenetics.”
Affiliations and expertise
Department of Pharmacology and Therapeutics, McGill University Medical School, Montreal QC, CanadaZN
Zsofia Nemoda
Zsofia Nemoda is an assistant professor at Semmelweis University in Budapest Hungary. She is a member of the Hungarian Biochemical Association, the International Society of Psychiatric Genetics, and the Hungarian Society of Human Genetics. She has 41 articles published in international journals with a cumulative impact factor of 168 and independent citations of 1139. In 2023 & 2024 she was affiliated the Douglas Mental Health University Institute, Montreal, Canada working with Dr. Linda Booij.
Affiliations and expertise
Assistant Professor, Semmelweis University, Budapest, Hungary