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Elsevier

Books in Applied immunology

This portfolio encompasses the translation of immunological research into clinical applications, including vaccine development, immunotherapy, and diagnostic innovations. It supports researchers, clinicians, and industry professionals working to harness immune mechanisms for disease prevention and treatment. Featuring cutting-edge studies, therapeutic strategies, and real-world case examples, these resources facilitate the development of innovative immunological solutions that address infectious diseases, cancer, and autoimmune conditions.

  • Microbiome and Tumorigenesis in Different Cancers

    • 1st Edition
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis in Different Cancers delves into the intricate relationship between the human microbiome and various health conditions, with a particular focus on cancer. It is divided into five parts, each addressing a critical aspect of microbiome research and its implications for health and disease. In 4 parts the book provides a foundational understanding of the human microbiome, examines the dual role of the microbiome in cancer development, discusses the role of dysbiosis in gastrointestinal, skin, oral, lung, genitourinary, and hematological malignancies and gives an overview of the methodologies used to study the microbiome. The final part explores the emerging field of pharmacomicrobiomics... focusing on the interaction between the microbiome and cancer therapies. This book serves as a valuable resource for researchers, clinicians, and students interested in understanding the complex interplay between the microbiome and cancer, offering insights into potential therapeutic strategies and future directions in microbiome research.

  • Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology

    • 1st Edition
    • Swagat Kumar Das + 2 more
    • English
    Emerging Trends and Imminent Applications in Immunology and Pharmaceutical Biotechnology delves into historical perspectives, current trends, and future projections for research and development of immunological and biopharmaceutical products. Sections explore immunostimulants, natural and synthetic immunostimulants in aquaculture and animal husbandry, immunomodulators, immune boosters, pre- and probiotics in health promotion, cutting-edge immunological techniques for disease diagnosis, immunotherapy in cancer treatment, and transplantation immunology. Following chapters explore the impact on pharmaceutical biotechnology, with discussions on traditional and modern approaches in drug delivery, in silico drug delivery modeling, biocomposites and their pharmaceutical applications, recent advances in monoclonal antibodies production, vaccine development, and much more. Finally, the book covers the pivotal role of AI, machine learning, and data analytics in the clinical study of immunotherapy and pharmaceutical drugs, thus paving the way for enhanced research and development efficiency. Researchers in industry and academia alike will gain valuable insights into the novel principles behind designing and developing immunological and drug products, making this title an essential resource.

  • Immunotherapy for Autoimmune Disorders

    Innovations and Insights
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Immunotherapy for Autoimmune Disorders: Innovations and Insights revolutionizes the therapeutic paradigm for autoimmune illnesses, offering new perspectives over traditional medication therapies. This complete and accessible resource examines how immunotherapy teaches the immune system to detect and fight targeted cells, enhancing the body's immune response by providing additional components to strengthen its defense mechanisms. The book covers a wide range of topics, including the pathophysiology, diagnosis, and classification of autoimmune diseases, the immunopathogenesis of these disorders, and the development and application of monoclonal antibodies. It explores immune checkpoint inhibitors, T-cell modulation therapies, cytokine targeting therapies, B-cell depletion strategies, and more.Additionally, it addresses immunomodulatory agents, small molecules, personalized immunotherapy approaches, and the application of immunotherapeutic strategies for specific autoimmune diseases. Future directions and emerging therapies, as well as regulatory and ethical considerations, are also discussed. This is essential reading for medical professionals, researchers, and students seeking to learn about immunotherapy as an alternative approach to treating autoimmune disorders.

  • Immunological Insights and Emerging Therapeutics in Medical Mycology

    • 1st Edition
    • Paschalis Vergidis + 1 more
    • English
    Immunological Insights and Emerging Therapeutics in Medical Mycology summarizes the current knowledge on interactions between host cells and human fungal pathogens and explains how certain immune defects lead to vulnerability to fungal infection.Chapters focus on immune response to such fungal infections as candidiasis, aspergillus, cryptococcosis, mucormycosis, pneumocystis.This title provides a basis for further study on antifungal immunity by enhancing understanding of antifungal immune responses. Further, this title offers new insights from the host immune response, improving understanding of disease pathogenesis and informing novel prophylactic and therapeutic approaches to fungal infections.

  • Glycobiology of the Immune System and Disease

    • 1st Edition
    • Shyamasree Ghosh + 1 more
    • English
    Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, it is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.

  • The Microbiome and Cancer Treatment

    Overcoming Resistance and Enhancing Efficacy
    • 1st Edition
    • Sadhna Aggarwal + 3 more
    • English
    The Microbiome and Cancer Treatment: Overcoming Resistance and Enhancing Efficacy delves into the intricate relationship between the microbiome and cancer treatment, highlighting the microbiome's critical role in drug resistance and therapeutic efficacy. The book's chapters are meticulously organized to provide a deep understanding of how the microbiome interacts with the immune system and influences cancer development and response to therapies. This book opens new avenues for investigation by providing a better understanding of the mechanisms of resistance and the role of microbiome alterations in chemoresistance.Sect... also address the complex "chicken-or-egg" relationship between microbiome alterations and chemoresistance. A diverse blend of chapters foster interdisciplinary collaboration across fields such as immunology, microbiology, oncology, and pharmacology, promoting holistic approaches to cancer treatment. Readers will benefit by gaining awareness and a better understanding of how the microbiome impacts health, particularly in the context of cancer, leading to more informed health choices.

  • Vaccinology and Immunizations

    • 1st Edition
    • Jahangir Moini + 2 more
    • English
    Vaccinology and Immunizations is a thorough resource on the immune system, the history of vaccines, vaccine preparation, the process of vaccine approval, and the prevention and eradication of diseases. It also includes chapters on vaccine safety and errors, and complete information on pediatric and adult immunizations. There is also discussion on elderly immunology and immunization for people who are seeking to travel abroad, as well as timely information about COVID-19.Its focus on the innate and adaptive defense systems of the body will ensure understanding of human immunity and how immunizations are effective. There is a variety of available titles related to vaccinology and immunizations, but many are now outdated.Vaccinology and Immunizations provides a new, updated resource that is widely needed, and will be welcomed by students of undergraduate, graduate and master level in vaccinology or immunology, and would also be of interest to nurses, researchers, and pharmacists.

  • Immunity to Immunotherapy in Cancer

    Mechanisms and Limitations
    • 1st Edition
    • Mukesh Nandave + 1 more
    • English
    Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and scientific solutions in development. The book examines molecular strategies of immune evasion within the tumor microenvironment, providing insights into factors like tumor heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, the book aims to enhance patient outcomes and advance cancer immunotherapy.Design... as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.

  • Inflammation and Cancer

    Mechanisms, Diagnosis, and Therapeutic Strategies
    • 1st Edition
    • Anoop Kumar + 4 more
    • English
    Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.

  • Inflammatory Arthritis Beyond the Joints

    Comorbidities and other Manifestations
    • 1st Edition
    • Volume 18
    • Fabiola Atzeni + 1 more
    • English
    Inflammatory Arthritis Beyond the Joints, Volume 18 in Elsevier’s Handbook for Systemic Autoimmune Diseases series, provides an extensive review of the most recent research on various comorbidities and EAMs associated with inflammatory arthritis. The book emphasizes early detection, which is crucial for improving patient quality of life and survivability outcomes, as many adults with inflammatory arthritis also suffer from other chronic conditions. The book's chapters cover comorbidities and EAMs in both early and late disease stages.They delve into the mechanisms behind the development of these conditions and examine the impact of new treatment strategies specific to inflammatory arthritis and related diseases, including cardiovascular disease, metabolic syndrome, metabolic bone disease, infection, neoplasia, respiratory disease, gastrointestinal disorders, kidney issues, mental health conditions, and neurological diseases. This book serves as a valuable reference for researchers and clinicians focused on inflammatory arthritis and its associated conditions.

  • Advancing Early Diagnosis in Chronic Diseases

    Tools, Techniques, and Technologies
    • 1st Edition
    • Sachchida Nand Rai + 2 more
    • English
    Advancing Early Diagnosis in Chronic Diseases: Tools, Techniques, and Technologies explores the transformative potential of early detection strategies and technologies in reshaping chronic disease outcomes. Addressing the urgent need for innovative approaches for managing conditions such as cardiovascular diseases, diabetes, cancer, neurodegenerative disorders, and pediatric, chronic conditions, this book underscores the importance of timely interventions to reduce disease burden. The book provides a comprehensive overview of cutting-edge tools, including predictive biomarkers, artificial intelligence, genomic and proteomic screening, wearable health devices, digital twins, and point-of-care testing. Readers will gain insights into how these advancements revolutionize early diagnosis and personalized treatment.Written by experts from interdisciplinary fields, the book bridges the gap between scientific discovery and clinical application, addressing challenges such as knowledge gaps, integration barriers, and accessibility of diagnostic innovations. It covers a broad spectrum of chronic conditions, including metabolic, inflammatory, respiratory, renal, hepatic, and neurodegenerative diseases, with added focus on pediatric patients and early detection in childhood disorders.

  • Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments

    • 1st Edition
    • Tuan Anh Nguyen + 2 more
    • English
    Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments provides a balanced exploration of the dual roles of nanotechnologies in oncology. Structured in four parts, the book begins with foundational knowledge of nanovaccines and nanomedicines, detailing their applications in cancer care and highlighting their precision in targeting cancer cells while reducing systemic toxicity. Importantly, the book addresses potential drawbacks, discussing side effects and safety concerns associated with these innovations. The final section emphasizes ethical, regulatory, and safety challenges, underscoring the need for careful oversight as nanotechnologies advance.For the academic audience, this book serves as a vital resource, offering insights that equip researchers and healthcare professionals to make informed decisions regarding clinical applications. Its focus on both benefits and risks, alongside forward-looking perspectives, ensures that readers are well-prepared for future developments in the field of nanomedicine and cancer therapy.

  • Encyclopedia of Immunobiology

    • 2nd Edition
    • Paul Kaye
    • English
    Encyclopedia of Immunobiology, Second Edition, Five Volume Set covers the full range of Immunology, presenting topics logically and making extensive use of "hot links" to refer the reader to related content. The new edition is not just an update of the original title; it vastly expands fields like immunotherapy, immunity to viral infection, vaccine development, inflammatory responses, and high throughput analyses. Containing 350 chapters written by world-leading experts, this edition integrates all concepts coherently and logically to paint a comprehensive picture of the evolving field of Immunology.The immune system, complex and multi-layered, has evolved to differentiate between "self" and foreign pathogens, providing protection against infections while dysregulation can cause diseases like autoimmunity, allergies, and inflammatory disorders. This understanding has led to numerous therapeutic interventions crucial for human health improvement.

  • Role of Medicinal Plants in Autoimmune Diseases

    Concepts, Perspectives, and Utilization
    • 1st Edition
    • Reetika Mahajan + 4 more
    • English
    Role of Medicinal Plants in Autoimmune Diseases: Concepts, Perspectives, and Utilization provides comprehensive knowledge of autoimmune diseases and the role of various medicinal plant products in their treatment. The book discusses the immune system as a group of complex biological structures and processes in an organism which gives protection against a wide range of pathogenic organisms while simultaneously distinguishing these pathogens from the organism’s own healthy cells and tissues, thus maintaining homeostasis in the body.It has been an age-old practice to use extracts and other parts of various plants in treating many diseases. Several plants contain various pharmacologically active substances which can be used to treat different diseases. Among these medicinal plants, many have shown good immunomodulatory properties and could act as natural immunosuppressant agents in treating autoimmune disorders.

  • Cytokine Response Against Major Human Viral Infections

    • 1st Edition
    • Mukesh Samant + 1 more
    • English
    Cytokine Response Against Major Human Viral Infections provides in-depth coverage of the immunological response against human viral infections and the role and impact of cytokines on disease pathogenesis and host immune response.Cytokines, as a part of innate immunity, initiate the development of antiviral and TH 1-type immune responses. Cytokines also affect the adaptive immune response and disease manifestation. In five sections, this book gives a comprehensive introduction to the clinical manifestations of viral and infectious diseases; details the role of cytokines in DNA virus infections, RNA virus infections, and reverse transcribing virus infections; and gives insights into the recent advances and strategies in diagnostic tools and therapeutic and prophylactic measures.Cytokine Response Against Major Human Viral Infections is valuable resource for both researchers in immunology and virology, as well as for those in the biotech and pharmaceutical industries, engaged in the study of cytokines and their immunological response against human viral infections.

  • A New Era in Alzheimer's Research

    Pathogenesis, Prevention, and Treatment
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    A New Era in Alzheimer's Research: Pathogenesis, Prevention, and Treatment is focused on the research and perspectives in Alzheimer's disease (AD), offering an update on the challenging aspects of neurodegenerative disorders. Each chapter of this book contains unique and valuable scientific information on the latest progress of research in neurodevelopmental diseases. Even after years of research, Alzheimer's disease is still far from being cured; this book addresses the most current issues within the many dimensions relevant to the pathogenesis, diagnosis, and prevention under one cover, making it useful for researchers, students, and clinicians, as well as those in pharmaceuticals.

  • Macrophages Biology and Tissue Inflammation in Health and Disease

    • 1st Edition
    • Stuart Goodman + 2 more
    • English
    Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats.

  • Advanced Vaccination Technologies for Infectious and Chronic Diseases

    A guide to Vaccinology
    • 1st Edition
    • Vasso Apostolopoulos + 2 more
    • English
    Advanced Vaccination Technologies for Infectious and Chronic Diseases is a comprehensive guide that delves into the intricate details of vaccine design, development across various platforms, and the path to commercialization. This book provides an introductory overview of vaccines, covering various types, developmental methodologies, delivery systems, adjuvants, immunization, and measurement of vaccine efficacy. It also showcases examples of vaccine research efforts targeting infectious diseases, autoimmune disorders, and cancer. The book concludes by exploring cutting-edge advances in proteogenomics, immunopeptidomics, and future vaccine technologies.The primary objective of this book is to inform a broad scientific audience about the fundamental concepts underlying vaccine and immunology. Further, it serves as an invaluable reference for understanding the critical steps in the journey from discovery to regulatory processes for human clinical trials, addressing common misconceptions and presenting factual information about vaccinations. Advanced Vaccination Technologies for Infectious and Chronic Diseases is a requisite reference for occupational health professionals whose roles involve supervision of immunization programs such as those working within the National Health Service, some sectors of higher education, or the pharmaceutical industry. It also caters to those researchers engaged in vaccine development and all who want to learn the processes involved from laboratory research to final product.

  • Nanomedicine in Cancer Immunotherapy

    • 1st Edition
    • Prashant Kesharwani
    • English
    Nanomedicine in Cancer Immunotherapy bridges the two disciplines of nanotechnology and immunology, summarizing the latest research into novel cancer treatments, often personalized to the patient. The book covers a wide range of nanomaterial types for use in cancer immunotherapy, including hydrogel, lipid, exosome, gold and peptide nanoparticles. The preparation, application, pros and cons of each nanomaterial class is reviewed, helping the reader understand the potential for each to tailor their own selections. Nanovaccines are also covered, along with a clinical evaluation and market analysis of nanomedicines for immunotherapy, offering an important clinical and commercial overview of this rapidly developing field.This book is an interesting reference for those working in the fields of nanotechnology, immunology, and cancer therapeutics, as well as clinicians with an interest in novel nano-based cancer treatments.

  • In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment

    Modeling and Simulation
    • 1st Edition
    • Muhammad Suleman
    • English
    In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.

  • System Vaccinology

    The History, the Translational Challenges and the Future
    • 1st Edition
    • Vijay Kumar Prajapati
    • English
    Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials. My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines. This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens. Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters.

  • Clinical Immunology

    • 1st Edition
    • Nima Rezaei
    • English
    Clinical Immunology not only introduces the reader to the human immune system, it also covers immunology from clinical manifestation to therapeutic approaches in a wide range of conditions. Each chapter describes an introduction, the clinical manifestations, the immunopathogenesis, diagnosis, lab tests and therapeutic approaches. The book guides clinicians, researchers and students to a better understanding of the matters of immunologic-based diseases that can lead to better decision-making for patients.Because of the growing knowledge regarding the function of immune system in health and disease conditions, clinicians, researchers and students increasingly require an exclusive scientific reference to guide them on matters of immunologic-based diseases. Accordingly, despite the existence of numerous high quality references in basic and cellular/molecular immunology which deeply explain different immunologic mechanisms, there is still a knowledge gap in the field of clinical immunology.

  • Microbial Crosstalk with Immune System

    New Insights in Therapeutics
    • 1st Edition
    • Asmita Das
    • English
    Our body is not sterile and harbors enumerable microflora that are now being understood to play a complex role in immune regulation and shaping of the immune system in a continuous and dynamic way. In 8 chapters, Microbial Crosstalk with Immune System: New Insights in Therapeutics provides an overall introduction with special focus on how the immune system which is specifically geared to get rid of non-self-antigens, allows numerous microbes to colonize the human body. In the presence of microbes there are several observations that suggest that there are multiple roles that are played by these microbes in tumor progression and shaping of our immune system which is explained at length in subsequent chapters. Microbial Crosstalk with Immune System: New Insights in Therapeutics discusses the emerging mechanisms of immune-therapeutics as well as its limitations while emphasizing the potential role of microbes in shaping immune-therapeutic and evolving novel strategies to deal with any limitations.

  • Macrophages in the Human Body

    A Tissue Level Approach
    • 1st Edition
    • Niels Olson Saraiva Camara + 1 more
    • English
    Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophage... in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.

  • Nanotheranostics for Treatment and Diagnosis of Infectious Diseases

    • 1st Edition
    • Keerti Jain + 1 more
    • English
    Nanotheranostics for Treatment and Diagnosis of Infectious Diseases comprises the latest information on the technological advancements made in the field of nanotechnology for application in therapeutics with diagnostic applications. The book focuses on the theranostic applications of nanomaterials in infectious diseases, highlighting that rapid diagnosis, safe and effective treatment and strong preventive measures like vaccines are urgently needed. It compiles all relevant information to help scientists, researchers and students understand the role of nanomaterials, how nanomaterials could be explored simultaneously for therapeutic and diagnostic applications, and how to ensure safety and efficacy of these nanomaterials. Sections cover fundamental concepts, emerging concerns and challenges to combat infectious diseases, the characterization of nanomaterials for theranostic applications, and the toxicity, biocompatibility and regulatory perspectives in the diagnosis and treatment of infectious diseases.

  • Immunoinformatics of Cancers

    Practical Machine Learning Approaches Using R
    • 1st Edition
    • Nima Rezaei + 1 more
    • English
    Immunoinformatics of Cancers: Practical Machine Learning Approaches Using R takes a bioinformatics approach to understanding and researching the immunological aspects of malignancies. It details biological and computational principles and the current applications of bioinformatic approaches in the study of human malignancies. Three sections cover the role of immunology in cancers and bioinformatics, including databases and tools, R programming and useful packages, and present the foundations of machine learning. The book then gives practical examples to illuminate the application of immunoinformatics to cancer, along with practical details on how computational and biological approaches can best be integrated.This book provides readers with practical computational knowledge and techniques, including programming, and machine learning, enabling them to understand and pursue the immunological aspects of malignancies.

  • Vaccinology and Methods in Vaccine Research

    • 1st Edition
    • Rebecca Ashfield + 3 more
    • English
    Vaccinology and Methods in Vaccine Research is a combination of cutting-edge methodologies, experimental approaches and literature reviews. The book covers all aspects of vaccine development, including basic immunology (focusing on the stimulation of adaptive immunity, which is required for vaccine efficacy), approaches to vaccine design and target validation, vaccine biomanufacturer and clinical development. Existing vaccinology resources are theoretical reference books, whereas this book provides a practical handbook for use in the research lab and classroom by those working in vaccinology and training others in the field. It is authored and edited by scientists actively engaged in vaccine research and development for day-to-day teaching/methodologi... advice.

  • Cancer Immunology and Immunotherapy

    Volume 1 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy
    • 1st Edition
    • Mansoor M. Amiji + 1 more
    • English
    Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

  • Epigenetics of the Immune System

    • 1st Edition
    • Volume 16
    • Dieter Kabelitz + 1 more
    • English
    Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications.

  • Stiehm's Immune Deficiencies

    Inborn Errors of Immunity
    • 2nd Edition
    • Kathleen E. Sullivan + 1 more
    • English
    Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy.

  • Maternal Immunization

    • 1st Edition
    • Elke Leuridan + 2 more
    • English
    Immunization during pregnancy with currently recommended vaccines prevents infection in the mother, the unborn fetus, and the young infant, and there is an increasing focus from different stakeholders to use this approach for other infections of importance to protect these vulnerable groups. The aim of this Maternal Immunization book is to provide a contemporary overview of vaccines used in pregnancy (and the lactation period), with emphasis on aspects of importance for the target groups, namely, rationale for the use of vaccines in pregnancy, safety, immunogenicity (immunology), timing to vaccinate, repeat doses, protective effects in the mother, fetus, and infant, and public acceptance and implementation, of existing and of future vaccines.

  • Basics of Chimeric Antigen Receptor (CAR) Immunotherapy

    • 1st Edition
    • Mumtaz Y. Balkhi
    • English
    Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field.

  • Fundamentals of Biologicals Regulation

    Vaccines and Biotechnology Medicines
    • 1st Edition
    • Rebecca Sheets
    • English
    Fundamentals of Biologicals Regulation: Vaccines and Biotechnology Medicines serves as an introduction to the international regulatory arena in which biologicals are developed and offers an overview of the processes and insight into the scientific concepts underpinning global regulations. This book will provide multiple levels of readership with guidance on basic concepts, a detailed look at regulatory challenges, and practical insight into how regulators consider regulatory science and regulatory process issues across various regions. With numerous case studies, learning activities, and real-world examples across several classes of biotechnological products, this book is a valuable and comprehensive resource for graduate students, professors, regulatory officials, and industry scientists working with biologicals.

  • Immunopotentiators in Modern Vaccines

    • 2nd Edition
    • Virgil E.J.C. Schijns + 1 more
    • English
    Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful.

  • Human Vaccines

    Emerging Technologies in Design and Development
    • 1st Edition
    • Kayvon Modjarrad + 1 more
    • English
    Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics—among other disciplines—that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens. For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology.

  • Micro- and Nanotechnology in Vaccine Development

    • 1st Edition
    • Mariusz Skwarczynski + 1 more
    • English
    This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.

  • The Vaccine Book

    • 2nd Edition
    • Barry R. Bloom + 1 more
    • English
    The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child’s risk.

  • Translational Neuroimmunology in Multiple Sclerosis

    From Disease Mechanisms to Clinical Applications
    • 1st Edition
    • Ruth Arnon + 1 more
    • English
    Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. More than 2.3 million people are affected by MS worldwide. Symptoms can vary widely, depending on the localization and amount of the damage induced by combined inflammatory, demyelinating, and neurodegenerative processes. Although a cure for MS does not currently exist, therapies can help treat MS attacks, attenuate disease activity, reduce progress of the disease, and manage symptoms. Translational Neuroimmunology in Multiple Sclerosis provides an overview of recent findings and knowledge of the neuroimmunology of multiple sclerosis, from experimental models and the human disease to the translation of this research to immunotherapeutic strategies. Chapters describe genetic and environmental factors underlying the disease pathogenesis of MS as a basis for development of immunotherapies, immunological markers of disease activity, pharmacogenetics, and responses to therapy. Immunomodulatory therapies currently in practice and future therapeutic strategies on the horizon—such as neuroprotective strategies, stem cells, and repair promotion—are discussed. Contributed by renowned leaders in the field, this cross-disciplinary volume is a great resource for basic scientists and clinical practitioners in neuroscience, neurology, immunology, pharmacology, and in-drug development.

  • Encyclopedia of Immunobiology

    • 1st Edition
    • Michael J.H. Ratcliffe
    • English
    Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject.

  • Immunotherapy of Cancer

    • 1st Edition
    • Volume 128
    • English
    Immunotherapy of Cancer provides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.

  • Developing Costimulatory Molecules for Immunotherapy of Diseases

    • 1st Edition
    • Manzoor Ahmad Mir
    • English
    Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation. The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases.

  • Immunocytochemistry

    Practical Applications in Pathology and Biology
    • 1st Edition
    • Julia M. Polak + 1 more
    • English
    Immunocytochemistry: Practical Applications in Pathology and Biology focuses on the processes, principles, methodologies, and approaches involved in the applications of immunocytochemistry in pathology and biology. The selection first takes a look at the development and scope of immunocytochemistry; techniques and practice used in immunocytochemistry; and raising and testing antibodies for immunocytochemistry. The book then ponders on raising antibodies to small peptides, use of semithin frozen sections in immunocytochemistry, and colloidal gold probes in immunocytochemistry. Discussions focus on the production of gold probes, localization of mouse serum albumin in the mammary gland, immunogens and the immune response, production of antisera, and antibody specificity in immunocytochemistry. The publication takes a look at double immunoenzymatic labelling, lectin histochemistry, immunocytochemical localization of noradrenaline, adrenaline, and serotonin, and immunocytochemistry of cell and tissue cultures. Immunocytochemistry in endocrine pathology and indirect immunofluorescence in the study and diagnosis of organ-specific autoimmune diseases are also discussed. The selection is a dependable source of information for researchers interested the practical applications of immunocytochemistry in pathology and biology.

  • The Value of BCG and TNF in Autoimmunity

    • 1st Edition
    • Denise Faustman
    • English
    The Value of BCG and TNF in Autoimmunity provides an overview of current research and thinking related to tumor necrosis factor (TNF) induction and the use of the bacillus Calmette-Guérin (BCG) vaccine as potential treatment approaches to diverse forms of autoimmunity. BCG, commonly known as an anti-tuberculosis vaccine, is being explored in worldwide clinical trials as an approach to the treatment of certain forms of autoimmunity. The scope of research behind this therapeutic approach spans from the basic science of TNF signaling to research in diverse autoimmune disciplines, such as type 1 diabetes and multiple sclerosis. Overall, the book focuses on the lessons that can be learned from the researchers' individual experiences and data, and provides a rationale for bringing the inexpensive, generic BCG vaccine to the forefront of clinical trials in different forms of autoimmunity.

  • Biological DNA Sensor

    The Impact of Nucleic Acids on Diseases and Vaccinology
    • 1st Edition
    • Ken Ishii + 1 more
    • English
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

  • Computer-Aided Vaccine Design

    • 1st Edition
    • Joo Chuan Tong + 1 more
    • English
    Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.Computer-... vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.

  • Cancer Immunotherapy

    Immune Suppression and Tumor Growth
    • 2nd Edition
    • George C. Prendergast + 1 more
    • English
    There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

  • Immunotherapy with Intravenous Immunoglobulins

    • 1st Edition
    • Paul Imbach
    • English
    The use of intravenous human antibodies in the treatment of primary immunodeficiencies is well recognized. However, it is now evident that they also have therapeutic potential for a wide range of other clinical disorders. This book describes the use of human antibodies in the management of secondary (virus-induced) immunodeficiencies, neonatal and perinatal infections, and autoimmunity. Insight into their mechanism of action is also provided.

  • Synthetic Vaccines

    • 1st Edition
    • Volume 114
    • English
    Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on synthetic vaccines.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 97
    • George F. Vande Woude + 1 more
    • English
    The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, “Molecular Oncology – From Bench to Bedside,” held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein’s combined 160th birthday. To honor this occasion, this volume brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called “Foundations in Cancer Research” was initiated and the tributes honoring the Kleins’ bodies of work presented at the minisymposium are especially appropriate for the series.

  • Immunopotentiators in Modern Vaccines

    • 1st Edition
    • Virgil E.J.C. Schijns + 1 more
    • English
    Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations.

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