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Elsevier

Books in Immunotherapy

  • Emerging and Established Therapeutic Targets in Cancer Immunotherapy

    From Bench to Bedside
    • 1st Edition
    • Eyad Elkord + 1 more
    • English
    Emerging and Established Therapeutic Targets in Cancer Immunotherapy: From Bench to Bedside provides a comprehensive overview of emerging and established therapeutic targets and strategies in cancer immunotherapy. As cancer immunotherapy continues to evolve, this volume connects fundamental scientific insights with therapeutic development and clinical translation, providing a valuable resource for researchers, clinicians, and students. Chapters examine immune checkpoints, including LAG-3, TIM-3, TIGIT, and VISTA; modulation of the tumor microenvironment through targeting myeloid-derived suppressor cells, regulatory T cells, and stromal components; and emerging approaches such as neoantigen-based vaccines, multispecific antibodies, and next-generation CAR-T cell therapies. Additional chapters address tumor mutational burden, metabolic reprogramming, epigenetic regulation, and the microbiome, alongside strategies to overcome therapeutic resistance and the application of multi-omics and artificial intelligence to target discovery. Regulatory and manufacturing considerations for clinical translation are also discussed. The volume provides current scientific insights, identifies promising research directions, and offers practical guidance for developing effective immunotherapies, helping researchers design innovative experiments and accelerate drug development, and clinicians understand emerging therapies and optimize patient care. It is a vital resource for advancing the next generation of cancer immunotherapy and improving outcomes for patients worldwide.

  • Sarcoma Immunology and Immunotherapy

    From Cellular Mechanisms to Clinical Translation
    • 1st Edition
    • Joseph Crompton
    • English
    Sarcoma Immunology and Immunotherapy offers a timely and comprehensive review of the rapidly evolving field of sarcoma immunology and immunotherapy. This book serves as an essential resource for healthcare professionals, scientists, and patients, providing insights into the immunologic features of sarcoma and the latest immune-based treatments. Focussing on the recent advances, the book discusses the sarcoma microenvironment and the development of innovative immunotherapies tailored for sarcoma patients. Readers will benefit from a thorough overview of existing knowledge, encompassing foundational concepts in sarcoma immunology, a detailed examination of laboratory research, and a complete summary of ongoing immunotherapy trials. This holistic approach ensures a robust understanding of the current landscape in sarcoma research and treatment. By equipping readers with essential background information and comprehensive reviews, this book fosters a deeper understanding of sarcoma immunology and therapeutic strategies. It empowers healthcare professionals and scientists to stay abreast of critical studies, ultimately enhancing patient care and outcomes in this challenging field.

  • Microbiome and Tumorigenesis

    Dysbiosis in Different Cancers
    • 1st Edition
    • Volume 1
    • Sanjana Mehrotra + 1 more
    • English
    Microbiome and Tumorigenesis: Dysbiosis in Different Cancers examines the intricate relationship between the human microbiome and cancer. Organized into three parts, the book opens with the conceptual and ecological foundations of the human microbiome and dysbiosis, tracing how microbial imbalance contributes to tumor development. The second part examines how microbiome dysbiosis drives carcinogenesis, covering its effects on tumor immunity, the dual role of microbial metabolites as both oncogenic drivers and protective effectors, and the contribution of fungal and viral dysbiosis to cancer development and treatment. The third part surveys dysbiosis across organ-specific cancers, including gastrointestinal, skin, oral, lung, head and neck, liver, and gynecologic malignancies. This book is a valuable resource for researchers, clinicians, and students seeking to understand the complex interplay between the microbiome and cancer, with insights into potential therapeutic strategies and future research directions.

  • Immunity and Immunotherapy in Inflammatory Bowel Diseases (IBD)

    Mechanisms and Innovations
    • 1st Edition
    • Deepa S. Mandlik + 1 more
    • English
    Covers detailed disease mechanisms and the full spectrum of immune cell biology, through to advanced clinical applications The book highlights the latest advances in immunotherapy, including cell-based and next-generation treatments. Immunity and Immunotherapy in Inflammatory Bowel Diseases (IBD): Mechanisms and Innovations bridges laboratory research with clinical practice, addressing diagnostics, biomarkers and real-world patient care. It tackles current challenges in IBD, such as therapy resistance, the integration of AI and multi-omic approaches. What sets this book apart is its extensive, up-to-date coverage of all immunotherapeutic strategies, such as monoclonal antibodies, cytokine inhibitors, JAK inhibitors, cell-based therapies, and novel targets such as CAR-T cells and immune checkpoint modulators. It also addresses emerging technologies, personalized medicine, resistance mechanisms, safety, and the gut microbiome, providing a holistic view of current and future directions in IBD immunotherapy.

  • Immunotherapy for Autoimmune Disorders

    Innovations and Insights
    • 1st Edition
    • Arun Kumar Singh + 4 more
    • English
    Immunotherapy for Autoimmune Disorders: Innovations and Insights revolutionizes the therapeutic paradigm for autoimmune illnesses, offering new perspectives over traditional medication therapies. This complete and accessible resource examines how immunotherapy teaches the immune system to detect and fight targeted cells, enhancing the body's immune response by providing additional components to strengthen its defense mechanisms. The book covers a wide range of topics, including the pathophysiology, diagnosis, and classification of autoimmune diseases, the immunopathogenesis of these disorders, and the development and application of monoclonal antibodies. It explores immune checkpoint inhibitors, T-cell modulation therapies, cytokine targeting therapies, B-cell depletion strategies, and more.Additionally, it addresses immunomodulatory agents, small molecules, personalized immunotherapy approaches, and the application of immunotherapeutic strategies for specific autoimmune diseases. Future directions and emerging therapies, as well as regulatory and ethical considerations, are also discussed. This is essential reading for medical professionals, researchers, and students seeking to learn about immunotherapy as an alternative approach to treating autoimmune disorders.

  • The Microbiome and Cancer Treatment

    Overcoming Resistance and Enhancing Efficacy
    • 1st Edition
    • Sadhna Aggarwal + 3 more
    • English
    The Microbiome and Cancer Treatment: Overcoming Resistance and Enhancing Efficacy delves into the intricate relationship between the microbiome and cancer treatment, highlighting the microbiome's critical role in drug resistance and therapeutic efficacy. The book's chapters are meticulously organized to provide a deep understanding of how the microbiome interacts with the immune system and influences cancer development and response to therapies. This book opens new avenues for investigation by providing a better understanding of the mechanisms of resistance and the role of microbiome alterations in chemoresistance.Sect... also address the complex "chicken-or-egg" relationship between microbiome alterations and chemoresistance. A diverse blend of chapters foster interdisciplinary collaboration across fields such as immunology, microbiology, oncology, and pharmacology, promoting holistic approaches to cancer treatment. Readers will benefit by gaining awareness and a better understanding of how the microbiome impacts health, particularly in the context of cancer, leading to more informed health choices.

  • Inflammation and Cancer

    Mechanisms, Diagnosis, and Therapeutic Strategies
    • 1st Edition
    • Anoop Kumar + 4 more
    • English
    Inflammation and Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies delves into the intricate relationship between inflammation and cancer, a crucial area of contemporary biomedical research. Sections provide an overview of inflammation's role in cancer, discussing molecular connections and signaling pathways. Chapters explore inflammatory pathways in various cancers, including breast, oral, lung, prostate, skin, and gastrointestinal cancers. The book also covers tumorigenesis, metastasis, preventive strategies, inflammatory biomarkers for cancer diagnosis, and innovative therapeutic designs. Final chapters focus on the dual role of platelets, targeting tumor-associated macrophages, novel treatment approaches, and recent advances in the field.This title offers substantial benefits to researchers, clinicians, and healthcare professionals by providing a thorough understanding of the cellular and molecular pathways linking inflammation and cancer, aiding in the development of effective anti-cancer immunotherapies. By highlighting the latest research and potential therapeutic strategies, this book serves as an essential resource for anyone dedicated to combating cancer through innovative and informed immunotherapeutic approaches.

  • Immunity to Immunotherapy in Cancer

    Mechanisms and Limitations
    • 1st Edition
    • Mukesh Nandave + 1 more
    • English
    Immunity to Immunotherapy in Cancer: Mechanisms and Limitations explores the intricate interplay between cancer therapy and the immune system, addressing why some patients do not respond to immunotherapy and scientific solutions in development. The book examines molecular strategies of immune evasion within the tumor microenvironment, providing insights into factors like tumor heterogeneity and immune checkpoint mechanisms that contribute to resistance. Highlighting promising approaches such as combination therapies, personalized medicine, and novel immunotherapeutic agents, the book aims to enhance patient outcomes and advance cancer immunotherapy.Design... as a comprehensive guide for professionals and researchers, this textbook offers an overview of the latest scientific discoveries and practical applications in cancer therapy. It serves as an invaluable resource for scientists, doctors, academicians, and students, presenting a path toward more effective, non-toxic, and customized cancer treatments. This book is essential for anyone interested in the future of cancer therapy.

  • Role of Medicinal Plants in Autoimmune Diseases

    Concepts, Perspectives, and Utilization
    • 1st Edition
    • Reetika Mahajan + 4 more
    • English
    Role of Medicinal Plants in Autoimmune Diseases: Concepts, Perspectives, and Utilization provides comprehensive knowledge of autoimmune diseases and the role of various medicinal plant products in their treatment. The book discusses the immune system as a group of complex biological structures and processes in an organism which gives protection against a wide range of pathogenic organisms while simultaneously distinguishing these pathogens from the organism’s own healthy cells and tissues, thus maintaining homeostasis in the body.It has been an age-old practice to use extracts and other parts of various plants in treating many diseases. Several plants contain various pharmacologically active substances which can be used to treat different diseases. Among these medicinal plants, many have shown good immunomodulatory properties and could act as natural immunosuppressant agents in treating autoimmune disorders.

  • Nanomedicine in Cancer Immunotherapy

    • 1st Edition
    • Prashant Kesharwani
    • English
    Nanomedicine in Cancer Immunotherapy bridges the two disciplines of nanotechnology and immunology, summarizing the latest research into novel cancer treatments, often personalized to the patient. The book covers a wide range of nanomaterial types for use in cancer immunotherapy, including hydrogel, lipid, exosome, gold and peptide nanoparticles. The preparation, application, pros and cons of each nanomaterial class is reviewed, helping the reader understand the potential for each to tailor their own selections. Nanovaccines are also covered, along with a clinical evaluation and market analysis of nanomedicines for immunotherapy, offering an important clinical and commercial overview of this rapidly developing field.This book is an interesting reference for those working in the fields of nanotechnology, immunology, and cancer therapeutics, as well as clinicians with an interest in novel nano-based cancer treatments.

  • In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment

    Modeling and Simulation
    • 1st Edition
    • Muhammad Suleman
    • English
    In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.

  • Nanotheranostics for Treatment and Diagnosis of Infectious Diseases

    • 1st Edition
    • Keerti Jain + 1 more
    • English
    Nanotheranostics for Treatment and Diagnosis of Infectious Diseases comprises the latest information on the technological advancements made in the field of nanotechnology for application in therapeutics with diagnostic applications. The book focuses on the theranostic applications of nanomaterials in infectious diseases, highlighting that rapid diagnosis, safe and effective treatment and strong preventive measures like vaccines are urgently needed. It compiles all relevant information to help scientists, researchers and students understand the role of nanomaterials, how nanomaterials could be explored simultaneously for therapeutic and diagnostic applications, and how to ensure safety and efficacy of these nanomaterials. Sections cover fundamental concepts, emerging concerns and challenges to combat infectious diseases, the characterization of nanomaterials for theranostic applications, and the toxicity, biocompatibility and regulatory perspectives in the diagnosis and treatment of infectious diseases.

  • Basics of Chimeric Antigen Receptor (CAR) Immunotherapy

    • 1st Edition
    • Mumtaz Y. Balkhi
    • English
    Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field.

  • Immunotherapy of Cancer

    • 1st Edition
    • Volume 128
    • English
    Immunotherapy of Cancer provides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology.

  • Immunotherapy with Intravenous Immunoglobulins

    • 1st Edition
    • Paul Imbach
    • English
    The use of intravenous human antibodies in the treatment of primary immunodeficiencies is well recognized. However, it is now evident that they also have therapeutic potential for a wide range of other clinical disorders. This book describes the use of human antibodies in the management of secondary (virus-induced) immunodeficiencies, neonatal and perinatal infections, and autoimmunity. Insight into their mechanism of action is also provided.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 97
    • George F. Vande Woude + 1 more
    • English
    The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. A very special event the Nobel Minisymposium, “Molecular Oncology – From Bench to Bedside,” held at the Karolinska Instituet, in Stockholm, Sweden, was marked the celebration of George and Eva Klein’s combined 160th birthday. To honor this occasion, this volume brings together contributions by their former students, colleagues and collaborators of the past fifty years into a volume of Advances in Cancer Research dedicated to George and Eva. Over a decade ago, a subdivision of ACR called “Foundations in Cancer Research” was initiated and the tributes honoring the Kleins’ bodies of work presented at the minisymposium are especially appropriate for the series.

  • Cancer Immunotherapy

    • 1st Edition
    • Volume 90
    • James Allison + 1 more
    • English
    For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens. This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

  • Practical Guidelines in Antiviral Therapy

    • 1st Edition
    • G.J. Galasso + 3 more
    • English
    This text was developed with the practicing physician in mind, however, it will be of considerable interest to the virologist, pharmacologist, chemist and all scientists interested in antiviral agents. Progress in the field of antiviral development is now moving rapidly and there is hope that one day there will be successful treatment modalities for most viral diseases. This work contains contributions from experts around the world, capturing worldwide practices. An online version providing the current status of antiviral research is planned for the near future.