In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment
Modeling and Simulation
- 1st Edition - February 28, 2023
- Imprint: Academic Press
- Author: Muhammad Suleman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 2 8 6 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 2 8 7 - 2
In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly an… Read more
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Request a sales quoteIn Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis.
This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications.
- Includes the diversities of cancer treatment modalities for their eradication with minimum damage to surrounding normal tissue
- Addresses tumors of different organs including liver, brain and breast
- Deals with mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies
- Provides insights on how to use hyperthermia in cancer treatments in addition to other conventional types of treatments
Oncologists, Bio-medical Engineers, Clinicians, MBBS Doctors, Nanotechnologists. Mathematical modelers in biology, Life sciences scientists, Physicists, Academicians
- Cover
- Title page
- Table of Contents
- Copyright
- Introduction
- Chapter 1: Basics of magnetic fluid hyperthermia
- Abstract
- 1.1: What is nanoscience and nanotechnology?
- 1.2: Basic types of biological experiments
- 1.3: Fundamental types of cancer and its statistics
- 1.4: Traditional techniques used for cancer treatment
- 1.5: Hyperthermia
- 1.6: Major types of hyperthermia
- 1.7: Magnetic nanoparticles (MNPs) and hyperthermia
- 1.8: Synthesis of MNPs
- 1.9: Loading MNPs at the tumor site
- 1.10: Types of flow
- 1.11: Blood vessels
- References
- Chapter 2: Historical background of magnetic fluid hyperthermia
- Abstract
- 2.1: Mathematical modeling approach toward MFH
- 2.2: Analytical modeling of MFH
- 2.3: Numerical modeling of MFH
- 2.4: Optimization in MFH
- 2.5: Integrated therapies
- 2.6: In vivo experimental studies of MFH
- 2.7: In vitro experimental studies on MFH
- 2.8: Case study on MFH
- References
- Chapter 3: The phenomena of heat dissipation by magnetic nanoparticles under applied magnetic field
- Abstract
- 3.1: The force acting on nanoparticles under an applied magnetic field
- 3.2: Maxwell's equations of electromagnetism
- 3.3: The magnetic vector potential
- 3.4: The scalar electric potential
- 3.5: Hysteresis curve and coercivity
- 3.6: Neel and Brownian relaxation
- 3.7: Heat dissipation by MNPs
- 3.8: Different heating sources used in magnetic fluid hyperthermia
- References
- Chapter 4: Mathematical models of physical processes involved in magnetic fluid hyperthermia
- Abstract
- 4.1: Modeling nanofluid flow in the injecting needle
- 4.2: Modeling nanofluid infusion in the tumor interstitium
- 4.3: Modeling nanofluid diffusion in the tumor interstitium
- 4.4: Modeling transfer of heat in the body tissue
- 4.5: Modeling estimation of a fraction of tumor injury
- 4.6: Physical properties of the nanofluid
- 4.7: Flux of the nanofluid
- 4.8: Nanofluid's mass concentration
- 4.9: Boundary conditions (BCs)
- 4.10: Initial conditions (ICs)
- References
- Chapter 5: Mathematical modeling and simulation of magnetic fluid hyperthermia of liver tumor
- Abstract
- 5.1: Mathematical modeling formulation of the problem
- 5.2: Results
- 5.3: Conclusions
- References
- Chapter 6: Modeling thermal therapy of poroelastic brain tumor using magnetic nanoparticles
- Abstract
- 6.1: Problem statement and strategy to handle the problem
- 6.2: Deformation of poroelastic tumor
- 6.3: Transport of the nanofluid in poroelastic tumor
- 6.4: Heat produced by the MNPs in the poroelastic brain tissue
- 6.5: Heat transfer in poroelastic brain tissue
- 6.6: The degree of tumor injury
- 6.7: Implementation in COMSOL multiphysics
- 6.8: Results and discussions
- 6.9: Conclusions
- References
- Chapter 7: Finite element modeling analysis of hyperthermia of female breast cancer in three dimensions
- Abstract
- 7.1: Physical properties of nanofluid
- 7.2: Mathematical modeling formulation of the problem
- 7.3: Sensitivity analysis
- 7.4: The AMF generated by the coil
- 7.5: Results
- 7.6: Conclusions
- References
- Chapter 8: Mathematical modeling and simulation of enhanced permeation and retention (EPR) effect with thermal analysis
- Abstract
- 8.1: Physical properties of nanofluid
- 8.2: Mathematical modeling formulation of the problem
- 8.3: Results and discussions
- 8.4: Conclusions
- References
- Chapter 9: Simulating the nanoflow around Happel's sphere in the porous tumor carrying the cell-model structure
- Abstract
- 9.1: Physical properties of nanofluids
- 9.2: Mathematical modeling formulation of the problem
- 9.3: Results
- 9.4: Conclusions
- References
- Chapter 10: Computational analysis of the reacting nanofluid in the porous tumor
- Abstract
- 10.1: Properties of nanofluid
- 10.2: Mathematical modeling formulation of the problem
- 10.3: Adding physics and geometry construction of the problem
- 10.4: Adding initial condition, boundary conditions, and material
- 10.5: Mesh generation of the problem
- 10.6: Results and discussions
- 10.7: Conclusions
- References
- Chapter 11: Thermal therapy of cylindrical tumor with optimization using Nelder-Mead method
- Abstract
- 11.1: Materials and methods
- 11.2: Nanofluid and its properties
- 11.3: Mathematical modeling formulation of the problem
- 11.4: Results
- 11.5: Conclusions
- References
- Supplementary material: Appendix A
- Supplementary material: Appendix B
- Supplementary material: Appendix C
- Supplementary material: Appendix D
- Supplementary material: Appendix E
- Heat produced by Fe3Q4 MXPs in the tumor
- Conclusions
- Future work
- Index
- Edition: 1
- Published: February 28, 2023
- Imprint: Academic Press
- No. of pages: 206
- Language: English
- Paperback ISBN: 9780443132865
- eBook ISBN: 9780443132872
MS
Muhammad Suleman
Dr. Muhammad Suleman PhD is currently working as senior faculty member at the department of Mathematics, Riphah Institute of Computing and Applied Science (RICAS), Riphah International University, Lahore, Pakistan. He has completed his Ph.D. in Mathematics with specialization in mathematical modeling and simulation of biological phenomena in 2022 from University of Engineering & Technology, Lahore, Pakistan. He is active researcher and is involved in many research activities. He has published quality research articles in reputed journals which are being flowing by many clinicians, modelers, scientists, and biomedical engineers
Affiliations and expertise
Senior Faculty Member, Department of Mathematics, Riphah Institute of Computing and Applied Science (RICAS), Riphah International University, Lahore, PakistanRead In Silico Approach Towards Magnetic Fluid Hyperthermia of Cancer Treatment on ScienceDirect