Books in Medicinal chemistry

Drug Discovery Stories, Volume 2

1st Edition
October 1, 2025
Bin Yu + 1 more
English

The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. By showcasing how their work is utilized or has the potential to be utilized in the realm of drug discovery, this series intends to foster interdisciplinary collaboration and knowledge exchange. Considering the dynamic nature of drug discovery and development, where progress is swift and continuous, the authors have planned to release updated editions of the book every few years, ensuring that the content remains up to date with the latest achievements and breakthroughs in the field. Drug Discovery Stories, Volume 2 presents drug discovery stories of blockbuster drugs recently approved (2023-2024) and other promising drug candidates, including the structural biology and biological functions of the targets of interest, the identification of hit compounds, hit-to-lead optimization, binding mode of the key compounds with the target of interest (practically those guiding the drug design), key biological and PK data of lead compounds, clinical results if any, other candidate compounds in preclinical and clinical stage against the same target, and other contents that the authors want to include based on their choices.

Advances in Treatment Methods Towards Emerging Contaminants

1st Edition
October 1, 2025
Nabisab Mujawar Mubarak + 3 more
English

Advances in Treatment Methods Towards Emerging Contaminants: Sources, Occurrences and Health Effects serves as a comprehensive guide to all aspects of emerging contaminant detection, monitoring, analysis, and remediation. This book provides a theoretical overview and practical guidance for researching all the fundamental aspects of emerging contaminants including transformations and toxicology of emerging pollutant and contaminants. In addition to outlining recent advances to existing detection techniques to monitor emerging contaminants, this book provides case studies for new remediation, transformation and monitoring techniques, including those that utilize green technology and nanotechnology. Advances in Treatment Methods Towards Emerging Contaminants will be a valuable guide for researchers, academics and industry experts working with environmental monitoring end emerging contaminants – including chemists and chemical engineers working on new analysis and remediation or transformation strategies to tackle the removal of environmental contaminants. This book will also be a useful guide to policy makers looking at pollution and contaminant control measures or students at graduate level and above working in waste treatment and remediation.

Amines to Azetidines

1st Edition
September 1, 2025
Navjeet Kaur
English
Paperback
9 7 8 0 4 4 3 2 7 6 8 4 2
eBook
9 7 8 0 4 4 3 2 7 6 8 5 9

Amines to Azetidines provides a comprehensive exploration of diverse synthetic routes for the preparation of azetidines from various amine-bearing compounds. Chapters offer a detailed analysis of key methodologies including addition reactions of amines to alkenes and alkynes, condensation reactions involving acid and amine moieties, and unique approaches combining amine and alcohol functionalities. The book explores the synthesis of β-lactams, a class of compounds with pharmaceutical significance, through the condensation of amine and alcohol moieties, while also examining the synthesis of azetidines from halo-substituted amine compounds. By presenting a systematic overview of synthetic strategies, this book serves as a valuable resource for researchers, chemists, and practitioners seeking to broaden their understanding of azetidine synthesis and explore innovative approaches to chemical transformations involving amines and related functional groups.

Robust Theoretical Models in Medicinal Chemistry

1st Edition
August 7, 2025
Luciana Scotti + 1 more
English
Paperback
9 7 8 0 4 4 3 2 7 4 2 0 6
eBook
9 7 8 0 4 4 3 2 7 4 2 1 3

Robust Theoretical Models in Medicinal Chemistry: QSAR, Artificial Intelligence, Machine Learning, and Deep Learning serves as a valuable resource chock full of applications extending into multiple knowledge domains. The meticulous construction of a robust model holds significance, not only in drug discovery but also in engineering, chemistry, pharmaceutical, and food-related research, illustrating the broad spectrum of fields where QSAR methodologies can be instrumental. The activities considered in QSAR span chemical measurements and biological assays, making this approach a versatile tool applicable across various scientific domains. Currently, QSAR finds extensive use in diverse disciplines, prominently in drug design and environmental risk assessment.Quantitative Structure-Activity Relationships (QSAR) represent a concerted effort to establish correlations between structural or property descriptors of compounds and their respective activities. These physicochemical descriptors encompass a wide array of parameters, accounting for hydrophobicity, topology, electronic properties, and steric effects, and can be determined empirically or, more recently, through advanced computational methods.

Drug Discovery and One Health Approach in Combating Infectious Diseases

1st Edition
August 1, 2025
Kanti Bhooshan Pandey + 2 more
English
Paperback
9 7 8 0 4 4 3 2 7 4 6 1 9
eBook
9 7 8 0 4 4 3 2 7 4 6 2 6

Drug Discovery and One Health Approach in Combating Infectious Diseases: A Multi-sectoral Approach to address Infections explores the intersection of drug discovery and the One Health Approach, along with the effectiveness of interdisciplinary approaches to combating infectious diseases. The book covers both holistic and innovative drug discovery methodologies and technologies such as natural compounds, harnessing genomics, proteomics, and nanotechnology. Additionally, the book reviews zoonotic diseases, vaccine development, ethical considerations, and regulatory pathways. Practice case studies demonstrate successful One Health and interdisciplinary initiatives to combating infectious disease.This catalogue of knowledge provides a toolbox of innovative and interdisciplinary solutions of complex issues in drug discovery and infectious disease. It will be a valuable resource to professionals and researchers working in the fields of biomedical sciences, pharmaceutical sciences, infectious disease research, and public health, as well as those engaged in drug discovery, development, and the management of infectious diseases.

Photonic Sensors for Detection of VOC Biomarkers

1st Edition
August 1, 2025
Sridhar Krishnaswamy + 2 more
English
Paperback
9 7 8 0 4 4 3 2 9 1 6 6 1
eBook
9 7 8 0 4 4 3 2 9 1 6 7 8

VOCs available in exhaled human breath are the products of metabolic activity in the body and, therefore, any changes in their control level can be utilized to diagnose specific diseases. More than 1000 VOCs have been identified in exhaled human breath along with the respiratory droplets which provide rich information on overall health conditions. This book cover the introductory information on VOCs, their source in the human body, associated diseases, potential sensing materials used for selective detection, and the advancement in their sensing technology. These VOCs offer great potential as a biomarker for a disease that can be sampled non-invasively from exhaled breath with breath biopsy. However, it is still a great challenge to develop a rapid responsive, highly selective, and sensitive VOC-sensing system. This book analyzes all the challenges and their possible solutions that can be used to achieve target-specific detection and real-time monitoring of the VOC molecules in the exhaled breath. It also covers a detailed discussion of all the sensing materials developed for selective and sensitive detection of VOC molecules and their integration with photonic devices in order to develop miniature technology. It covers various miniature sensing systems that are being exploited in VOC sensing such as interferometer, Bragg grating, microstructured fiber, 3D printed optical sensing systems, etc. The book will also provide an overview of the FEM technique and computation methods used to optimize the optical sensing devices before their practical realization. Photonic sensors for detection of VOC biomarkers aims to provide comprehensive information to early career professionals and boost their existing knowledge in the area of Chemistry and Biomedical Engineering.

Discovery and Development of Anti-Prostate Cancerous Agents from Natural Products

1st Edition
February 17, 2025
Goutam Brahmachari
English
Paperback
9 7 8 0 4 4 3 2 1 8 4 2 2
eBook
9 7 8 0 4 4 3 2 1 8 4 3 9

Discovery and Development of Anti-Prostate Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This new volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogues that show promising potential to act as anti-prostate cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.It will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for prostate cancer, highlighting several key structures from natural products and exploring possible future developments in the area.

Human Microbiome Drug Targets

1st Edition
October 23, 2024
Genevieve Dable-Tupas + 3 more
English
Paperback
9 7 8 0 4 4 3 1 5 4 3 5 5
eBook
9 7 8 0 4 4 3 1 5 4 3 6 2

Human Microbiome Drug Targets: Modern Approaches in Disease Management presents fundamental information on the human microbiome, looking into the relationship between the microbiome and how it changes with specific diseases. Delving into the multifaceted roles of the microbiome in health and disease, the book's chapters discuss the role of the human microbiome in the pathophysiologic understanding of relevant diseases or disorders and their management. As changes in the human microbiome can provide clues to the probable cause and effect of diseases or disorders, as well as the impacts of therapy or intervention, this book is a welcomed addition to the existing research.Explaining how a better understanding of the microbiome and its impact on health and disease can pave the way for future discoveries leading to better health outcomes, this book will be of interest to drug developers, medicinal chemists, microbiologists, infectious disease specialists, biochemists, and students.

Progress in Medicinal Chemistry

1st Edition
Volume 63
October 4, 2024
Jonathan Bentley + 1 more
English
Hardback
9 7 8 0 4 4 3 2 9 7 8 0 9
eBook
9 7 8 0 4 4 3 2 9 7 8 1 6

Progress in Medicinal Chemistry, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this release include Harnessing conformational drivers in drug design, Recent Advances in the Medicinal Chemistry of Heterobifunctional Derivatives for Protein Homeostasis, and A Decade of Antimalarial Drug Discovery: New Targets, Tools and Molecules.

Advances in Prodrugs

1st Edition
September 25, 2024
Claudiu Trandafir Supuran + 2 more
English
Paperback
9 7 8 0 4 4 3 1 5 6 3 5 9
eBook
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Advances in Prodrugs: Design and Therapeutic Applications provides a versatile tool in prodrug design and development as well as a concrete perspective on clinical and preclinical studies currently available on prodrugs. The first part of this book discusses different chemical classes of prodrugs, with particular emphasis on metabolic pathways and mechanisms involved in the activation of their functional groups. The second part of the book covers therapeutic applications of prodrugs against the most discussed diseases, providing detailed discussion on recent achievements in the field. This book offers researchers involved in drug discovery key criteria for the successful development of prodrug-based therapeutic tools.Prodrugs are inactive drug precursors which undergo different chemical transformation by metabolic processes to provide pharmacologically active compounds. Prodrugs include a broad range of structurally diverse molecules employed for the treatment of several diseases.

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