Phosphonate Chemistry: Technology and Applications gathers important information on the synthetic aspects of phosphonic acids, metal phosphonate hybrid materials, phosphonates as scale inhibitors, phosphonates as corrosion inhibitors, catalytic properties of metal phosphonates, magnetic and optical properties of metal phosphonates, phosphonates as drugs for calcium-related disorders, metal-bisphosphonates as controlled release systems, metal phosphonates for energy applications, gas capture and storage, imaging applications, electrocatalytic transformations, water splitting, sensing applications, for photodynamic applications, and several others.This comprehensive book includes crucial bibliographic information and covers the latest developments of the past decade. Expanding its thematic scope significantly, it explores the world of organic phosphonate compounds, surpassing conventional boundaries. This exploration includes diverse applications derived from these compounds, enhancing the reader's grasp of this dynamic and evolving field.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
The field of drug discovery and development has experienced rapid evolution, with numerous new drugs receiving approval each year. While several books have been published on this subject, there is a pressing need for a new book series that accurately reflects the current advancements in drug discovery. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology. By showcasing how their work is utilized or has the potential to be utilized in the realm of drug discovery, this series intends to foster interdisciplinary collaboration and knowledge exchange. Considering the dynamic nature of drug discovery and development, where progress is swift and continuous, the authors have planned to release updated editions of the book every few years, ensuring that the content remains up to date with the latest achievements and breakthroughs in the field. Drug Discovery Stories, Volume 2 presents drug discovery stories of blockbuster drugs recently approved (2023-2024) and other promising drug candidates, including the structural biology and biological functions of the targets of interest, the identification of hit compounds, hit-to-lead optimization, binding mode of the key compounds with the target of interest (practically those guiding the drug design), key biological and PK data of lead compounds, clinical results if any, other candidate compounds in preclinical and clinical stage against the same target, and other contents that the authors want to include based on their choices.
Advances in Treatment Methods Towards Emerging Contaminants: Sources, Occurrences and Health Effects serves as a comprehensive guide to all aspects of emerging contaminant detection, monitoring, analysis, and remediation. This book provides a theoretical overview and practical guidance for researching all the fundamental aspects of emerging contaminants including transformations and toxicology of emerging pollutant and contaminants. In addition to outlining recent advances to existing detection techniques to monitor emerging contaminants, this book provides case studies for new remediation, transformation and monitoring techniques, including those that utilize green technology and nanotechnology. Advances in Treatment Methods Towards Emerging Contaminants will be a valuable guide for researchers, academics and industry experts working with environmental monitoring end emerging contaminants – including chemists and chemical engineers working on new analysis and remediation or transformation strategies to tackle the removal of environmental contaminants. This book will also be a useful guide to policy makers looking at pollution and contaminant control measures or students at graduate level and above working in waste treatment and remediation.
Advances in Organometallic Chemistry, Volume 84, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Chapters in this new release include Pd-catalysis: a useful tool in the field of polymer synthesis. Recent advances and applications, Modern Mechanistic Approaches for the Depolymerization of Commodity Plastics via Homogeneous Metal Catalysis, Functionalization of fullerenes by transition metal catalyzed cyclization reactions, and Synergistic Metal-Ligand Reactivity in Half-Sandwich Complexes of Fe, Co, and Ni for Bond Activation and Catalysis.
The Organic Chemistry of Drug Design and Drug Action, Fourth Edition presents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action. The book's coverage allows readers to extrapolate core principles and mechanisms to many related classes of drug molecules. It reflects the significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while also including significant changes in format and coverage.It is designed for undergraduate and graduate students in chemistry who are studying medicinal chemistry or pharmaceutical chemistry. Users, including research chemists and biochemists working in pharmaceutical and biotechnology industries will find this update to be useful in their daily work.
Amines to Azetidines provides a comprehensive exploration of diverse synthetic routes for the preparation of azetidines from various amine-bearing compounds. Chapters offer a detailed analysis of key methodologies including addition reactions of amines to alkenes and alkynes, condensation reactions involving acid and amine moieties, and unique approaches combining amine and alcohol functionalities. The book explores the synthesis of β-lactams, a class of compounds with pharmaceutical significance, through the condensation of amine and alcohol moieties, while also examining the synthesis of azetidines from halo-substituted amine compounds. By presenting a systematic overview of synthetic strategies, this book serves as a valuable resource for researchers, chemists, and practitioners seeking to broaden their understanding of azetidine synthesis and explore innovative approaches to chemical transformations involving amines and related functional groups.
Advances in Heterocyclic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
The Alkaloids: Chemistry and Biology, Volume 94, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on topics such as guanidine alkaloids from marine sponges, the chemistry and biology of imidazole, oxazole, and thiazole alkaloids, quinoline and quinazoline alkaloids, pyrazole and indazole alkaloids, and Stemona alkaloids, offering valuable insights into their structures, biosynthesis, and biological activities.
Azetidine Synthesis offers a comprehensive exploration of various methods for the synthesis of azetidines, a class of heterocyclic compounds with diverse applications. Specifically, the significance of azetidine synthesis has grown largely due to the importance of these molecules as constituents of antibiotics. Chapters cover different synthetic pathways, starting with the general synthesis of azetidines and progressing to specific methods using various starting materials. From the copper-catalyzed synthesis of azetidines from nitrones to the synthesis from isoxazoles, oxazines, and diazo compounds, each chapter delves into the unique strategies and mechanisms involved. Rhodium-catalyzed approaches, cycloaddition reactions of imines to carbonyl compounds, and the use of isocyanides and isocyanates for azetidine synthesis are discussed in detail. The book also explores photochemical methods for azetidine synthesis, including the photochemical synthesis of fused azetidines. By providing a comprehensive overview of diverse synthetic routes to azetidines, this book serves as a valuable resource for researchers and practitioners in the field of organic chemistry, offering insights into the versatility and potential applications of these important heterocyclic compounds.