Chalcone is one of the most versatile scaffolds with wide range of applications. It is used as a precursor for diverse classes of organic molecules, natural flavonoids and possesses interesting biological activities and physical properties like semiconductor, non-linear optical, fluorescence, and electronic properties to name a few. Chalcones have been the subject of intense research due to their biological activities and the ability to tweak their biological activity and other properties by small changes along the a, b-unsaturated backbone. Besides their inherent biological activities, they have found uses in food industry and cosmetic industry as additives, due to their UV protection properties. They have also found applications as chemosensors and probes. These diverse features make chalcones one of the most fascinating molecules Chalcones and their Derivatives: From Synthesis to Applications features this molecule, different methods and approaches to synthesis, significance of this scaffold in biology, and other diverse fields. It serves as a comprehensive literature guide for researchers and a reference material for the postgraduate students involved with the development and use of chalcone based molecules.
Over the past 50 years, more than 20,000 natural compounds have been identified in the marine environment, with an increasing focus on marine metabolites as potential sources for developing effective therapeutic agents. The field of marine drug discovery has seen remarkable growth in recent years, with numerous marine-derived therapeutic candidates in various stages of clinical trials or awaiting approval. The ocean is a potential source of natural products with diverse pharmacological properties, including antimicrobial, anticancer, antiviral, antioxidative, and anti-inflammatory activities. However, commercializing marine natural products has been challenging due to low yields and specificity of specialized (secondary) metabolites. Marine Specialized (Secondary) Metabolites and their Diverse Applications provides a broad overview of marine specialized metabolites and their potential in various industries. With comprehensive coverage, relevance to current trends, interdisciplinary approach, and practical applications, this book includes specific compounds or organisms, with a particular focus on addressing the challenges and limitations associated with them.
Antidiabetic Drug Discovery from Natural Products provides up-to-date and in-depth information, practical understanding, and guidance in a comprehensive, systematic and easy-to-understand manner to scientists, researchers, and graduate students on important and emerging biochemical topics related to current antidiabetic drug discovery research. This book analyzes and studies natural active substances and their medicinal chemistry in preventing and treating diabetes and its complications. It covers a wide range of critical issues to assist chemists in the discovery and development of safer, more affordable treatments, from identifying promising leads from medicinal plants to the extraction and synthesis of bioactive compounds.Following an introduction to bioactive chemical compounds from plants with antidiabetic effects, the book describes the discovery and extraction of antidiabetic drugs and antioxidants from natural sources. It also examines antidiabetic plants before delving deeper into the chemistry behind major medicinal substances and their derivatives like Mangiferin and Resveratrol, discussing both current and prospective uses.
Advances in Organometallic Chemistry, Volume 83, the latest release in this longstanding serial, is known for its comprehensive coverage of topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. Chapters in this new release include Pd-catalysis: a useful tool in the field of polymer synthesis. Recent advances and applications, Modern Mechanistic Approaches for the Depolymerization of Commodity Plastics via Homogeneous Metal Catalysis, Functionalization of fullerenes by transition metal catalyzed cyclization reactions, and Synergistic Metal-Ligand Reactivity in Half-Sandwich Complexes of Fe, Co, and Ni for Bond Activation and Catalysis.
The Organic Chemistry of Drug Design and Drug Action, Fourth Edition presents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action. The book's coverage allows readers to extrapolate core principles and mechanisms to many related classes of drug molecules. It reflects the significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while also including significant changes in format and coverage.It is designed for undergraduate and graduate students in chemistry who are studying medicinal chemistry or pharmaceutical chemistry. Users, including research chemists and biochemists working in pharmaceutical and biotechnology industries will find this update to be useful in their daily work.
Phytochemicals for Health presents the state of the art in the field of Phytochemicals. It highlights how, following the interactions of plants and the environment, an analytical approach for standardization and quality control is of fundamental importance to product quality control.Parts I and II cover the main problems relatied to natural products (plants, extraction, quantitative analysis, relationship with the surrounding environment). Part III presents the main classes of organic compounds identified and reported, and Part IV includes inorganic compounds. It also includes a chapter covering all the natural compounds that have become Active Principle Ingredients (API), highlighting next challenges.Phytochemicals for Health is a valuable tool for senior scientists working in natural products field interested in investigating the correlation between chemical profile and biological activity in order to obtain a product that is safe for human health.
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.Studies in Natural Products Chemistry, volume 84 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Advances in Heterocyclic Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.
The Alkaloids: Chemistry and Biology, Volume 93, the latest release in a series that has been exploring the topic for over 60 years, delves into key aspects of alkaloid chemistry, biology, and pharmacology. This volume discusses the chemistry of quinoline and quinazoline alkaloids, guanidine alkaloids from marine sponges, the chemistry and biology of stemona alkaloids, and the chemistry and biology of pyrazole and indazole alkaloids.
Discovery and Development of Anti-Prostate Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This new volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogues that show promising potential to act as anti-prostate cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.It will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for prostate cancer, highlighting several key structures from natural products and exploring possible future developments in the area.