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Books in Bioorganic chemistry

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    • Advances in Microscale Electro- and Liquid Phase-Based Separation Techniques

      • 1st Edition
      • Ziad El Rassi
      • English
      Advances in Microscale Electro- and Liquid Phase-Based Separation Techniques comprehensively summarizes Microscale separation techniques characterized by fast, high resolution, and high efficiency with very reduced sample and solvent consumption. Microscale separation is a rapidly evolving field with a need for high efficiency techniques to reduce the production of hazardous waste. The book summarizes the existing body of knowledge, including hyphenated version to mass spectrometry (cLC-MS), capillary electrophoresis (CE), capillary zone electrophoresis (CZE and CZE-MS), micellar electrokinetic capillary chromatography (MEKC), capillary gel electrophoresis (CGE), capillary isoelectric focusing (CIEF) and capillary isotachophoresis (CITP), and capillary electrochromatograph... (CEC), as well as microfluidics and microchips. The book then demonstrates the applicability of these techniques to existing and future problems in the analysis of complex mixtures of biochemicals, pharmaceuticals, environmental, and natural products. Advances in Microscale Electro- and Liquid Phase-Based Separation Techniques is valuable to separation scientists, applications scientists, and technicians industrial outlets such as pharmaceuticals, biomedicals, biotechnologies, food, and environmental, as well as students and professors study separation techniques.

    • Antimicrobial Peptides

      A Roadmap for Accelerating Discovery and Development
      • 1st Edition
      • Luis H. Reyes + 2 more
      • English
      Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide.Discoverin... novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.

    • Glycosphingolipids in the Central Nervous System

      Diversity in Structure, Metabolism, Distribution, and Function
      • 1st Edition
      • Zhongwu Guo
      • English
      Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity.

    • Semisynthesis of Bioactive Compounds and their Biological Activities

      • 1st Edition
      • Sasadhar Majhi + 1 more
      • English
      Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented. Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.

    • Advances in Bioorganometallic Chemistry

      • 1st Edition
      • Toshikazu Hirao + 1 more
      • English
      Advances in Bioorganometallic Chemistry examines the synthesis, structure and reactivity of bioorganometallics, their pharmaceutical applications, hydrogenase, vitamin B12-like systems, and metalloproteins. It is written by the top researchers in the field and compiled by editors Toshikazu Hirao and Toshiyuki Moriuchi. Developments in this new field of bioorganometallic chemistry, a hybrid between biology and organometallic chemistry, happen very quickly and this comprehensive reference offers the latest research and findings in the field. The book features a discussion of the synthesis, structure, and reactivity of bioorganometallics, and an examination of hydrogenase-like systems, which were designed to demonstrate catalytic activities and functional properties. Advances in Bioorganometallic Chemistry also includes a discussion of bioorganometallics as they relate to medicinal chemistry, specifically applications of metalloproteins, metalloenzymes, and applications in bioimaging. The book concludes with coverage of vitamin B12-like systems, including the latest developments in derivatives designed to perform bio-inspired catalytic reactions. This work is a valuable resource for chemists working in organometallic chemistry and biology, including biochemists, bioorganic chemists, bioinorganic chemists, as well as pharmaceutical scientists, medicinal chemists, and students studying in these areas. Representative authors: R. H. Fish, T. Moriuchi, T. Hirao, H.-B. Kraatz, H. Takaya, T. P. Curran, G. van Koten. E. Rosenberg, J. M. Lynam, C. G. Hartinger, U. Schatzschneider, G. S. Smith, R. Alberto,S. Takenaka, T. Ihara, T. Hayashi, T. Ueno, P. Schollhammer, Y. Shomura, Y. Hisaeda, H. Shimakoshi, B. Kräutler

    • Reactive Species Detection in Biology

      From Fluorescence to Electron Paramagnetic Resonance Spectroscopy
      • 1st Edition
      • Frederick A. Villamena
      • English
      Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis, computations, or experimental applications.

    • Purines, Pyrimidines and Nucleotides and the Chemistry of Nucleic Acids

      • 1st Edition
      • T. L. V. Ulbricht
      • Robert Robinson
      • English
      Purines, Pyrimidines and Nucleotides and the Chemistry of Nucleic Acids is a five-chapter text that presents a simple introduction to the basic chemistry of purines and pyrimidines and their derivatives. The opening chapters describe the general properties, reactions, and synthesis of purines and pyrimidines. The next chapter deals with the structure, synthesis, mechanism, and stereochemistry of nucleosides and their analogues. These topics are followed by a discussion on the reactions and biosynthesis of nucleotides. The final chapter focuses on the structure and biosynthesis of DNA, RNA, and other nucleic acids. This book is of value to organic chemists and biochemists, as well as researchers in the allied fields.

    • Applications of NMR Spectroscopy: Volume 2

      • 1st Edition
      • Atta-ur Rahman + 1 more
      • English
      Applications of NMR Spectroscopy, Volume 2, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of plant polyphenols, the role of NMR spectroscopy in neuroradiology, NMR–based sensors, studies on protein and nucleic acid structure and function, and mathematical formations for NMR spectroscopy in structural biology. The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field.

    • Techniques in Protein Chemistry

      • 1st Edition
      • Tony Hugli
      • English
      Techniques in Protein Chemistry compiles reports of methods and techniques presented at the second symposium of the Protein Society in August 1988. This book includes methods and applications in protein sequencing, advanced applications of mass spectrometry and nuclear magnetic resonance technology, limitations of amino acid microanalysis, and advances in high-performance liquid chromatography. The structure of synthetic test peptide-3 (STP-3), a peptide designed to test the analytical limits of current technology in the field of protein chemistry is also elaborated. This publication is suited for chemists and researchers conducting work on the analytical techniques available for the molecular characterization of proteins.