Semisynthesis of Bioactive Compounds and their Biological Activities
- 1st Edition - November 25, 2023
- Imprint: Elsevier
- Authors: Sasadhar Majhi, Sivakumar Manickam
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 6 9 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 7 0 - 2
Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural d… Read more
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Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented.
Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.
- Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives.
- Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts.
- Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.
Medicinal chemists, Synthetic and semisynthetic chemists, Biochemists, Pharmacologists, Botanists, Green chemists, Phytochemists, Researchers, and students in the associated fields
1. Introduction1a. Concept of semisynthesis1b. Why do we need semisynthesis?1c.Recent advances in the potential applications of semisynthetic derivatives (R2)1d. Relationship of semisynthesis to drug delivery (R2)2. Semisynthesis of Antibiotics2a. Current resistance mechanisms of antibiotics2b. Chemical derivatization of antibiotics2c. Recent advances in the clinical applications of antibiotics and their analogues (R2)3. Semisynthesis of Alkaloids3a. Function of plant alkaloids on human health3b. Semisynthetic modification of alkaloids3c. Semisynthesis of bioactive marine alkaloids (R2)3d. Recent progress in semisynthesis and potential applications of semisynthetic alkaloid derivatives (R2)4. Semisynthesis of Flavones4a. Spectral characteristics of flavonoids (R2)4b. Chemical derivatization of flavones4c. Chemistry and biological activities of flavones and their analogues5. Semisynthesis of Lignans5a. Gastrointestinal tract metabolism of lignans in humans5b. Chemical derivatization of lignans5c. Recent developments in the bioactivities of semisynthetic lignan analogues ( R2)6. Semisynthesis of Phenolic Compounds6a. Ultrasound-assisted extraction of phenolic compounds 6b. Microwave-mediated extraction of phenolic compounds6c. Chemical derivatization of phenolic compounds6d. Recent advances on the bioactivities of semisynthetic derivatives of phenolic compounds (R2)7. Semisynthesis of Anthocyanins7a. Anthocyanins as food colourants and additives7b. The effect of pH on the chemical structure of anthocyanins7c. Chemical derivatization of anthocyanins7d. Anticancer activities of chemically modified anthocyanins 8. Semisynthesis of Natural Products at Room Temperature (R2)8a. Concept of room temperature chemical transformations8b. Chemical derivatization of natural products at room temperature8c. Potential agricultural biotechnology applications of semisynthetic derivatives9. Semisynthesis of Natural Products under Greener Conditions9a. Concept of sustainability9b. Semisynthesis of natural products using green tools9c. Semisynthesis of natural products using green solvents9d. Semisynthesis of natural products under catalyst-free conditions9e. Sustainability of natural products as a drug resource (R2)9f. Targeted microbial transformations (R2)10. Semisynthesis of Natural Products through Insertion of Oxygen Atom under Metal-free Conditions10a. Concept of toxicity10b. Merits of metal-free reactions10c. Semisynthesis of different natural products via insertion of an oxygen atom11. An adaptation of organic reactions in the bioactive compounds industry (R1)12. Regulatory aspects of the novel derivative as nutraceuticals (R1)13. Computational chemistry of Natural Product Analogues (R2)13a. Binding studies13b. Molecular modelling13c. Spectroscopic and X-ray analysis of active sites13d. Strategies in biological assessment13e. Molecular networking13f. Machine learning for target identification and synthesis13g. High throughput automated synthesis and testing13h. Summary and use of existing databases for rational drug design13i. Targeted drug repurposing13j. Network pharmacology13k. Additive printing of reaction ware (R2)14. Semi-synthesis for neglected and tropical diseases (R2)
- Edition: 1
- Published: November 25, 2023
- Imprint: Elsevier
- Language: English
SM
Sasadhar Majhi
Sasadhar Majhi received B.Sc. (Honours) degree in Chemistry and M.Sc. (Organic specialization), both from Visva-Bharati (a Central University founded by Rabindranath Tagore, a Nobel laureate). He received M.Phil (Chemistry) in 2009 and obtained a PhD from Visva-Bharati University under the supervision of Prof. Goutam Brahmachari. Currently, he serves as the coordinator of the department of chemistry (UG & PG departments) of Triveni Devi Bhalotia College (Government Sponsored and Affiliated to the Kazi Nazrul University, Asansol, previously affiliated to the Burdwan University), Raniganj, West Bengal, India. He started his professional career as an Assistant Professor of this college and worked as Assistant Lecturer at Patha-Bhavana, Visva-Bharati University (a Central University), Santiniketan, West Bengal. He is a member of IQAC and the Coordinator of the environmental science of TDB College. He teaches undergraduate and postgraduate students of chemistry and also undergraduate students of biochemistry. With over ten years of teaching experience, Dr Majhi has published several research papers in national and international journals of high reputate. Dr Majhi is co-editor of Science and Technology: A Concise History and Evolution. He has also participated in various national and international conferences and symposia. His research interests focus on the isolation and structural determination of natural products, semisynthetic products, total synthesis, green chemistry, as well as biological activities of phytochemicals.
Affiliations and expertise
Department of Chemistry (UG & PG Dept.), Trivenidevi Bhalotia College, Raniganj, Dist-Paschim Bardhaman, West Bengal, India-713347.SM
Sivakumar Manickam
Prof. Sivakumar Manickam (Siva) is a chemical engineer with over 25 years of experience in nanomaterials, nanopharmaceuticals, and process engineering. Currently at the University of Technology Brunei, he previously worked at the University of Nottingham Malaysia, serving in leadership roles including Director of Research and founding director of the Centre for Nanotechnology. His research focuses on cavitation reactors, natural product extraction, water treatment, pharmaceutical nanoemulsions, and biosensors. He has authored over 250 papers, supervised 50+ students, and received numerous awards. He is also an executive editor of Ultrason Sonochem.
Affiliations and expertise
Chemical and Nanopharmaceutical Process Engineering, Department of Chemical and Petroleum Engineering, Faculty of Engineering, Universiti Teknologi BruneiRead Semisynthesis of Bioactive Compounds and their Biological Activities on ScienceDirect