
Semisynthesis of Bioactive Compounds and their Biological Activities
- 1st Edition - November 25, 2023
- Imprint: Elsevier
- Authors: Sasadhar Majhi, Sivakumar Manickam
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 6 9 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 7 0 - 2
Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural d… Read more
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Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented.
Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.
- Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives.
- Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts.
- Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.
- Edition: 1
- Published: November 25, 2023
- Imprint: Elsevier
- Language: English
SM
Sasadhar Majhi
SM
Sivakumar Manickam
Professor Sivakumar Manickam is a Chemical Engineer with a specialization in the process engineering of nanomaterials, especially nanopharmaceuticals, and has over 25 years of experience in this field. He is currently working with the University of Technology Brunei (UTB), Brunei; before that, he worked at the University of Nottingham, International Campus in Malaysia. A major focus of his research is the development of cavitation-based reactors for the production of nanomaterials of technological importance, greener extraction of natural products, water treatment, development of pharmaceutical nanoemulsions, and use of novel carbon nanomaterials to develop biosensors for earlier diagnosis of cancer and diabetes. While at the University of Nottingham, he served in a variety of leadership roles, including Director of Research, Founding Director for the Centre for Nanotechnology and Advanced Materials, Head - Manufacturing and Industrial Research Division and Associate Dean for Research and Knowledge Exchange. He serves as Deputy Dean (Research) of the Faculty of Engineering at UTB. Over the course of his career, he has completed more than 20 industrial and government-funded projects and supervised more than 50 students in research projects. Throughout his career, he has published more than 250 peer-reviewed papers in journals and conferences. According to Scholar Google, he has a h-index of 59. In addition, he is also the Executive Editor of the Ultrasonics Sonochemistry Journal. His affiliations include service on the board of the Asia Oceania Sonochemical Society as well as the Fellow of the Higher Education Academy (UK) and the Fellow of the Royal Society of Chemistry (FRSC).