Semisynthesis of Bioactive Compounds and their Biological Activities
- 1st Edition - November 25, 2023
- Authors: Sasadhar Majhi, Sivakumar Manickam
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 6 9 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 2 7 0 - 2
Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural d… Read more
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Request a sales quoteSemisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented.
Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.
- Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives.
- Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts.
- Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.
- Cover image
- Title page
- Table of Contents
- Copyright
- Chapter One. Preliminary concept of semisynthesis and its importance
- 1.1. Introduction
- Chapter Two. Semisynthesis of antibiotics
- 2.1. Current antibiotic resistance mechanism
- 2.2. Chemical derivatization of antibiotics
- 2.3. Recent advances in the clinical applications of antibiotics and their analogs
- Chapter Three. Semisynthesis of alkaloids
- 3.1. Function of plant alkaloids on human health
- 3.2. Semisynthetic modification of alkaloids
- 3.3. Semisynthesis of bioactive marine alkaloids
- 3.4. Recent progress in semisynthesis and potential applications of semisynthetic alkaloid derivatives
- Chapter Four. Semisynthesis of flavones
- 4.1. Spectral characteristics of flavonoids
- 4.2. Chemical derivatization of flavonoids
- 4.3. Chemistry and biological activities of flavonoids and their analogs
- Chapter Five. Semisynthesis of lignans
- 5.1. Gastrointestinal tract metabolism of lignans in humans
- 5.2. Chemical derivatization of lignans
- 5.3. Recent developments in the bioactivities of semisynthetic lignan analogs
- Chapter Six. Semisynthesis of phenolic compounds
- 6.1. Merits of ultrasound-assisted extraction of phenolic compounds
- 6.2. Microwave-assisted extraction of phenolic compounds
- 6.3. Chemical derivatization of phenolic compounds
- 6.4. Recent advances in the bioactivities of semisynthetic derivatives of phenolic compounds
- Chapter Seven. Semisynthesis of anthocyanins
- 7.1. Anthocyanins as food colorants and additives
- 7.2. The effect of pH on the chemical structure of anthocyanins
- 7.3. Chemical derivatization of anthocyanins
- 7.4. Anticancer activities of anthocyanidins and their derivatives
- Chapter Eight. Semisynthesis of natural products at room temperature
- 8.1. Room-temperature chemical transformations: a concept
- 8.2. Chemical derivatization of natural products at room temperature
- 8.3. Potential agricultural biotechnology applications of semisynthetic derivatives
- Chapter Nine. Semisynthesis of natural products under greener conditions
- 9.1. Concept of sustainability
- 9.2. Semisynthesis of natural products using green tools
- 9.3. Semisynthesis of natural products using water as a green solvent
- 9.4. Sustainability of natural products as a drug resource
- 9.5. Targeted microbial transformations
- Chapter Ten. Semisynthesis of natural products through the insertion of oxygen atom under metal-free conditions
- 10.1. Concept of toxicity
- 10.2. Merits of metal-free reactions
- 10.3. Semisynthesis of different natural products via insertion of the oxygen atom
- Chapter Eleven. Adaptation of organic reactions in the industrial production of bioactive compounds
- 11.1. Cholesterol-lowering drug
- 11.2. Analgesic drug
- 11.3. Antimalarial drug
- 11.4. Anti-influenza
- 11.5. Inhibitory neurotransmitter
- 11.6. Anticancer drug
- 11.7. Miscellaneous
- Chapter Twelve. New derivatives as nutraceuticals: regulatory considerations
- 12.1. Nutraceutical
- 12.2. Regulatory Aspects
- Chapter Thirteen. Computational chemistry of natural product analogues
- 13.1. Binding studies
- 13.2. Molecular modeling
- 13.3. Spectroscopic and X-ray analysis of active sites
- 13.4. Strategies in biological assessment
- 13.5. Molecular networking
- 13.6. Machine learning for target identification and synthesis
- 13.7. High throughput automated synthesis and testing
- 13.8. An overview of existing databases and their use in rational drug design
- 13.9. Repurposing of targeted drugs
- 13.10. Network pharmacology
- 13.11. 3D printing of reactionware (additive manufacturing)
- Chapter Fourteen. Developing semisynthesis methods for neglected tropical diseases
- 14.1. Brief overview of neglected tropical diseases (NTDs)
- 14.2. Development of semisynthesis methods for neglected tropical diseases
- Index
- No. of pages: 500
- Language: English
- Edition: 1
- Published: November 25, 2023
- Imprint: Elsevier
- Paperback ISBN: 9780443152696
- eBook ISBN: 9780443152702
SM
Sasadhar Majhi
SM
Sivakumar Manickam
Professor Sivakumar Manickam is a Chemical Engineer with a specialization in the process engineering of nanomaterials, especially nanopharmaceuticals, and has over 25 years of experience in this field. He is currently working with the University of Technology Brunei (UTB), Brunei; before that, he worked at the University of Nottingham, International Campus in Malaysia. A major focus of his research is the development of cavitation-based reactors for the production of nanomaterials of technological importance, greener extraction of natural products, water treatment, development of pharmaceutical nanoemulsions, and use of novel carbon nanomaterials to develop biosensors for earlier diagnosis of cancer and diabetes. While at the University of Nottingham, he served in a variety of leadership roles, including Director of Research, Founding Director for the Centre for Nanotechnology and Advanced Materials, Head - Manufacturing and Industrial Research Division and Associate Dean for Research and Knowledge Exchange. He serves as Deputy Dean (Research) of the Faculty of Engineering at UTB. Over the course of his career, he has completed more than 20 industrial and government-funded projects and supervised more than 50 students in research projects. Throughout his career, he has published more than 250 peer-reviewed papers in journals and conferences. According to Scholar Google, he has a h-index of 59. In addition, he is also the Executive Editor of the Ultrasonics Sonochemistry Journal. His affiliations include service on the board of the Asia Oceania Sonochemical Society as well as the Fellow of the Higher Education Academy (UK) and the Fellow of the Royal Society of Chemistry (FRSC).