Semisynthesis of Bioactive Compounds and their Biological Activities

1st Edition - November 25, 2023
Authors: Sasadhar Majhi, Sivakumar Manickam
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 2 6 9 - 6
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 2 7 0 - 2

Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural d… Read more

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Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented.

Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development.

Cover image
Title page
Table of Contents
Copyright
Chapter One. Preliminary concept of semisynthesis and its importance
1.1. Introduction
Chapter Two. Semisynthesis of antibiotics
2.1. Current antibiotic resistance mechanism
2.2. Chemical derivatization of antibiotics
2.3. Recent advances in the clinical applications of antibiotics and their analogs
Chapter Three. Semisynthesis of alkaloids
3.1. Function of plant alkaloids on human health
3.2. Semisynthetic modification of alkaloids
3.3. Semisynthesis of bioactive marine alkaloids
3.4. Recent progress in semisynthesis and potential applications of semisynthetic alkaloid derivatives
Chapter Four. Semisynthesis of flavones
4.1. Spectral characteristics of flavonoids
4.2. Chemical derivatization of flavonoids
4.3. Chemistry and biological activities of flavonoids and their analogs
Chapter Five. Semisynthesis of lignans
5.1. Gastrointestinal tract metabolism of lignans in humans
5.2. Chemical derivatization of lignans
5.3. Recent developments in the bioactivities of semisynthetic lignan analogs
Chapter Six. Semisynthesis of phenolic compounds
6.1. Merits of ultrasound-assisted extraction of phenolic compounds
6.2. Microwave-assisted extraction of phenolic compounds
6.3. Chemical derivatization of phenolic compounds
6.4. Recent advances in the bioactivities of semisynthetic derivatives of phenolic compounds
Chapter Seven. Semisynthesis of anthocyanins
7.1. Anthocyanins as food colorants and additives
7.2. The effect of pH on the chemical structure of anthocyanins
7.3. Chemical derivatization of anthocyanins
7.4. Anticancer activities of anthocyanidins and their derivatives
Chapter Eight. Semisynthesis of natural products at room temperature
8.1. Room-temperature chemical transformations: a concept
8.2. Chemical derivatization of natural products at room temperature
8.3. Potential agricultural biotechnology applications of semisynthetic derivatives
Chapter Nine. Semisynthesis of natural products under greener conditions
9.1. Concept of sustainability
9.2. Semisynthesis of natural products using green tools
9.3. Semisynthesis of natural products using water as a green solvent
9.4. Sustainability of natural products as a drug resource
9.5. Targeted microbial transformations
Chapter Ten. Semisynthesis of natural products through the insertion of oxygen atom under metal-free conditions
10.1. Concept of toxicity
10.2. Merits of metal-free reactions
10.3. Semisynthesis of different natural products via insertion of the oxygen atom
Chapter Eleven. Adaptation of organic reactions in the industrial production of bioactive compounds
11.1. Cholesterol-lowering drug
11.2. Analgesic drug
11.3. Antimalarial drug
11.4. Anti-influenza
11.5. Inhibitory neurotransmitter
11.6. Anticancer drug
11.7. Miscellaneous
Chapter Twelve. New derivatives as nutraceuticals: regulatory considerations
12.1. Nutraceutical
12.2. Regulatory Aspects
Chapter Thirteen. Computational chemistry of natural product analogues
13.1. Binding studies
13.2. Molecular modeling
13.3. Spectroscopic and X-ray analysis of active sites
13.4. Strategies in biological assessment
13.5. Molecular networking
13.6. Machine learning for target identification and synthesis
13.7. High throughput automated synthesis and testing
13.8. An overview of existing databases and their use in rational drug design
13.9. Repurposing of targeted drugs
13.10. Network pharmacology
13.11. 3D printing of reactionware (additive manufacturing)
Chapter Fourteen. Developing semisynthesis methods for neglected tropical diseases
14.1. Brief overview of neglected tropical diseases (NTDs)
14.2. Development of semisynthesis methods for neglected tropical diseases
Index

Sasadhar Majhi

Sasadhar Majhi received B.Sc. (Honours) degree in Chemistry and M.Sc. (Organic specialization), both from Visva-Bharati (a Central University founded by Rabindranath Tagore, a Nobel laureate). He received M.Phil (Chemistry) in 2009 and obtained a PhD from Visva-Bharati University under the supervision of Prof. Goutam Brahmachari. Currently, he serves as the coordinator of the department of chemistry (UG & PG departments) of Triveni Devi Bhalotia College (Government Sponsored and Affiliated to the Kazi Nazrul University, Asansol, previously affiliated to the Burdwan University), Raniganj, West Bengal, India. He started his professional career as an Assistant Professor of this college and worked as Assistant Lecturer at Patha-Bhavana, Visva-Bharati University (a Central University), Santiniketan, West Bengal. He is a member of IQAC and the Coordinator of the environmental science of TDB College. He teaches undergraduate and postgraduate students of chemistry and also undergraduate students of biochemistry. With over ten years of teaching experience, Dr Majhi has published several research papers in national and international journals of high reputate. Dr Majhi is co-editor of Science and Technology: A Concise History and Evolution. He has also participated in various national and international conferences and symposia. His research interests focus on the isolation and structural determination of natural products, semisynthetic products, total synthesis, green chemistry, as well as biological activities of phytochemicals.

Affiliations and expertise

Department of Chemistry (UG & PG Dept.), Trivenidevi Bhalotia College, Raniganj, Dist-Paschim Bardhaman, West Bengal, India-713347.

Sivakumar Manickam

Professor Sivakumar Manickam is a Chemical Engineer with a specialization in the process engineering of nanomaterials, especially nanopharmaceuticals, and has over 25 years of experience in this field. He is currently working with the University of Technology Brunei (UTB), Brunei; before that, he worked at the University of Nottingham, International Campus in Malaysia. A major focus of his research is the development of cavitation-based reactors for the production of nanomaterials of technological importance, greener extraction of natural products, water treatment, development of pharmaceutical nanoemulsions, and use of novel carbon nanomaterials to develop biosensors for earlier diagnosis of cancer and diabetes. While at the University of Nottingham, he served in a variety of leadership roles, including Director of Research, Founding Director for the Centre for Nanotechnology and Advanced Materials, Head - Manufacturing and Industrial Research Division and Associate Dean for Research and Knowledge Exchange. He serves as Deputy Dean (Research) of the Faculty of Engineering at UTB. Over the course of his career, he has completed more than 20 industrial and government-funded projects and supervised more than 50 students in research projects. Throughout his career, he has published more than 250 peer-reviewed papers in journals and conferences. According to Scholar Google, he has a h-index of 59. In addition, he is also the Executive Editor of the Ultrasonics Sonochemistry Journal. His affiliations include service on the board of the Asia Oceania Sonochemical Society as well as the Fellow of the Higher Education Academy (UK) and the Fellow of the Royal Society of Chemistry (FRSC).

Affiliations and expertise

Chemical and Nanopharmaceutical Process Engineering, Department of Chemical and Petroleum Engineering, Faculty of Engineering, Universiti Teknologi Brunei

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health