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Antimicrobial Peptides
A Roadmap for Accelerating Discovery and Development
- 1st Edition - December 1, 2024
- Editors: Luis H. Reyes, Juan C. Cruz, Gregory R. Wiedman
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 9 3 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 3 9 4 - 5
Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process o… Read more
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Request a sales quoteAntimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide.
Discovering novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.
- Covers computational tools (including emerging artificial intelligence algorithms) and microfluidic systems for discovery and high-throughput screening of AMPs
- Discusses the application of bioprocess engineering scale-up approaches for AMPs' production and purification with the aid of process simulation tools and rapid prototyping
- Highlights user-centered design and formulation of products with AMPs
- Describes the whole pipeline for AMPs production
Organic chemists, analytical chemists, formulation chemists, Translational scientists, bioanalytical scientists
Introduction. Antimicrobial peptides: from the bench to the bedside
Section 1. Computational approaches
1. Bioinformatic methods for the design of antimicrobial peptides
2. Fundamentals of molecular dynamics for antimicrobial peptides' discovery
3. Artificial intelligence for the discovery of antimicrobial peptides
4. Computational tools for handling large databases of biological relevance
5. Statistical analysis and data interpretation
Section 2. Experimental approaches
6. Chemical synthesis of peptides: conventional and novel routes
7. Physicochemical and biochemical characterization
8. Non-rational approaches based on microbial surface display
9. Classical and emerging approximations for the screening of peptide libraries
10. Scaling-up of biological production processes
11. Downstream processing
12. Physicochemical and biochemical characterization
Section 3. Translational studies
13. Biological characterization: in vitro and in vivo studies
14. Pre-clinical and clinical studies
15. Formulation and product design
16. Packaging, long-term stability, and usability
17. Quality control and assurance
- No. of pages: 350
- Language: English
- Edition: 1
- Published: December 1, 2024
- Imprint: Elsevier
- Paperback ISBN: 9780443153938
- eBook ISBN: 9780443153945
LR
Luis H. Reyes
JC
Juan C. Cruz
GW